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Type_inhibitor Report for: Benzyloxycarbonyl

Comment

Carboxybenzyl or benzyloxycarbonyl or Cbz or Z (in honor of discoverer Leonidas Zervas) is an amine protecting group in organic chemistry. The protected amine can be deprotected by catalytic hydrogenation or treatment with HBr, yielding a terminal carbamic acid that then readily decarboxylates to yield the free amine. Commonly used for oligopeptide synthesis introduced by Max Bergmann in 1932. Building block for some inhibitors of enzymes

Inhibitor nameFormulaStructure
Fragment-588C8H9NO3
THL-10dC33H53NO6
Z-Ala_prolinalC16H20N2O5
Z-Gly-Gly-Phe-chloromethyl-ketoneC22H24ClN3O5
Z-Gly-ProC15H18N2O5
Z-Pro-ProlinalC18H22N2O4
Z-Pro-Prolinal-IC1C25H38N2O4
Z-Pro-Prolinal-IC2C20H26N2O4
Z-Pro-Prolinal-IC3C20H25N3O2
Z-Pro-Prolinal-IC4C19H25N3O4
Z-Pro-Prolinal-derivedC19H26N2O4

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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