Type_inhibitor Report for: Trimethylammonium

Charged part of the choline product of hydrolysis of Acetylcholine. Binds the anionic sites (CAS and PAS) of acetylcholinesterase. Building block for many inhibitors of cholinesterase (analogy with substrate gives the high afinity)

Inhibitor	Main targeted enzyme families	Type

3-Hydroxy-Phenyl-Trimethyl-Ammonium	ACHE	Trimethylammonium

3-Trimethylammonium-aniline	ACHE	Trimethylammonium

4-Trimethylammonium-aniline	ACHE	Trimethylammonium

4-hydroxy-N,N,N-trimethylpentanaminium	ACHE	Analogue of substrate \| Trimethylammonium

4-oxo-N,N,N-trimethylpentanaminium	ACHE	Analogue of substrate \| Trimethylammonium

8AM1-5a	BCHE	Pyridine \| Trimethylammonium

AMTS13	ACHE	Sulfur Compound \| Trimethylammonium

BW62C47	ACHE	Bisquaternary \| Trimethylammonium

BisQ	ACHE	Analogue of substrate \| Bisquaternary \| Nicotinic agonist \| Not A/B H target \| Photoswitch \| Trimethylammonium

CHMP-thiocholine	ACHE	Organophosphate \| Sulfur Compound \| Trimethylammonium

Carbachol	ACHE \| BCHE	Analogue of substrate \| Carbamate \| Drug \| Not A/B H target \| Trimethylammonium

Carpronium	ACHE	Analogue of substrate \| Trimethylammonium

Choline	ACHE \| BCHE	Natural \| Trimethylammonium

DMBMP-thiocholine	ACHE	Organophosphate \| Sulfur Compound \| Trimethylammonium

Decamethonium	BCHE	Bisquaternary \| Drug \| Neuromuscular Nondepolarizing Agents \| Nicotinic antagonist \| Not A/B H target \| Trimethylammonium

Decidium	ACHE	Bisquaternary \| Phenanthridinium \| Trimethylammonium

Demecarium	ACHE \| BCHE	Bisquaternary \| Drug \| Trimethylammonium

EA-3990	ACHE	Bisquaternary \| Carbamate \| Chemical Warfare Agent \| Nerve Agent Carbamate \| Trimethylammonium

EA-4056	ACHE	Bisquaternary \| Carbamate \| Chemical Warfare Agent \| Nerve Agent Carbamate \| Trimethylammonium

Echothiophate	BCHE	Drug \| Organophosphate \| Organothiophosphate \| Sulfur Compound \| Trimethylammonium

Hexamethonium	ACHE	Bisquaternary \| Nicotinic antagonist \| Trimethylammonium

N-p-phenylazophenylcarbamylcholine		Nicotinic agonist \| Not A/B H target \| Photoswitch \| Trimethylammonium

NBD-5-acylcholine	ACHE	Analogue of substrate \| Benzoxadiazole \| NBD-nitro-benzoxadiazol-fluorescent \| Trimethylammonium

Neostigmine~Prostigmine	ACHE \| BCHE	Carbamate \| Trimethylammonium

Nu-1197	ACHE	Carbamate \| Trimethylammonium

Nu-1250	ACHE	Carbamate \| Trimethylammonium

Ro-2-0683	BCHE	Carbamate \| Trimethylammonium

Succinylcholine~Suxamethonium	BCHE	Bisquaternary \| Neuromuscular Nondepolarizing Agents \| Not A/B H target \| Trimethylammonium

T-1123		Carbamate \| Chemical Warfare Agent \| Nerve Agent Carbamate \| Trimethylammonium

TMAmethylborinicacid	ACHE	Boron compound \| Quaternary compound \| Trimethylammonium

TMTFA	ACHE	Halo ketone \| Quaternary compound \| Transition state analogue \| Trifluoro \| Trimethylammonium

Tetramethylammonium	ACHE	Quaternary compound \| Trimethylammonium

p-phenylazophenyltrimethylammonium		Nicotinic agonist \| Not A/B H target \| Photoswitch \| Trimethylammonium

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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