Type Substrate

Tree Display

AceDB Schema

XML Display

Feedback

Type_substrate Report for: Choline ester

Acylcholines are acyl chain esterified to choline. Acetylcholine acts as a neurotransmitter in the central and peripheral nervous systems as well as an inhibitor of cytokine production by macrophages and immune cells. Acylcholines are metabolized by cholinesterases acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE). Long-chain acylcholines show greater stability in circulation. Metabolomic profiling studies have expanded endogenously produced members of the acylcholine class to include long-chain esters. This entry also contains phosphatidylcholine (phospholipids that incorporate choline as a headgroup) major component of biological membranes
See also this moiety in type of inhibitors: Choline ester

SubstrateMain targeted enzyme familiesTypeStructure
1-Stearoyl-2-arachidonylphosphatidylcholineHepatic_Lipase | PC-sterol_acyltransferase Choline ester | Diacylglycerol | Phosphatidylcholine | Phospholipid | Trimethylammonium
1-palmitoyl-2-linoleoylphosphatidylcholineHepatic_Lipase | Lipoprotein_Lipase | PC-sterol_acyltransferase | Plant_phospholipase Choline ester | Diacylglycerol | Phosphatidylcholine | Phospholipid | Trimethylammonium
AcetylazacholineACHE Acetate | Choline ester | Trimethylammonium
AcetylbetamethylcholineACHE Acetate | Choline ester | Trimethylammonium
AcetylbetamethylthiocholineACHE Acetate | Choline ester | Chromogen | Trimethylammonium
AcetylcholineACHE | BCHE | Cholinesterase | Cholinesterase-like Acetate | Choline ester | Natural | Trimethylammonium
AcetylselenocholineACHE Acetate | Choline ester | Trimethylammonium
AcetylthiocholineACHE | BCHE | Cholinesterase | Cholinesterase-like Acetate | Choline ester | Chromogen | Trimethylammonium
BenzoylcholineACHE | BCHE Benzoate | Choline ester | Trimethylammonium
BenzoylthiocholineACHE | BCHE Choline ester | Chromogen | Trimethylammonium
ButyrylcholineBCHE Butyrate | Choline ester | Trimethylammonium
ButyrylthiocholineBCHE Butyrate | Choline ester | Chromogen | Trimethylammonium
C14-lysophosphatidylcholineabh_upf0017 Choline ester | Lysophospholipid | Phospholipid | Trimethylammonium
CarbacholACHE Analogue of substrate | Carbamate | Choline ester | Drug | Not A/B H target | Trimethylammonium
DNPGPAF-Acetylhydrolase Choline ester | pNP
DiheptadecanoylphosphatidylcholineHepatic_Lipase Choline ester | Phospholipid | Trimethylammonium
DioleoyllecithinPhospholipase Choline ester | Diacylglycerol | Phosphatidylcholine | Phospholipid | Trimethylammonium
DipalmitoylphosphatidylcholinePC-sterol_acyltransferase | PlaB Choline ester | Diacylglycerol | Hexadecanoate | Palmitate | Phosphatidylcholine | Phospholipid | Surfactant | Trimethylammonium
HeptadecanoylphosphatidylcholineAlphaBeta_hydrolase | Hepatic_Lipase | PlaB Choline ester | Lysophospholipid | Phospholipid | Trimethylammonium
HeptanoylcholineBCHE Choline ester | Trimethylammonium
HexanoylcholineBCHE Choline ester | Hexanoate | Trimethylammonium
Myristoylcholine Choline ester | Trimethylammonium
PAFLYsophospholipase_carboxylesterase | PAF-Acetylhydrolase Choline ester | Natural | Not A/B H target | Trimethylammonium | Water-insoluble medium and long chain ester
PAF-2-ThioLYsophospholipase_carboxylesterase | PAF-Acetylhydrolase Choline ester | Trimethylammonium
POPCMbeg1-like | PC-sterol_acyltransferase | Phospholipase | Plant_phospholipase Choline ester | Diacylglycerol | Hexadecanoate | Palmitate | Phosphatidylcholine | Phospholipid | Trimethylammonium
PentanoylcholineBCHE Choline ester | Trimethylammonium
PropionylcholineACHE | BCHE Choline ester | Propionate | Trimethylammonium
PropionylthiocholineACHE | BCHE Choline ester | Chromogen | Propionate | Trimethylammonium
QA-CblBCHE Choline ester | Drug | Pro-Drug
RedGreen-BODIPY-PC-A2 BODIPY-derivative | Boron compound | Choline ester | Fluorescent Probe | Not A/B H target
Succinylcholine~SuxamethoniumBCHE Choline ester | Trimethylammonium
SuccinyldithiocholineBCHE Choline ester | Chromogen | Trimethylammonium

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer