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Type_inhibitor Report for: Urea derivative

Urea, also known as carbamide, is an organic compound with chemical formula CO(NH2)2. Building block for many inhibitors of enzymes

InhibitorMain targeted enzyme familiesTypeStructure
(4-fluoroanilino)thioureaPectinacetylesterase-Notum Fragment inhibitor of Notum | Sulfur Compound | Urea derivative
1,3-DibenzylureaEpoxide_hydrolase Natural | Urea derivative
1,3-DicyclohexylureaEpoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-butyric-acidEpoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-ethanoic-acidEpoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-heptanoic-acidEpoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-hexanoic-acidEpoxide_hydrolase Urea derivative
5ALI-Q3BEpoxide_hydrolase Imidazole | Pyrimidine | Urea derivative
5ALZ-XQ9Epoxide_hydrolase Adamantyl | Piperidine | Sulfonamide | Sulfonyl | Sulfur Compound | Urea derivative
6H12-(R)2ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative
6H13-(R)3ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative
6H14-(S)6ACHE Derivative of Tacrine | Derivative of Valmerin | GSK-3 kinase inhibitor | Isoindole | Multitarget | Triazol | Urea derivative | beta-carboline
6N3K-1Epoxide_hydrolase Urea derivative
6N3Z-4Epoxide_hydrolase Trifluoro | Urea derivative
6N5G-2Epoxide_hydrolase Carboxamide | Urea derivative
AAFDPP4N_Peptidase_S9 Benzoate | Pyrrolidine | Urea derivative
AEPUEpoxide_hydrolase Adamantyl | Urea derivative
AM6580Monoglyceridelipase_lysophospholip Fluoren | Piperazine | Urea derivative
AM6701ABHD6-Lip | Monoglyceridelipase_lysophospholip Biphenyl | Cannabinoid-Receptor-ligand | Carboxamide | FAAH inhibitor | Multitarget | Tetrazol | Urea derivative
AUDAEpoxide_hydrolase Adamantyl | Dodecanoate | Urea derivative
Ar9281Epoxide_hydrolase Adamantyl | Urea derivative
AtglistatinCarb_B_Chordata Biphenyl | Urea derivative
B401Epoxide_hydrolase Adamantyl | Piperidine | Urea derivative
BAYHormone-sensitive_lipase_like Piperidine | Urea derivative
CDUEpoxide_hydrolase Urea derivative
CHEMBL1615216Epoxide_hydrolase Carboxamide | Cyclopropyl | Oxadiazol | Piperidine | Urea derivative
CHEMBL1818384Epoxide_hydrolase Adamantyl | Urea derivative
CHEMBL3114611Epoxide_hydrolase Carboxamide | Cyclopropyl | Piperidine | Urea derivative
CHEMBL3401634Epoxide_hydrolase Cyclopropyl | Urea derivative
CHEMBL3633668Epoxide_hydrolase Adamantyl | Urea derivative
CIUEpoxide_hydrolase Urea derivative
CPUEpoxide_hydrolase Urea derivative
DH376Lipase_3 Piperidine | Triazol | Urea derivative
DO264ABHD12-PHARC Sulfur Compound | Urea derivative
Dihydroindole-thiourea-73Epoxide_hydrolase 5-Lipoxygenase inhibitor | Indole | Multitarget | Sulfur Compound | Urea derivative
DiphenylureaEpoxide_hydrolase Urea derivative
DiuronACHE | Epoxide_hydrolase Herbicide | Not A/B H target | Urea derivative
EC5026Epoxide_hydrolase Piperidine | Trifluoro | Urea derivative
EprotiromeCFTR-inhibitory-factor_Cif Drug | Thyroid hormone analogue | Urea derivative
Fragment-049-notum-screenPectinacetylesterase-Notum Fragment inhibitor of Notum | Urea derivative
Fragment-063-notum-screenPectinacetylesterase-Notum Benzoxadiazole | Fragment inhibitor of Notum | Urea derivative
Fragment-064-notum-screenPectinacetylesterase-Notum Fragment inhibitor of Notum | Urea derivative
Fragment-110Pectinacetylesterase-Notum Fragment inhibitor of Notum | Pyridine | Urea derivative
Fragment-828Pectinacetylesterase-Notum Fragment inhibitor of Notum | Urea derivative
GSK-264220ALipoprotein_Lipase Sulfonamide | Sulfur Compound | Urea derivative
GSK2256294AEpoxide_hydrolase Carboxamide | Cyanide | Urea derivative
Imidocarb Drug | Urea derivative
Isatin-thiosemicarbazone-cpd13 Indole | Urea derivative
JCP276 Coumarin | Urea derivative
KK023-N1RsbQ-like Strigolactone receptors ligand | Triazol | Urea derivative
KK023-N2RsbQ-like Strigolactone receptors ligand | Triazol | Urea derivative
KK052RsbQ-like Piperazine | Triazol | Urea derivative
KK073RsbQ-like Triazol | Trifluoro | Urea derivative
KK094RsbQ-like Strigolactone receptors ligand | Triazol | Urea derivative
KT129A85-EsteraseD-FGH Triazol | Urea derivative
KT130A85-EsteraseD-FGH Triazol | Urea derivative
LF-14 Pyridine | Urea derivative
LK864Epoxide_hydrolase Azaspiro | Sulfur Compound | Trifluoro | Urea derivative
LY2183240ABHD6-Lip | Arylacetamide_deacetylase | Monoglyceridelipase_lysophospholip Biphenyl | Cannabinoid-Receptor-ligand | Carboxamide | FAAH inhibitor | Multitarget | Tetrazol | Urea derivative
ML225PAF-Acetylhydrolase Pyrrolidine | Triazol | Urea derivative
MMUEpoxide_hydrolase Natural | Urea derivative
Morpholino-TalinololEpoxide_hydrolase Adrenergic-Receptor-ligand | Morpholine | Not A/B H target | Urea derivative | tert-Butyl
N-1-adamantyl-N'-cyclohexylureaEpoxide_hydrolase Adamantyl | Urea derivative
PTUPBEpoxide_hydrolase Multitarget | Pyrazole | Sulfonamide | Sulfur Compound | Trifluoro | Urea derivative
Piperidinyl-1,2,3-triazole-urea-inhibitor-11LYsophospholipase_carboxylesterase Piperidine | Triazol | Urea derivative
Piperidinyl-1,2,3-triazole-urea-inhibitor-12LYsophospholipase_carboxylesterase Piperidine | Triazol | Urea derivative
Piperidinyl-1,2,3-triazole-urea-inhibitor-2ABHD11-Acetyl_transferase | Carb_B_Chordata | Cholesterol_esterase | LYsophospholipase_carboxylesterase | PAF-Acetylhydrolase Piperidine | Triazol | Urea derivative
RegorafenibEpoxide_hydrolase Carboxamide | Not A/B H target | Trifluoro | Urea derivative
SCHEMBL15272467 Piperidine | Trifluoro | Urea derivative
SCHEMBL19358888Epoxide_hydrolase Benzoate | FAAH inhibitor | Multitarget | Urea derivative
SCHEMBL22462761Monoglyceridelipase_lysophospholip Azetidin | PET probe | Trifluoro | Urea derivative
SR-4995CGI-58_ABHD5_ABHD4 Sulfur Compound | Urea derivative
SorafenibEpoxide_hydrolase Carboxamide | Not A/B H target | Trifluoro | Urea derivative
TPPUEpoxide_hydrolase Piperidine | Trifluoro | Urea derivative
TPPU-6-Chlorotacrine-12cACHE | Epoxide_hydrolase Derivative of Tacrine | Multitarget | Piperidine | Trifluoro | Urea derivative
TPPU-methylEpoxide_hydrolase Piperidine | Trifluoro | Urea derivative
TUPSEpoxide_hydrolase Piperidine | Sulfonamide | Sulfur Compound | Trifluoro | Urea derivative
TalinololEpoxide_hydrolase Adrenergic-Receptor-ligand | Not A/B H target | Urea derivative
Tiratricol-derivative-8cCFTR-inhibitory-factor_Cif Carboxamide | Thyroid hormone analogue | Urea derivative
Tiratricol-derivative-8hCFTR-inhibitory-factor_Cif Thyroid hormone analogue | Urea derivative
Tr-EH-urea-13Epoxide_hydrolase Trifluoro | Urea derivative
UB-EV-52Epoxide_hydrolase Adamantyl | Urea derivative
ZINC10109382-S0A-3WK4Epoxide_hydrolase Cyclopropyl | Urea derivative
ZINC1603176-7WI-4C4YEpoxide_hydrolase Urea derivative
ZINC395065-W9L-4C4ZEpoxide_hydrolase Naphthalen | Urea derivative
nbAUDAEpoxide_hydrolase Adamantyl | Dodecanoate | Urea derivative
sEH-LTA4H-14Epoxide_hydrolase LTA4-hydrolase-inhibitor | Multitarget | Sulfur Compound | Urea derivative
t-AUCBEpoxide_hydrolase Adamantyl | Urea derivative
t-AUCMBEpoxide_hydrolase Adamantyl | Multitarget | Urea derivative
t-MTUCBEpoxide_hydrolase Multitarget | Urea derivative
t-MTUCB-NHEpoxide_hydrolase Multitarget | Urea derivative
t-TUCBEpoxide_hydrolase FAAH inhibitor | Multitarget | Urea derivative

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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