Type Reactivator

Tree Display

AceDB Schema

XML Display

Feedback

Type_reactivator Report for: Derivative of Tacrine

Comment

Tacrine is one of the first cholinesterase inhibitor used to treat Alzheimer's disease. The rational for associating a molecule of tacrine with an oxime is to improve the afinity of the compound with cholinesterase and place the reactivtor close to the phosphorylated active site

Reactivator nameFormulaStructure
7-MEOTA-4-pyridinealdoximeC25H33BrN4O2
Tacrine-pyridinealdoxime-1C23H27N4O2
Tacrine-pyridinealdoxime-2C23H25ClN4O2

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer