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Type_substrate Report for: Pro-drug

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. For example, salicin is a beta-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. Many prodrugs are synthetized to slow down the delivery of the active compound. Esterases often hydrolyze prodrugs and are targeted for that role. Genetic variants of these esterases may act differently and explain variation of response in patients bearing these variant
See also this moiety in type of inhibitors: Pro-drug

SubstrateMain targeted enzyme familiesTypeStructure
2-oxo-clopidogrelCarb_B_Chordata Acetate | Drug | Not A/B H target | Pro-drug | Pyridine
BambuterolBCHE Carbamate | Drug | Pro-drug | tert-Butyl
Beclomethasone-dipropionateArylacetamide_deacetylase Drug | Not A/B H target | Pro-drug | Propionate | Steroid
CHEMBL1784957 Carbamate | Derivative of Rivastigmine | Drug | Pro-drug
CapecitabineCarb_B_Chordata | Carboxylesterase Carbamate | Drug | Pro-drug | Pyrimidine
CiclesonideCarb_B_Chordata Butyrate | Drug | Not A/B H target | Pro-drug
CurDDBCHE | CMBL | Carb_B_Chordata Drug | Natural_modified | Pro-drug
Dabigatran-etexilateCarb_B_Chordata Drug | Not A/B H target | Pro-drug | Propionate | Pyridine
Dimethyl-fumarateCarb_B_Chordata Drug | Not A/B H target | Pro-drug
DipivefrinACHE | BCHE | Carb_B_Chordata Drug | Not A/B H target | Pro-drug | Propionate
EnalaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Pro-drug | Pyrrolidine
Eslicarbazepine-acetateArylacetamide_deacetylase | Carb_B_Chordata Acetate | Benzazepin | Carbamate | Carboxamide | Drug | Pro-drug
Ethyl-CarprofenHormone-sensitive_lipase_like Alkyl ester | Carbazol | Drug | Not A/B H target | Pro-drug | Propionate
Ethyl-FlurbiprofenBacterial_lip_FamI.3 | Canar_LipB | Hormone-sensitive_lipase_like Alkyl ester | Drug | Not A/B H target | Pro-drug | Propionate
Ethyl-ZaltoprofenBacterial_lip_FamI.3 | Hormone-sensitive_lipase_like Alkyl ester | Drug | Not A/B H target | Pro-drug | Propionate
Ibuprofen-Ethyl-EsterHormone-sensitive_lipase_like Drug | Pro-drug | Profen prodrug | Propionate
Idalopirdine-rivastigmineBCHE 5-HT-receptor-ligand | Carbamate | Derivative of Rivastigmine | Drug | Multitarget | Pro-drug
ImidaprilCarb_B_Chordata Drug | Not A/B H target | Pro-drug
Isosorbide-2-aspirinate-5-salicylateBCHE | Carb_B_Chordata Acetate | Benzoate | Drug | Pro-drug | Salicylic
Ketoprofen-Butyl-EsterCanar_LipB Aryl ester | Drug | Pro-drug | Profen prodrug | Propionate
Ketoprofen-Ethyl-EsterBacterial_lip_FamI.3 | Canar_LipB | CarbLipBact_1 | Hormone-sensitive_lipase_like | Lipase_2 Aryl ester | Drug | Pro-drug | Profen prodrug | Propionate
Ketoprofen-Glycerol-EsterCanar_LipB Drug | Pro-drug | Profen prodrug | Propionate
Ketoprofen-Vinyl-EsterCanar_LipB Aryl ester | Drug | Pro-drug | Profen prodrug | Propionate
MGS0274Carb_B_Chordata Drug | Not A/B H target | Pro-drug
MolnupiravirCarb_B_Chordata Drug | Not A/B H target | Pro-drug | Propionate
Naproxen-Ethyl-Ester6_AlphaBeta_hydrolase | Canar_LipB | Hormone-sensitive_lipase_like Drug | Naphthalen | Pro-drug | Profen prodrug | Propionate
Naproxen-Methyl-Ester6_AlphaBeta_hydrolase | Hormone-sensitive_lipase_like Drug | Naphthalen | Pro-drug | Profen prodrug | Propionate
OseltamivirCarb_B_Chordata Drug | Not A/B H target | Pro-drug
QuinaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Isoquinoline | Not A/B H target | Pro-drug
RemdesivirCarb_B_Chordata | Carboxypeptidase_S10 Drug | Not A/B H target | Pro-drug | Propionate
S-bromobenzylglutathione-dicyclopentyl-esterCarb_B_Chordata Drug | Not A/B H target | Peptide | Pro-drug | Sulfur Compound
SacubitrilCarb_B_Chordata Drug | Not A/B H target | Oxobutanoate | Pro-drug
SelexipagCarb_B_Chordata Drug | Not A/B H target | Pro-drug
TemocaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Azepane | Drug | Not A/B H target | Pro-drug
Tenofovir-alafenamideCarb_B_Chordata | Carboxypeptidase_S10 Aminopurin | Drug | Pro-drug | Propionate
TrandolaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Pro-drug | Pyrrolidine
W22-methyl-esterBacterial_esterase | Canar_LipB Benzodiazepin | Drug | Not A/B H target | Pro-drug

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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