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Type_inhibitor Report for: Indole

Fusion of benzene and pyrazole. Building block for many inhibitors of enzymes. Indole has only one nitrogen atom in position 1 of the pyrazol. Indazol is an analog with nitrogen atoms in position 1 and 2. Benzimidazole, an analog with the nitrogen atoms in positions 1 and 3.

InhibitorMain targeted enzyme familiesTypeStructure
1-methylindol-3-oneACHE Indole
6QAA-HUNBCHE Derivative of Tryptophan | Indole
6QAB-HUQBCHE Derivative of Tryptophan | Indole
6QAC-HUTBCHE Derivative of Tryptophan | Indole
6QAD-HUZBCHE Derivative of Tryptophan | Indole
6QAE-HUKBCHE Derivative of Tryptophan | Indole
6XTA-cpd18BCHE Azepane | Derivative of Tryptophan | Indole
A87-7BO4BCHE Cycloheptyl | Derivative of Tryptophan | Indole
ARUK3002704Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003718Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003906Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003907Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003910Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3004048 Fragment inhibitor of Notum | Indole
ARUK3004308Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004470Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004552Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004556Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004558Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004876Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3004877Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004903Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3005518Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3005522Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3006560Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006561Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006562Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
C0I-7QHDBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Indole | Piperidine
CHEMBL4293015 Alkyl linked bis-ligand | Derivative of Donepezil | Indole | Piperidine
CHEMBL57478Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Piperidine
Cpd-6-8AI7BCHE Carbamate | Indole
Cpd14-BChEin-5-HT6 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd27-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd37-Fluoroindol-carbamateMonoglyceridelipase_lysophospholip Carbamate | FAAH inhibitor | Indole | Multitarget
Cpd54-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound | tert-Butyl | tert-Butyloxycarbonyl
Cpd70-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget
Dihydroindole-thiourea-73Epoxide_hydrolase 5-Lipoxygenase inhibitor | Indole | Multitarget | Sulfur Compound | Urea derivative
GramineACHE | BCHE Alkaloid | Indole | Natural | Not A/B H target
HypaphorineACHE Derivative of Tryptophan | Indole | Natural | Not A/B H target | Propionate
IA4-7BO3BCHE Cycloheptyl | Derivative of Tryptophan | Indole
ICeD-2 Indole | Pyrrolidine
Indol-carbodithioate-azepaneLipase_3 Azepane | Indole | Sulfur Compound
Indolesufonamide1DPP4N_Peptidase_S9 Indole | Sulfonamide | Sulfur Compound
Isatin-thiosemicarbazone-cpd13 Indole | Urea derivative
Lys-phospho-isoindolineDPP4N_Peptidase_S9 Acetanilide | Indole | Organophosphate | Peptide
NP61ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole
PsilocybinACHE | BCHE Alkaloid | Indole | Natural | Organophosphate
ZINC12863377Monoglyceridelipase_lysophospholip Carboxamide | Indole | Pyrrolidine
ZINC59501712BCHE Indole | Phthalimido | Sulfonamide | Sulfur Compound

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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