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Type_inhibitor Report for: Derivative of Tacrine

Tacrine (tetra trahydroaminacrine) was the first inhibitor of AChE used in Alzheimer's disease but has many side effects and is dicontinued. Tacrine was used as a building block to find less toxic inhibitors or multi target drugs

InhibitorMain targeted enzyme familiesTypeStructure
(R)-Tacrine(10)-HupyridoneACHE Alkyl linked bis-ligand | Derivative of Huperzine | Derivative of Tacrine | Quinoline
6-chlorotacrineACHE Derivative of Tacrine
6H12-(R)2ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative
6H13-(R)3ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative
6H14-(S)6ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative | beta-carboline
6o-5-HT3ACHE | BCHE 5-HT-receptor-ligand | Carboxamide | Derivative of Tacrine | Multitarget
7-MEOTA-4-pyridinealdoximeACHE Acridine | Derivative of Tacrine | Pyridine
7-MethoxytacrineACHE Acridine | Derivative of Tacrine
7-NitrotacrineACHE Acridine | Derivative of Tacrine
9-Amino-6-chloro-2-methoxyacridineCarb_B_Chordata | Carboxylesterase Acridine | Derivative of Tacrine
ACHE-GSK-3-27gACHE Derivative of Tacrine | GSK-3 kinase inhibitor | Multitarget
Aroylacrylic-acid-amide-Tacrine-10ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine
AzoTHAACHE Acridine | Derivative of Tacrine | Photoswitch
Bis3-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bis5-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bis7-tacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine
Bromophenyl-tacrine6iACHE | BCHE Derivative of Tacrine
Bucricaine Derivative of Tacrine | Local anesthetic
C0I-7QHDBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Indole | Piperidine
C4I-7QHEBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Naphthalen | Piperidine
CB1R-ACHE-20ACHE Cannabinoid-Receptor-ligand | Carboxamide | Derivative of Tacrine | Imidazole | Multitarget
CI-1002ACHE Derivative of Tacrine | Muscarinic antagonist | Quinazoline
CMP-DDAOACHE Derivative of Tacrine | Flu-OP | Nerve Agent G-series | Organophosphate | Surrogate OP
Chlorotacrine-jugloneACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Naphthalen | anti-Abeta-aggregation
Chlorotacrine-tryptophan-hybridACHE | BCHE Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Compound4TacrineACHE Derivative of Tacrine
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfur Compound | anti-Abeta-aggregation
DTE-bis8-TacrineACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Photoswitch
E0ZACHE Derivative of Tacrine | Triazol
E1KACHE Derivative of Tacrine
E1NACHE Derivative of Huperzine | Derivative of Tacrine
EMP-DDAOACHE Derivative of Tacrine | Flu-OP | Nerve Agent V-series | Organophosphate | Surrogate OP
FBQACHE Derivative of Tacrine | Quinoline | Sulfur Compound | Transition state analogue | Trifluoro
HuprineWACHE Derivative of Huperzine | Derivative of Tacrine | Natural_modified | Quinoline
HuprineXACHE Derivative of Huperzine | Derivative of Tacrine | Natural_modified | Quinoline
IMP-DDAOACHE Derivative of Sarin | Derivative of Tacrine | Flu-OP | Nerve Agent G-series | Organophosphate | Surrogate OP
K-1234ACHE Derivative of Huperzine | Derivative of Tacrine
LipocrineACHE Antioxidant | Derivative of Tacrine | Multitarget | Sulfur Compound
N-ammoniooctyl-tacrineACHE Acridine | Derivative of Tacrine
N-octyl-tacrineACHE Acridine | Derivative of Tacrine
NF595ACHE Alkyl linked bis-ligand | Derivative of Tacrine | Sulfur Compound
NIK-247ACHE | BCHE Derivative of Tacrine | Quinoline
NP61ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole
PE154ACHE | BCHE Derivative of Tacrine | Hydrazide | Multitarget
PMP-DDAOACHE Derivative of Soman | Derivative of Tacrine | Flu-OP | Nerve Agent G-series | Organophosphate | Surrogate OP
Phenothiazine-Tacrine-1dCACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Phenothiazine | anti-Abeta-aggregation
Propargyl-Tacrine-15ACHE | BCHE Alkyne | Derivative of Tacrine | Monoamine-oxidase-inhibitor | Multitarget
QTC-4-MeOBnEACHE BACE1-inhibitor | Derivative of Tacrine | Multitarget | Triazol
SCHEMBL1532301 Acridine | Alkyl linked bis-ligand | Derivative of Donepezil | Derivative of Tacrine | Isoindol
Salicylamide-8-TacrineACHE | BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Salicylic
TADEACHE | BCHE Derivative of Tacrine
TFAH-tacrine-ferulic-acid-hybrid-10n Antioxidant | Derivative of Tacrine | Hydroxycinnamic-ester | Multitarget
TPPU-6-Chlorotacrine-12cACHE | Epoxide_hydrolase Derivative of Tacrine | Multitarget | Piperidine | Trifluoro | Urea derivative
TZ2PIQA5 Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Quinoline | Triazol
TacrineACHE Acridine | Derivative of Tacrine
Tacrine(8)-4-aminoquinolineACHE Alkyl linked bis-ligand | Derivative of Tacrine | Quinoline
Tacrine-BenzofuranACHE Acridine | Alkyl linked bis-ligand | BACE1-inhibitor | Benzofuran | Derivative of Tacrine | Multitarget
Tacrine-Donepezil-hybrid3ACHE Derivative of Donepezil | Derivative of Tacrine
Tacrine-Melatonin-Feruloyl-5c Antioxidant | Derivative of Tacrine | Derivative of Tryptamine | Hydroxycinnamic-ester | Multitarget
Tacrine-Resveratrol-12ACHE Antioxidant | Derivative of Tacrine | Multitarget
Tacrine-Trolox-7uACHE Antioxidant | Carboxamide | Derivative of Tacrine | Multitarget
Tacrine-dihydropyrimidine-4e Calcium Channel Antagonist | Derivative of Tacrine | Multitarget | Pyrimidine | Quinoline | Sulfur Compound
Tacrine-dipicolylamine-13a Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Tacrine-methylanacardate-cpd5BCHE Alkyl linked bis-ligand | Benzoate | Derivative of Tacrine | Multitarget | Salicylic
Tacrine-nicotinamideACHE Alkyl linked bis-ligand | Carboxamide | Derivative of Nicotine | Derivative of Tacrine | Nicotinamide
Tacrine-pentylmethylene-tolylsulfonamide Alkyl linked bis-ligand | Derivative of Tacrine
Tacrine-pyridinealdoxime-1ACHE Acridine | Derivative of Tacrine
Tz2ACHE Acridine | Azido | Derivative of Tacrine
Tz2Pa5-anti1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa5-syn1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa6-anti1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
Tz2Pa6-syn1ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Phenanthridinium | Triazol
ZAACHE Acridine | Derivative of Tacrine
ZAIACHE Acridine | Derivative of Tacrine
[11C]N-methyl-tacrineACHE Acridine | Derivative of Tacrine | PET probe

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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