<Journal class="Journal" value="EMBO Journal" /> <Page class="#txt" value="3561"> <Page-2 class="#txt" value="8" /> </Page> <Volume class="#txt" value="11" /> <Year class="Year" value="1992" /> </Reference> <Author class="Author" value="Shafferman A" /> <Author class="Author" value="Velan B" /> <Author class="Author" value="Ordentlich A" /> <Author class="Author" value="Kronman C" /> <Author class="Author" value="Grosfeld H" /> <Author class="Author" value="Leitner M" /> <Author class="Author" value="Flashner Y" /> <Author class="Author" value="Cohen S" /> <Author class="Author" value="Barak D" /> <Author class="Author" value="Ariel N" /> <Medline class="Medline" value="1396557" /> <Mutation class="Mutation" value="D74N_human-ACHE" /> <Mutation class="Mutation" value="Y341A_human-ACHE" /> <Mutation class="Mutation" value="D74K_human-ACHE" /> <Mutation class="Mutation" value="D74G_human-ACHE" /> <Mutation class="Mutation" value="D74E_human-ACHE" /> <Mutation class="Mutation" value="W86A_human-ACHE" /> <Mutation class="Mutation" value="W86E_human-ACHE" /> <Mutation class="Mutation" value="E202A_human-ACHE" /> <Mutation class="Mutation" value="E202Q_human-ACHE" /> <Mutation class="Mutation" value="E202D_human-ACHE" /> <Mutation class="Mutation" value="W286A_human-ACHE" /> <Mutation class="Mutation" value="E334N_human-ACHE" /> <Mutation class="Mutation" value="Y337A_human-ACHE" /> <Mutation class="Mutation" value="Y337F_human-ACHE" /> <Mutation class="Mutation" value="F338A_human-ACHE" /> <Mutation class="Mutation" value="WT_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_WT_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_D74E_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_D74N_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_D74G_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_D74K_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_E202Q_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_E202D_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_E202A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_W286A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_Y337F_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_Y337A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_F338A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Acetylthiocholine_Y341A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_WT_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_D74E_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_D74N_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_D74G_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_D74K_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_E202Q_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_E202D_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_E202A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_W286A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_Y337F_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_Y337A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_F338A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Edrophonium_Y341A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_WT_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_D74E_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_D74N_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_D74G_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_D74K_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_E202Q_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_E202D_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_E202A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_W286A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_Y337F_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_Y337A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_F338A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Propidium_Y341A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_WT_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_D74E_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_D74N_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_D74G_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_D74K_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_E202Q_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_E202D_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_E202A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_W286A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_Y337F_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_Y337A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_F338A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="Decamethonium_Y341A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_WT_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_D74E_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_D74N_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_D74G_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_D74K_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_E202Q_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_E202D_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_E202A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_W286A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_Y337F_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_Y337A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_F338A_human-ACHE" /> <Kinetic_parameter class="Kinetic_parameter" value="BW284C51_Y341A_human-ACHE" /> <Abstract class="LongText" value="Shafferman_1992_EMBO.J_11_3561" /> <Inhibitor class="Inhibitor" value="BW284C51" /> <Inhibitor class="Inhibitor" value="Decamethonium" /> <Inhibitor class="Inhibitor" value="Edrophonium" /> <Inhibitor class="Inhibitor" value="Propidium" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Km_Acetylthiocholine_Y341A_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Kcat_Acetylthiocholine_Y341A_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Kapp_Acetylthiocholine_Y341A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Edrophonium_Acetylthiocholine_Y341A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Propidium_Acetylthiocholine_Y341A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_Decamethonium_Acetylthiocholine_Y341A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_WT_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_D74E_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_D74N_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_D74G_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_D74K_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_E202Q_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_E202D_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_E202A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_W286A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_Y337F_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_Y337A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_F338A_human-ACHE" /> <Kin_value class="Kin_value" value="Ic50_BW284C51_Acetylthiocholine_Y341A_human-ACHE" /> </Paper>