Type Inhibitor

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Type_inhibitor Report for: Alkyl linked bis-ligand

Comment

Multitarget compound inhibitors of cholinesterase often bear an alkyl linker that span the active site gorge from the catalytic anionic site to the peripheral anionic site.

Inhibitor nameFormulaStructure
(R)-Tacrine(10)-HupyridoneC32H44N4O
(S,S)-(-)-bis(10)-hupyridoneC28H42N4O2
(S,S)-(-)-bis(12)-hupyridoneC30H46N4O2
8U2-7AIX7AY-compound5iC32H37ClN6O3
8U5-7AIW-compound5gC35H46ClN3O3
8UE-7AIV-compound5fC34H34ClN3O3
8UH-7AIS-compound5bC31H36ClN3O3
8UK-7AIT-compound5cC32H38ClN3O3
8UQ-7AIU-compound5dC33H42ClN3O3
Aroylacrylic-acid-amide-Tacrine-10C39H48N4O2
Bis-galanthamineC42H56N2O6 Br
Bis3-tacrineC29H32N4
Bis5-tacrineC31H36N4
Bis7-tacrineC33H40N4.2HCl
Bivalent-4-Aminopyridine-12iC20H30N4
CHEMBL4293015C25H31N3O
Chlorotacrine-jugloneC25H22ClN3O3
Cpd14-BChEin-5-HT6C31H37N3O3S
Cpd17-Tacrine-5-HT6C31H32N4O3S
Cpd27-BChEin-5-HT6C23H22N2O3S
Cpd35-Rivastigmine-5-HT6C29H34N4O5S
Cpd54-BChEin-5-HT6C27H35N3O5S
Cpd70-BChEin-5-HT6C28H37N3O3
DTE-bis8-TacrineC59H74N6O2S2
MethoctramineC36H62N4O2
N-piperidinopropylgalanthamineC24H34N2O3
N-saccharinohexylgalanthamineC31H38N2O6S
NF595C34H41N3S
NP61C29H33ClN4O
Phenothiazine-Tacrine-1dCC30H30ClN3S
Phthalimido-Galanthaminium-4dC32H37N2O5
Phthalimido-Galanthaminium-8dC32H37N2O5
Salicylamide-8-TacrineC28H35N3O2
Tacrine(8)-4-aminoquinolineC30H36N4
Tacrine-BenzofuranC29H35N3O
Tacrine-dipicolylamine-13aC32H38N6O
Tacrine-methylanacardate-cpd5C30H38N2O3
Tacrine-nicotinamideC25H30N4O
Tacrine-pentylmethylene-tolylsulfonamideC25H31N3O2S
Tz2Pa5-anti1C41H43N8
Tz2Pa5-syn1C41H43N8
Tz2Pa6-anti1C42H45N8
Tz2Pa6-syn1C42H45N8
bis9-(-)-nor-meptazinolC37H58N2O2

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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