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Type_inhibitor Report for: Indole

Fusion of benzene and pyrazole. Building block for many inhibitors of enzymes. Indole has only one nitrogen atom in position 1 of the pyrazol. Indazol is an analog with nitrogen atoms in position 1 and 2. Benzimidazole, an analog with the nitrogen atoms in positions 1 and 3.

InhibitorMain targeted enzyme familiesTypeStructure
1-Dodecylindoline-2,3-dioneCarb_B_Chordata Indole
1-methylindol-3-oneACHE Indole
1G244DPP4N_Peptidase_S9 Indole | Isoindole | Piperazine
3-(Dimethylamino)-N-propanamide-TryptanthrinACHE Derivative of Deoxyvasicinone | Indole | Quinazoline
5-hydroxy-tryptamineACHE | BCHE 5-HT-receptor-ligand | Derivative of Tryptamine | Indole | Natural | Not A/B H target
6H12-(R)2ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Indole | Isoindole | Multitarget | Triazol | Urea derivative
6H13-(R)3ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Indole | Isoindole | Multitarget | Triazol | Urea derivative
6H14-(S)6ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Indole | Isoindole | Multitarget | Triazol | Urea derivative | beta-carboline
6H6-Heptyl-CarbamateBCHE Carbamate | Derivative of Tryptamine | Indole
6QAA-HUNBCHE Derivative of Tryptophan | Indole
6QAB-HUQBCHE Derivative of Tryptophan | Indole
6QAC-HUTBCHE Derivative of Tryptophan | Indole
6QAD-HUZBCHE Derivative of Tryptophan | Indole
6QAE-HUKBCHE Derivative of Tryptophan | Indole
6XTA-cpd18BCHE Azepane | Derivative of Tryptophan | Indole
A87-7BO4BCHE Cycloheptyl | Derivative of Tryptophan | Indole
ARUK3002704Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003718Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003906Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003907Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3003910Pectinacetylesterase-Notum Indole | Oxobutanoate
ARUK3004048Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004308Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004470Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004552Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004556Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004558Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004876Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3004877Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3004903Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3005518Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3005522Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole
ARUK3006560Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006561Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ARUK3006562Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Trifluoro
ASS234ACHE Alkyl linked bis-ligand | Indole | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
Adamantyl-urea-Cpd28Epoxide_hydrolase Adamantyl | Indole | Urea derivative
BChE-IN-3BCHE Carbamate | Cycloheptyl | Derivative of Tryptamine | Derivative of Tryptophan | Indole
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6bACHE | BCHE Carboxamide | Derivative of Donepezil | Indole | Multitarget | Pirimidine | Sulfur Compound
Benzylpiperidin-oxoindolin-acetamide-Cpd23 Derivative of Donepezil | Indole | Piperidine
Bis-NoreserolineACHE Derivative of physostigmine-eserine | Indole | Leaving group
BisnorcymserineACHE | BCHE Carbamate | Derivative of physostigmine-eserine | Indole
C0I-7QHDBCHE Acridine | Alkyl linked bis-ligand | Carboxamide | Derivative of Donepezil | Derivative of Tacrine | Indole | Piperidine
CHEMBL1086968S9N_PPCE_Peptidase_S9 Cyclopropyl | Indole | Peptide | Sulfur Compound | Thiazolidine
CHEMBL3125346Cholesterol_esterase Indole | Quinoline
CHEMBL3125351Cholesterol_esterase Indole | Quinoline
CHEMBL4293015BCHE Alkyl linked bis-ligand | Derivative of Donepezil | Indole | Piperidine
CHEMBL57478Pectinacetylesterase-Notum Fragment inhibitor of Notum | Indole | Piperidine
CID656508 Carbamate | Derivative of physostigmine-eserine | Indole
CatharanthinePlant_carboxylesterase Alkaloid | Indole | Natural
Chloroalkane-Cyanine3-fluorophoreHaloalkane_dehalogenase-HLD2 Cyanide | HaloTag-ligand | Indole
Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5bACHE | BCHE Carboxamide | Indole | Multitarget | Sulfonamide | Sulfur Compound
Chlorotacrine-tryptophan-hybridACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation
ContilisantACHE | BCHE Histamine-Receptor3-H3-Antagonist | Indole | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
Cpd-6-8AI7BCHE Carbamate | Indole
Cpd14-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfur Compound
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Cpd27-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfonamide | Sulfur Compound
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Cpd37-Fluoroindol-carbamateMonoglyceridelipase_lysophospholip Alkyl linked bis-ligand | Carbamate | FAAH inhibitor | Indole | Multitarget
Cpd54-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget | Sulfonamide | Sulfur Compound | tert-Butyl | tert-Butyloxycarbonyl
Cpd70-BChEin-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Indole | Multitarget
CymserineBCHE Carbamate | Derivative of physostigmine-eserine | Indole
Debromoflustramine-BBCHE Derivative of physostigmine-eserine | Indole | Natural | Pyrrolidine
DehydroevodiamineACHE Derivative of Evodiamine | Indole | Natural | Natural_modified | Pyridine | beta-carboline
DialiforACHE Indole | Insecticide | Isoindole | Organophosphate | Sulfur Compound
Dialifor-oxonACHE Indole | Insecticide | Isoindole | Organophosphate | Sulfur Compound
Dihydroindole-thiourea-73Epoxide_hydrolase 5-Lipoxygenase inhibitor | Indole | Multitarget | Sulfur Compound | Urea derivative
Dimethoxy-phenyl-pyrazino-indol-cpd5i Indole | Multitarget
Donepezil-Melatonin-4uACHE Alkyl linked bis-ligand | Antioxidant | Derivative of Donepezil | Derivative of Tryptamine | Indole | Multitarget
EserolineACHE Derivative of physostigmine-eserine | Indole
FL217Epoxide_hydrolase Cyclopropyl | Indole | Multitarget | PPARgamma ligand | Sulfonamide | Sulfur Compound
GanstigmineACHE Carbamate | Derivative of physostigmine-eserine | Indole
GeneserineACHE | BCHE Carbamate | Derivative of physostigmine-eserine | Indole | Natural
Geneseroline Derivative of physostigmine-eserine | Indole | Natural
GramineACHE | BCHE Alkaloid | Indole | Natural | Not A/B H target
H327BCHE Carbamate | Derivative of Tryptamine | Indole
Harmine Alkaloid | Indole | Natural | Not A/B H target | beta-carboline
HeptylphysostigmineACHE Carbamate | Derivative of physostigmine-eserine | Indole
HypaphorineACHE Derivative of Tryptophan | Indole | Natural | Not A/B H target | Propionate
IA4-7BO3BCHE Cycloheptyl | Derivative of Tryptophan | Indole
ICeD-2DPP4N_Peptidase_S9 Indole | Pyrrolidine
Indol-adamantyl-carbamate-Cpd42DPP4N_Peptidase_S9 Adamantyl | Carbamate | Gliptin | Indole
Indol-carbodithioate-azepaneLipase_3 Azepane | Indole | Sulfur Compound
Indol-thioxotetrahydropyrimidine-Cpd5ACHE Indole | Pyrimidine | Sulfur Compound
Indol-thioxotetrahydropyrimidine-Cpd7BCHE Indole | Pyrimidine | Sulfur Compound
Indole-piperidine-amide-cpd23a BACE1-inhibitor | Carboxamide | Derivative of Donepezil | Indole | Multitarget | Piperidine
Indolesufonamide1DPP4N_Peptidase_S9 Indole | Sulfonamide | Sulfur Compound
Isatin-thiosemicarbazone-cpd13ACHE | BCHE Indole | Sulfur Compound | Urea derivative
KK023-N1RsbQ-like Indole | Strigolactone receptors ligand | Triazol | Urea derivative
KK023-N2RsbQ-like Indole | Strigolactone receptors ligand | Triazol | Urea derivative
KK094RsbQ-like Indole | Strigolactone receptors ligand | Triazol | Urea derivative
Lys-phospho-isoindolineDPP4N_Peptidase_S9 Acetanilide | Indole | Organophosphate | Peptide
M-18CMonoglyceridelipase_lysophospholip Carboxamide | Indole | Piperidine
MF217ACHE Carbamate | Derivative of physostigmine-eserine | Indole | Morpholine
MF268ACHE Carbamate | Derivative of physostigmine-eserine | Indole | Morpholine
MelatoninPectinacetylesterase-Notum Derivative of Tryptamine | Indole | Natural | Not A/B H target
Melatonin-alkylbenzylamine-Cpd5BCHE Alkyl linked bis-ligand | Antioxidant | Derivative of Tryptamine | Indole | Multitarget
Methylene-blue-carboline-2ACHE | BCHE | Cholinesterase Dye | Indole | Multitarget | Phenothiazine | Sulfur Compound | beta-carboline
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamidePectinacetylesterase-Notum Derivative of Tryptamine | Indole | Not A/B H target
N-acetylserotoninPectinacetylesterase-Notum Derivative of Tryptamine | Indole | Natural | Not A/B H target
N1-PhenethylnorcymserineBCHE Carbamate | Derivative of physostigmine-eserine | Indole
NP61ACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole
Nijmegen-1RsbQ-like Butenolide | Cotylimide | Indole | Isoindole | Phthalimido | Strigolactone receptors ligand
P-10358ACHE | BCHE Carbamate | Indole | Pyridine
PhenserineACHE Carbamate | Derivative of physostigmine-eserine | Drug | Indole
PhosmetACHE Indole | Insecticide | Isoindole | Organophosphate | Organothiophosphate | Sulfur Compound
PhosmetoxonACHE Indole | Insecticide | Isoindole | Organophosphate | Organothiophosphate | Phthalimido | Sulfur Compound
Phthalimido-Galanthaminium-8dACHE Alkaloid | Alkyl linked bis-ligand | Benzazepin | Derivative of Galanthamine | Indole | Isoindole | Natural_modified | Phthalimido
Physostigmine-methiodideACHE Carbamate | Derivative of physostigmine-eserine | Indole | Natural_modified
Physostigmine~EserineACHE | Arylacetamide_deacetylase | BCHE Carbamate | Derivative of physostigmine-eserine | Drug | Indole | Natural
PhysovenineACHE Carbamate | Derivative of physostigmine-eserine | Indole | Natural
PosiphenACHE Carbamate | Derivative of physostigmine-eserine | Drug | Indole
PsilocybinACHE | BCHE Alkaloid | Indole | Natural | Organophosphate
QuilostigmineACHE Carbamate | Derivative of physostigmine-eserine | Indole | Isoquinoline
R-Pro-(decarboxy-Pro)-X99S9N_PPCE_Peptidase_S9 Indole | Isoindole | Pyrrolidine
SCHEMBL1532301ACHE Acridine | Alkyl linked bis-ligand | Derivative of Donepezil | Derivative of Tacrine | Indole | Isoindole
Sigma1R-ACHE-6aACHE 5-HT-receptor-ligand | Derivative of Donepezil | Indole | Multitarget | Piperidine | Sigma1R
Sigma1R-ACHE-6bACHE 5-HT-receptor-ligand | Derivative of Donepezil | Indole | Multitarget | Piperidine | Sigma1R
TRaQ-G-ILQHaloalkane_dehalogenase-HLD2 HaloTag-ligand | Indole | Sulfur Compound
TabersoninePlant_carboxylesterase Alkaloid | Indole | Natural
Tacrine-Melatonin-Feruloyl-5cBCHE Acrylate | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Derivative of Tryptamine | Feruloyl | Hydroxycinnamic-ester | Indole | Multitarget
Tetracyclic-carbamate-melatonine-3c Alkyl linked bis-ligand | Carbamate | Derivative of Evodiamine | Derivative of Tryptamine | Indole | Isoquinoline | Natural_modified | Quinazoline
TolserineACHE | BCHE Carbamate | Derivative of physostigmine-eserine | Indole | NTE inhibitor | Not A/B H target
TryptamineACHE Derivative of Tryptamine | Indole | Natural
ZINC12863377Monoglyceridelipase_lysophospholip Carboxamide | Indole | Pyrrolidine
ZINC59501712BCHE Indole | Phthalimido | Sulfonamide | Sulfur Compound
ZLWH-23ACHE Carboxamide | Cyclopropyl | GSK-3 kinase inhibitor | Indole | Multitarget | Piperidine | beta-carboline
ZTL-11ACHE Carboxamide | Cyclopropyl | GSK-3 kinase inhibitor | Indole | Multitarget | Triazol | beta-carboline
ZYH-deriv-FMonoglyceridelipase_lysophospholip Azetidin | Carboxamide | Indole | PET probe | Piperazine | Pyrimidine
isoquinolinederivative18DPP4N_Peptidase_S9 Indole | Isoindole | Piperazine
tacrine-isatin-Cpd7dBCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation
tacrine-isatin-Cpd7kACHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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