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Type_substrate Report for: Pro-Drug

Comment

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. For example, salicin is a beta-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. Many prodrugs are synthetized to slow down the delivery of the active compound. Esterases often hydrolyze prodrugs and are targeted for that role. Genetic variants of these esterases may act differently and explain variation of response in patients bearing these variant

Substrate nameFormulaStructure
2-oxo-clopidogrelC16H16ClNO3S
BambuterolC18H29N3O5
CHEMBL1784957C20H26N2O2
CapecitabineC15H22FN3O6
CiclesonideC32H44O7
CurDDC33H36O12
Dabigatran-etexilateC34H41N7O5
DipivefrinC19H29NO5
EnalaprilC20H28N2O5
Eslicarbazepine-acetateC17H16N2O3
Ethyl-CarprofenC17H16ClNO2
Ethyl-FlurbiprofenC17H17FO2
Ethyl-ZaltoprofenC19H18O3S
Ibuprofen-Ethyl-EsterC15H22O2
Idalopirdine-rivastigmineC21H24FN3O2
ImidaprilC20H27N3O6
Isosorbide-2-aspirinate-5-salicylateC22H20O9
Ketoprofen-Butyl-EsterC20H22O3
Ketoprofen-Ethyl-EsterC18H18O3
Ketoprofen-Glycerol-EsterC19H20O5
Ketoprofen-Vinyl-EsterC18H16O3
MGS0274C21H32FNO7
MolnupiravirC13H19N3O7
Naproxen-Ethyl-EsterC16H18O3
Naproxen-Methyl-EsterC15H16O3
OseltamivirC16H28N2O4
QuinaprilC25H30N2O5
RemdesivirC27H35N6O8P
S-bromobenzylglutathione-dicyclopentyl-esterC27H38BrN3O6S
SacubitrilC24H29NO5
SelexipagC26H32N4O4S
TemocaprilC23H28N2O5S2
Tenofovir-alafenamideC21H29N6O5P
TrandolaprilC24H34N2O5
W22-methyl-esterC13H16N2O3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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