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Type_inhibitor Report for: anti-Abeta-aggregation

The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process

InhibitorMain targeted enzyme familiesTypeStructure
Ass-IN-10BCHE BACE1-inhibitor | Multitarget | anti-Abeta-aggregation | anti-tau-aggregation | tert-Butyl
BIGI-3hACHE | BCHE Calcium Channel Antagonist | GSK-3 kinase inhibitor | Monoamine-oxidase-inhibitor | Multitarget | anti-Abeta-aggregation
Chlorotacrine-jugloneACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Naphthalen | anti-Abeta-aggregation
Chlorotacrine-tryptophan-hybridACHE | BCHE Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
Donepezil-idebenone-cpd9BCHE Antioxidant | Derivative of Donepezil | Multitarget | anti-Abeta-aggregation
MTDL-cpd36-diphenylacetamideBCHE BACE1-inhibitor | Diphenylacetamide | GABA-transporter-inhibitor | Multitarget | anti-Abeta-aggregation | tert-Butyl
MTDL-cpd51-diphenylacetamideBCHE BACE1-inhibitor | Diphenylacetamide | GABA-transporter-inhibitor | Multitarget | anti-Abeta-aggregation
Phenothiazine-Tacrine-1dCACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Phenothiazine | anti-Abeta-aggregation
Tacrine-dipicolylamine-13a Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Tetracyclic-triterpene-36e Natural_modified | Terpenoid | anti-Abeta-aggregation

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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