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Type_inhibitor Report for: Multitarget

Multitarget directed ligand (MTDL). In case of Alzheimer disease enzymes or pathways targeted include: Inhibition of AChE and or BCHE, Inhibition of glycogen synthase kinase-3 (GSK-3 kinase), BACE1-inhibitor (beta-secretase-1), antioxidant, Cannabinoid-Receptor-ligand, Sigma1R, Histamine-Receptor3-H3-Antagonist, H1-antihistamine, 5-HT-receptor-agonist, NMDA-ligand, Ca2+ channels block, Abeta aggregation, Metal ion chelator. Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. The targets include in these cases soluble epoxide hydrolase (sEH), 5-lipoxygenase (5-LOX), LTA4-hydrolase-inhibitor, dual sEH/FAAH

InhibitorMain targeted enzyme familiesTypeStructure
11a-quinoxalineACHE | BCHE | Cholinesterase Histamine-Receptor3-H3-Antagonist | Multitarget | Quinoxaline
15d-PGJ2Epoxide_hydrolase Multitarget | PPARgamma ligand
18-E100ACHE | BCHE | Cholinesterase Azepane | Histamine-Receptor3-H3-Antagonist | Multitarget | Piperidine
3,5-dihydroxybenzamido-huprine-hybrid-11ACHE | BCHE Alkyl linked bis-ligand | BACE1-inhibitor | Derivative of Huperzine | Multitarget
3-butyl-6-benzyloxyphthalide-Mannich-base-7dACHE Benzofuran | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
40VBCHE Carboxamide | Inden | Metal ion chelator | Multitarget | Piperidine | Quinoline
4c2-AChE-IN-24 Multitarget | Piperidine | Sulfur Compound
6F7Q-cpd11BCHE Antioxidant | Carboxamide | Inden | Metal ion chelator | Multitarget | Piperidine | Quinoline
6H12-(R)2ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative
6H13-(R)3ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative
6H14-(S)6ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative | beta-carboline
6SAM-cpd13BCHE Carbamate | Inden | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
6ZWE-Cpd3ACHE | BCHE Antioxidant | Benzodioxo | Multitarget
6o-5-HT3ACHE | BCHE 5-HT-receptor-ligand | Carboxamide | Derivative of Tacrine | Multitarget
7QAK-Cpd1 Coumarin | Monoamine-oxidase-inhibitor | Multitarget
7QB4-Cpd2 Coumarin | Derivative of Donepezil | Monoamine-oxidase-inhibitor | Multitarget
8U2-7AIX7AY-compound5iACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8U5-7AIW-compound5gACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UE-7AIV-compound5fACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UH-7AIS-compound5bACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UK-7AIT-compound5cACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UQ-7AIU-compound5dACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
ACHE-GSK-3-27gACHE Derivative of Tacrine | GSK-3 kinase inhibitor | Multitarget
AI0-7QBQ Monoamine-oxidase-inhibitor | Multitarget | Quinoline
AI6-7QBR Monoamine-oxidase-inhibitor | Multitarget | Piperazine | Quinoline | tert-Butyl
AM6701ABHD6-Lip | Monoglyceridelipase_lysophospholip Biphenyl | Cannabinoid-Receptor-ligand | Carboxamide | FAAH inhibitor | Multitarget | Tetrazol | Urea derivative
ARN14140ACHE Derivative of Galanthamine | Multitarget | NMDA-ligand
ASS234ACHE Monoamine-oxidase-inhibitor | Multitarget | Piperidine
Amantadine-M30D-hybrid5e Adamantyl | Carbamate | Monoamine-oxidase-inhibitor | Multitarget
Ass-IN-10BCHE BACE1-inhibitor | Multitarget | anti-Abeta-aggregation | anti-tau-aggregation | tert-Butyl
BIA-10-2474ABHD6-Lip | Carb_B_Chordata Carboxamide | FAAH inhibitor | Imidazole | Multitarget | Pyridine
BIGI-3hACHE | BCHE Calcium Channel Antagonist | GSK-3 kinase inhibitor | Monoamine-oxidase-inhibitor | Multitarget | anti-Abeta-aggregation
CB1R-ACHE-20ACHE Cannabinoid-Receptor-ligand | Carboxamide | Derivative of Tacrine | Imidazole | Multitarget
CB2R-BCHE-20aBCHE Cannabinoid-Receptor-ligand | Carboxamide | Imidazole | Multitarget | Piperidine
CB2R-BCHE-xBCHE Cannabinoid-Receptor-ligand | Carboxamide | Imidazole | Multitarget | Piperidine
CHEMBL440526 Carbamate | Coumarin | Multitarget
CHEMBL4442990 Benzofuran | Cannabinoid-Receptor-ligand | Multitarget
Chlorotacrine-jugloneACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Naphthalen | anti-Abeta-aggregation
Chlorotacrine-tryptophan-hybridACHE | BCHE Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
ChlorpromazineACHE | BCHE Drug | Multitarget | Not A/B H target | Phenothiazine | Sulfur Compound
ContilisantACHE | BCHE Histamine-Receptor3-H3-Antagonist | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
Cpd14-BChEin-5-HT6 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd27-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd37-Fluoroindol-carbamateMonoglyceridelipase_lysophospholip Carbamate | FAAH inhibitor | Indole | Multitarget
Cpd54-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound | tert-Butyl | tert-Butyloxycarbonyl
Cpd70-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget
DFAH-12ACHE | BCHE Antioxidant | Derivative of Donepezil | Hydroxycinnamic-ester | Multitarget | Piperidine
DPH6 Derivative of Donepezil | Monoamine-oxidase-inhibitor | Multitarget | Quinoline
Di-tert-butyl-4-Amino-2,3-cycloheptaquinoline-8c Antioxidant | Multitarget | Quinoline | tert-Butyl
Diclofenac-derivative-39ACHE 5-Lipoxygenase inhibitor | Monoamine-oxidase-inhibitor | Multitarget | Pyrazole | Sulfonamide | Sulfur Compound
Dihydroindole-thiourea-73Epoxide_hydrolase 5-Lipoxygenase inhibitor | Indole | Multitarget | Sulfur Compound | Urea derivative
Dihydroquinazoline-carboxamide-34Epoxide_hydrolase 5-Lipoxygenase inhibitor | Carboxamide | Multitarget | Quinazoline | Sulfur Compound
DimethylhydroxycarbaphenBCHE Carbamate | Multitarget | Muscarinic antagonist | Not A/B H target | Pro-Drug | Propionate
DonecoprideACHE 5-HT-receptor-ligand | Derivative of Donepezil | Multitarget | Piperidine
Donepezil-8-Hydroxyquinoline-2bBCHE Antioxidant | Derivative of Donepezil | Multitarget | Quinoline
Donepezil-Melatonin-4u Antioxidant | Derivative of Donepezil | Derivative of Tryptamine | Multitarget
Donepezil-idebenone-cpd9BCHE Antioxidant | Derivative of Donepezil | Multitarget | anti-Abeta-aggregation
Evodiamine Derivative of Evodiamine | Multitarget | Natural | Not A/B H target | beta-carboline
FL217Epoxide_hydrolase Cyclopropyl | Multitarget | PPARgamma ligand
FluoropezilACHE Antioxidant | Derivative of Donepezil | Multitarget | Sulfur Compound
IDFPMonoglyceridelipase_lysophospholip | PC-sterol_acyltransferase FAAH inhibitor | Multitarget | Organophosphate
IDFPenPC-sterol_acyltransferase FAAH inhibitor | Multitarget | Organophosphate
Idalopirdine-rivastigmineBCHE 5-HT-receptor-ligand | Carbamate | Derivative of Rivastigmine | Drug | Multitarget | Pro-Drug
JM-20 Benzodiazepin | Multitarget | Not A/B H target | Pyridine
JZL184ABHD6-Lip | Carb_B_Chordata | Monoglyceridelipase_lysophospholip Benzodioxo | FAAH inhibitor | Multitarget | Piperidine | pNP
JZL195ABHD6-Lip | Carb_B_Chordata | Monoglyceridelipase_lysophospholip FAAH inhibitor | Multitarget | Phenoxyphenyl | Piperazine | pNP
LY2183240ABHD6-Lip | Arylacetamide_deacetylase | Monoglyceridelipase_lysophospholip Biphenyl | Cannabinoid-Receptor-ligand | Carboxamide | FAAH inhibitor | Multitarget | Tetrazol | Urea derivative
LadostigilACHE | BCHE Carbamate | Drug | Inden | Monoamine-oxidase-inhibitor | Multitarget
LipocrineACHE Antioxidant | Derivative of Tacrine | Multitarget | Sulfur Compound
M30DACHE Carbamate | Monoamine-oxidase-inhibitor | Multitarget | Quinoline
MT-031ACHE | BCHE Carbamate | Monoamine-oxidase-inhibitor | Multitarget
MTDL-cpd36-diphenylacetamideBCHE BACE1-inhibitor | Diphenylacetamide | GABA-transporter-inhibitor | Multitarget | anti-Abeta-aggregation | tert-Butyl
MTDL-cpd51-diphenylacetamideBCHE BACE1-inhibitor | Diphenylacetamide | GABA-transporter-inhibitor | Multitarget | anti-Abeta-aggregation
Mebbpp Derivative of Donepezil | Multitarget | Piperidine | Sulfur Compound
MemoquinACHE Antioxidant | BACE1-inhibitor | Multitarget
Methyl-arachidonyl-fluorophosphonateCGI-58_ABHD5_ABHD4 | Monoglyceridelipase_lysophospholip | PC-sterol_acyltransferase Cannabinoid-Receptor-ligand | FAAH inhibitor | Multitarget | Organophosphate
Methylene-blueACHE | BCHE Drug | Dye | Multitarget | Phenothiazine | Sulfur Compound | anti-tau-aggregation
Methylene-blue-carboline-2ACHE | BCHE | Cholinesterase Drug | Dye | Multitarget | Phenothiazine | Sulfur Compound | beta-carboline
NMDA-BCHE-C-2hBCHE Carbazol | Multitarget | NMDA-ligand
OWW-6YL4Epoxide_hydrolase 5-Lipoxygenase inhibitor | Multitarget | Trifluoro
PE154ACHE | BCHE Derivative of Tacrine | Hydrazide | Multitarget
PGN33BCHE Cannabinoid-Receptor-ligand | Multitarget
PTUPBEpoxide_hydrolase Multitarget | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro | Urea derivative
PhenothiazineACHE Drug | Multitarget | Not A/B H target | Phenothiazine | Sulfur Compound
Phenothiazine-Tacrine-1dCACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Phenothiazine | anti-Abeta-aggregation
Propargyl-Tacrine-15ACHE | BCHE Alkyne | Derivative of Tacrine | Monoamine-oxidase-inhibitor | Multitarget
Pyridophen-10ACHE Carbamate | Multitarget | Muscarinic antagonist | Not A/B H target | PET probe | Pro-Drug | Propionate
QTC-4-MeOBnEACHE BACE1-inhibitor | Derivative of Tacrine | Multitarget | Triazol
Quinone-polyamine-NSAID-4BCHE 5-Lipoxygenase inhibitor | Multitarget
RS67333ACHE 5-HT-receptor-ligand | Multitarget | Piperidine
SCHEMBL19358888Epoxide_hydrolase Benzoate | FAAH inhibitor | Multitarget | Urea derivative
SPB01403 Carbamate | FAAH inhibitor | Multitarget | Sulfur Compound
Salicylamide-8-TacrineACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Salicylic
Sigma1R-ACHE-6aACHE 5-HT-receptor-ligand | Derivative of Donepezil | Multitarget | Piperidine | Sigma1R
Sigma1R-ACHE-6bACHE 5-HT-receptor-ligand | Derivative of Donepezil | Multitarget | Piperidine | Sigma1R
TFAH-tacrine-ferulic-acid-hybrid-10n Antioxidant | Derivative of Tacrine | Hydroxycinnamic-ester | Multitarget
TK90Epoxide_hydrolase Butyrate | Carboxamide | Multitarget | PPARgamma ligand | Trifluoro
TPPU-6-Chlorotacrine-12cACHE | Epoxide_hydrolase Derivative of Tacrine | Multitarget | Piperidine | Trifluoro | Urea derivative
Tacrine-BenzofuranACHE Acridine | Alkyl linked bis-ligand | BACE1-inhibitor | Benzofuran | Derivative of Tacrine | Multitarget
Tacrine-Melatonin-Feruloyl-5c Antioxidant | Derivative of Tacrine | Derivative of Tryptamine | Hydroxycinnamic-ester | Multitarget
Tacrine-Resveratrol-12ACHE Antioxidant | Derivative of Tacrine | Multitarget
Tacrine-Trolox-7uACHE Antioxidant | Carboxamide | Derivative of Tacrine | Multitarget
Tacrine-dihydropyrimidine-4e Calcium Channel Antagonist | Derivative of Tacrine | Multitarget | Pyrimidine | Quinoline | Sulfur Compound
Tacrine-dipicolylamine-13a Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Tacrine-methylanacardate-cpd5BCHE Alkyl linked bis-ligand | Benzoate | Derivative of Tacrine | Multitarget | Salicylic
URB597Monoglyceridelipase_lysophospholip Biphenyl | Carbamate | FAAH inhibitor | Multitarget
UW-MD-71ACHE | BCHE | Cholinesterase Histamine-Receptor3-H3-Antagonist | Multitarget | Quinazoline
WMY90-5f Derivative of Donepezil | Monoamine-oxidase-inhibitor | Multitarget | Quinoline
ZLWH-23 Carboxamide | Cyclopropane | GSK-3 kinase inhibitor | Multitarget | Piperidine | beta-carboline
ZTL-11 Carboxamide | Cyclopropane | GSK-3 kinase inhibitor | Multitarget | Triazol | beta-carboline
sEH-LTA4H-14Epoxide_hydrolase LTA4-hydrolase-inhibitor | Multitarget | Sulfur Compound | Urea derivative
t-AUCMBEpoxide_hydrolase Adamantyl | Multitarget | Urea derivative
t-MTUCBEpoxide_hydrolase Multitarget | Urea derivative
t-MTUCB-NHEpoxide_hydrolase Multitarget | Urea derivative
t-TUCBEpoxide_hydrolase FAAH inhibitor | Multitarget | Urea derivative

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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