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Type_substrate Report for: Multitarget

Multitarget directed ligand (MTDL). In case of Alzheimer disease enzymes or pathways targeted include: Inhibition of AChE and or BCHE, Inhibition of glycogen synthase kinase-3 (GSK-3 kinase), BACE1-inhibitor (beta-secretase-1), antioxidant, Cannabinoid-Receptor-ligand, Sigma1R, Histamine-Receptor3-H3-Antagonist, H1-antihistamine, 5-HT-receptor-agonist, NMDA-ligand, Ca2+ channels block, Abeta aggregation, Metal ion chelator. Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. The targets include in these cases soluble epoxide hydrolase (sEH), 5-lipoxygenase (5-LOX), LTA4-hydrolase-inhibitor, dual sEH/FAAH
See also this moiety in type of inhibitors: Multitarget

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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