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Type_substrate Report for: Pyrethroid

Comment

The targets of pyrethroids are not Alpha/beta hydrolases. The synthetic pyrethroids delay closure of the sodium channel, resulting in a sodium tail current that is characterized by a slow influx of sodium during the end of depolarization. Carboxylesterases are involved in elimination of Pyrethroids and mutations can enhance resistance to pyrethroids

Substrate nameFormulaStructure
DeltamethrinC22H19Br2NO3
FenpropathrinC22H23NO3
PermethrinC21H20Cl2O3
lambda-CyhalothrinC23H19ClF3NO3
trans-BifenthrinC23H22ClF3O2

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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