Type Inhibitor

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Type_inhibitor Report for: Carbamate

Comment

Derived from carbamic acid (NH2COOH). Carbamates can also inhibits many enzymes whose catalytic active site contains a nucleophilic Serine. This serine can be carbamylated. The first naturally occurring carbamate discovered was physostigmeine( eserine). Many carbamates were developped as insecticides or nerve agents (inhibitors of cholinesterases) but also in medicine. Polymers whose units are joined by divalent carbamate groups NH(C=O)O are an important family of plastics, the polyurethanes.

Inhibitor nameFormulaStructure
123I-PIPC13H10INO2
3-Cholesteryl-N-butylcarbamateC32H55NO2
3-Cholesteryl-N-octylcarbamateC36H63NO2
5-deoxo-3-hydroxyevodiamine-heptyl-carbamateC27H34N4O2
6AX1-cp3C15H11F6N3O3
6EUL-BY2C14H22N2O3
6H6-Heptyl-CarbamateC31H34N4O3
6SAM-cpd13C21H24N2O2
8UE-7AIV-compound5fC34H34ClN3O3
ABC44C31H40N6O5
ABC47C31H32N4O5
ABC99C22H21ClN4O5
ABX-1431C20H22F9N3O2
AM9928C23H21N3O3
AS115C21H32FNO4
AlanycarbC17H25N3O4S2
AldicarbC7H14N2O2S
AldoxycarbC7H14N2O4S
Amantadine-M30D-hybrid5eC30H41N3O4
AminocarbC11H16N2O2
BambuterolC18H29N3O5
BanolC10H12ClNO2
BarbanC11H9Cl2NO2
BendiocarbC11H13NO4
BenfuracarbC20H30N2O5S
BenomylC14H18N4O3
Benzimidazole-phenyl-azetidine-carboxylate-11d
Bis(N-propylcarbamic-acid)ethylene-esterC10H20N2O4
BiscarbofuranC24H28N2O6S2
BisnorcymserineC21H25N3O2
BufencarbC13H19NO2
ButocarboximC7H14N2O2S
ButoxycarboximC7H14N2O4S
CAY10499C18H17N3O5
CBD-carbamate-C16C30H38ClNO3
CHEMBL1784957C20H26N2O2
CHEMBL238787C19H19F3N2O4
CHEMBL3585776C17H20N2O5S
CHEMBL440526C28H36N2O5
CHEMBL4454960C28H38N4O3
CHEMBL4454960-PETC29H39FN4O3
CHEMBL49895C22H33N3O4
CarbacholC6H15N2O2
CarbarylC12H11NO2
CarbofuranC12H15NO3
CarbosulfanC20H32N2O3S
ChlorprophamC10H12ClNO2
CosbanC10H13NO2
Cpd-6-8AI7C22H34N3O2
Cpd35-Rivastigmine-5-HT6C29H34N4O5S
Cpd37-Fluoroindol-carbamateC21H21FN2O4
CronetonC11H15NO2S
CymserineC23H29N3O2
DO34C26H28F3N5O4
DioxacarbC11H13NO4
DistigmineC22H32N4O4+2
DiuronC9H10Cl2N2O
EA-3990C30H502Br2N6O4
EA-4056C31H52N6O4Br2
ENA-713~RivastigmineC14H22N2O2
EPTCC9H19NOS
FenobucarbC12H17NO2
FenoxycarbC17H19NO4
FormetanateC11H15N3O2
FosthietanC6H12NO3PS2
Fragment-588C8H9NO3
FurathiocarbC18H26N2O5S
GanstigmineC22H28ClN3O3
GeneserineC15H21N3O3
HeptylphysostigmineC21H33N3O2
Idalopirdine-rivastigmineC21H24FN3O2
ImidocarbC19H20N6O
IrinotecanC33H38N4O6
IsoprocarbC11H15NO2
Isosorbide-2-benzylcarbamate-5-benzoateC21H21NO6
Isosorbide-2-benzylcarbamate-5-benzyl-etherC21H23NO5
Isosorbide-2-benzylcarbamate-5-salicylateC21H21NO7
JCP-265C21H18BrClN2O6
JCP678C14H12FNO4S
JJH221C25H33ClN4O6
JJH251C27H30BrClN4O4
JW480C22H23NO2
JW651C21H18Cl2F6N2O2
KML29C24H21F6NO7
LadostigilC16H20N2O2
M30DC17H19N3O2
MF217C26H42N4O3
MF268C28H46N4O3
MJN110C22H21Cl2N3O4
MT-031C16H22N2O2
MecarbamC10H20NO5PS2
MethiocarbC11H15NO2S
MethomylC6H12N2O3S
MetolcarbC9H11NO2
MiotineC12H18N2O2
MolinateC9H17NOS
N-10-Phenothiazine-1-Naphtyl-carbamateC23H15NO2S
N-10-Phenothiazine-2-Pyrrlidinylethyl-carbamateC19H20N2O2S
N-10-Phenothiazine-3-(dimethylamino)phenyl-carbamateC21H18N2O2S
N-10-Phenothiazine-isopropyl-carbamateC16H15NO2S
N-Methyl-7-dimethylcarbamoxyquinoliniumC13H15N2O2+
N-acyl-prolylpyrrolidine-inhibitor-2C28H41N7O5
N-methyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamideC14H13NOS
Neostigmine~ProstigmineC12H19BrN2O2
Nu-1197C18H23N2O2Br
Nu-1250C17H20N2O2ClBr
OxamylC7H13N3O3S
P-10358C16H15FN4O2
PF-06795071C18H17F4N3O3
PNPMPCC11H14N2O4
PNPPCC10H12N2O4
PhenmediphamC16H16N2O4
PhenserineC20H23N3O2
Phenyl-benzyl-carbamateC14H13NO2
Physostigmine-methiodideC16H24IN3O2
Physostigmine~EserineC15H21N3O2
PhysovenineC14H18N2O3
PirimicarbC11H18N4O2
PosiphenC20H23N3O2
PromecarbC12H17NO2
PropoxurC11H15NO3
PyridostigmineC9H13BrN2O2
QuilostigmineC23H27N3O2
Quinazolin-carbamate-2pC22H31N3O2S
Rhc80267C20H34N4O4
Ro-2-0683C19H25BrN2O2
S11-1014C26H28FN3O2
SA-57C17H23ClN2O3
SB31184-49R-4Y2UC14H20N2O2
SPB01403C14H18N2O2S
T-1123C13H21IN2O2
TerbamC12H17NO2
Tetracyclic-carbamate-cp8C25H32FN3O2
ThiobencarbC12H16ClNOS
TolserineC21H25N3O2
TriallateC10H16Cl3NOS
URB597C20H22N2O3
URB602C19H21NO2
WAY-121898C19H21NO3
WWL113C29H26N2O4
WWL123C28H24N2O3
WWL222C14H18N2O4
WWL229C16H22N2O5
WWL50C14H18FNO2
WWL70C27H23N3O3
Z-Gly-Gly-Phe-chloromethyl-ketoneC22H24ClN3O5
ZectranC12H18N2O2
p-nitrophenyl-N-butyl-N-methyl-carbamateC12H16N2O4
p-nitrophenyl-N-butyl-carbamateC11H14N2O4
p-nitrophenyl-N-octyl-carbamateC15H22N2O4

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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