Type Inhibitor

Tree Display

AceDB Schema

XML Display

Feedback

Type_inhibitor Report for: Derivative of Donepezil

Donepezil used in treatment of Alzheimer Disease, trademark is Aricept Reversible inhibitor of AChE but not of BChE. Used as a building block of new inhibitors and also multi-target drug candidates

InhibitorMain targeted enzyme familiesTypeStructure
5DYT-5hbBCHE Derivative of Donepezil | Naphthalen | Piperidine | Sulfonamide | Sulfur Compound
5DYW-5hfBCHE Derivative of Donepezil | Naphthalen | Piperidine | Sulfonamide | Sulfur Compound
5DYW-5hf-C11BCHE Derivative of Donepezil | Naphthalen | PET probe | Piperidine | Sulfonamide | Sulfur Compound
5DYW-5hf-FBCHE Derivative of Donepezil | PET probe | Piperidine | Sulfonamide | Sulfur Compound
5DYY-5hhBCHE Derivative of Donepezil | Naphthalen | Piperidine | Sulfonamide | Sulfur Compound
7QB4-Cpd2ACHE Coumarin | Derivative of Donepezil | Monoamine-oxidase-inhibitor | Multitarget
Aricept~Donepezil~E2020ACHE Derivative of Donepezil | Drug | Inden | Piperidine
Aurone-Donepezil-Cpd5gACHE Benzofuran | Derivative of Donepezil | Flavonoid | Multitarget
Aurone-Donepezil-Cpd6b Benzofuran | Derivative of Donepezil | Flavonoid | Multitarget
BIGI-3hACHE | BCHE Calcium Channel Antagonist | Derivative of Donepezil | GSK-3 kinase inhibitor | Monoamine-oxidase-inhibitor | Multitarget | anti-Abeta-aggregation
BYYT-25ACHE | BCHE | Cholinesterase Derivative of Donepezil | Inden | Pyrrolidine
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6bACHE | BCHE Carboxamide | Derivative of Donepezil | Indole | Multitarget | Pirimidine | Sulfur Compound
Benzylpiperidin-oxoindolin-acetamide-Cpd23 Derivative of Donepezil | Indole | Piperidine
C0I-7QHDBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Indole | Piperidine
C4I-7QHEBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Naphthalen | Piperidine
C7653ACHE Derivative of Donepezil | Piperidine
CHEMBL4293015BCHE Alkyl linked bis-ligand | Derivative of Donepezil | Indole | Piperidine
Compound19n-quinolinolACHE Derivative of Donepezil | Metal ion chelator | Multitarget | Quinoline | Trifluo | anti-Abeta-aggregation
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiolACHE BACE1-inhibitor | Carboxamide | Cyanide | Derivative of Donepezil | Multitarget | Oxadiazol | Piperidine | Sulfur Compound | anti-Abeta-aggregation
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3bACHE Carboxamide | Coumarin | Derivative of Donepezil | Piperidine
DFAH-12ACHE | BCHE Antioxidant | Derivative of Donepezil | Hydroxycinnamic-ester | Multitarget | Piperidine
DPH6ACHE | BCHE Derivative of Donepezil | Monoamine-oxidase-inhibitor | Multitarget | Quinoline
DonecoprideACHE 5-HT-receptor-ligand | Derivative of Donepezil | Multitarget | Piperidine
Donepezil-8-Hydroxyquinoline-2bBCHE Antioxidant | Derivative of Donepezil | Multitarget | Quinoline
Donepezil-Melatonin-4uACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Donepezil | Derivative of Tryptamine | Indole | Multitarget
Donepezil-derivative-DZ0ACHE Derivative of Donepezil | Inden | Piperidine
Donepezil-derivative-DZ7ACHE Derivative of Donepezil | Inden | Piperidine
Donepezil-idebenone-cpd9BCHE Antioxidant | Derivative of Donepezil | Multitarget | anti-Abeta-aggregation
FG1912 Carboxamide | Cyclopropyl | Derivative of Donepezil | GSK-3 kinase inhibitor | Multitarget | Piperidine | Pyridine
FluoropezilACHE Antioxidant | Derivative of Donepezil | Multitarget | Sulfur Compound
GD29ACHE Carboxamide | Cyclopropyl | Derivative of Donepezil | GSK-3 kinase inhibitor | Multitarget | Piperidine | Pyridine | Thiazole
IcopezilACHE Derivative of Donepezil | Piperidine
Indole-piperidine-amide-cpd23aACHE BACE1-inhibitor | Carboxamide | Derivative of Donepezil | Indole | Multitarget | Piperidine
J8-A34ACHE Derivative of Donepezil | Piperidine | Quinoline | Sulfonamide | Sulfur Compound
MC1420ACHE Carboxamide | Derivative of Donepezil
MebbppACHE Derivative of Donepezil | Multitarget | Piperidine | Sulfur Compound
Rivastigmine-Donepezil-COR783 Adamantyl | Cannabinoid-Receptor-ligand | Carbamate | Derivative of Donepezil | Derivative of Rivastigmine | Multitarget | Sulfur Compound
SB-1448ACHE | BCHE BACE1-inhibitor | Derivative of Donepezil | Multitarget | Piperidine
SCHEMBL1532301ACHE Acridine | Alkyl linked bis-ligand | Derivative of Donepezil | Derivative of Tacrine | Indole | Isoindole
SelenepezilACHE Derivative of Donepezil | Organoselenium | Piperidine | Thiol-reactive
Sigma1R-ACHE-6aACHE 5-HT-receptor-ligand | Derivative of Donepezil | Indole | Multitarget | Piperidine | Sigma1R
Sigma1R-ACHE-6bACHE 5-HT-receptor-ligand | Derivative of Donepezil | Indole | Multitarget | Piperidine | Sigma1R
TAK-147ACHE Benzazepin | Derivative of Donepezil | Piperidine | Transition state analogue
Tacrine-Donepezil-hybrid3ACHE Derivative of Donepezil | Derivative of Tacrine
WMY90-5fACHE Derivative of Donepezil | Monoamine-oxidase-inhibitor | Multitarget | Quinoline
ZINC11709541ACHE Derivative of Donepezil | Trifluoro
ZINC11996936ACHE Derivative of Donepezil | Trifluoro
ZINC22029744ACHE | BCHE BACE1-inhibitor | Derivative of Donepezil | Multitarget | Oxadiazol | Piperazine | Sulfur Compound

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer