Gene_Locus Report

Biblio print

Add to basket

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Gene_locus Report for: xanag-pham

Name Class
xanag-phamNameXanthobacter agilis. o-phthalyl amidase
SpeciesXanthobacter agilis
BlockX
Family6_AlphaBeta_hydrolase
DatabaseSwissProtP0C2Y0 PHAM_XANAG
GenbankI14148
TremblP0C2Y0
NCBI_TaxID47492
PaperBriggs_1996_J.Mol.Catal.B.Enzym_2_53
Black_1996_Biotechnol.Lett_18_875
CommentPhthalimido is a stable protecting group in beta-lactam chemistry but no conventional chemical methods effectively removes this group. xanag-pham catalyzes the removal of the phthalyl group from phthalyl amides generating phthalate and an amine. The enzyme has a broad substrate specificity and hydrolyzes phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines; substitutions allowed on the phthalyl group include 6-F, 6-NH2, 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine.
Proteinxanag-pham
Peptidexanag-pham
SubstrateN-(3-Carboxy-4-nitrophenyl)phthalamidic-acid
Tree_node6_AlphaBeta_hydrolase8265
Abhydrolase_653724

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer