Type Inhibitor

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Type_inhibitor Report for: Natural

Substrates or inhibitors found in nature. Toxins are harmful substances produced within living cells or organisms

Inhibitor	Main targeted enzyme families	Type

1,3-Dibenzylurea	Epoxide_hydrolase	Natural \| Urea derivative

18-carboxymethoxy-cleaviminium	Plant_carboxylesterase	Alkaloid \| Natural

2-Tridecanone	Hydroxynitrile_lyase	Ketone \| Natural

3-Alkylpyridinium-Polymers	ACHE	Natural \| Polymer

5-Deoxystrigol	RsbQ-like	Inden \| Natural \| Plant hormone \| Strigolactone \| Strigolactone receptors ligand

5-hydroxy-tryptamine	ACHE \| BCHE	5-HT-receptor-ligand \| Derivative of Tryptamine \| Natural \| Not A/B H target

Aflatoxin-B1	ACHE	Mycotoxin-metabolite \| Natural \| Toxin

Aflatoxin-M1	ACHE \| BCHE	Mycotoxin-metabolite \| Natural \| Toxin

ArisugacinA	ACHE	Meroterpenoid \| Natural

ArisugacinB	ACHE	Meroterpenoid \| Natural

Atropine	ACHE	Alkaloid \| Drug \| Muscarinic antagonist \| Natural \| Not A/B H target \| Propionate

Berberine	ACHE \| BCHE	Alkaloid \| Benzodioxo \| Isoquinoline \| Natural \| Not A/B H target

Betulinic-acid	ABHD12-PHARC \| Carb_B_Chordata	Natural \| Terpenoid

CGA-134-735	ACHE	Cyclic OP \| Natural \| Organophosphate

CGA-134-736	ACHE	Cyclic OP \| Natural \| Organophosphate

Caffeic-acid-phenethyl-ester	ACHE \| BCHE	Acrylate \| Hydroxycinnamic-ester \| Natural \| Not A/B H target

Caffeine	Lipase_3 \| Pectinacetylesterase-Notum	Alkaloid \| Drug \| Natural \| Not A/B H target \| Purine

Canadine	ACHE \| BCHE \| Cholinesterase	Alkaloid \| Natural

Carltonine-A	BCHE	Alkaloid \| Natural

Carltonine-B	BCHE	Alkaloid \| Natural

Chelerythrine	ACHE	Alkaloid \| Benzodioxo \| Natural \| Not A/B H target \| Phenanthridinium

Choline	ACHE \| BCHE	Natural \| Trimethylammonium

Cinchonidine	BCHE	Alkaloid \| Derivative of Cinchonine \| Natural \| Quinoline

Cinchonine	BCHE	Alkaloid \| Derivative of Cinchonine \| Natural \| Quinoline

Cinnamoylphosphoramide	ACHE	Natural \| Organophosphate

Cocaine	BCHE	Alkaloid \| Benzoate \| Drug \| Natural \| Not A/B H target

Coelenteramide	Haloalkane_dehalogenase-HLD2	Luciferin \| Natural

Cotinine	Pectinacetylesterase-Notum	Alkaloid \| Derivative of Nicotine \| Drug \| Natural \| Nicotinic agonist \| Not A/B H target \| Pyrrolidine

Crystal-Violet	ACHE \| BCHE	Dye \| Natural \| Triarylmethane

Cyclipostin-P	Cutinase \| Hormone-sensitive_lipase_like \| Monoglyceridelipase_lysophospholip	Cyclic OP \| Lipase inhibitor \| Natural \| Organophosphate

Cyclophostin	ACHE	Cyclic OP \| Natural \| Organophosphate

Cynaroside	Lipoprotein_Lipase	Glycoside \| Natural

D-tubocurarine	ACHE	Alkaloid \| Drug \| Natural \| Neuromuscular Nondepolarizing Agents \| Not A/B H target

Debromoflustramine-B	BCHE	Derivative of physostigmine-eserine \| Natural \| Pyrrolidine

Decanoate	Hydroxynitrile_lyase \| Lipase_3 \| Pectinacetylesterase-Notum	Fatty acid \| Natural

Dehydroevodiamine	ACHE	Derivative of Evodiamine \| Natural \| Natural_modified \| Pyridine \| beta-carboline

Desoxypeganine	ACHE \| BCHE	Alkaloid \| Natural \| Not A/B H target \| Quinazoline

Didemnin-B	Palmitoyl-protein_thioesterase	Carboxamide \| Natural \| Peptide \| Pyrrolidine

Dihydrobetulonic-acid	ABHD12-PHARC	Natural \| Terpenoid

Dihydrotanshinone-I	ACHE \| Carb_B_Chordata	Benzofuran \| Natural

Ebelactone-A	ACPH_Peptidase_S9 \| Homoserine_transacetylase \| Pancreatic_lipase	Natural \| Oxooxetan

Ebelactone-B	Carboxypeptidase_S10 \| Cutinase \| Hepatic_Lipase \| Lipoprotein_Lipase \| Pancreatic_lipase	Natural \| Oxooxetan

Emetine	Hydrolase_RBBP9_YdeN	Alkaloid \| Drug \| Isoquinoline \| Natural \| Quinoline

Epicatechin-gallate	Arylacetamide_deacetylase	Benzoate \| Derivative of Gallate \| Natural \| Polyphenol

Epigallocatechin-gallate	Arylacetamide_deacetylase	Benzoate \| Derivative of Gallate \| Natural \| Polyphenol

Esterastin	Acidic_Lipase \| Pancreatic_lipase	Lipase inhibitor \| Natural \| Oxooxetan

Euphol	ABHD6-Lip \| Monoglyceridelipase_lysophospholip	Natural \| Terpenoid

Evodiamine	BCHE	Derivative of Evodiamine \| Multitarget \| Natural \| Not A/B H target \| beta-carboline

Fasciculin1	ACHE	Natural \| Peptide

Fasciculin2	ACHE	Fasciculin2 variant \| Natural \| Natural_modified \| Peptide

Fasciculin3	ACHE	Natural \| Peptide

Fluoride	BCHE	Inorganic chemicals \| Natural

Galangin	Fungal-Bact_LIP \| Pancreatic_lipase	Flavonoid \| Natural

Galanthamine	ACHE	Alkaloid \| Derivative of Galanthamine \| Drug \| Natural

Geneserine	ACHE \| BCHE	Carbamate \| Natural

Geneseroline		Natural

Geranylphenazinediol	ACHE	Natural \| Phenazine

Ginkgetin	Carb_B_Chordata	Flavonoid \| Natural

Glabridin	Carb_B_Chordata	Flavonoid \| Natural

Goodyschle-A	BCHE	Natural

Gramine	ACHE \| BCHE	Alkaloid \| Indole \| Natural \| Not A/B H target

Guanitoxin	ACHE	Imidazole \| Natural \| Organophosphate

Harmine		Alkaloid \| Natural \| beta-carboline

Hopeahainol-A	ACHE	Benzofuran \| Natural \| Polyphenol

HuperzineA	ACHE	Alkaloid \| Derivative of Huperzine \| Natural

HuperzineB	ACHE	Alkaloid \| Derivative of Huperzine \| Natural

Hydroxy-D-ring	RsbQ-like	Butenolide \| Natural \| Plant hormone \| Strigolactone \| Strigolactone receptors ligand

Hypaphorine	ACHE	Derivative of Tryptophan \| Indole \| Natural \| Not A/B H target \| Propionate

ILAPPER	DPP4N_Peptidase_S9	Natural \| Peptide

Kaempferol	Fungal-Bact_LIP	Flavonoid \| Natural

Kurarinone	Carb_B_Chordata	Flavonoid \| Natural

LASSBio-767	ACHE	Derivative of Spectaline \| Natural \| Piperidine

LASSBio-822	ACHE	Derivative of Spectaline \| Natural \| Piperidine \| tert-Butyl

Laurate	Lipase_3 \| Pectinacetylesterase-Notum	Dodecanoate \| Fatty acid \| Natural

Leupeptin	S9N_PREPL_Peptidase_S9	Natural \| Peptide

Lipstatin	Pancreatic_lipase	Lipase inhibitor \| Natural \| Oxooxetan

Lycocasuarine-C	ACHE	Derivative of Huperzine \| Natural

Lycocasuarinine-D	ACHE	Derivative of Huperzine \| Natural

MMU	Epoxide_hydrolase	Natural \| Urea derivative

Mahanimbine		Alkaloid \| Natural

Maslinic-acid	ABHD12-PHARC	Natural \| Terpenoid

Melatonin	Pectinacetylesterase-Notum	Derivative of Tryptamine \| Natural \| Not A/B H target

Mevastatin	Carb_B_Chordata \| Carboxylesterase	Antibiotic \| Drug \| Naphthalen \| Natural \| Not A/B H target

Mycophenolic-acid	MpaH	Benzofuran \| Natural

Myricetin	Fungal-Bact_LIP	Flavonoid \| Natural

Myristic-acid	Pectinacetylesterase-Notum	Fatty acid \| Natural

Myristoleic-acid	Pectinacetylesterase-Notum	Fatty acid \| Natural

N-acetylserotonin	Pectinacetylesterase-Notum	Derivative of Tryptamine \| Natural \| Not A/B H target

N-demethylhuperzinine	ACHE \| BCHE	Derivative of Huperzine \| Natural

Nevadensin	Carb_B_Chordata	Natural \| Terpenoid

Nicotine	ACHE \| BCHE \| Pectinacetylesterase-Notum	Alkaloid \| Derivative of Nicotine \| Drug \| Natural \| Nicotinic agonist \| Not A/B H target \| Pyrrolidine

Octanoate	AlphaBeta_hydrolase \| Pectinacetylesterase-Notum	Fatty acid \| Natural \| Octanoate

Oleanolic-acid	ACHE	Natural \| Not A/B H target \| Terpenoid

Onchidal	ACHE	Acetate \| Natural

Palmatine		Alkaloid \| Isoquinoline \| Natural \| Not A/B H target

Palmitate	Carb_B_Chordata \| Homoserine_transacetylase \| Lipase_3 \| Palmitoyl-protein_thioesterase	Fatty acid \| Hexadecanoate \| Natural

Palmitoleic-acid	Pectinacetylesterase-Notum	Fatty acid \| Natural

Panclicin-D	Pancreatic_lipase	Natural \| Oxooxetan

ParazoanthoxanthinA	ACHE	Imidazole \| Natural

Pentagalloylglucose	Pancreatic_lipase	Derivative of Gallate \| Natural \| Polyphenol

Physostigmine~Eserine	ACHE \| Arylacetamide_deacetylase \| BCHE	Carbamate \| Derivative of physostigmine-eserine \| Drug \| Natural

Physovenine	ACHE	Carbamate \| Natural

Piperine	Pectinacetylesterase-Notum	Benzodioxo \| Fragment inhibitor of Notum \| Natural \| Piperidine

Pristimerin	Monoglyceridelipase_lysophospholip	Natural \| Terpenoid

Pseudozoanthoxanthin-like	ACHE	Imidazole \| Natural

Psilocybin	ACHE \| BCHE	Alkaloid \| Indole \| Natural \| Organophosphate

Quercetin	Fungal-Bact_LIP	Flavonoid \| Natural

Rosmarinic-acid	AlphaBeta_hydrolase	Hydroxycinnamic-ester \| Natural

Salicylic-acid	Hydroxynitrile_lyase	Natural \| Salicylic

Salinipostin-A	ABHD13-BEM46 \| ABHD17-depalmitoylase \| Duf_676 \| PGAP1 \| Plasmodium_subtelomeric_PST-A	Cyclic OP \| Lipase inhibitor \| Natural \| Organophosphate

Sanguinarine		Alkaloid \| Benzodioxo \| Natural \| Not A/B H target \| Phenanthridinium

Sanguinine	ACHE	Alkaloid \| Derivative of Galanthamine \| Natural

Scopoletin		Coumarin \| Natural

Selagine	ACHE	Derivative of Huperzine \| Natural

Solanidine	BCHE	Alkaloid \| Natural \| Steroid

Solanine	BCHE	Alkaloid \| Carbohydrate \| Glycoside \| Natural

Spermidine	CarbLipBact_2	Natural

Spermine	S9N_PREPL_Peptidase_S9	Natural

Tanshinone-IIA	Carb_B_Chordata	Benzofuran \| Natural

Taurodeoxycholate		Detergent \| Natural \| Steroid \| Surfactant

Taxifolin	ACHE	Flavonoid \| Natural

TerreulactoneA	ACHE	Meroterpenoid \| Natural

TerreulactoneB	ACHE	Meroterpenoid \| Natural

TerreulactoneC	ACHE	Meroterpenoid \| Natural

TerreulactoneD	ACHE	Meroterpenoid \| Natural

TerritremA	ACHE	Benzodioxo \| Meroterpenoid \| Natural

TerritremB	ACHE	Meroterpenoid \| Natural

TerritremC	ACHE	Meroterpenoid \| Natural

Thalictricavine	ACHE \| BCHE \| Cholinesterase	Alkaloid \| Natural

Theophylline	Pectinacetylesterase-Notum	Alkaloid \| Natural \| Not A/B H target

Tiratricol	CFTR-inhibitory-factor_Cif	Drug \| Natural \| Thyroid hormone analogue

Tryptamine	ACHE	Derivative of Tryptamine \| Natural

Ulosantoin	ACHE	Imidazole \| Natural \| Organophosphate

Undecanoic-acid	ABHD6-Lip	Fatty acid \| Natural

Ursolic-acid	ABHD12-PHARC \| ACHE	Natural \| Not A/B H target \| Terpenoid

Valilactone	Pancreatic_lipase	Natural \| Oxooxetan

Vibralactone		Lactone \| Lipase inhibitor \| Natural

Wedelolactone	Epoxide_hydrolase	Natural

ZFR	Zearalenone-hydrolase	Mycotoxin-metabolite \| Natural \| Toxin

ZGR	Zearalenone-hydrolase	Mycotoxin-metabolite \| Natural \| Toxin

Zeatin	ACHE	Natural \| Not A/B H target \| Purine

alpha-Chaconine	BCHE	Alkaloid \| Glycoside \| Natural

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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