Type Inhibitor

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Type_inhibitor Report for: Alkyl linked bis-ligand

Multitarget compound inhibitors of cholinesterase often bear an alkyl linker that span the active site gorge from the catalytic anionic site to the peripheral anionic site.

InhibitorMain targeted enzyme familiesTypeStructure
(R)-Tacrine(10)-HupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Derivative of Tacrine | Quinoline
(S,S)-(-)-bis(10)-hupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Quinoline
(S,S)-(-)-bis(12)-hupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Quinoline
3,5-dihydroxybenzamido-huprine-hybrid-11ACHE | BCHE Alkyl linked bis-ligand | BACE1-inhibitor | Derivative of Huperzine | Multitarget
8U2-7AIX7AY-compound5iACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8U5-7AIW-compound5gACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UE-7AIV-compound5fACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UH-7AIS-compound5bACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UK-7AIT-compound5cACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UQ-7AIU-compound5dACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
Aroylacrylic-acid-amide-Tacrine-10ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine
Bis-galanthamineACHE Alkaloid | Alkyl linked bis-ligand | Derivative of Galanthamine
Bis3-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bis5-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bis7-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bivalent-4-Aminopyridine-12iACHE Alkyl linked bis-ligand | Pyridine
C0I-7QHDBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Indole | Piperidine
C4I-7QHEBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Naphthalen | Piperidine
CHEMBL4293015 Alkyl linked bis-ligand | Derivative of Donepezil | Indole | Piperidine
Chlorotacrine-jugloneACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Naphthalen | anti-Abeta-aggregation
Cpd14-BChEin-5-HT6 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd27-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd54-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound | tert-Butyl | tert-Butyloxycarbonyl
Cpd70-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget
DTE-bis8-TacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Photoswitch
Methoctramine Alkyl linked bis-ligand | Muscarinic antagonist | Not A/B H target
N-piperidinopropylgalanthamineACHE Alkaloid | Alkyl linked bis-ligand | Derivative of Galanthamine | Natural_modified | Piperidine
N-saccharinohexylgalanthamineACHE Alkaloid | Alkyl linked bis-ligand | Derivative of Galanthamine | Natural_modified | Sulfur Compound
NF595ACHE Alkyl linked bis-ligand | Derivative of Tacrine | Sulfur Compound
NP61ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole
Phenothiazine-Tacrine-1dCACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Phenothiazine | anti-Abeta-aggregation
Phthalimido-Galanthaminium-4dACHE Alkaloid | Alkyl linked bis-ligand | Derivative of Galanthamine | Isoindole | Natural_modified | Phthalimido
Phthalimido-Galanthaminium-8dACHE Alkaloid | Alkyl linked bis-ligand | Derivative of Galanthamine | Isoindole | Natural_modified | Phthalimido
SCHEMBL1532301 Acridine | Alkyl linked bis-ligand | Derivative of Donepezil | Derivative of Tacrine | Isoindol
Salicylamide-8-TacrineACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Salicylic
TZ2PIQA5 Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Quinoline | Triazol
Tacrine(8)-4-aminoquinolineACHE Alkyl linked bis-ligand | Derivative of Tacrine | Quinoline
Tacrine-BenzofuranACHE Acridine | Alkyl linked bis-ligand | BACE1-inhibitor | Benzofuran | Derivative of Tacrine | Multitarget
Tacrine-dipicolylamine-13a Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Tacrine-methylanacardate-cpd5BCHE Alkyl linked bis-ligand | Benzoate | Derivative of Tacrine | Multitarget | Salicylic
Tacrine-nicotinamideACHE Alkyl linked bis-ligand | Carboxamide | Derivative of Nicotine | Derivative of Tacrine | Nicotinamide
Tacrine-pentylmethylene-tolylsulfonamide Alkyl linked bis-ligand | Derivative of Tacrine
Tz2Pa5-anti1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa5-syn1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa6-anti1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa6-syn1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
bis9-(-)-nor-meptazinolACHE Alkyl linked bis-ligand | Azepane

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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