CLUSTAL multiple sequence alignment human-LIPI LCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQ---- human-LIPH ---LCLSRSDAEETCPSFTRLSFHSA---VVGTGLNVRLMLYTRKNLTCAQTI------- rabit-Q9BDJ4 ---LCLVRSDTDETCPSFTKLSFHSA---VVGTELNVRLLLYTRKNYTCAQII------- mouse-LIPH ---MCLVKSDTDETCPSFTRLSFHSA---VVGTGLSVRLMLYTQRDQTCAQII------- ratno-q6p6s8 ---MCLVKSDTDETCPSFTRLSFHSA---VVGTGLSVRLMLYTQRDQTCAQVI------- xenla-LIPHA GCLLSWGRSDTEGQCHTFTDLNIHNA---IIGTGLKVQLLLYTRENPNCAQDLNED---- xentr-q5xge9 GCLLSWGRSDTEEQCHTFTDLNIHNS---IIGTGLKVQLLLYTRENPKCAQDLNVD---- xenla-q641f6 GCLLSWGRSDTEGQCHSFTDLNIHNS---IIGTALKVQLLLYTPENPKCAQDLNED---- danre-LIPH -------DTHRAQECEEMTDLNFKDS---LAGTSLKVRLLLYTRADPSCGQLLSHQ---- tetng-q4sfm7 LLLLLIDQHTCDQGCDEFTDLSFSHS---FIGTSVRVRLLLYTSEGGTCGSLVSHT---- human-PLA1A -GSSGDAPPTPQPKCADFQSANL------FEGTDLKVQFLLFVPSNPSCGQLVEGS---- ponpy-q5ref0 -GSSGDAPPTPQPNCADFQSANL------FEGTDLKVQFLLFVPSNPSCGQLVEGS---- bovin-q5e9h0 -GSTGDAPPTPQTNCTDFQNANL------LRGTNLKVQFLLFTPLDPSCGQLVEES---- mouse-psplip -GSSGNVPPTTQPKCTDFQSANL------LRGTNLKVQFLLFTPSDPSCGQLVEEG---- ratno-P97535 -GRSGNVPPTTQPKCTDFQSANL------LRGTNLKVQFLLFTPSDPGCGQLVEED---- danre-q6nyz4 TSALGDDEEASASKCADFNNTTWLEY---RQATKLQVQYLLLTRKNANCASLFTQDCLNH * : . . : . :: . . *.. . human-LIPI NNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIY human-LIPH NSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIY rabit-Q9BDJ4 NSTTFGNLNVTKKTTFVVHGFRPTGSPPVWLQDLVKALLMVEDMNLVVVDWNRGATTVIY mouse-LIPH NSTALGSLNVTKKTTFIIHGFRPTGSPPVWIEELVQSLISVQEMNVVVVDWNRGATTVIY ratno-q6p6s8 NSTALGSLNVTKKTTFIIHGFRPTGSPPVWMEELVQSLISVQEMNVVVVDWNRGATTVIY xenla-LIPHA NSTGFQYLNVTRKTVFIIHGYRPTGSPPVWIDDIVKKFLDIQDFNVIVVDWNRGATTVLY xentr-q5xge9 NSTGFQYLNVTRRTVFITHGYRPTGSPPVWIDDIVKKFLDIQDFNVIVVDWNRGATTVLY xenla-q641f6 NSTGFQYLNVTRKTVFITHGYRPTGSPPVWIDNIVTKFLDIQDFNVILVDWNRGATTVLY danre-LIPH EPFSNSQFNVSSVTTFLIHGYRPTGSPPVWMKQFVEFLLNRRDMNVIVVDWNRGATNMNY tetng-q4sfm7 DPSAHPRFNFSRPTTFLIHGYRPTGSPPKWLSNITKLLLAGTHTNLIIVDWNYGAANVNY human-PLA1A SDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTG-VY ponpy-q5ref0 SDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDKFIRTLLLATNANVIAVDWIYGSTG-VY bovin-q5e9h0 SDIQNSGFNATLGTKLVIHGFRALGTKPSWIDRFIDALLRAADANVIAVDWVYGSTA-AY mouse-psplip SDIRSSEFNASLRTKVIIHGFRALGTKPSWIDKFISAVLRAADANVIAVDWVYGSTG-VY ratno-P97535 SDIRNSEFNASLGTKLIIHGFRALGTKPSWINKFIRALLRAADANVIAVDWVYGSTG-MY danre-q6nyz4 TQKHTAYFNSSLPTKVIVHGYRALGSKPSWVSGLAQALLREEDVNVLVVDWVYGASF-AY :* * : **:* *: * *:. : .: . *:: *** *:: * human-LIPI NRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGL human-LIPH THASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGL rabit-Q9BDJ4 TQASNKTRKVAIILKEFIDQMLARGASLDDIYMIGVSLGAHISGFVGKMYNGQLGRITGL mouse-LIPH PHASSKTRQVASILKEFIDQMLVKGASLDNIYMIGVSLGAHIAGFVGESYEGKLGRVTGL ratno-q6p6s8 PHASSKTRKVALILKEFIDQMLAKGASLDNIYMIGVSLGAHIAGFVGEMYSGKLGRITGL xenla-LIPHA HNAAANTRKVADILKRLIDNMLSQGATLDSVYMVGVSLGAHISGFVGKMYNGSIGRITGL xentr-q5xge9 HNAAANTRKVADILKRFIDNMLSQGATLDSIYMVGVSLGAHISGFVGKMYNGSIGRITGL xenla-q641f6 HNAAAKTRKVADILKRLIDNMLSQGATLDSIYMVGVSLGAHISGFVGKMYNGSIGRITGL danre-LIPH WQVVKNTRKVANNLTDLIQKMKDNGANLSSIHMIGVSLGAHISGFTGANFNGEIGRITAL tetng-q4sfm7 LIAARNTHAVAENLTAFVERLKEKGLSLSSIHMIGVSLGAHISGFVGANMNGSIGRITAL human-PLA1A FSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGL ponpy-q5ref0 FSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGL bovin-q5e9h0 FSAVENVIKLGLEISRFLRKLLALGVSESSIHIIGISLGAHVGGMVGHFYNGQLGQITGL mouse-psplip YSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGQITGL ratno-P97535 FSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGRITGL danre-q6nyz4 NLVVENYKEVAVQISVLINQLTKYGSTLESFHFIGVSLGAHVSGFVGTLFHGKLGRITGL . : :. :. : .: * . ...:::*:*****:.*:.* * :*::*.* human-LIPI DPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSI human-LIPH DPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTI rabit-Q9BDJ4 DPAGPLFNGKPPQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGVDQPGCPKTI mouse-LIPH DPAGPLFNGRPPEERLDPSDALFVDVIHSDTD--GYKEALGHIDFYPNGGLDQPGCPKTI ratno-q6p6s8 DPAGPLFNGRPPEDRLDPSDAQFVDIIHSDTDALGYREALGHIDFYPNGGLDQPGCPKTI xenla-LIPHA DPAGPLFNGKPPEERLHYTDAQFVDVVHTDIDGLGYKESLGHIDFYPNGGTDQPGCPKTI xentr-q5xge9 DPAGPLFNGKPPEERLHYTDAQFVDVVHSDTDGLGYKESLGHIDFYPNGGTDQPGCPKTI xenla-q641f6 DPAGPLFNGKPPEERLHYTDAQFVDVVHTDTDGLGYKESLGHIDFYPNGGTDQPGCPKTI danre-LIPH DPAGPEFNGRPPEDRLDPSDALFVEALHTDMDALGYRNLLGHIDYYANGGADQPGCPKTI tetng-q4sfm7 DPAGPLFTGTLPKDRLDPSDAQFVDVLHTDIDALGFRGPLGHIDFYPNGGTDQPGCPNNI human-PLA1A DPAGPEYTRASVEERLDAGDALFTEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFF ponpy-q5ref0 DPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFF bovin-q5e9h0 DPAGPEYTRASLEERLDPGDALFVEAIHTDTDNLGIRIPVGHVDYFINGGQDQPGCPTSI mouse-psplip DPAGPEYTRASLEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFF ratno-P97535 DPAGPEYTRASLEERLDSGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFI danre-q6nyz4 DPAGPMFKSADPFDRLDSSDALFVEAIHTDSDYFGISIPVGHVDFFLNGGMDQAGCARSR ***** :. .**. ** *.: :*:* : * :*::*:: *** .*.**. human-LIPI F-SGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLG human-LIPH L-GGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLG rabit-Q9BDJ4 FEAGMQYFKCDHQMSVYLYLSSLRKNCTITAYPCDSYRDYRNGKCINCGLPQGKPCPLLG mouse-LIPH F-GGIKYFKCDHQMSVYLYLASLQNNCSITAYPCDSYRDYRNGKCVSCGAGQIVPCPRVG ratno-q6p6s8 F-GGIKYFKCDHQMSVFLYLASLQNNCSITAYPCDSYRDYRNGKCVSCGAGHIVSCPSLG xenla-LIPHA L-AGSEYFKCDHQRSVYLYISSLKKNCDLVGFPCKSYRDYRIGNCTDCKEFLPLSCPVLG xentr-q5xge9 L-AGSEYFKCDHQRSVFLYIASLTKSCDLVAFPCKSYRDYRIGNCTDCKEFLPLSCPVLG xenla-q641f6 L-SGSEYFKCDHQRSVFLYIASLTNNGDLVGFPCKSYRDYRIGNCTNCKEFLPLSCPVFG danre-LIPH L-SGSEYFKCDHQRSVFLYMSSVNGSCPIIAYPCESYTDFQDGTCMDCGKFKSAGCPIFG tetng-q4sfm7 F-SGLSYFKCDHQRSVYLYMDSISRVCDSRAYPCQSYQDFLNGLCSSCERFGDAGCPVFG human-PLA1A Y-AGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIG ponpy-q5ref0 Y-AGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIG bovin-q5e9h0 Y-AGYSYLICDHMRAVHLYISALENSCPLVAFPCTNYKDFLAGQCLDCFNPFLLSCPRIG mouse-psplip H-AGYNYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIG ratno-P97535 H-AGYSYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIG danre-q6nyz4 FASMYGYVICDHMRALHVYMSALNGSCPLIGFPCSGYEEFLAGKCITCDDPFNGTCPQIG . :. *:* ::.::: :: .:** .* : . * * ** .* human-LIPI YQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLN human-LIPH YYADNWKDHLRGK---DPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRD rabit-Q9BDJ4 YYADNWKDYLSEK---DPPMTKAFFDTAEKEPYCMYHYFVDIITWNKSIRRGSITIKLKD mouse-LIPH YYADSWKEYLWDR---DPPMTKAFFDTAETKPYCMYHYFVDIVSWNKSVRRGFITIKLRG ratno-q6p6s8 YYADNWREYLWDR---DPPMTKAFFDTAETKPYCIYHYFVDIISWNKSVRRGFITIKLRG xenla-LIPHA FYADKWKDHLVEK---NPPGTKAFFDTAAKDPFCKFHYYLDFMTWSSQTKRGYITIKLKS xentr-q5xge9 FYADKWKDHLVKR---NHPGTTAFFDTAAKDPYCIFHYYLDFMTWSSQIRRGYITIKLTS xenla-q641f6 FYADKWKDHLVKK---NPPGTKAFFDTAAKDPFCIFHYYLDIMTWSSQTRRGYITIRLMS danre-LIPH YDSVRWRDTLVQL-----EQTRTYFQTNKASPFCKVGYKVDIVSWNQKTHWGYLTIKLSN tetng-q4sfm7 YYVTQWKDVLLKL-----NQTNVYFTTNSASPFCTAQYTVDVTVWNKAVRWGYLTVKLYS human-PLA1A LVEQG--GVKIEP---LPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLS ponpy-q5ref0 LVEQG--GVKIEP---LPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLS bovin-q5e9h0 LVEQG--GVKIEP---LPKEVKVYLLTTSMAPYCVHHSLVEFHLQEPRNKDTCITVTFLS mouse-psplip LVERG--GVMIEP---LPKEVKVYLLTTSSAPYCVHHSLVEFYLKEKRKKDTSIEVTFLS ratno-P97535 LVERG--GVKIEP---LPKEVRVYLQTTSSAPYCVHHSLVEFNLKEKRKKDTSIEVTFLG danre-q6nyz4 LLKNS--GITATP---LPNQEKVYLLTTASGPFCAHHILVELNVSR---LDKTAEVQLIL .:: * *:* :.. . : human-LIPI QLG--MIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKI human-LIPH KAG--NTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLM-FSTGSLIGPRYKLRI rabit-Q9BDJ4 EAG--NTTESKINHEPVTFEKYHQVSLLARFNQDLDKVAEISLV-FSTGAVIGPKYKLRI mouse-LIPH EDG--NITESKIDHEPSAFEKYHQVSLLARFNRDLDKVAEISLL-FSTGSVVGPKYKLRV ratno-q6p6s8 EDG--NITESKIDHEPSAFQKYHQVSLLARFNRDLDKVAEISLL-FSTKSVVGPKYKLRV xenla-LIPHA LDG--NVTESKLDKDHATFQQYKETSLLAKFDQDLDQISKISVT-FTTGSIIGPKYKLRV xentr-q5xge9 LDG--NVTESKLDKDAAVFEQYKEESLLAKFDQDMDPISRISVT-FTTGSVIGPKYKLRV xenla-q641f6 LNG--NVTESKLDKDHATFEQYKEVSLLAKFDQDLDPMTRISVT-FTTGSVIGPKFKLRV danre-LIPH GT---EETQVELNHKSLKFERFQETSVLAQFERDIQPVKKITLK-FCPRKGLRPRKKLRL tetng-q4sfm7 AD---QEAVATIDHTAFTFKRFTETRLLAQFDKDIKSVEKMSLK-FSTGSVLQPKYKLRV human-PLA1A SNI---TSSSKI---TIPKQQRYGKGIIAH-ATPQCQINQVKFK-FQSSNRVWKKDRTTI ponpy-q5ref0 SNV---TSSSKI---TIPKQQRYGKGIIAH-ATPQCQINQVKFK-FQSSNRVWKKDRTTI bovin-q5e9h0 SSV---TSSVKI---TIPRHQRVGKGVLAH-PSPQCQINQVKLK-LQASHRVWKKDQTTI mouse-psplip NNV---TSSVKI---TIPKQQLEGRGVMAH-PNPQCQINQVKLK-FQVSSRVWRKDRTPV ratno-P97535 NNV---TSSVKI---TIPKDHLEGRGIIAH-QNPHCQINQVKLK-FHISSRVWRKDRTPI danre-q6nyz4 KSIGHPETELNL---KLYTDETRYKTVAAH-PEQLCKIDSMQL--INTGGRFYRQGDIHF : . : *: : : . : . human-LIPI QR---LMLKSLTYPERPPLCRYNIVLKDREEVFLNPN--TCTPKNT human-LIPH LR---MKLRSLAHPERPQLCRYDLVLMENVETVFQPI--LCPELQL rabit-Q9BDJ4 LR---MKLRSLAHPERPQLCRYDLVLTENVETPFQPI--VCQKLQM mouse-LIPH LQ---MKLRSLAHPDRPHLCRYDLVLMENVETSFQPI--LCSQQQM ratno-q6p6s8 LR---MKLRSLAHPDRPHLCRYDLVLMENVETFFQPI--LCSKQQM xenla-LIPHA LR---MRLRPLTNRDRPILCRYDFVLLENIEMEFIPI--PCEDTNL xentr-q5xge9 LR---MRLRPFTNRNRPILCRYDFVLLENIETEFIPI--PCEDTNL xenla-q641f6 LR---MRLRPLTNTNRPILCRYDFVLLENVEMEFNPI--PCEDTNL danre-LIPH LH---IRLTPLQNHLRP-LCRYDLLLEESKDVTFKPI--PCEDSNF tetng-q4sfm7 LR---VRLTPLEREERP-LCRYDIVAAEDREVTFRPL--PCEDS-- human-PLA1A IGKFCTALLPVNDREKM-VCLPEPVNLQASVTVSCDLKIAC----V ponpy-q5ref0 IGKFCTALLPVNDREKM-VCLPEPVNLQASVTVSRDLNLAC----V bovin-q5e9h0 IGRFCTAPLPVNDNKKM-VCLPEPVNLQASETVSHDLKITC----I mouse-psplip VGTFCTAPLPVNDSKKT-VCIPEPVRLQAGVPAFQDLKIAC----V ratno-P97535 VGTFCTAPLPVNDSKKT-VCIPEPVRLQVSMAVLRDLKMAC----V danre-q6nyz4 EY-ICISEIPQTRGMDP-LCVKN-IHIGRGVPWSHDFVQVC----- . :* : : *