Reference sequence (1): human-C2orf43 Identities normalised by aligned length. Colored by: consensus/70% and property |
1 human-LDAH 100.0% --------MDSE-----LKEEIPVHEEFILCGGA--ETQVLKCGPWT---------DLFHDQSVKRPKLLIFIIPGNPGFSAFYVPFAKALYSLT--------------NRRFPVWTISH 2 ponab-cb043 97.2% --------MDSE-----LKEEIPVHEEFILCGGA--ETQVLKCGPWT---------DLFNDQSVKRPKLLIFIIPGNPGFSAFYVPFAKALYSLT--------------NRCFPVWTISH 3 mouse-Ldah 66.0% --------MASE-----VEEQIPVREEFFLCGGV--ETKIIKCGPWT---------NLFEKQDVSKPKQLIFIIPGNPGYSAFYVPFAKALYTLM--------------KSRFPVWIISH 4 rat-Ldah 65.8% --------MASE-----VEDGVPVHEEFFLCGGV--ETQIIKCGPWT---------NLFDKQGVSKPKHLIFVIPGNPGLSPFYVPFAKALYSLV--------------KGHFPVWIISH 5 chick-cb043 52.7% --------MRSV-----SEEPVPLHEEFIYCCGA--ATHVLKCGPWK---------DLSKDESKNLPRLLFMIIPGNPGLAGYYRTFIKALYCGL--------------NQQYPVWVVSH 6 xentr-q0vfe8 48.9% --------HRTM-----SEDHFPVHDEFIYCSGG--ATEVLKFGPWK---------DLQKSNGESKPKLLILIIPGNPGVVGFYRTFMQSLYCSL--------------DQRYPVWAISH 7 danre-b3dii8 44.5% --------MNSSGS---EGPGEDASVEFVYCRGV--VTELLKYGPKD---------LHTASKGPNSPKTLILVIPGNPGVVGFYKTYMWTLYQKF--------------LQRYPVWAVSH 8 tetng-q4t826 42.3% --------MKDLV----LKTSREGQTDFIYCCGV--ATELLRFGP-----------------CLPGCRLLFLVIPGNPGVVGFYRTFMQTIHSVC--------------GYTHPVWAVSH 9 brafl-c3yr72 34.6% -----VKEMSQKSV-------PKVRSEFLCVDGT--PTHVLKCGDF---------------PTDQGKNYLYLIIPGNPGVIGYYDKFMRELYRKH--------------GGRIPVWGVSH 10 nemve-a7sqk0 33.1% --------------------------------------------------------------DESSSNLCAVIIPGNPGLIEYYDDFIISLFQWS--------------GKTLPIYGVSH 11 nemve-a7rqa8 28.5% ------------------------------------PTKI-----------------SCATPRQDAEKVCVVVIPGNPGSIEFYDIFIATLFSES--------------GGKIPIYGVGH 12 triad-b3s478 27.5% --------MTDTTRQL-----YNLTRSVCYTGKI--PTKYFTLSPV---------------NANREGDKRILIIPGNPGICDYYITFAIRLFQAT--------------GCRLSIDCVDH 13 ixosc-b7qa78 31.1% --------MEAGQ----VATKSKAHYDYIIVNDV--PTKLLTIGK--------------TSISDCSQEPLFIFFPGNPGIIEYYEEFLQEIYDNF--------------EGKLHVCGLAH 14 acypi-c4wsr5 29.1% ---------------------LKARDLWVDVNGV--PTRVLCWGQPI------------DEDNKHELKRVVLCVCGNPGVTEFYEKFLQEVYRTL----------------NVPVWVLSH 15 aedae-q1hqe6 29.3% --------MQ---------------ESYPVVGNV--PTHILTWGKWI-------------EESLGDHKEIVLCITGNPGLPGFYTKFLSTVHECL--------------NKEMPVWVIGH 16 culqu-b0wiv0 29.1% --------MQ---------------ESYPVVGKV--PTHILTWGKWI-------------EESLNDQKEIVICITGNPGLPGFYTQFLSTIHECL--------------NKELPVWVIGH 17 anoga-q7qa52 27.9% --------MQ---------------ESYPVIAKV--PTHILTWGKWI-------------EESLGDQKEIVLCITGNPGLPGFYTKFLSTVYECL--------------NKELPVWVIGQ 18 drome-CG9186 29.9% --------MQ---------------EAYVNINSI--PTHIFTWGRWI--------------EETITEKEIVICITGNPGLPGFYTEFAGTLQKEL---------------GDLPVWVIGH 19 caebr-a8y1r7 22.8% --------MGADL-----------------------SDEMLEIPA----------------NKENENRVVILMIPGNPGNEGFYAHFGREVLRNLLARDAETQ---RNEKNEYLFYTVSS 20 caeel-F26A3.1 23.4% --------MGLDI-----------------------SDETLKIQK----------------KKENENRVIILMIPGNPGNEGFYAHFGREVLQNLIKKDEDEQ---KNLKNQYLFYTVSS 21 dicdi-u554 22.5% --------MELIE--------EIINLDEAIQGET--RTEIIYT------------------KSQTPSNIKIIVIAGNPGIESFYQEFVKVLNLSF--------------NSKYDIYGVGH 22 9chlo-c1fhv2 20.2% --------VSSPG--------VEVTSRVVRVGPRKIPTELITIPS---------------DQSVKAPKYDLVIVPGNPGVPSFYEHYAKTLHALL--------------DGDVDIEIFGY 23 ostlu-a4s8s1 14.6% --------VSRDIVRDRAASSASASTSSSTLTGC--EYEIIRA------------------RRADGKGPRVFVVPGNPGCAAFYATFAKTLCDELD---------------AVRVDVVGY 24 ostta-q00tt1 16.6% --------ASSSSVVERAVKSSEVRRSNVTIASC--EYEVVRV------------------ERELGRGPRVFVVPGNPGVARFYETFASSLSERLD---------------ARAVDVVGY 25 arath-T19F11.2 20.1% --------METQNK-LMNETKRHVKSRLCRVSGS--MTEMMEIQA-------------------ENPTFHVLFIPGNPGVVSFYKDFLESLYEFL--------------GGNASVIAIGQ 26 poptr-b9iip0 20.8% --------MSCPNL-LLSNPRKHATLRLSKVSGH--TTELLEIQS-------------------DKPTFHVLFIPGNPGVVSFYKDFLESLYELL--------------GGSASVTAIGH 27 ricco-b9svy8 21.8% --------MNLEN--SHSTLKSTVDFRVCNVSGY--KTELLEICS-------------------DDPRLHILFIPGNPGVVSFYKDFLGSLYEFL--------------GRSASVTAIGH 28 maize-b4fuv1 20.2% --------METAR----LTPREQATTRICQVSSF--ATELLEIRS-------------------KEPSLHVLLIAGNPGIAAFYKDCVEALYENL--------------GGQASITAIGH 29 orysa-B9EWJ8 17.7% --------MEKAR--LRAFQREQATAKTCMVSSF--ATDFLEIRA-------------------KEPSVHVLVIPGNPGIVAFYKDFVEELYENL--------------GGQASITAIGH 30 phypa-a9s6w1 22.1% --------MG-----LPSVSTPPVSFRVDRIGGH--ATEIVDLRA-------------------DKPAFHVFFVPGNPGVVAYYKDFLEALFDHL--------------AGQASVTAISH 31 copc7-a8n2c2 21.2% MLPHFLRSISSTQKHKTSAA----------------LNAVFEHNPPL---DTAHAHWWPPKIQNTPPKCVLLFVPGNPGLIEFYTPFLEALYNRDT-------------SGRLAILAHAH 32 lacbs-b0cr66 24.6% --------MSHTL-----------------SGGQPNAKVILQLSSFS---------SYLHNGCTDSSS-----FPGNPGLLDFYLPFLNALYQKDT-------------TTTLAILAIGH 33 leibr-a4hen1 20.7% --------MSSPN--------TIVAWKAPVAGGV--VVDVLQSSSNLLQYLTTVESSNGGCELPNSNRKLLVFFPGNPGLVQFYEPMCACLE-----------------KNKFDVLVMGY 34 leiin-a4i1v9 21.0% --------MSSPN--------TIVAWRAPVAGGA--VVDVLQSSSNLLQYLSTEESSNDGRRLPSSHRKLLVFFPGNPGLVQFYEPLCAFLE-----------------TNKFDVLVMGY 35 leima-q4q9g9 21.0% --------MSSPN--------TIVAWRAPVAGGA--VVDVLQSSSNLLQYLSTEESSNDGRRLPSSHRKLLFFFPGNPGLVQFYEPLCAFLE-----------------TNKFDVLVMGY 36 tryb2-q57v42 18.5% VN------TTSSN--------LIVTWRSRRCVAP--VVEVLQSRPHLLDCLTMFPNGTKALHSPTTCKKMFVLFPGNPGIVNFYEQFVELLS-----------------LKDVDVLVMGY 37 trycr-q4dp03 20.1% --------MSLPN--------AIVTWQCPNRPFS--VVEVLQSCPNLLDYLCETSCTEAMRRPPSPHRKLFILFPGNPGLVHFYERFVELMT-----------------LRRLDVLVMGF 38 trycr-q4dvl8 20.1% --------MSLPN--------AIVTWQCPSQPFS--VVEVLQSCPNLLDYLCETSCTEAMRRPPSPHRKLFILFPGNPGLVHFYERFVELMT-----------------LRRLDVLVMGF 39 ashgo-q753k6 20.2% --------MSSQT--TKEAAKARTVVETLCDPDI--DADMLHI--------------W---SEWIQPECILIFLPGNPGLINFYREFLRSIHEK---------------NPTWEIVGISH 40 canga-q6fku7 18.8% --------MS---------------VQGYHDSAL--PTCIIHIKP--------------TVTNNDESSPLFVWIPGNPGLLEYYQEFLAKVHDK---------------NPTWEILGISH 41 lactc-c5dja0 18.9% --------MK---------------IEASFVGGE--PSSILHLKS--------------GVSSLGSDACLFVFIPGNPGLIEYYVPFLQQVHEK---------------NPDWEILGISH 42 vanpo-a7tp79 18.3% --------MS--------------LVKVFEDSIY--PTSIVHLDPL-------------TKELSPEDSPLFVWIPGNPGLLEYYVDFLALVHKK---------------NPTWEVLGISH 43 zygrc-c5dvx0 19.2% --------MS---------------IRYLAGARL--PTSVLHIKP----------------KSPSPSSPLFVWIPGNPGIVQYYEEFLNLLHEK---------------YDSFEILAISH 44 yeast-YPR147C 16.7% --------MT---------------VKEYTKSKL--PCSILNIKP--------------TVTKSGEDAPLLVWIPGNPGLLYYYQEMLHHLHLK---------------HPDWEILGISH 45 canal-q5a042 15.9% --------MT----------------VTYLNTTP--KTPVYHKPP----------------LEKSTATNIFVLIPGNPGLVDFYISYLDSIRKH---------------FPQFETLCIGH 46 candc-b9wlf0 16.2% --------MT----------------VTYLNTTP--KTPVYHKPP----------------LERFATTNIFVLIPGNPGLVDFYISYLDSIRKH---------------FPQFETLCIGH 47 cantt-c5m3y5 15.9% --------MS----------------VTYINTTP--KTPVYHKPS----------------KTIKPAKDILILIPGNPGLVDFYISYLDFIHEK---------------FPNFEILCIGH 48 clal4-c4xvt8 16.9% --------MS----------------VTTNKDYP--LTSEY-----------------FLASKNGPSPKLLAFIPGNPGLIDYYVTYLELLAES---------------NPDFNILAVSH 49 debha-q6bxr7 17.4% --------MT----------------LKTFPHEE--YTSIYHKNPL---------------QHSASVRPLLVLIPGNPGLVDFYITYLNLIQKR---------------NPNLEILCISH 50 picst-a3lqt4 16.6% --------MA----------------VQTYEKSP--STTIYHKLPLK-----------INNDRARDTSSILVMIPGNPGLIEFYTTYLDLIQTE---------------FPALEVLCISH 51 picgu-a5d9u2 17.2% --------MD---------------SLSTYQGLP--HTTVLHRPAL------------------KDQEGVLILIPGNPGLVEFYITYLDEIQKH---------------RPELEIYAVSH 52 picpg-c4r7h5 17.4% --------MYREFRLP-------------------NATRGLHF------------------AGDDKSKPLILFIPGNPGLIDYYHEFLKRLS-----------------LAGYEVCGTDH 53 aspcl-a1cas0 21.1% --------MSAHH-----------------RPRI-TPDTFLHTVSL----------PNRTGPIQPSPPITIFLISGNPGLISYYHTFLSLLSEKLNQKLKSHT-TSQVHPPSFQIYGHSL 54 aspfu-q4wub2 19.5% --------MSTSP-----------------QPRI-TRDTFLHTVSLQ---------KNRPGTIPSSHHVTIFMISGNPGLIGYYHTFLSLLADKLGSRGAPSTIQSRSHTCEFQIYGHSL 55 neofi-a1df46 19.1% --------MSTPP-----------------QPRI-TRDTFVHTVSLQ---------KNRPASIPSSDRVTIFMISGNPGLIGYYHTFLSLLADKLGSRGAQSTITSRSHACEFQIYGHSL 56 aspfn-b8nfb2 18.7% --------MSSTG-----------------QPHI-SADSFFHTSS---------------ACDPSLSPITIYMISGNPGLIGYYHTFLSVLSDRLNTQSAQRT----RKNHAFQIYGHSL 57 asptn-q0cd92 18.6% --------MPTPQ-----------------VPHI-SEDNFHYAIS------------TSPSSAQSSSPIVIYLIAGNPGLIGYYHTFLSLLSENIKSQAIR-----QEQKCTYHVYGHSL 58 pencw-b6hpz6 19.3% --------MEPTW--ESPTADPMIQAKQKMAPGI-TPNTFLTTTG-----------------SPSDQKKTIFFISGNPGLIGYYHPFLSLLSNYLDEEKEENL----PSPPSFQIYGCSL 59 podan-b2b5e4 17.4% --------MSTTTTIKED------------------AIPYLEFPS-------------PNRNNPSRKQCLVFFITGNPGLASYYTPFLTHLRHLLDTLESSN-------KAAYHIYTRNL 60 phano-q0ufs1 17.1% --------MSLAP-----------------------PTSKLHLRT-----------PPEPGKKSAQTTYLIYFITGNPGLIEYYRTFLTHLYGVLSQNTAS------DRSIEFQVYGRSL 61 pyrtr-b2vvk1 16.3% --------MS-SP-----------------------PVSQIHLRT-----------PPEPGKKSAARTYIIYFITGNPGLVEYYRTFLTHLYGLLSHDTAS------DRDVEFQVYSRSL 62 phano-q0udr2 16.3% --------MKTQPPTKSS------------------SQDIWHKPPL---------------ASSSNGEYVIYMLPGNPCIMTYYQPFLSTLFTSINAALSPR-------HMSAHVGGYTP 63 penmq-b6qkg9 16.7% ------------------------------------MTQIHHCRDFI------------SLPSPSASPYHIFFLPGNPGLVEYYAKFLSLLHSALNQAPS---------TTQFNIAGCSY 64 entdi-b0ee33 18.7% --------MNIQF-----------------------TNNIICNQPCL------------FSSEKIDSPLAFIVIPGNPSIIEFYEEFSKALIELF--------------NYPTIIVSLCK 65 enthi-c4lve4 17.5% --------MNIQF-----------------------TYNIICNQHCL------------FSSEKIDSPLAFIVIPGNPSIIEFYKEFSCALIELF--------------NYPTIIVSLCK 66 entdi-b0efs6 18.9% --------MEFKL----------------------ENHPFLHYTNIC-------GQTCIQSNNYLSAPRCILFFTGNPSLLAFYIDFCEMLHEK---------------YPEDSILVVSL 67 enthi-c4m3r1 18.6% --------MEFKL----------------------ENHPFLHYTNIC-------GQTCIQSDNYLSAPRCILFFTGNPSLLAFYIDFCEMLHEQ---------------YPDDSILVVSL consensus/100% .........................................................................hsGNPs...aY..h...h.......................h..hs. consensus/90% ........ht.............................hhp...........................hhhhhsGNPGh.taY..aht.l....................th.lhshuh consensus/80% ........Mp...........................sphhph.....................tt.t.hhhhlsGNPGlhtaY..ahp.l.p..................ph.lhshuh consensus/70% ........Mp.....................s.....spllph.s................tt.spsphhlhhIPGNPGlltaYppFhphLhp................t.phtlhslua 1 human-LDAH 100.0% AGHALAPKDKKILTTSE-DSNAQEIKDIYGLNGQIEHKLAFLRTHVP-------------KDMKLVLIGHSIGSYFTLQMLKRVPE-----------------LPVIRAFLLFPTIERMS 2 ponab-cb043 97.2% AGHALAPKDKKILTTSE-DSNAQEIKDIYGLNGQIEHKLAFLRTHVP-------------KDMKLVLIGHSVGSYFTLQMLKRVPE-----------------LPVIRAFLLFPTIERMS 3 mouse-Ldah 66.0% AGFSVTPKDKKVLAAPQEESNAQKIEDVYGLNGQIEHKIAFLRAHVP-------------KDVKLILIGHSVGTYMTLHVMKRVLE-----------------LPVAHAFLLFPTIERMS 4 rat-Ldah 65.8% AGFCLTPKDKKILTAPQ-EPNAQEIEDIYGLNGQIEHKIAFLRAHVP-------------KDVKLIFIGHSVGSYIALHVMNRAPE-----------------LPVVHTFLLFPTIERMS 5 chick-cb043 52.7% AGHCKPPSGMEMIE----DTDIKELEDVFGLNGQVEHKLNFLKKNVS-------------KDIKLVLIAHSIGCYITLEMMKRASE-----------------LQVLRSVLLFPTIERMA 6 xentr-q0vfe8 48.9% AGHCSPPRGMDMTQ----EYD--QMEDVFGLNGQIEHKLSFMKEHVP-------------ADIKLILIGHSIGCYIILEMMKRAAD-----------------LKVLQSIMLFPTIERMA 7 danre-b3dii8 44.5% AGHCMPPESFDMIE----DASVTEKEDVFGLDGQIEHKLAFLRKHVP-------------QGTNLLLIGHSIGCYIILEMMKRDPE-----------------LKVVKAVMLFPTIERMA 8 tetng-q4t826 42.3% AGHCATPHSMDMVE----DPSAAEHGDAFGLSGQVEHKLAFIRTHVP-------------KGTKLVLVGHSIGCYIILEMMKRSPE-------------LEVCVSVLKSVMLFPTIERMA 9 brafl-c3yr72 34.6% AGHVIIPDHAKKGNS---GKKNLKQAGTYGFQDQITHKISFIKNHVP-------------RDTHLILIGHSVGCYMVLEILKRCPE-----------------VNVLKGIQLLPMIEHFE 10 nemve-a7sqk0 33.1% AGKLKNKQDEEA------SPECTICTGTYSLQEQIKHKQDYIENHIP-------------PSMKIVLIGHSIGAYIALKLLKESSR----------------AADIVKLILLFPTIERMA 11 nemve-a7rqa8 28.5% AGHTKLEESSVFKCGRP-KQYEQEFPTDMHLDDQITHKLSFIAYHIP-------------KDCKVILVGHSIGAYIVLQMMKRYHD----------------KDKFIKGILLFPTIEHVM 12 triad-b3s478 27.5% AGHSGL------------------ETDVYTLSQQIQHKLDYVKQYIP-------------DSANLILIGHSIGAHIAIELTKSLPY-----------------ARVIKSFLLFPTIERMA 13 ixosc-b7qa78 31.1% AGHDILPRNLR-------APPPNENWHLYGLQGQVAHKVDFVKTHIS-------------NVRPVFLAGHSIGAYMVLQTLNQRKE-----------------LNVKRSFLLFPVFERLA 14 acypi-c4wsr5 29.1% AGHEVPPSNLGLT-----VPDPQKYPDLYTVKGQIEHKLRFIEKYIP-------------DNCDLYFVGHSVGSKIISELLKDSAM--------------AQRLSVKRSVFLFPTLQKMR 15 aedae-q1hqe6 29.3% AGHDEARDSPYKKP----VPPIEKNEHLYNLQGQLQHKIDFIRKYVP-------------ADVKIHLIGHSIGCYLALELLKIPDI----------------SERIQHCYFLFPTIERMA 16 culqu-b0wiv0 29.1% AGHDEEQDGPYKKR----LPPLEGNESLYSLAGQLQHKVDFIRKYVP-------------SDVKIHLIGHSIGAYLALELLKIPDI----------------SDRVQHCYMLFPTIERMV 17 anoga-q7qa52 27.9% AGHDEADESPYKKP----VPPLKGNEEMFNLKGQLQHKIEFIRKYVP-------------EDVKIHLIGHSIGAYMALELLKVPDI----------------SDRIQHCYFLFPTLERMA 18 drome-CG9186 29.9% AGHDDPPEASIRE-----VPQLSGNEELFNLDGQIRHKIAFIEKYVP-------------SDVKIHLIGHSIGAWMILQLLENERI----------------RSRIQKCYMLFPTVERMM 19 caebr-a8y1r7 22.8% LNHVRMPDHLN-------SDGEHRNHDRISLEEQVSHKLAFCKELLP-------------RGKQLYVLGHSIGSYMMLRILPEVIL---------------EGFHVAKAVGLFPTIVNMA 20 caeel-F26A3.1 23.4% LNHVRMPDHLK-------DDGEHRNHDRISLEEQVNHKLSFVKEHLP-------------RGKQLYILGHSIGSYMMLRIIPEVIK---------------EGFHVEKAVGLFPTIVHMA 21 dicdi-u554 22.5% IGHCGK-----------------IENKTFSVEEQIKHKELFLEYLLKNKYGDK----DR-KDIKFILIGHSVGSYISLKVVSRFSE----------------KFEFLSVVNLFPTFKNLY 22 9chlo-c1fhv2 20.2% KGHTTDRY-------------ADTTGDWFTLQDQLDHLREYLKSRTSR------------SRDGTVLVGHSIGAEMSLDAMDKLGT-----------------GVVRGVVGLMPFVLVNT 23 ostlu-a4s8s1 14.6% LGHTEAE--------------RRGRSEWFSLDEQKTHVCEYIDRCCDDE-----------GPEPVVVVGHSIGAHLALHAMSELGF-----------------DRVSGVVGLMPFLHVNT 24 ostta-q00tt1 16.6% LGHTERD--------------RPGRREWFTLDEQKAHVRDYVDATLRASSD---------DRRECVVVGHSIGAHLALFTAKELGF-----------------DRIDGVVGLMPFLHVNR 25 arath-T19F11.2 20.1% ISHTSK---------------DWESGRLFSFQEQIDHKIDFIRQELES------------VKVPIILVGHSIGSYISLELLKKFSD------------------KVVYCIGLYPFLTLNQ 26 poptr-b9iip0 20.8% ISHTEK---------------NWEHGKLFSLQDQIDHKVDFIKQELQN------------NELPIVLVGHSIGSYISHEIL-RFLE------------------KVTYLIGLYPFLMLNP 27 ricco-b9svy8 21.8% ISHTAK---------------NWELGKLFSLEQQIEHKVEFIKQELQN------------VEVPIMLVGHSIGSYISLETLRRSPK------------------KLRFCVGLYPFLMFNP 28 maize-b4fuv1 20.2% ISHSQK---------------DCEHGRLFSLYEQIDHKVDFIEQELQH------------SEQPIVLVGHSIGAYIGLEVFKRLQN------------------KIKFIVGLYPFLKMNK 29 orysa-B9EWJ8 17.7% ISHSK--------------------------------KVDFIEQEFQH------------SEQSLVLVGHSIGAYICLEIFKRLQK------------------KVKLCVGLYPFLTLNK 30 phypa-a9s6w1 22.1% IAHVSK---------------DWELGRLFTLQDQIKHKVEFVRDIILLES----------PEVPIFLVGHSIGAYIALEILKEFPS------------------QVHHVIGLYPFLTLNK 31 copc7-a8n2c2 21.2% IGHTPG---------------VGSAKSDHGLTSQVQSAIEAFDALQSAYP----------ADTKIVLIGHSL---MVLQVLKARTE------------------NVHAVFLLFPTLSYIG 32 lacbs-b0cr66 24.6% IGHSPVIS-------------APQSIDSCSLPSQVESVARALDALKMEYG----------GTAKFALVGHSIGAWISLQVLKSRQP------------------DVSAIFLLFPTISNIA 33 leibr-a4hen1 20.7% AGHSLT---------------QLNKGRVFSLAEQMDIADSFVATLINKNTELK-------YKKNIYVGGHSIGGFVALQMGARYAS-------------------IKKCFGLCPVISHLR 34 leiin-a4i1v9 21.0% AGHSLT---------------ELNEGRVFSLADQVDIAESFVATLMNKNAERK-------YNGNIYAAGHSVGGFVALQMVARYST-------------------IKKCFGLCPVMSHMR 35 leima-q4q9g9 21.0% AGHSLT---------------ELNEGRVFSLADQVDIAESFVATLMNKNTERK-------YNGNIYAAGHSIGGFVALQMVARYSV-------------------IKKCFGLCPVMSHMR 36 tryb2-q57v42 18.5% SGHSIC---------------DRNNGKVYGLRDQIDNARDFFDSIQERALS-------Y-YGNDIYIGGHSIGAFIAAKILVVFPC-------------------IRRCFSLCGVLSRIQ 37 trycr-q4dp03 20.1% AGHSFV---------------DQNNGRVFDLQDQVETAEHFLRAVLTPYTQKW-------YGKHIYIGGHSIGAFVAMQMLTRFPC-------------------IKRCFSLCGLLSNAQ 38 trycr-q4dvl8 20.1% AGHSFV---------------DQNNGRVFDLQDQVETAEHFLRAVLTPYTLKW-------YGKHIYIGGHSIGAFVAMQMLTRFPC-------------------IKRCFSLCGLLSNAQ 39 ashgo-q753k6 20.2% TGMSAKTG-------------PEDLKRVYTLVEQVEHKVKAINDFVENR-----------GNLAVKLVGHSIGAYMAQKVVVHPAL----------------RVNVEMVGLLTPTIIDIH 40 canga-q6fku7 18.8% AGTVIESSQLKKF--------RKNPLPIYDLKQQTQHKIDIINKINND------------PNRELVIMGHSVGAYIAQHVVSSPDL----------------VGRVSKLGLITPTIRDIH 41 lactc-c5dja0 18.9% AGMNSC---------------NDIACPVYTLQEQINHKVDVINSYAQ-------------GNKKITIMGHSVGAFIAQKVVTSGLL----------------NDEVARVGLLTPTVIDIH 42 vanpo-a7tp79 18.3% AGMSYDGNEKKK------KTSSNDKFKVFDLEEQVQHKVDIINKFSS-------------KNRPLIIMGHSVGAYLTQRVIMTNKL----------------NGKLIKVGYLTPTVVDIH 43 zygrc-c5dvx0 19.2% AGMATEDPDL-----------QKRKATIYTLDDQIQHKVEIINQFSA-------------KDRPLIVMGHSVGAYMAQHVVLAEKL----------------LGRVVKLGLITPTVVDIH 44 yeast-YPR147C 16.7% AGMTLN---------------AHSNTPIFSLQDQVDHQVEVINNFSC-------------KNRKIIIMGHSVGAYIVQKVCLSNKL----------------VGSVQKVGLVTPTVMDIH 45 canal-q5a042 15.9% VGFL-----------------DSTKRKIYDVPSQIEHKYDVLKQLILTKNESN-------IIPNLYFLHHSMGSFVYQRTIRKLYHDEN----------LNGKFNIKFSGFVTPTIYNIS 46 candc-b9wlf0 16.2% VGFL-----------------DSTKRKTYDVSYQIEHKYDVLKQLILTKNESN-------IIPNLYFLHHSMGSFVYQRTIRRLYHDKN----------LNGKFNIKFSGFVTPTIHNIS 47 cantt-c5m3y5 15.9% AGFL-----------------KSKSTKTYNLEFQIDHKYDILKQMILSKNEQG-------IVPNFYFLHHSMGSFVYQRALSKLYKDGS----------LKDGFNVKFSGFITPTITDIA 48 clal4-c4xvt8 16.9% AGYQTSDDFV--------AAGKSEKQPYFNLEYQINHKYEILRKQVLR------------GHTELYILCHSMGAYVTQRVVKMLLNDEE----------VSKVVKIKFIGLICPTIVDIA 49 debha-q6bxr7 17.4% AGFKSDGNII----------DDDSVFTYYNLEFQIEHKIDILKYFILNEN----------RNTELYFLSHSVGSYINQRVVHRLLNNSE----------LQNKMDIKFLGLICPTIIDIG 50 picst-a3lqt4 16.6% AGFQTSEPV------------NSEKFKFYDLEYQIKHKFDIISEFIAQKLDDG-----Y-NNVELYFLSHSVGSYVHQRVIRMLLQEKE----------LHGKFSIKFTGLICPTIVDIA 51 picgu-a5d9u2 17.2% AGFSTTEP-------------LDSTVEYYPLSYQIQHKCDFITQIAEKSNH---------EKVPIYLLAHSMGAYVLQNVAKRLSD--------------NPKIDFRFAGLICPTIMDIA 52 picpg-c4r7h5 17.4% LGY------------------HESDSKIYTLEEQIQQKLELLKVLSLERKG-------Y-STRKLILIGHSMGCWLLQRIYIAVIQDET----------LSQSYQVVFNGLLTPTINDIG 53 aspcl-a1cas0 21.1% GGFALQTPQH-------------PHPCDYDLEDQIGYVQGKLDEFLSSPEGCG-SSAAE-GKSKVILIGHSVGSYIAMEILRRHRERAASAAAATAPHGSTASFDIIGGIMLFPTVMDIA 54 aspfu-q4wub2 19.5% GGFELEQHED-----------LDVRKRLFDLEDQICYVQEKLDEFLAGGE----------TKQKVILVGHSVGAYIAMEILRRHRERSDAKVRTGA---DKADFDIVGGIMLFPTVVDIA 55 neofi-a1df46 19.1% GGFELEQHED-----------LDAEKGLFDLEGQICYVQGKLDGFLAGGE----------TKQKVILVGHSVGAYIAMEILRRHRKRSDAKVRAGA---DKADFDIVGGIMLFPTVVDIA 56 aspfn-b8nfb2 18.7% GGFELTKTPG-------------PKPRYYDLEEQICFVQNKLNDFLTSSSNAS-NGVPS-PKPKVILIGHSVGSYIAMEILRRHRERSTSG---TSP---SVDFDIIGGVMLFPTVVDIA 57 asptn-q0cd92 18.6% AGFELEERASD---------DAVPHARYYDLEEQIRFVQNKLDTFIATLKGIS-AGASSNPKPKVILIGHSVGSYIAMETLRRHRDRTKSG-------DSPIDFDIIGGAMLFPTVVDIA 58 pencw-b6hpz6 19.3% GGFEIDERQSS----------PSNNSIDLDLEDQICFVQDKLTTLMGDEGNGNGNGNAG-TRQKVILVGHSVGAYIAMEILRRHRE--------SKP---ESAFDIIGGAMLFPTVKDIA 59 podan-b2b5e4 17.4% LGFSDHDHSPPFGNT---LPPSNLPTQPFTLEDQIISLTSTLVSLNTPT-----------PFTSCILIGHSVGAYIATEIFHRHHL--------T---PLSALLNLTSAILLFPTLTHIA 60 phano-q0ufs1 17.1% SGFEVNSSEIKTY--------KYRRDPPYGLQDQIRHAEDDVVELVEDLKDNG-----A-KDVRVILVGHSVGAYISLEIVRRLRAHGVA--------GEDFDTRISGVVGLFPTVVDLA 61 pyrtr-b2vvk1 16.3% SGFEMTSAEIKTM--------KWRKQPPYGLQDQIRHCEDELTELVEEVKEQG-----A-KDVRVILVGHSVGAYISLEVIRRLRAHGMA--------GEDFETRIVGAVGLFPTVVDIA 62 phano-q0udr2 16.3% PGFRVSPGH------------ISEVKLPASLQDQIGYAKKLIDAAIKQHIKSA-------SRPKLILVAHSIGTYMALEILRRYKDGHS----------TLAHADIIGAVLLCPTIIQMA 63 penmq-b6qkg9 16.7% AGFETENSSS-----------KENDGKLYDITEQVTFCLDQLQEYINGGTKDM---LAE-TKPKVILIGHSFGTFVIAEIMKRLYTSSAQ--------DEKQNYEIIGNIHLFPPIPDLA 64 entdi-b0ee33 18.7% NG-----------------------EHSLKVHQAIHLKIQFFNEIFQRY-----------PNTKFIILGHSIGNYITLQALRQIDQ-----------------SRIIGYYGLFPALINLK 65 enthi-c4lve4 17.5% NG-----------------------EHSLGVHQAIHLKIQFFNEIFQKY-----------PNTKFIILGHSIGNYITLQALRQIDQ-----------------SRIVGYYGLFPALINLK 66 entdi-b0efs6 18.9% HSTPMN---------------NVFPSWKTSLFEVIKVKLNLIDWVLRELP----------PTTHFLLLTHSLGAFVALHTLPQRPE---------------LECRVDQIIHLFPAIRDLK 67 enthi-c4m3r1 18.6% HCTPMN---------------NVFPSWKTSLYEVIKVKLNLIDWVLRELP----------QTTHFLLLTHSLGAFVALHVLPQRPE---------------LEHRVDQIIHLFPAIRDLK consensus/100% .s.......................................h......................hhhhtHSh...h...hh........................h...h.lhs.h.... consensus/90% huh.........................hsl..Qlphh.thlpt.................t..hhhhuHShGsah..phh.t......................l.h.hhlhPhl...t consensus/80% hGa......................tthasLptQlpht.phlpthh...............p.plhllGHSlGuahh.phhtp.....................pl.hshhLhPsl.pht consensus/70% sGas...................pttphasLptQlpaphshlcphl..............tphplhllGHSlGualshchlpph.p..................plhtshhLhPsl.cht 1 human-LDAH 100.0% ESPNGRIATPLLC----WFRYVLYV------------TGY-LLLKPCPETIKSLLIRRGLQ-----VMNL----------ENEFSP-LNILEPFCLANAAYLGGQEMMEVV-KRDDE--- 2 ponab-cb043 97.2% ESPNGRIATPLLC----WSRYVLYV------------TGY-LLLKPCPEKIKSLLIRRGLQ-----VMNL----------ENEFSP-LNILEPFCLANAAHLGGQEMMEVV-KRDDE--- 3 mouse-Ldah 66.0% ESPNGKFATPFLC----QFRYLLYA------------TSY-LLFKPCPEVIKSFIIQKLMG-----QMNI----------KLELPL-TDILQPFCLANAAYLGSQEMVQIV-KRDDD--- 4 rat-Ldah 65.8% ESPNGKFATPFLC----RFRYMLYA------------ASY-LIFKPCPEMIKSFIVQKVLE-----KMSF----------KSELRL-TDLLQPFCLANAAYLGGQEMIHVV-KRDDG--- 5 chick-cb043 52.7% QSPQGKLMTPLLC----KLRYALYM------------PVY-LL-SFLPEGVKASLVRFALRG--MKTCDE----------SSITTS-VNLFSVDCIANILYMASQEMMKVV-ERDST--- 6 xentr-q0vfe8 48.9% QSPQGKIMTPLLC----SLRYVFYM------------PLY-LL-SFLPENLKTSLVRFVLRG--IKSVDE----------ASVEAC-LNLFRMDCAANAMYMGSQEMVKVL-ERDNN--- 7 danre-b3dii8 44.5% CSPQGKVMTPVLC----RLRYAFYL------------PIF-LL-SLLPERLKVGIVHLAMRN--LYALDN----------SIIPAT-VSLINVDCAANGMYMGSQEMRLVV-ERDNA--- 8 tetng-q4t826 42.3% RTPQGRVLTPVLC----HLRYLAYL------------PLF-LL-SLLPDRVKASLISLAFGG--IHSLDR----------TVIQPT-VQLLSGDCAANAMYMAGQEMVKVL-ERDNV--- 9 brafl-c3yr72 34.6% KTPNGSRMKPLLL----YFRWLAVF------------VAF-LM-SFLPDVVKHWLVQLYFM---GRKVDE----------GAVEAS-LNLFDPKVTNSSLFMASQELRQVH-EPDLH--- 10 nemve-a7sqk0 33.1% ATPNGRIITPIVN----YFKWFAVS------------TVS-VV-SYLPTSFTRLLVRWWFS---GKNTTN----------SVVDTT-MKLLTSDASNNCLGMAYCEMQEVQ-DLDTE--- 11 nemve-a7rqa8 28.5% DSPSGRLWWVLCF----YLQWPFLF------------LTL-CF-SLMPSVFQKWSISWWMYFN-KFSCHD----------STVSAT-QGFLNYRAMENMLRIGR-DLGTIK-EIDAS--- 12 triad-b3s478 27.5% VSPNGVRLVPKFAS--KFYRASMVW------------GCF-LV-SCLPRSFLEGLV--------PTNADR----------YCVEAT-SRLINKDVVSNCLYMANTEFREVV-NLDMD--- 13 ixosc-b7qa78 31.1% QTPNAKALVLSSL----LLKLATWL------------LVA-LL-FVLPEFVKDALIEWHFKDI-QPSMRS----------RIKKAT-LTLFTPAVFKLMINMAEDELDQVK-QRDEG--- 14 acypi-c4wsr5 29.1% ETPNGRKLVNFTAS---NFLPITIF------------LSW-IF-TTFPAFIKTFLVNMTLIIMEGGRVED----------HVIRSA-VRLVHPMVLRNVFSMAVDEMDKIY-DSDFK--- 15 aedae-q1hqe6 29.3% DARNGFILTKIIN----PIYRVVQW------------FYR-CF-ALLPTIIKVWIIYCYFL---VTGTPK----------HYLGTA-LKYTNPAVIDKVWFMALDEMEKVR-NLDLN--- 16 culqu-b0wiv0 29.1% NTKNGFILTRIVK----PFYFLVQW------------FYH-CF-ALLPTVVKVWIIYAYFV---VSRTPK----------HFLGTG-LKYTNPAVVHKVWTMALDEMEKVR-ELDVE--- 17 anoga-q7qa52 27.9% KSRNGFIVTRIIN----PMWCVWQW------------FYR-MF-DMLPLFIRTWIIYMYYL---VDGIPK----------YYLGTG-LKYMNPSVIDKIWFLAIDEMEKVK-DLDTD--- 18 drome-CG9186 29.9% ESPNGWVFTKVAM----PLYSVFGYI-----------FFS-FF-NFLPVWLRLMLIQIYFL---IFSIPR----------QFLGTA-LKYSKPSVAEKVVFLADDEMARVR-GIQRE--- 19 caebr-a8y1r7 22.8% TSPNGRRLQGTLAT-LNHHDWLTKS------------ICW-WV-DYLPSFVKKFLVGLNLR---HPNTPP----------EIVDAA-VELVHLDVFRNIVHMSNDELDIVL-DLDER--- 20 caeel-F26A3.1 23.4% NSPNGKRLHGTLAT-LNHHDWLTKT------------ICW-WV-DYLPNSIKKFLVGLNLR---HPNTPP----------EIVDAA-VELVHMDVFRNIVHMSNDELDIVL-DLDER--- 21 dicdi-u554 22.5% DGLSPFIKMVVMRE------------------STRNGLST-FL-HYIPSIVVSNVLKWIL----PSDESR----------IAVQSK----INYYSALNILYMAYTETEDIK-EIDDE--- 22 9chlo-c1fhv2 20.2% KSALQKFLSALVHI--TPLVYLVAA------------IVG-FI-GALPIPGLKRLAFSPI----TGTMSA----------SPADLT-RRWLRSDSIKNMALMGRTEFDALT-ALDTS--- 23 ostlu-a4s8s1 14.6% QSTLQSSLSFVTRL--SVVVHALGR------------FLD-ALRFVAP-GVRLALLKNTV----TKSMDS----------AAADIT-SAWLRWQSLINMVFMGRTEFAQLTTPVSEC--- 24 ostta-q00tt1 16.6% RSALQRALGVVTRL--NFLAHAIGG------------ALD-GLKKAVP-FVRAALLRRTV----TKNMDA----------VAAEIT-GAWLRWQSLINMVFMGRTEFVALVRPIDEC--- 25 arath-T19F11.2 20.1% QSTKQSLIGKLAAS--SVLSATASF------------LIA-SL-RLLPMSAARLLVSKSI----GASWSD----------TAVQATCTHLRQYHTMRNVLFMAKSEFRELAAEPDWD--- 26 poptr-b9iip0 20.8% LSKQQSNIQNVAES--SILSALLSF------------SVA-SL-GLLPQCTLRFILSKSL----GSSWSD----------TAIDAACSHLLQYHTIRNMLYMALMEFRKLSEMPDWA--- 27 ricco-b9svy8 21.8% LSEKQTSIQKIAES--PVLSALISF------------SIA-SV-GVLPRCASRLIVSKSI----GKSWSI----------SAVDAACSHLLQYHTFRNMIFMALTEFRKLSEKPDWA--- 28 maize-b4fuv1 20.2% SSVTQSAIGYIARS--SLLSKWASL------------FAS-FI-GSLRPSITRGIVRRFL----GPSWSV----------TAVDAACSHLLRYNTMRNVLFMAMTEFQKLTEEPDWT--- 29 orysa-B9EWJ8 17.7% KSMKQSAIGYIARS--SLLSKGVSS------------FVS-FI-GLLQASVTRGIVRRLL----GPSWSV----------TAVEATCGHLLWYHTMRNVLFMAMTEFTKLSEEPDWN--- 30 phypa-a9s6w1 22.1% HSKFQSILGQVAAT--PALCTTIST------------FAG-LV-GRLPKGLGRILVKVLL----GRVWDP----------LAVDVTCQYMLQKNVVHNFLYMGRTEFASLSQEPDLA--- 31 copc7-a8n2c2 21.2% DTPNGRRLWRIFT---PTGRWIVSK------------LGH-LA-RLVPVQVLGRLFP---------EWPS----------SQLEVLKDLVGDPRSIVAALTMASDEMHAIK-ELDVA--- 32 lacbs-b0cr66 24.6% NTPNGKRLSWAFS---PTSISILSL------------LSR-FV-KYLPTYILCTIFR---------GWPL----------SQVLVLQRLLYSPSSIAAALSMAGEEMIAVQ-GLDLI--- 33 leibr-a4hen1 20.7% DSPNGRRLFYLSNT---VTQCCVAM------------GAA-LL-ELLPYKLRHLLIARW-----EPKLSP----------ALAEAL-AHHCHRWCLMNSLYMAMTEFRMLL-QPDAV--- 34 leiin-a4i1v9 21.0% DSPNGRRLFYLSST---LAQWCLAM------------LAV-LL-ELLPYKLRLLLITTS-----EPSLSL----------ALAETL-AHHLHRWCLTNSLYMAMTEFRMLL-QPDAA--- 35 leima-q4q9g9 21.0% DSPNGRRLFYLSST---FVQCCLAM------------VAA-LL-GLLPYKLRLLLITTL-----EPNLSF----------ALGEAL-AHHFHRRCLTNSLYMAMTEFRMLL-QPDAA--- 36 tryb2-q57v42 18.5% ETPNGRHMFFVGGN--VIFYYVFVYL-----------VVA-VL-VLLPRFVSSWFIRRQ-----APTLSP----------VLVSQF-IEHYNTGALRNCFSMCREEFQVVR-EPDQQ--- 37 trycr-q4dp03 20.1% NSPNGKRLFFLFSH--AVIYGLFTY------------CVM-LL-LLMPKAVVSMFLRWY-----APSVSP----------PLRRLM-TRHLNPNILWNCFFMARQELRQVR-EIDRP--- 38 trycr-q4dvl8 20.1% NSPNGKRLFFLCSH--AVIYSLFTY------------CVM-LL-LLMPKAVVSMFLRWY-----APSVSP----------PLRRLM-TRHLNPNILWNCFFMARQELRQVR-EIDRP--- 39 ashgo-q753k6 20.2% RSPKGVQLTRISEW-FPRFYEYVSI------------VDRVLLEWLLPATWISWLARKII----GGS-DE----------CVLQSAEKLVKNPSYVRQALGMAQLEMHQVRNQWDFQE-E 40 canga-q6fku7 18.8% KSSHGLIFTRVFNY-ISNVNEYLSF------------ISSNIFNKLIPAYWTKLLISFAM----GCSFDE---------YHIILGTFLLLTQRETLRQVLGLAAHEMLEIRDDWAFQE-N 41 lactc-c5dja0 18.9% KSEKGLKLTAITER-FPRFHQLVSA------------LDWIAFEKLFPDFLTSWIISHFA----DDPKT-----------CLGAATRLLLTNSRFVKQALGLATEEMQVIRSDWEYQK-D 42 vanpo-a7tp79 18.3% LSDKGIKMTKVFNW-TSNLPHHVGW------------ISQFIFHKLLPLFFVKFFISKMI----KCSEDS----------NAVLASGTLLRNANLIEQALGLATYEMEAIHDDWGFHK-K 43 zygrc-c5dvx0 19.2% RSQKGTQLTRAFYW-VKYLPDIAAW------------VSDMLFNKLSSIMFTDQVISLFM----GVDKES----------VPVATSKSLVQNPEIIRQALGLAALEMQQIRGCWPFQK-K 44 yeast-YPR147C 16.7% TSEMGIKMTAALRY-IPPLAHVVSL------------FSYIFFYWILSEGFSRFIIDKFM----GCGSTG---------YQAVLSTRIFLTHRQFVRQSLGLAAQEMEEITTNWEFQD-R 45 canal-q5a042 15.9% ASSSGRVLSGLMQRNVPIVSIVLVFR---------------FFVSLIPALTLRKLLHYHL----LGNKTG------DGFENSVEGAYKIVKSGTVVNQALEMAKEEMLIIDTQDDIND-W 46 candc-b9wlf0 16.2% ASSSGRVLSGLMQKKVPIVSIVLVFR---------------FFVSLIPALILRKLLYYHL----LGNKTG------NGFENSVEGAYKIVKSGTVVKQALEMAKEEMLVIDTQDDIND-W 47 cantt-c5m3y5 15.9% GSSSGQKLTTLMKWNIPIIPIALWLS---------------FIVGFLPDFVIRTLIKYQL----VTSKIGNKDIDISSYENSIEGVYKIVQSETVINQALTMAQEEMKHIAFDIDVND-W 48 clal4-c4xvt8 16.9% KSRSGVAFSRLFNY-LPLVTVAVWF------------IS--LLHFILPDSTAELIIRKFV----ISHPVLRDSKSMESRHNSIEATLKIYKSKRIVRQALNLAEEELLVIHRDDTLND-W 49 debha-q6bxr7 17.4% RSNSGQIITKMFAY-LPIIQIAIYL------------SV--LINSLFPESFVKFVVKNVV----IDKSSSTREESQESIENSTIGALKIFRSKNIIKQALNLAKEEMKTILKDDEFND-W 50 picst-a3lqt4 16.6% QSDNGQFFTKLFSL-LPIISISLWVAW--------------LLNTILPEAMAKSIIAKRF----VEKPKSNDTDSVESWQNSVTGAYKLYSSQRLIEQALNLARQEMLVITRDDIIND-W 51 picgu-a5d9u2 17.2% SSGSGELVTRIRAK-VPVVQPVVAV------------AS--FLRSVLPTSLARGLVQATV----KKGKSE------EGYRYAIEACWKLFSSPRLIKQALEMAMEEMDQIKHDRPLQD-W 52 picpg-c4r7h5 17.4% LSRKGVPFTWAYQK--SLIPSAVWVHGHFGRVMSWSGLSR-YL-NPLVHNVVSWVLK---------TEDS----------HCIDSTIDLTTNNQVLNQTLSMAYEEMQRIDSDYEINT-T 53 aspcl-a1cas0 21.1% KSPSGRKLTRLLCV-VPQLALVVGF------------LAR-VLVALLPASWLRGLIRVVM----GSAMPE----------NAVETTAAFVQSKTGVRQALHMAADEMRTITADKWSDDVW 54 aspfu-q4wub2 19.5% KSPSGQKLTRLLYF-IPQLALVVGF------------LAR-VLAMLLPDALLRGLIKNVM----GSP-PD----------SAVETTAAFIKSKCGVRQALHMASDEMQTITSDKWGDDVW 55 neofi-a1df46 19.1% KSPSGQKLT---------LALVVGF------------LAR-VLAMLLPGALLRGLIKNVM----GSP-PD----------SAVETTAAFIKSKRGVRQALHMAADEMRTITSDKWDDDVW 56 aspfn-b8nfb2 18.7% RSPSGQKLTRMLFF-IPQLAVVVGF------------LVR-ILTVLLPGSLLRSLIRFYM----GSP-RD----------NMVETTAAFLESGYGVQQALHMAADEMQTITSDKWSDDVW 57 asptn-q0cd92 18.6% KSPSGQKLT---------LALVAGL------------LVR-VLVALVPHSVLRSLVSFYM----GSP-PD----------GAVDTTTAFIKSVRGVRQALHMAADEMQTITSDQWNDDVW 58 pencw-b6hpz6 19.3% ASPSGQKLTTLLSI-IPRLAVVVSL------------FAR-LLTFLLPASLLRPVVRLVM----NDP-PV----------HALDTTCGFLKSRGGVRQALHMAADEMRTITSDKWSDDVW 59 podan-b2b5e4 17.4% RSPSGQKLSFIASQ--PLLNSYTHI------------LAK-SIINCLPTPIVSLILSKIM------KQPP----------HALSTTLSFLQSQDGIWQAIHMGKDEMSTITEEKWSSDLW 60 phano-q0ufs1 17.1% RSESGMKAAPFVKN--SNFVVFLSV------------IAG-FISMLLPLSLLTKLIASVM------SFPQ----------DAAHTTASFVKSPHGVLQALHMARDEMFQIDTDIWDEDIW 61 pyrtr-b2vvk1 16.3% RSESGMKAAPFLKN--SNFSVFAAL------------FVS-FITMFLPISFLATLVAKFM------DFPP----------DAAHTTASFVKSPHGIQQALHMARDEMFQIDTDIWDEEIW 62 phano-q0udr2 16.3% DAENEGVADYFFRI--PGFPTILGA------------LVK-IPTFPLSLSVISWIACKVGNAP-----------------HVAQAFAEFVKGPHAVRQTMHLLRDSCQEVGEDKWTEKIW 63 penmq-b6qkg9 16.7% KSPRGVKAAGVATW--KYLPSIMSF------------IAN-AV-YNLPLSWSNAVVRYMT----AFPSDS----------DALYTTRQFFGSRTGVAQALYLVKFEFDEIKLSRWEEAFR 64 entdi-b0ee33 18.7% NSFC--TLYKIITY-SPFIIACLAF------------STR-LL-QILPLSLIIFFFSLVT------DVPK----------QFIPIL-KDHLDPQMTGQMLSLCKDEGVQIK-EYPDD--- 65 enthi-c4lve4 17.5% QSFC--TLYKIITY-SPFIITCLAF------------STH-LL-QLLPLSLITFFFSLVT------DVPK----------QYIPIL-KDHLDPQMTGQMLSLCKDEGVQIK-EYPDD--- 66 entdi-b0efs6 18.9% HSID--LTVRLLAR-ITLIYPLISM------------TTY-LL-KLLPLFIFTLFIQIVS------TTPP----------HQAKMM-QQDLNPHHIAQVAYFTLDEEEIIT-DHDKQ--- 67 enthi-c4m3r1 18.6% HSID--LIVRLLAR-LTLIYPLISM------------TTY-LL-KLLPLFIFTLFIQLVS------TTPP----------QQAKMM-QQDLNPHHIAQVAYFTLDEEEVIT-DHDKQ--- consensus/100% .s.....h..........................................h....h...........................................h.h...p...l.......... consensus/90% to.pt.hh..h.......h..hh.h................hh...hP..hh..hh..........................h..h...h.p..hh.phh.hs.pEh..l..p...t... consensus/80% pS.pt.hhh.hht.....h..hh.h............h...hh..hlP..hhphllphhh......s.s...........t.htsh...hhp.thhtphhhhu.pEh..lh.p...t... consensus/70% pSssGthhshlhp....hh.hhh.h............hsh.hl.thLP..lhphllphhh......shs...........phlpss.hhhhp.psltpslhhutpEhtplp.chs.p... 1 human-LDAH 100.0% ---TIKE------HLCKLTFYYGTIDPWCPKEYYEDIKKDFPE---------------------GDIRLCEK------NIPHAFI--THFNQE--MADMIADSLKD-DLSKIGNP---- 2 ponab-cb043 97.2% ---TIRE------HLCKLTFYYGTIDPWCPKEYYEDIKKDFPE---------------------GDIRLCEK------NIPHAFI--IHFNQE--MADMIADSLKD-DLSKM------- 3 mouse-Ldah 66.0% ---IIKE------FLPKLKFYYGKTDGWCPVKYYEDMKKDFPE---------------------GNIYLCEK------GIPHAFV--LDFSQE--MATIVAEWINN-RPPRK------- 4 rat-Ldah 65.8% ---IIKE------LLPKLTFYYGKTDGWCPVNYYEDMKRDFPE---------------------ANLHLCEK------GIPHAFV--LGFSQE--MAAMVADWINN-RLPKK------- 5 chick-cb043 52.7% ---TIKQ------NLKKLIFYYGTGDSWCPQNYYDEIKMDFPD---------------------GDIRLCEK------GLRHAFV--LDASKE--MAAMITDWLRD-DLTKL------- 6 xentr-q0vfe8 48.9% ---TIKR------NLQKLIFYYGATDNWCPVQYYEEMKKAFPE---------------------GSILLCEK------GIRHAFV--LDSSNE--VATMTIDWLKKRSLC--------- 7 danre-b3dii8 44.5% ---TIHQ------HLSKIIFYYGATDHWCPVKYCHDIRKDFPE---------------------GDIRLCER------GIRHAFV--LDAGEE--MAKMTAEWISD-DLRTL------- 8 tetng-q4t826 42.3% ---TIGK------HLGKIIFYYGATDHWCPVEYYHDLRKDFPH---------------------GDLRLCEM------GFRHAFV--LDAGSD--VAKLVVDWVRA-DLR--------- 9 brafl-c3yr72 34.6% ---CIGQ------HLDKLIFYYGASDGWAPVSFYQRMKNSFPQ---------------------GDIRLCER------GILHAFV--LEQSTE--MAGMVAEWIEQ-ATAAEGGR---- 10 nemve-a7sqk0 33.1% ---VIGN------NLKKIIFYYGSSDQWAPVSYYEELKSRFPE---------------------GEIYLCQR------GFEHAFV--LSASVE--VAEMVWGWIEG-MAPYE------- 11 nemve-a7rqa8 28.5% ---SVQE------NLDKLVFYYGSRDPWVPRTCHEELSRKFPD---------------------ANVIVCDD------NIQHAFV--LDASEE--VAKKVWGWMEG-DLVMV------- 12 triad-b3s478 27.5% ---GIRA------NLDRLHFHYGPNDEWAPQTYYQDLVDKFPQ---------------------GQIVLDSE------NAPHAFV--IKFSEH--IANIVSKEILK-----------LW 13 ixosc-b7qa78 31.1% ---TIRD------NLKRLTFYYGSEDKWCPIEYFRDMRRAFPD---------------------ADLNLCEH------NLKHAFT--LHSTCE--MSAFVSGRVKD-SLP--------- 14 acypi-c4wsr5 29.1% ---PLKD------NAKRLHMYFGKTDNWCPTSFYDDISKCVPE---------------------AETVLCDK------GYQHAFV--IGHSDE--IAGIVCDWLQL-DLGDA------- 15 aedae-q1hqe6 29.3% ---TIEQ------NKHRLKFYYGTTDGWVPVKYYKELRQKVPD---------------------ADAELCTR------KIEHAFV--LRSAAQ--MGFMVGEWILKHRVVM-------- 16 culqu-b0wiv0 29.1% ---NIKA------NKHRLKFYYGTTDGWVPVKFYRDLMEAVPD---------------------VDAELCTR------KYEHAFV--LASASQ--MGFMVGEWILKYRV---------- 17 anoga-q7qa52 27.9% ---TLIK------NKQRIKLYYGSKDGWVPVQYYHDLKQRIPD---------------------IDAELCTR------NYEHAFV--LRSAAQ--MGFSVGEWILKYRA---------- 18 drome-CG9186 29.9% ---IVEQ------NLDLLKFYYGTTDGWVPISYYDQLKKDYPK---------------------VDAQLDTK------KIDHAFV--LRHSQP--MAVIVRDMIQQHRRV--------- 19 caebr-a8y1r7 22.8% ----LME------KQDMVHFYYGLKDGWCPVEHGYSMRERLGD---------------------GQVTLDEH------DCEHAFV--ISEGDI--MAKNVVKYFD-------------- 20 caeel-F26A3.1 23.4% ----LLE------KQDVVHFYYGLKDGWCPVQHGYSMRDRLGE---------------------EQVTLDED------NCEHAFV--ISEGDI--MARNVIKYFD-------------- 21 dicdi-u554 22.5% CHSVFNS------RLNQLLFIYGQTDSYTPKSFYDEMKQLYPA---------------------GNIEYSSS------YVPHAFV--LHHSQE--VALRVSEWLSL-NILKN------- 22 9chlo-c1fhv2 20.2% ---RWKR------HKDRTSLLYCPGDHWAPLHQMEDFERMKELRGM------------------ETVLESAP------GVDHAFV--LHDKSC--LRHNTR------------------ 23 ostlu-a4s8s1 14.6% --ALVRR----GADNGRFVAVYAHDDHWAPFHQRDALAAL-----------------------DVGVFTVDD-----LSVKHDFV--VNDAAAELVAKQTAKLAHR------------F 24 ostta-q00tt1 16.6% --ELIAS----ANAPGRFAALYAHDDHWAPLHQRDALEAL-----------------------GVDVSTVED------DVRHDFV--VVDASARLVAHRAVDIMYR-LAHDRARH---- 25 arath-T19F11.2 20.1% ---FMRE------NQSKLAFLFGIDDHWGPLQLFEEISKQAPH---------------------TSLSIERG------GHTHGFC--CTVAGSAWVAQHVATLIKN-RFSQLQ------ 26 poptr-b9iip0 20.8% ---FMRE------NHEKIAFLFGVDDHWGPLQMFEEISKQVPG---------------------ISLSIERE------GHTHSFC--CTEAGSEWVAHHVASLIKK-KISS-------- 27 ricco-b9svy8 21.8% ---FMRE------NQSKIAFLFGVDDHWGPLEMYEEIAKQAPG---------------------IALSIERE------GHMHNFC--CTEAGSAWVAQHVANLLKN-QVLSSSQ----- 28 maize-b4fuv1 20.2% ---FIRA------QEDKMAFLFGVDDHWGPLSHLEEISKHAPR---------------------VTLSVETE------GHTHGYC--CTEAGSVWVADYIANLIKN-QMLLWNN----- 29 orysa-B9EWJ8 17.7% ---FISA------KQDQIAFLFDVDDHWGPLAHLEEISKRAPG---------------------VALSVETE------GHTHGYC--CTEAGSFWAADYVANLIKT-KF---------- 30 phypa-a9s6w1 22.1% ---YLKE------NQNKTSFLFGIDDHWGPLTLLDEISENIPE---------------------LYLSVERE------GHLHAFC--CSKAGSNWVARFAADTILS-KKPSARL----- 31 copc7-a8n2c2 21.2% ---LFES------CKGKLRFYYAERDDWVGEERERVLKVLHTSESGIP----------------VEVVHDEH------GIPHAFC--IMNNWQ--------------SNALNGWKG--- 32 lacbs-b0cr66 24.6% ---LLEE------HRQRLWFYYAGHDDWVGPEKHKLLSSFYPDERS------------------QRIVQDKF------EIPHAFC--IMARSL-------------------------- 33 leibr-a4hen1 20.7% ---LLRH------VQERLILYYVQNDGWAPLSYAEEIKRICPQLG-------------------AYVLEEDA------GVPHAWC--LDRSET--VVRNAI--------------LKHC 34 leiin-a4i1v9 21.0% ---LLRC------VQERLILYYVKKDGWAPLSFAEEIGGVCPRLG-------------------ACVIEEDA------GVPHAWC--LNHSET--VARNAI--------------LKHC 35 leima-q4q9g9 21.0% ---LLRC------VQERLILYYVKKDGWAPLSFAEEIGGICPRLG-------------------ACVIEEDA------GVPHAWC--LNHSET--VARNAI--------------LKHC 36 tryb2-q57v42 18.5% ---FLGL------VGKRMVFYCVQDDGWAPLSHVQEAKELCGDCA-------------------GFVVESDP------SVIHAWC--LSNNET--VIEKGI--------------LPFM 37 trycr-q4dp03 20.1% ---LMKA------VEDRMVFFYVTSDRWAPPQHAQEVKVACEGHA-------------------GFVMETDP------NVPHSWC--LDHNEL--VVERGV--------------MPFL 38 trycr-q4dvl8 20.1% ---LMKA------VEDRMVFFYVTSDRWAPPHHAQEVKVACEGHA-------------------GFVMETDP------NVPHSWC--LDHNEL--VVERGV--------------MPFL 39 ashgo-q753k6 20.2% FIKTCQE------RRSSLWLLFSGHDHWVHSDTMKDIVEFYEAKYGT--------------NADSLLRITID-----EHISHSFV--VKDTTK--VVNIYF------------------ 40 canga-q6fku7 18.8% LLTKCKD------NGTKLWLLFSDNDHWVSQHTQAELIKFLKDRYPE-----------------LLLRVDVD-----KDIKHSFV--VKDVDL--VTRRYF------------------ 41 lactc-c5dja0 18.9% FLHYCET------KGAKIWWLFSDNDHWVSSETRKDLIQFYERHSSP-----------------ELVSIDVS-----TAIEHAFV--RRHAQV--VVQHYF------------------ 42 vanpo-a7tp79 18.3% LIDYCNE------TGVKTWFLFAEDDHWVAHSTRKEVIDFYQYHNKP-----------------ENIRIDID------TIPHAFV--IKKSKY--IVDQYF------------------ 43 zygrc-c5dvx0 19.2% LIDHCNS------NEIETKFVFSANDPWVSNATREALMVFYRENYRD-----------------RNLEISVS-----QDLAHSFI--VKHSKY--IVDEYF------------------ 44 yeast-YPR147C 16.7% FINYCEE------NGISIWFLFSSNDHWVSGKTRSHLSDYYKDKVKQ-----------------ERLKIDVT-----DKIPHSFV--VKHAEY--AINAFF------------------ 45 canal-q5a042 15.9% YFNHSNK-------GIKNWLFFARNDHWVANEIREYLIDKYGNSDNTL----------------CEVCDDET-----NPISHSFC--VAQSDQ--FAKITVARIKE-ICNIDLD----- 46 candc-b9wlf0 16.2% YFKHSDN-------GIKNWLFFARDDHWVANETREYLINKYGNSDNTI----------------CEVCDDEV-----NPISHSFC--VAQSEQ--FANITVERIKE-ICNVDLD----- 47 cantt-c5m3y5 15.9% YFKNSDK------LGIKNWLFFAKTDHWVNDETRDFLIDRYHDDKVTV----------------CEICNDEE-----NPISHSFC--VTQSEQ--FAKITIDRIKT-LCELDLD----- 48 clal4-c4xvt8 16.9% FFRDLPE-----THGTVIWSFFAYKDHWVHDNTRDYILTRYHGPKST--------------LVHFEVGNTNN--ENCPAITHSFC--IDQSVE--FAEITCKALSF-----------AV 49 debha-q6bxr7 17.4% FFKGLPS-----KYDIRIWAYFAHTDHWVHDTTKDYILARYHSDSNK--------------KLSFQIGDMED------SITHSFC--VNESIE--FSQITSEKLSD-ILP--------- 50 picst-a3lqt4 16.6% FFQQLSE--------IKIWTFFAEKDHWVHNSSRDYTLRKYHDLTNN--------------NLLFEVGSSED------AITHSFC--VNQSVE--FSKLTIKAIRSLDLDIAYE----- 51 picgu-a5d9u2 17.2% FFNTFSK-------KCSIWGFFAATDHWVADSTRASILEYSQK------------------NVRFQVETLPD-------ISHSFC--VDQSVE--FAAVTLEAMAS------------K 52 picpg-c4r7h5 17.4% FLNTCQD------KGTTCWLFHVENDPWCSSLTRDQLTEFCKQ----------------F----NFISIDIL-----PDCAHSFT--LNPNHRKEVLSMLQKQLDQ----------LSC 53 aspcl-a1cas0 21.1% GVSTADE------PLARLVFYFGRNDHWVAERTRDEIIELRGRVEG----G-------------PTMLVCED------GLPHAFC--LRHNEV--MAGKVADMVMD-IVSE-------- 54 aspfu-q4wub2 19.5% GVSTASE------PLTRLFFYFGRNDHWVAERTRDEIIDLRGRVEG----G-------------PTMSVCEL------GLPHAFC--LRHNDI--MAEKVADMVMD-IVSA-------- 55 neofi-a1df46 19.1% GVSTANE------PLTRLFFYFGRNDHWVAERTRDEIIDLRGRVEG----G-------------PTMSVCEL------GLPHAFC--LRHNDI--MAEKVADMVMD-IVSA-------- 56 aspfn-b8nfb2 18.7% GMSDVKD------PVTRLFFYFGRNDHWVAEQTRDEIIELRGRTES----G-------------PKMVVCEE------GLPHAFV--LKHSDV--VAKKVADMVLD-IVKD-------- 57 asptn-q0cd92 18.6% GMSTVQD------PVSRLFFYFGRNDHWVAERTRDEIIELRGQAPD----G-------------PKMVVCEE------GLPHAFC--LRHSDV--MAKKVATMIMD-ITAD-------- 58 pencw-b6hpz6 19.3% GAASARE------PIAKLFFYFGRNDHWVADQTRDDIVAVRGQKGGQA--G-------------PTMVVCEE------GLPHAFC--LKHSDV--MAQKVAGMIRQ-IVA--------- 59 podan-b2b5e4 17.4% HLADDTE-----HNGEKFYFYFAKKDHWVADEVRDAFIERREKDQN----GR------------TKATICEE------GVPHAFC--IHHSET--VAEKAGVWIRE-ITGSWTD----- 60 phano-q0ufs1 17.1% GAAADAPVSKHPHPRPTLRFLFAKKDHWVADETRDQLIRTRGRFSY----GDEVEVEG-PESWKPVMEVDET-----EGWVHSFC--VRHGVP--VAERVAGYIRG-IVERDLKR---- 61 pyrtr-b2vvk1 16.3% GASAAEPATTHPHPRPLLRFLFARKDHWVADSTRDALMNNRGRFGT----GGVEEIEGVGENWKPIMEIDER-----EGWSHGFC--IRHSVP--VAEKVAVWVRG-IVAQDSTK---- 62 phano-q0udr2 16.3% GAANQAE-----NEAVPLKLYFAENDGWVSRSARDALIASRGRTEDC--------------PWKPEMIVDGN------GIGHGFNEDLDHSHL--VAEKVARMIEE-FIEHDTNK---- 63 penmq-b6qkg9 16.7% SIASYHKH--QQQKKFPIRIFFGANDHWVDNELRDAFMYKYCDPSGPLAFGKEA-----L-DLKARIDPSRDGDEGSVVIPHDFS--IGHSEH--VVPYVAEYVEE-IMGSRA------ 64 entdi-b0ee33 18.7% FIQFLNT------FHSKLHLIYGKNDVYGNENVARDMMQRCPE---------------------AQITIT--------DILHAFV--LGYVQN--VIDVISPMLKE-TIQLFEHQ---- 65 enthi-c4lve4 17.5% FIQFLNT------FHSKLHLIYGKNDVYGNENVARDMMQRCPQ---------------------AQIIIT--------DILHAFV--LGYVQN--VIEVISPMLKE-TIQLFEHQ---- 66 entdi-b0efs6 18.9% TQECLLK------TSNKTTVVFGQFDKYTPLWIRNEFKERYPD-----------------------VRVIET------TIKHAFV--LGKSKE--MFDFLKQSNVL------------L 67 enthi-c4m3r1 18.6% TQECLLK------TSNKTTVVFGQFDKYTPLWIRNEFKERYPD-----------------------VRVIET------TIKHAFV--LGKSKE--MFDFLKQNNVF------------L consensus/100% ....................hhs..D.as.......h.............................h............h.Hsa...h............................... consensus/90% ....h.t..........hhhhas.pD.Wss.phhp.h.t.h.t.......................h..p........th.Huas..ht.s....hh..h................... consensus/80% ...hhtp.........phhhhautpDtWss.phhcthhp.h.p......................th..spt......sh.HuFs..lptst...hsthhh.................. consensus/70% ...hhpp.......ht+lhhhaupsDtWss.phhcplhphhsp.....................spl.lspp......sl.HuFs..lppupt..huphsht.h............... |
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