Type Inhibitor

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Type_inhibitor Report for: Bisquaternary

Comment

The bisquaternary ligand are oriented along the narrow gorge of AChE leading to the active site; one quaternary group is apposed to the indole of Trp-84 and the other to that of Trp-279, near the top of the gorge. Ligands of both the CAS (catalytic active site) and the PAS (peripheral active site). The PAS is supposed to be part of some of the non catalytic properties od ACHEs

Inhibitor nameFormulaStructure
AmbenoniumC28H42Cl4N4O2
BW284C51C27H38N2OBr2
BW62C47C23H34I2N2O
BisQC20H30N4+2
C-547C37H56N6O6
CisatracuriumC53H72N2O12
DecamethoniumC16H38Br2N2
DecidiumC32H44I2N4
DemecariumC32H52Br2N4O4
DoxacuriumC56H78N2O16
EA-3990C30H502Br2N6O4
EA-4056C31H52N6O4Br2
HexamethoniumC12H30N2Cl2
MivacuriumC58H80N2O14
N-p-phenylazophenylcarbamylcholineC18H23IN4O2
Succinylcholine~SuxamethoniumC14H30Br2N2O4
T-1123C13H21IN2O2
p-phenylazophenyltrimethylammoniumC15H18N3+

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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