Type Reactivator

Tree Display

AceDB Schema

XML Display

Feedback

Type_reactivator Report for: Bispyridinium

Comment

Pyridinium refers to the cation [C5H5NH]+. Often present in oximes as in the first reactivator of OP inhibited cholinesterase Pralidoxime (2-PAM). These are charged oximes which poorly cross the blood brain barrier. When two pyridinium molecules are joined by an appropriate linker one could bind to the PAS and the other attach the phosphorus of OP inhibited cholinesterase and eventually reactivate the enzyme

Reactivator nameFormulaStructure
BDB-108C16H18Br2N4O2
BI-6C16H18N4O2
DMB-4C14H16N4O2+2
HI-6C14H16Cl2N4O3
HLo-7C15H17I2N5O4
HS-3C14H16Cl2N4O3
HS-6C14H16Cl2N4O3
K005C15H18N4O2
K027C15H18N4O2
K027-Cl2C15H16Cl2N4O2+
K033C16H20N4O2
K048C16H20N4O2
K074C14H16N4O2+2
K075C16H18N4O2
K117C16H20N4O3+2
K127C16H20Br2N4O3
K131C19H21Br2N3O
K142C19H21Br2N3O
K153C15H19Br2N3O
K156C14H17N3O
K203C16H18N4O2
K206C16H17N4O2
K298C26H30Br2N2
K344C19H28Br2N2
K454C20H21Br2N3O
K456C16H19Br2N3O2
K458C15H19Br2N5O2
K474C25H40Br2N2
K524C28H34Br2N2
K727C24H22Br2N4O2
K733C22H24Br2N3O3
K792C24H32Br2N2
K869C16H19Br2ClN4O2
MB327C21H3N2O
MMB-4C13H14Br2N4O2
Ortho-7C19H26N4O2-2+
R665C17H22I2N4O4
SAD-128C20H30Cl2N2O
ToxogoninC14H16Cl2N4O3
Triazole-annulated-oxime-14AC17H19N7O2
Triazole-annulated-oxime-2AC19H22N5O
Triazole-annulated-oxime-3AC19H22N7O2
TrimedoximeC15H18Br2N4O2

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer