Type Inhibitor

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Type_inhibitor Report for: BACE1-inhibitor

Comment

The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. BACE1 is not an alpha beta hydrolase but multitarget compounds are studied that inhibit both BACE1 and cholinesterases for example

Inhibitor nameFormulaStructure
Ass-IN-10C29H38N2O
MTDL-cpd36-diphenylacetamideC35H40N2O2
MTDL-cpd51-diphenylacetamideC29H36N2O2
MemoquinC38H56N4O4
QTC-4-MeOBnEC21H18ClN5O2
Tacrine-BenzofuranC29H35N3O

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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