Type_substrate Report for: pyrethroid

The targets of pyrethroids are not Alpha/beta hydrolases. The synthetic pyrethroids delay closure of the sodium channel, resulting in a sodium tail current that is characterized by a slow influx of sodium during the end of depolarization. Carboxylesterases are involved in elimination of Pyrethroids and mutations can enhance resistance to pyrethroids
See also this moiety in type of inhibitors: pyrethroid

Substrate	Main targeted enzyme families	Type

Cypermethrin	6_AlphaBeta_hydrolase \| Carb_B_Arthropoda \| Carb_B_Chordata \| LYsophospholipase_carboxylesterase	Cyanide \| Cyclopropane \| Insecticide \| Not A/B H target \| Phenoxyphenyl \| pyrethroid

Deltamethrin	6_AlphaBeta_hydrolase \| Carb_B_Arthropoda \| Carb_B_Bacteria \| Carb_B_Chordata \| Carboxylesterase \| HNLyase_Bact	Cyanide \| Cyclopropane \| Insecticide \| Phenoxyphenyl \| pyrethroid

Esfenvalerate	Carb_B_Arthropoda \| Carb_B_Chordata	pyrethroid

Fenpropathrin	Carb_B_Arthropoda	Acaricide \| Cyanide \| Cyclopropane \| Insecticide \| Not A/B H target \| Phenoxyphenyl \| pyrethroid

Permethrin	Carb_B_Arthropoda \| Carb_B_Bacteria \| Carb_B_Chordata \| Carboxylesterase	Cyclopropane \| Drug \| Insecticide \| Not A/B H target \| Phenoxyphenyl \| pyrethroid

lambda-Cyhalothrin	6_AlphaBeta_hydrolase \| CarbLipBact_1 \| Carb_B_Arthropoda \| HNLyase_Bact	Cyanide \| Cyclopropane \| Insecticide \| Phenoxyphenyl \| pyrethroid

trans-Bifenthrin	Carb_B_Arthropoda \| HNLyase_Bact	Carbamate \| Cyclopropane \| Insecticide \| Not A/B H target \| Trifluoro \| pyrethroid

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

For technical information about these pages see:
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