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Type_inhibitor Report for: Alkyl linked bis-ligand

Multitarget compound inhibitors of cholinesterase often bear an alkyl linker that span the active site gorge from the catalytic anionic site to the peripheral anionic site.

InhibitorMain targeted enzyme familiesTypeStructure
(R)-Tacrine(10)-HupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Derivative of Tacrine | Quinoline
(S,S)-(-)-bis(10)-hupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Quinoline
(S,S)-(-)-bis(12)-hupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Quinoline
10c-Salicylimine-TacrineBCHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Salicylic
3,5-dihydroxybenzamido-huprine-hybrid-11ACHE | BCHE Alkyl linked bis-ligand | BACE1-inhibitor | Derivative of Huperzine | Multitarget
6ZWE-Cpd3ACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Benzodioxo | Multitarget
6o-5-HT3ACHE | BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carboxamide | Derivative of Tacrine | Multitarget
7-methoxytacrine-memantine-Cpd4ACHE Adamantyl | Alkyl linked bis-ligand | Multitarget | NMDA-Ligand | Sulfur Compound | Urea derivative
8U2-7AIX7AY-compound5iACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8U5-7AIW-compound5gACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UE-7AIV-compound5fACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UH-7AIS-compound5bACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UK-7AIT-compound5cACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
8UQ-7AIU-compound5dACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Capsaicin | Derivative of Huperzine | Multitarget | Quinoline
ARN14140ACHE Adamantyl | Alkyl linked bis-ligand | Derivative of Galanthamine | Multitarget | NMDA-Ligand
ARN14140-doubleboundlinkACHE Adamantyl | Alkyl linked bis-ligand | Derivative of Galanthamine | Multitarget | NMDA-Ligand
ASS234ACHE Alkyl linked bis-ligand | Indole | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
Amantadine-M30D-hybrid5eBCHE Adamantyl | Alkyl linked bis-ligand | Carbamate | Monoamine-oxidase-inhibitor | Multitarget
Aroylacrylic-acid-amide-Tacrine-10ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine
Ass-IN-10BCHE Alkyl linked bis-ligand | BACE1-inhibitor | Multitarget | anti-Abeta-aggregation | anti-tau-aggregation | tert-Butyl
Bis-galanthamineACHE Alkaloid | Alkyl linked bis-ligand | Benzazepin | Derivative of Galanthamine
Bis3-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bis5-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bis7-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bivalent-4-Aminopyridine-12iACHE Alkyl linked bis-ligand | Pyridine
C0I-7QHDBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Indole | Piperidine
C4I-7QHEBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Naphthalen | Piperidine
CB1R-ACHE-20ACHE Alkyl linked bis-ligand | Cannabinoid-Receptor-ligand | Carboxamide | Derivative of Tacrine | Imidazole | Multitarget
CHEMBL4293015BCHE Alkyl linked bis-ligand | Derivative of Donepezil | Indole | Piperidine
CarbacrineACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | NMDA-Ligand
Chlorotacrine-jugloneACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Naphthalen | anti-Abeta-aggregation
Chlorotacrine-tryptophan-hybridACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation
Cpd14-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Cpd27-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfonamide | Sulfur Compound
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Cpd37-Fluoroindol-carbamateMonoglyceridelipase_lysophospholip Alkyl linked bis-ligand | Carbamate | FAAH inhibitor | Indole | Multitarget
Cpd54-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfonamide | Sulfur Compound | tert-Butyl | tert-Butyloxycarbonyl
Cpd70-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget
DTE-bis8-TacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Photoswitch | Sulfur Compound
Di-tert-butyl-phenol-octylamino-acridine-17dACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | tert-Butyl
Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18dBCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Quinoline | tert-Butyl
Donepezil-Melatonin-4uACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Donepezil | Derivative of Tryptamine | Indole | Multitarget
FUB833ACHE | BCHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Histamine-Receptor3-H3-Antagonist | Multitarget | Piperidine
LipocrineACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Sulfur Compound
Melatonin-alkylbenzylamine-Cpd5BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tryptamine | Indole | Multitarget
MemagalACHE Alkyl linked bis-ligand | Benzazepin | Derivative of Galanthamine | Multitarget | NMDA-Ligand
MemoquinACHE Alkyl linked bis-ligand | Antioxidant | BACE1-inhibitor | Multitarget
Methoctramine Alkyl linked bis-ligand | Muscarinic antagonist | Not A/B H target
N-alkyl-quinuclidine-cpd14ACHE | BCHE Alkyl linked bis-ligand | Bisquaternary | Oxime
N-piperidinopropylgalanthamineACHE Alkaloid | Alkyl linked bis-ligand | Benzazepin | Derivative of Galanthamine | Natural_modified | Piperidine
N-saccharinohexylgalanthamineACHE Alkaloid | Alkyl linked bis-ligand | Derivative of Galanthamine | Natural_modified | Sulfur Compound
NF595ACHE Alkyl linked bis-ligand | Derivative of Tacrine | Sulfur Compound
NP61ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole
Phenothiazine-Tacrine-1dCACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Phenothiazine | Sulfur Compound | anti-Abeta-aggregation
Phthalimido-Galanthaminium-4dACHE Alkaloid | Alkyl linked bis-ligand | Benzazepin | Derivative of Galanthamine | Isoindole | Natural_modified | Phthalimido
Phthalimido-Galanthaminium-8dACHE Alkaloid | Alkyl linked bis-ligand | Benzazepin | Derivative of Galanthamine | Indole | Isoindole | Natural_modified | Phthalimido
Piperidine-4-carboxamide-alkyl-tacrine-cpd16ACHE | BCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Tacrine | Piperidine
Quinolinetrione-tacrine-Cpd3ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | Quinoline | anti-Abeta-aggregation
Quinone-polyamine-NSAID-4BCHE 5-Lipoxygenase inhibitor | Alkyl linked bis-ligand | Multitarget
SCHEMBL1532301ACHE Acridine | Alkyl linked bis-ligand | Derivative of Donepezil | Derivative of Tacrine | Indole | Isoindole
Salicylamide-8-TacrineACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Salicylic
TFAH-tacrine-ferulic-acid-hybrid-10nBCHE Acrylate | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Hydroxycinnamic-ester | Multitarget
TPPU-6-Chlorotacrine-12cACHE | Epoxide_hydrolase Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | Piperidine | Trifluoro | Urea derivative
TZ2PIQA5ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Quinoline | Triazol
Tacrine(8)-4-aminoquinolineACHE Alkyl linked bis-ligand | Derivative of Tacrine | Quinoline
Tacrine-BenzofuranACHE Acridine | Alkyl linked bis-ligand | BACE1-inhibitor | Benzofuran | Derivative of Tacrine | Multitarget
Tacrine-Melatonin-Feruloyl-5cBCHE Acrylate | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Derivative of Tryptamine | Feruloyl | Hydroxycinnamic-ester | Indole | Multitarget
Tacrine-Sibiriline-Cpd7ACHE | BCHE Acridine | Alkyl linked bis-ligand | Carbamate | Derivative of Tacrine | Multitarget | Pyridine | Pyrrolidine
Tacrine-Trolox-7uACHE Alkyl linked bis-ligand | Antioxidant | Carboxamide | Derivative of Tacrine | Multitarget
Tacrine-dipicolylamine-13aACHE Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Tacrine-methylanacardate-cpd5BCHE Alkyl linked bis-ligand | Benzoate | Derivative of Tacrine | Multitarget | Salicylic
Tacrine-nicotinamideACHE Alkyl linked bis-ligand | Carboxamide | Derivative of Nicotine | Derivative of Tacrine | Nicotinamide
Tacrine-pentylmethylene-tolylsulfonamideACHE | BCHE Alkyl linked bis-ligand | Benzenesulfonamide | Derivative of Tacrine | Sulfonamide | Sulfur Compound
Tacrine-selegiline-7dACHE | BCHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Monoamine-oxidase-inhibitor | Multitarget
Tacrine-selegiline-8gACHE | BCHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Monoamine-oxidase-inhibitor | Multitarget
Tetracyclic-carbamate-ferulicacid-4aBCHE Alkyl linked bis-ligand | Antioxidant | Carbamate | Derivative of Evodiamine | Feruloyl | Isoquinoline | Natural_modified | Quinazoline
Tetracyclic-carbamate-melatonine-3c Alkyl linked bis-ligand | Carbamate | Derivative of Evodiamine | Derivative of Tryptamine | Indole | Isoquinoline | Natural_modified | Quinazoline
Tz2Pa5-anti1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa5-syn1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa6-anti1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa6-syn1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
benzohomoadamantane-chlorotacrine-18bACHE | BCHE Adamantyl | Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | NMDA-Ligand
bis9-(-)-nor-meptazinolACHE Alkyl linked bis-ligand | Azepane
tacrine-isatin-Cpd7dBCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation
tacrine-isatin-Cpd7kACHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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