Reference sequence (1): human-PLA2G15 Identities normalised by aligned length. Colored by: consensus/70% and property |
1 human-PLA2G15 100.0% PAGRHPPVVLVPGDLGNQLEAKL-D----KPTVVHYLC-----SKKTESYF--TIW-LNLELLLPV--IIDCWIDNIRLVYNKTSRATQFP-DGVDVRVP-GFGKTFSLEFLDPS--KSS 2 canfa-q6xpz3 93.1% LAGRRPPVVLVPGDLGNQLEAKL-D----KPTVVHYLC-----SKRTESYF--TLW-LNLELLLPV--IIDCWIDNIRLVYNRTSRATQFP-DGVDVRVP-GFGKTFSLEFLDPS--KSS 3 mouse-C87498 91.8% PAQRHPPVVLVPGDLGNQLEAKL-D----KPKVVHYLC-----SKKTDSYF--TLW-LNLELLLPV--IIDCWIDNIRLVYNRTSRATQFP-DGVDVRVP-GFGETFSMEFLDPS--KRN 4 ratno-q675a5 91.5% PAQRHPPVVLVPGDLGNQLEAKL-D----KPKVVHYLC-----SKRTDSYF--TLW-LNLELLLPV--IIDCWIDNIRLVYNRTSRTTQFP-DGVDVRVP-GFGETFSLEFLDPS--KRN 5 bovin-LPLA2 83.2% PAGSRPPVVLVPGDMGNQLEAKL-D----KPSVVHYVC-----SKRTDHYF--TLW-LNLELLLPV--IIDCWIDNVRLIYNQTSHTTQFP-EGVDVRVP-GFGDTFSMEFLDPS--KSS 6 xenla-q566i0 71.0% GCSPGPPVVLVPGDLGNQLEAKL-D----KPSVVHYMC-----SKKTNDYF--TLW-LDLELLLPI--IIDCWIDNIRLVYNKTSKTTAPP-EGVDIRVP-GFGQTYSLEFLDPS--KRS 7 danre-q6nyh6 68.6% VCSVRPPVVLIPGDLGNQLEAKL-D----KPSVVHYIC-----YKKTEDYF--TLW-LNLELLVPV--AIDCWIDNMRLLYNRTNHLSEPP-PGVDIRVP-GFGETYSLEYLDPS--KRS 8 tetng-q4t6m1 70.4% ---------VVPGDLGNQLEAKL-D----KPSVVHYIC-----YKKTNTFF--TLW-LNLELLVPV--AIDCWIDNIRLIYNKTTHTTSSP-PGVDIRVP-GFGQTFSLEYVDPS--ERS 9 human-LCAT 48.4% LSNHTRPVILVPGCLGNQLEAKL-D----KPDVVNWMC-----YRKTEDFF--TIW-LDLNMFLPL--GVDCWIDNTRVVYNRSSGLVSNA-PGVQIRVP-GFGKTYSVEYLDSS--K-- 10 rabit-lcat 47.9% LSNHTRPVILVPGCLGNQLEAKL-D----KPSVVNWMC-----YRKTEDFF--TIW-LDLNMFLPL--GVDCWIDNTRVVYNRSSGRVVIS-PGVQIRVP-GFGKTYSVEYLDNN--K-- 11 bovin-lcat 49.7% LSNHTRPVILVPGCLGNQLEAKL-D----KPSVVNWMC-----YRKTEDFF--TIW-LDLNMFLPL--GVDCWIDNTRVVYNRSSGRVSNA-PGVQIRVP-GFGKTYSVEYLDSS--K-- 12 cavpo-lcat 47.6% LSNHTRPVILVPGCLGNQLEAKL-D----KPDVVNWMC-----YRKTEDFF--TIW-LDLNMFLPF--GVDCWIDNTRVVYNRSSGRVSNA-PGVEIRVP-GFGKTYSVEYLDSN--K-- 13 tupgl-lcat 47.1% LSNHTRPVILVPGCLGNQLEAKL-D----KPDVVNWMC-----YRKTEDFF--TIW-LDLNMFLPL--GVDCWIDNTRVTYNHSSGRVSNA-PGVQIRVP-GFGKTYPVEYLDNS--K-- 14 mouse-lcat 47.1% LSNHTRPVILVPGCLGNRLEAKL-D----KPDVVNWMC-----YRKTEDFF--TIW-LDFNLFLPL--GVDCWIDNTRIVYNHSSGRVSNA-PGVQIRVP-GFGKTESVEYVDDN--K-- 15 ratno-lcat 46.6% LSNHTRPVILVPGCMGNRLEAKL-D----KPNVVNWLC-----YRKTEDFF--TIW-LDFNMFLPL--GVDCWIDNTRVVYNRSSGHMSNA-PGVQIRVP-GFGKTYSVEYLDDN--K-- 16 anapl-lcat 52.6% PTNSTPPVVLVPGCLGNQLEAKL-D----KPDVVNWMC-----YRKTEDYF--TIW-LNLNTFLPV--GVDCWIDNTRVVYNRTSRKMSNA-PGVHIRVP-GFGKTYSVEYLDQS--K-- 17 chick-lcat 51.9% PTNSTPPWCLVPGFLGNQLEAKL-D----KPDVVNWMC-----YRKTEDYF--TIW-LNLNTFLPV--GVDCWIDNTRVVYNRTARKMTNA-PGVHIRVP-GFGKTYSVEYLDQS--K-- 18 xenla-q66j38 52.9% QTNSTPPVVLVPGCFGNQLEAKV-D----KEDVVNWVC-----YKKTDDYF--TIW-LNLNMFLPL--GIDCWIDNIRVVYNKTTRMASNA-PGVDVQVP-GFGKTHSVEYLDKS--K-- 19 caebr-A8Y168 45.8% DQPKGLPVILVPGDGGSQLESNLTG----KPSVVHYVC-----SKQTADFF--DLW-LNLELFTPL--VIDCWADNMQLVFNTTTGLSENM-PGVDIRVV-GFGATEAVEWLDKS--KAS 20 caeel-M05B5.4 44.8% SQAKGLPVILVPGDGGSQLESNLTG----KPSVVHYVC-----SKQTADYF--DLW-LNLQLFTPL--VIDCWADNMQLVFNTTTGLSENM-PGVDIRVA-GFGATESVEWLDKS--KAS 21 drome-GH02384 38.3% PEPKLSPVIFVPGDGGSQMDARL-N----KPNSPYLIC------QKTHDWY--NLW-LDLEQLVIP--IVYCWIDNVKLYYDKVTRTTHNT-PGVETRIP-GWGNPEVVEWIDPT--KNS 22 schja-Q86F58 35.4% ---------MIPGTAGCQAFAVLKN----EPD---------------QKPL--PVW-LNLKLFA----FIKHFTDYFKLQYDAKTGLSYDA-DGVDIIFP-GWGETWSIENLDET--PNM 23 arath-LCAT1 34.0% VGSNVYPLILVPGNGGNQLEVRLDRE--YKPSSVWCSSWLYPIHKKSGGWF--RLW-FDAAVLLSP--FTRCFSDRMMLYYDPDLDDYQNA-PGVQTRVP-HFGSTKSLLYLDPR--LRD 24 medtr-q71ce5 33.2% SNNNLNPVILIPGNGGNQLEAKLTTK--YKPSTLICDPW-YPPFKKKNGWF--RLW-FDSSVLLAP--FTKCFASRMTLYYDQDLDDYFNV-PGVETRVP-SFGSTSSLLYLNPR--LKL 25 orysa-Q851F0 32.5% KQQQLHPVILIPGAGGNQLEARLTEE--YAPSSLACRVW--PVVRGRGGWF--RLW-FDPSVVVAP--LTRCFADRMTLFYDSVADDYRNA-PGVETRVS-DFGSTSTLRYLDPN--LKL 26 orysa-Q8S5X5 27.9% GGSDLHPVVLVPGYGSNRLYARLTAA--YEPAAPRCGA-----REGKDEWF--QLWPIDAAASEPA--QAPCLAEKMSLVYDPVADDYRNV-AGVVTRVP-SFASTRALVGWDP------ 27 enthi-c4m7v0 25.3% ETCTRHPVIIIPGIMASMLNAKINIPKNVDFCDRKLDC------DRSKDWF--TLW-LNLLDGIPY--VNDCYIAYLTCHYNSTSGRMENV-EGVQIEPP-RFGSTYAVDTISPSFPLKT 28 enthi-q51cz6 24.7% TCDSRSPVVLIPGLMASIIEAKINVADDFQPWPKSGKC------EKNKDWF--RAW-VNVDIAVPW--KSECYINYLSGIWNNQTNKLETI-PGIDLRIP-EFGSTYACDQLDPVFLIGS 29 plaba-q4z5z8 20.7% DKKIKNSVYLIPGLGGSTLIAEY-N----DADIESCSS-----KLLHSKPY--RIW-LSISR-FSIRSNVYCLFDTLKLDYDRENKIYRNK-PGVIINVE-NYGYIKGVAFLDYV--KNK 30 playo-q7rh25 21.8% ----KSSVYLVPGLGGSTLIAEY-N----HAQIDSCSS-----KALHSKPY--RIW-LSLSRLFSIRSNVYCLFDTLKLDYDRKKKMYRNK-PGVFINVE-HYGYIKGVAFLDYI--KNK 31 plafa-MAL6P1.135 24.2% ----KPTTYLLPGLGGSTLIAEY-K----NATIHSCSR-----YLLNSKPF--RIW-ISLSRLLSIQSNIYCTFDTIRLKYDEKKNIYYNQ-PGVFIDVE-KFGNLKGIEYLDYF--NNT 32 ashgo-q755k2 19.2% ELCDKHPVVMVPGVTSTGIESWGLYK--------DAEC-------DSEPHFRRRLW-GSFYMLKTMVLDKACWLRHVML--DPETGL--DP-PNYKLRAVQGFE---AADFF-------- 33 klula-q6cl20 18.7% NLTDKHPLVIVPGVISTGIESWGLYK--------DEEC-------DSEPYFRKRLW-GSFYMLKTMVLEKSCWLKHIKL--DPETGL--DP-PNYKLRAAQGFE---AADFF-------- 34 yeast-pdat 17.6% NIEAKHPVVMVPGVISTGIESWGVIG--------DDEC-------DSSAHFRKRLW-GSFYMLRTMVMDKVCWLKHVML--DPETGL--DP-PNFTLRAAQGFE---STDYF-------- 35 canal-q5abf2 18.2% NFTADHNVVMVPGVISTGLESWGTTT--------TGDC-------PSIGHFRKRLW-GSFYMLRTMVLDKTCWLRHIML--DTTTGL--DP-PNIKVRAAQGFE---AADFF-------- 36 debha-q6bsc3 18.3% NLTSKHSVVMVPGVISTGIESWSLEQ--------PADC-------PSVNHFRKRLW-GSFYMLRTMILDKACWLKYIML--DPETGL--DP-PKIKLRAAQGFE---AADFF-------- 37 aspor-q2ul81 18.1% GIQAKHPIVMIPGVISTGLESWGTEV-------------------SSRQYFRRRLW-GSWSMMRALVLDKAEWKNHIML--DKDTGL--DP-PGIKLRAAQGFD---ATDFF-------- 38 gibze-q4i8t3 18.5% GLGVHHPMIMIPGVISTGLESWGTAN-------------------ISKPYFRKRLW-GSWTMMRALVMDKEVWKKHVML--DKRTGL--DP-PDVKLRAAQGFD---ATDFF-------- 39 neucr-q7s4e3 18.1% GLSADHPIVMIPGVISTGLESWSTSE-------------------LSLPYFRKRLW-GSWTMMRALVMDKEAWKRHIML--DKTTGL--DP-PGIKLRAAQGFD---ATDFF-------- 40 schpo-pdat 18.1% GYRSDHPVIMVPGVISSGLESWSFNN-------------------CSIPYFRKRLW-GSWSMLKAMFLDKQCWLEHLML--DKKTGL--DP-KGIKLRAAQGFE---AADFF-------- 41 leima-q4qhs0 18.5% YLPRRHPVVIMPGFITGALEVWETSL----------PC--A-RQKSFFSGFRQRMF-GP-QMIYLILSDPQCWLDMFSM--NKKTGM--DR-NDTKVRADSGFA---SVDYF-------- 42 tryb2-q382l4 18.9% TMRRKHPVMIIPGFISTALEVWQDVV----------EC--T-TSQAYSSRFRQRMF-GP-SMLFLLATDPACYMKLFSL--DKGTGF--DP-PGVKIRPDMGFG---AADFF-------- 43 trycr-q4dqa6 19.1% TMRRKHPVMIIPGFISTALEVWKDNL----------EC--VQAQRSIASNFRQRMF-GP-RLLFLLFMDPLCYLRLFSL--DKRTGF--DP-PGVKIRPDIGFS---ASDFF-------- 44 arath-LCAT4 13.1% VDPNLNPVLLVPGIAGSILNAVD-H--------------------ENGNEE--RVW-VRIFG------ADHEFRTKMWSRFDPSTGKTISLDPKTSIVVPQDRAGLHAIDVLDPDMIVGR 45 lyces-q71lx7 17.0% IDPTLDPVLLVPGVAGSILNAVD-K--------------------KTGRTE--RVW-VRILG------ADHEFCDKLWCRFDPSTGKTTNLDPDTSIEVPEDRYGLYAIDNLDPDMIIGS 46 orysa-q7xts6 15.8% VDPTLDPVLLVPGIGGSILEAVD----------------------EAGKKE--RVW-VRILA------ADHEFRAHLWSKFDASTGKTVSVDEKTNIVVPEDRYGLYAIDTLDPDMIIGD consensus/100% .........hhPG.hss.h.s.................................ha.h..............h.t.h....s...t.......th.h....th....s...h........ consensus/90% ......shhhlPG.hus.l.u.........................t...a..plW.hs..h.h.......pahp.h.h..s.psth......shphpss.tat...uhthh........ consensus/80% ...th.PVlhlPG.hustLEuhh.t............s.......tstshF..plW.hshthhhsh...htCahcphhl..stpoth..ss.sslplRss.sFs...uh-ah........ consensus/70% ..spp.PVlllPGshustLEuhh.s..........h.s.......popsaF..plW.hshphhhsh...hpCahcphpl.aspsoth..ss.PGVplRss.GFu.h.uh-als....... 1 human-PLA2G15 100.0% ---VGSY--FHTMVESLV-GWGYTRGEDVRGAPYDWRRAPNE-------NGPYFLALREMIEEMYQ-LYGGPVVLVAHSMGNMYTLYFLQRQ----------PQAWK------------- 2 canfa-q6xpz3 93.1% ---VGSY--FHTMVESLV-DWGYIRGEDVRGAPYDWRRAPNE-------NGPYFLALREMIEEMYQ-LYGGPVVLVAHSMGNMYTLYFLQRQ----------PQAWK------------- 3 mouse-C87498 91.8% ---VGSY--FYTMVESLV-GWGYTRGEDVRGAPYDWRRAPNE-------NGPYFLALREMIEEMYQ-MYGGPVVLVAHSMGNVYMLYFLQRQ----------PQVWK------------- 4 ratno-q675a5 91.5% ---VGSY--FYTMVESLV-GWGYTRGEDVRGAPYDWRRAPNE-------NGPYFLALQEMIEEMYQ-MYGGPVVLVAHSMGNMYMLYFLQRQ----------PQAWK------------- 5 bovin-LPLA2 83.2% ---VGSY--LHTMVESLV-SWGYERGKDVRGAPYDWRRAPNE-------NGPYFLALRKMIEEMYQ-LYGGPVVLVAHSMGNMYMLYFLQHQ----------PQDWK------------- 6 xenla-q566i0 71.0% ---VGSY--FYTLVQSLV-AWGYTRDENVRGVPYDWRKAPNE-------NSEYFVAVRKLVESMFE-SYQSPVVLVAHSMGNLYTLYFLNQQ----------TQDWK------------- 7 danre-q6nyh6 68.6% ---VGMY--FFTIVQSLV-DWGYTRNDDVRGAPYDWRKAPNE-------NKEYFLRLQQMIEEMAH-KAGGPVVLIAHSMGNMYTLYFLNHQ----------PQAWK------------- 8 tetng-q4t6m1 70.4% ---VGMY--FFTIVQALV-DSGYTRGDDVRGAPYDWRKAPNE-------NKEYFLQLQRMIEEMAS-KAGGPVVLIAHSMGNMYTLYFLSQQ----------PQAWK------------- 9 human-LCAT 48.4% ---LAGY--LHTLVQNLV-NNGYVRDETVRAAPYDWRLEPGQ-------QEEYYRKLAGLVEEMHA-AYGKPVFLIGHSLGCLHLLYFLLRQ----------PQAWK------------- 10 rabit-lcat 47.9% ---LAGY--MHTLVQNLV-NNGYVRDETVRAAPYDWRLEPSQ-------QEEYYGKLAGLVEEMHA-AYGKPVFLIGHSLGCLHLLYFLLRQ----------PQSWK------------- 11 bovin-lcat 49.7% ---LAGY--MHTLVQNLV-NNGYVRDETVRAAPYDWRLEPSQ-------QEEYYLKLAGLVEEMHA-TYGKPVFLIGHSLGCLHLLYFLLRQ----------PQTWK------------- 12 cavpo-lcat 47.6% ---LAGY--MHTLVQNLV-NNGYVRDETVRAAPYDWRLEPGQ-------QEEYYQKLARLVEEMHA-AYGKPVFLIGHSLGCLHLLYFLLRQ----------PQSWK------------- 13 tupgl-lcat 47.1% ---LAGY--MHTLVQNLV-NNGYVRDETVRAAPYDWRLGPKQ-------QEEYYRDLARLVEEMHA-TYGKPVFLIGHSLGCLHLLHFLLHQ----------PQSWK------------- 14 mouse-lcat 47.1% ---LAGY--LHTLVQNLV-NNGYVRDETVRAAPYDWRLAPHQ-------QDEYYKKLAGLVEEMYA-AYGKPVFLIGHSLGCLHVLHFLLRQ----------PQSWK------------- 15 ratno-lcat 46.6% ---LAGY--LNTLVQNLV-NNGYVRDETVRAAPYDWRLAPRQ-------QDEYYQKLAGLVEEMYA-AYGKPVFLIGHSLGCLHVLHFLLRQ----------PQSWK------------- 16 anapl-lcat 52.6% ---LAGY--LHTLVQNLV-NNGYVRDQTVRAAPYDWRVGPQE-------QPEYFQNLKALIEEMHD-EYQQRVFLIAHSMGNLNVLYFLLQQ----------RQAWK------------- 17 chick-lcat 51.9% ---LAGY--LHTLVQNLV-NNGYVRDQTVRAAPYDWRVGPQE-------QPEYFQNLKALIEEMHD-EYQQRVFLIGHSMGNLNVLYFLLQQ----------KQAWK------------- 18 xenla-q66j38 52.9% ---LAGY--FHTLVQNLV-NNGYVRDQTVRAAPYDWRIAPNG-------QKEYFEKLKNLIEEMSV-EYNEPVFIIGHSLGNLYLLYFLNHQ----------PQEWK------------- 19 caebr-A8Y168 45.8% ---QGRY--FFDIVDSMV-SWGYRRGKDVVGAPFDWRRSPNE-------LNDYLIQLKTLIETTYRWNENKKIVLVGHSMGNPLSLYFLNNYV---------DQAWK------------- 20 caeel-M05B5.4 44.8% ---QGRY--FFDIVDSMV-SWGYRRGKNVIGAPFDWRKSPNE-------LNDYLIQLKSLIETTYRWNDNQKIVLVGHSMGNPLSLYFLNNYV---------DQAWK------------- 21 drome-GH02384 38.3% ---AGAY--FKDIANELV-KLGYIRKQNIHGAPYDFRKAPNE-------NQQFFIDLKQLVEDSYEANNQSAVTFISHSMGSLMTLVFLQEQ----------TLQWK------------- 22 schja-Q86F58 35.4% ---FSEY--FGALVYVLRKDPFYVSNFTMRGAPYDFRKAPNE-------NVEFFDKLKGLIEETYVNAKQRPIVLLPHSMGCLYALWFLKKC----------DIQWK------------- 23 arath-LCAT1 34.0% ---ATSY--MEHLVKALEKKCGYVNDQTILGAPYDFRYGLAASGHPSRVASQFLQDLKQLVEKTSSENEGKPVILLSHSLGGLFVLHFLNRT----------TPSWR------------- 24 medtr-q71ce5 33.2% ---VTGY--MAPLVESLE-QLGYIDGQNLFGAPYDFRYGLAAPSHPSQVGSKFLNDLKNLIEKASNSNGGKPVILVSHSLGGLFVLELLNRN----------PSSWR------------- 25 orysa-Q851F0 32.5% ---LTGY--MNVLASTLE-KAGYEEGFDLFGAPYDFRYGLAGPGHPSRVGSAYLERLRKLVESACAANGGRPAILVAHSLGGLYALQMVARS----------PPAWR------------- 26 orysa-Q8S5X5 27.9% ------------LVRQLE-AMGHRDGGSLFAAPYDFRYAVAPRGHPSAVGERYFARLTRLIERASRLNGGRPAVVVAHSFGCALTYQFLRAR----------PLAWR------------- 27 enthi-c4m7v0 25.3% ---FSRA--FHEVIKGLQ-KIGYKDEFDLFSAPYDWRYYH---------HDEYYEKVKELIIKAYE-NTGNKVVLVSHSMGGLTTYILLDKL----------GKEFC------------- 28 enthi-q51cz6 24.7% ---FTNS--FHKIIEHLK-SVGYKDQIDMFGASYDWRTVDL--------PKTYFEGVKGLIYEGFK-NSGKKVVIISHSMGGFVSYKLFDYL----------GKDFC------------- 29 plaba-q4z5z8 20.7% PLRLTRY--YGILADKFL-ENEYIDGKDILSAPYDWRFPL---------SQQKYNVLKSHIEHIYKIKQEIKVNLIGHSLGGLFINYFLSQFV---------DEEWK------------- 30 playo-q7rh25 21.8% PLRLTRY--YGILADKFL-ENGYIDGKDILSAPYDWRFPL---------SQQKYEVLKSHIEYIYGLKKGTKVDLIGHSLGGLFINYFLSQFV---------DEEWK------------- 31 plafa-MAL6P1.135 24.2% GIGITKY--FNVVGQYFT-SHGYVDGESIIGAPYDWRYPL---------SQQNYKILKEHIEYIYEKRNGTKVNLIGHSLGGLYLNFFLSRVV---------SKKWK------------- 32 ashgo-q755k2 19.2% ---MAGFWIWNKILQNLG-AIGY-EPNKMVTAAYDWRLAFLDLER----RDRYFSKLKMQVEMMYD-ATGEKSVLVGHSMGSQIIFYFLKWVEAEGELYGNGGPGWV------------- 33 klula-q6cl20 18.7% ---MAGYWLWNKVLQNLG-AIGY-ESNKMVTAAYDWRLSYLDLEV----RDRYFTKLKMQIELQLE-QTGEKSVLVGHSMGSQVVFYFLKWIEASGEGYGNGGEGWV------------- 34 yeast-pdat 17.6% ---IAGYWIWNKVFQNLG-VIGY-EPNKMTSAAYDWRLAYLDLER----RDRYFTKLKEQIELFHQ-LSGEKVCLIGHSMGSQIIFYFMKWVEAEGPLYGNGGRGWV------------- 35 canal-q5abf2 18.2% ---MAGYWIWNKILQNLA-VIGY-GPNNMISASYDWRLTYIDLEK----RDGYFSKLKAQVEIVKQ-LTGKKSVLVGHSMGSQIIYYFLKWVEAKGEYYGNGGPNWV------------- 36 debha-q6bsc3 18.3% ---VAGYWIWNKILQNLA-VIGY-NPNNMISASYDWRLAYLDLEK----RDAYFSKLKAQIEMTKG-VSGEKSVLVGHSMGSQVIYYFLKWAEASGEYYGNGGSKWC------------- 37 aspor-q2ul81 18.1% ---ITGYWIWNKILENLA-TIGY-DPTNAFTAAYDWRLSYLNLEV----RDQYFSRLKSYIETAVL-VKGEKVALASHSMGSQVLFYFFKWVEHPE--HGKGGSDWV------------- 38 gibze-q4i8t3 18.5% ---ITGYWIWSKIFENLA-SIGY-DPTNSFTAAYDWRLSYPNLEV----RDRYFTRLKSHIEIAVA-TEDKKVVLASHSMGSQVLYYFLHWVQSER--GGRGGPDWV------------- 39 neucr-q7s4e3 18.1% ---ITGYWIWNKILENLA-SLGY-DPTNSYTAAYDWRLAYANLEV----RDHYFSRLKSYIEQAVF-IHKKKVVLTSHSMGSQVLFYFFHWVASKK--GGQGGQDWV------------- 40 schpo-pdat 18.1% ---ITGYWIWSKVIENLA-AIGY-EPNNMLSASYDWRLSYANLEE----RDKYFSKLKMFIEYSNI-VHKKKVVLISHSMGSQVTYYFFKWVEAEG--YGNGGPTWV------------- 41 leima-q4qhs0 18.5% ---VPGYWVWAKVLINLA-DIGY-DPQSMAVVTYDWRLSPDKAHE----RDGFFYQVRNSLHFLCR-RNRKRAVVISHSYGATVALAFFRWAEQR-------EGGFM------------- 42 tryb2-q382l4 18.9% ---MPGYWVWAKIFVNLA-DIGY-DPQSMGISSYDWRLSPRGIHR----RDGYYYHLKNYLMYLYH-KNEERVVIVSHSYGSLVVVDFLRWADEH-------EAGWT------------- 43 trycr-q4dqa6 19.1% ---MPGYWVWAKVLLNLA-DIGY-DPQSVGVFSYDWRLSPRRMHQ----RDGYYYYLRNQLLYLYE-KNGEKVVIISHSYGTDVLIDFLRWSDSH-------EPGWV------------- 44 arath-LCAT4 13.1% --ESVYY--FHEMIVEMI-GWGFEEGKTLFGFGYDFRQSNR--------LQETLDQFAKKLETVYKASGEKKINVISHSMGGLLVKCFMGLH----------SDVCKSLFLYSYSRSMYR 45 lyces-q71lx7 17.0% --DCVYY--YHDMIVEML-SWGYQEGKTLFGFGYDFRQSNR--------LQETMECFAQKLESIHTASGGKKINIISHSMGGLLVKCFMALH----------SDIF-------------- 46 orysa-q7xts6 15.8% --DSVCY--YHDMIVQMI-KWGYQEGKTLFGFGYDFRQSNR--------LSETLDRFSRKLESVYIASGEKKINLITHSMGGLLVKCFMSLH----------SDVF-------------- consensus/100% ............hh..h.....a.t..p.h..saDaR................h..ht..l........t....hhsHShGs.....hh................h.............. consensus/90% ....s.Y..h..hh.th..t.GY.cstshhsssYDaRh............t.hh.tltt.lc.h.....tt.h.lluHShGs.hhh.Fh...............tah............. consensus/80% ...hstY..htpllpsLh.s.GY.cspshhuAsYDWRhs..t.......tptaa.tLpthlE.hht...tp.lhLluHShGs.hhhhFlth...........s.sWh............. consensus/70% ...hssY..htpllpsLs.s.GY.cspslhuAsYDWRhu.tt.......pppYa.pLpthlEphht.thsp.VsLluHShGshhhhaFLph...........spsWp............. 1 human-PLA2G15 100.0% -----------------------DKYIRAFVSLGAPWGGVAKTLRVLASGDNNRI------------PVIGPLKIREQQRSAVSTSWLLPYN--YTWSPEK------------------- 2 canfa-q6xpz3 93.1% -----------------------NKYIQAFVALGAPWGGVAKTLRVLASGDNNRI------------PVIRPLKIREQQRSAVSTSWLLPYN--YTWSPEK------------------- 3 mouse-C87498 91.8% -----------------------DKYIHAFVSLGAPWGGVAKTLRVLASGDNNRI------------PVIGPLKIREQQRSAVSTSWLLPYN--HTWSHEK------------------- 4 ratno-q675a5 91.5% -----------------------DKYIQAFVSLGAPWGGVAKTLRVLASGDNNRI------------PVIGPLKIREQQRSAVSTSWLLPYN--HTWSHEK------------------- 5 bovin-LPLA2 83.2% -----------------------DKYIRAFVALGPPWGGVPKTLRVLASGDNNRI------------PVIRSLKIRAQQRSAVSTTWLLPYS--YTWSPQK------------------- 6 xenla-q566i0 71.0% -----------------------DKYIHSFVALGAPWGGVSKTLRVLASGDNNRI------------PVISSLKLRDQQRSAVSTNWLLPYN--NTWPQKK------------------- 7 danre-q6nyh6 68.6% -----------------------DRYIKAYVSLGPPWAGVAKTLRVMATGDNNRI------------PVISPLKIRTQQRTAVSTTWLLPYA--HTWPKDM------------------- 8 tetng-q4t6m1 70.4% -----------------------DKYIKAFISLGPPWAGVAKTLRVLISGDNNRI------------PVISSLKIRAQQRTAVSTSWLLPYA--HTWPNDK------------------- 9 human-LCAT 48.4% -----------------------DRFIDGFISLGAPWGGSIKPMLVLASGDNQGI------------PIMSSIKLKEEQRITTTSPWMFPSR--MAWPEDH------------------- 10 rabit-lcat 47.9% -----------------------DRFIDGFISLGAPWGGSIKPMLVLASGDNQGI------------PLMSSIKLREEQRITTTSPWMFPSQ--GVWPEDH------------------- 11 bovin-lcat 49.7% -----------------------DRFIDGFISLGAPWGGTIKPMLVLASGDNQGI------------PVMSSIKLKEEQRMTTTSPWMLPAR--QTWPEDH------------------- 12 cavpo-lcat 47.6% -----------------------DHFIDGFISLGAPWGGSTKPMLVLATGNNQGI------------PLMSSIKLREEQRITTTSPWMFPSY--RVWPEGH------------------- 13 tupgl-lcat 47.1% -----------------------DRFIDGFISLGAPWGGSIKPMQVLASGDNQGI------------PIMSSIKLKEEQRITTTSPWMFPSS--EVWPEDH------------------- 14 mouse-lcat 47.1% -----------------------DHFIDGFISLGAPWGGSIKAMRILASGDNQGI------------PILSNIKLKEEQRITTTSPWMLPAP--HVWPEDH------------------- 15 ratno-lcat 46.6% -----------------------DHFIDGFISLGAPWGGSIKPMRILASGDNQGI------------PIMSNIKLREEQRITTTSPWMFPAH--HVWPEDH------------------- 16 anapl-lcat 52.6% -----------------------DQYIGGFISLGAPWGGSVKPLRVLASGDNQGI------------PLMSNIKLREEQRMTTTSPWMFPTS--LAWPEDH------------------- 17 chick-lcat 51.9% -----------------------DQYIGGFISLGAPWGGSVKPLRVLASGDNQGI------------PLMSNIKLREEQRMTTTSPWMFPTS--LAWPEDH------------------- 18 xenla-q66j38 52.9% -----------------------DKYVKGFISLGAPWGGAVKPLLVLMSGDNHGI------------PMVSNIKIREEQRMTTTNPWMLPTN--LGWPESH------------------- 19 caebr-A8Y168 45.8% -----------------------DKYINSFVSLAAPWAGSMQIVRLFASGYNMNY----------YRVILPPSALRGMQRSFTSSAFLFPSP--VAWKPTD------------------- 20 caeel-M05B5.4 44.8% -----------------------DKYISSFVSLAAPWAGSMQIVRLFASGYNMNY----------YRVILPPSSLRAMQRSFSSSAFLFPSP--VAWKPHE------------------- 21 drome-GH02384 38.3% -----------------------AKYVKRMISLAGVWAGSFKAVKVFAMGDDLDS------------FALSAKILKAEQITHPSTAWLLPSP--LFWKPTE------------------- 22 schja-Q86F58 35.4% -----------------------KKYIKSVVFSSCPFGGSVKTVKVEASGDNFGV------------FLRSPLSFRQVQRSMPSLTFLFPDS--RLWPPSE------------------- 23 arath-LCAT1 34.0% -----------------------RKYIKHFVALAAPWGGTISQMKTFASGNTLGV------------PLVNPLLVRRHQRTSESNQWLLPST--KVFHDRT------------------- 24 medtr-q71ce5 33.2% -----------------------KKFIKHFIALSAPWGGTVDEMFTSASGNTLGV------------PLVNPLIVRNEQRTSESNLWLLPNP--KMFDIDK------------------- 25 orysa-Q851F0 32.5% -----------------------AANVKRLVTLSAPWGGSVQEMLTFASGNTLGV------------PFVDASLIRDEQRTAESNLWLLPAP--RVFGNTT------------------- 26 orysa-Q8S5X5 27.9% -----------------------QRFVKHAVLLAAALGGFAEGMDGLASGAGSGL------------PNLAPPARARLARSQQSALWRLPTP--MVFGDRP------------------- 27 enthi-c4m7v0 25.3% -----------------------DKYIHRWVAMSTPFIGTTIANDVVLAGYNMGY-------------PVSKELIKKAARTFETVAMMGPIG--EYWDQNE------------------- 28 enthi-q51cz6 24.7% -----------------------DKYIQKWIAISAPFIGTGVVPKQMTVGENLGL-------------PIKAEYARDLSRSIESVLALSPNE--EKWNDDI------------------- 29 plaba-q4z5z8 20.7% -----------------------KKHINIVIHINVPFAGSIKAIRALLYNNKDYTLFKLKNI---LKVSISGSLMRAISHNMGSPLDLLPYR--KYYDRDQ------------------- 30 playo-q7rh25 21.8% -----------------------KKYINIVMHINVPFAGSIKAIRALLYSSKDYTLFKLRNI---LKVSISGSLMKAISHNMGSPFDLIPYR--KYYDRDQ------------------- 31 plafa-MAL6P1.135 24.2% -----------------------QKHLSKIIFISTPFKGSVKTIRALIQSRKDFISFRITKL---IKLSIPESMMKALGNSLGSLFDILPYR--EYYKRDQ------------------- 32 ashgo-q755k2 19.2% -----------------------EKHIDSFVNVAGTLLGVPKAMPALLSGEMKDTIDLNALAMYGLEKFFSRKERLDLLRSWGGIPSMIPKGGNLIWGNMTYSVED-------------- 33 klula-q6cl20 18.7% -----------------------DKHIAAFVDIAGTLLGAPKCVPALISGEMKDTIQLNTLAMYGLEKFFSRRERLEMIQTWGGIPSMLPKGGELIWGDLDFSVEDNA------------ 34 yeast-pdat 17.6% -----------------------NEHIDSFINAAGTLLGAPKAVPALISGEMKDTIQLNTLAMYGLEKFFSRIERVKMLQTWGGIPSMLPKGEEVIWGDMKSSSED-------------- 35 canal-q5abf2 18.2% -----------------------EDYVEAFVDISGSSLGTPKAIPALISGEMKDTVQLNALAVYGLEQFFSRRERVDMLRSFGGIASMIPKGGDKIWGNLTYAPDDEIVAFDT-----EK 36 debha-q6bsc3 18.3% -----------------------NDNIAAVVDISGSTLGAPKTIPALISGEMRDTVQLNALAVYGLEKFFSRKERVDMLRTFGGVPSMLPKGGEVIWGNSTHAPDDPSNTLMTPLSSNET 37 aspor-q2ul81 18.1% -----------------------NRHVASWINISGCMLGAVKGLTAVLSGEMRDTAQLNAFAVYGLEKFLSKEERAEIFRAMPGISSMLPKGGEAVWGNATWAPDD-------------- 38 gibze-q4i8t3 18.5% -----------------------ERHIDAWINISGCMLGAVKDLTAVLSGEMRDTAQLNPFAIYGLEKFLSKEERAEIFRGMPGISSMLPIGGNSVWGNLTWAPDD-------------- 39 neucr-q7s4e3 18.1% -----------------------ERHVDSWINISGCMLGAVKDVTAILSGEMRDTAQMNAFAVYGLEKFLSKEERAEIFRAMPGISSMLPMGGNAVWGELDWAPDD-------------- 40 schpo-pdat 18.1% -----------------------NDHIEAFINISGSLIGAPKTVAALLSGEMKDTGIVITLNI--LEKFFSRSERAMMVRTMGGVSSMLPKGGDV-------APDD-------------- 41 leima-q4qhs0 18.5% -----------------------DRHVAYYVNVGGVAMGVGKAASALLLGDARDTLNIQWAARKMLDTFISQEARYGLSRSWSCLVSMLPRGCEEAWPGLTVLP---------------- 42 tryb2-q382l4 18.9% -----------------------NKHVANWINIGGTTMGVSKTVSALLSGEAKDTLALPGTARAILENYFSRNLRTETFRTWSCQAAMLPSGCEGVHPQILRLH---------------- 43 trycr-q4dqa6 19.1% -----------------------DKHMAFWINIGGPVLGVAKSVSAVLTGDAKDTLTLPSPVRQVLETHLSRSLRAEAMRTWSCLTAMYPFGCDALFPDILTLP---------------- 44 arath-LCAT4 13.1% IGLLLLLHFEVSSLTCGTSDSTGDNYHTDWFRIID--SGAPGYITSTLLNGMSFVNGWEQN------FFVSKWSMHQL------------------------------------------ 45 lyces-q71lx7 17.0% -----------------------EKYVKNWIAIAAPFQGAPGYITSSLLNGTSFVHGWEER------FFISKWSMHQLLIECPSIYELMGCP-DFHWEHAP------------------- 46 orysa-q7xts6 15.8% -----------------------EKYIKSWIAIAAPFQGAPGYITTSLLNGMSFVEGWESR------FFISKWSMQQLLLECPSIYELLANS-TFQWEDTP------------------- consensus/100% .......................tt.ht.hh...s...G........h.s...................h....h............................................. consensus/90% .......................pcaltthltlusshhGs.t.h.hhh.ut...h..............hs...hht..p.h.s...hhP.....ha....................... consensus/80% .......................p+alptalsluushhGs.csh.shhsGp.pth.............hhu...htt..R.hss...hhP....hhas..p................... consensus/70% .......................c+aIpsalsluushhGssKshpslhSGctpth.............hhSt.thpp..Rshso.s.hhP.s..hhWsptp................... 1 human-PLA2G15 100.0% ------------VF--------VQTPTI------N---------------------------------YTLRDYRKFFQDI-------------GFEDGWLMR------------QDTEG 2 canfa-q6xpz3 93.1% ------------IF--------VHTPTA------N---------------------------------YTLRDYHQFFQDI-------------GFKDGWLMR------------QDTEG 3 mouse-C87498 91.8% ------------VF--------VYTPTT------N---------------------------------YTLRDYHRFFRDI-------------GFEDGWFMR------------QDTEG 4 ratno-q675a5 91.5% ------------VF--------VYTPTA------N---------------------------------YTLRDYHRFFQDI-------------GFEDGWFMR------------QDTQG 5 bovin-LPLA2 83.2% ------------VF--------VRTPKA------N---------------------------------YTLQDYRQFFQDI-------------GFKDGWSMR------------QDTEG 6 xenla-q566i0 71.0% ------------VF--------VRTPQK------N---------------------------------YTIKDYKMFYEDI-------------GFQDGWEMR------------KETEG 7 danre-q6nyh6 68.6% ------------VL--------VYTPNT------T---------------------------------YTVQDYQRFFKDI-------------DYEDGWAMR------------QDTEP 8 tetng-q4t6m1 70.4% ------------VL--------VQTPTV------N---------------------------------YTVLDHKRLYTDI-------------GFEDGWMMR------------QDTEP 9 human-LCAT 48.4% ------------VF--------ISTPSF------N---------------------------------YTGRDFQRFFADL-------------HFEEGWYMW------------LQSRD 10 rabit-lcat 47.9% ------------VF--------ISTPSF------N---------------------------------YTGRDFKRFFEDL-------------HFEEGWYMW------------LQSRD 11 bovin-lcat 49.7% ------------VF--------ISTPSI------N---------------------------------YTSRDMQRFFTDL-------------HFEEGWYMW------------LQSRD 12 cavpo-lcat 47.6% ------------VF--------ISTPSF------N---------------------------------YTGRDFQRFFGDL-------------HFEDGWYMW------------LQSRD 13 tupgl-lcat 47.1% ------------VF--------ISTPSF------N---------------------------------YTIRDYQRFFVDV-------------HFEEGWYMW------------LQSRD 14 mouse-lcat 47.1% ------------VF--------ISTPNF------N---------------------------------YTVQDFERFFTDL-------------HFEEGWHMF------------LQSRD 15 ratno-lcat 46.6% ------------VF--------ISTPNF------N---------------------------------YTGQDFERFFADL-------------HFEEGWHMF------------LQSRD 16 anapl-lcat 52.6% ------------IF--------ISTPSY------N---------------------------------YTYRDYKQFFTDV-------------NLEDGWYMW------------EDMKD 17 chick-lcat 51.9% ------------VF--------ISTPSY------N---------------------------------YTYRDYQRFFTDV-------------NLEDGWYMW------------EDMKD 18 xenla-q66j38 52.9% ------------VF--------ISTPSD------N---------------------------------YTYKDYQKLFHDI-------------GFEDGWYMW------------EDTKG 19 caebr-A8Y168 45.8% ------------IL--------AQTALK------N---------------------------------YTVSNIKEFFQDI-------------NYMTGWEQY------------QQAAR 20 caeel-M05B5.4 44.8% ------------IL--------ATTADK------N---------------------------------YTVGNIKEFFQDI-------------NYMVGWEQY------------KQAAR 21 drome-GH02384 38.3% ------------VL--------AMTPSR------N---------------------------------YTMAQLEEFFKDL-------------DYMTGWEMR------------KDTIR 22 schja-Q86F58 35.4% ------------PL--------IITPTT------N---------------------------------YSSVDYERFFNDI-------------NYTIGYRMW------------KDTHS 23 arath-LCAT1 34.0% -----------KPL--------VVTPQV------N---------------------------------YTAYEMDRFFADI-------------GFSQGVVPYK-----------TRVLP 24 medtr-q71ce5 33.2% ------------SL--------VTTPYR------N---------------------------------YSAHDMIDFLKDI-------------GFPEGVYPYE-----------TRILP 25 orysa-Q851F0 32.5% -------------L--------VVSRHH------N-------------------------------RSYSAKNMTQFLRDI-------------GFAEGVEPYR-----------ERIRP 26 orysa-Q8S5X5 27.9% -------------V--------VVTKNS------T---------------------------------YSANNITEFLDAI-------------GFTEGVQPYV-----------TRVLP 27 enthi-c4m7v0 25.3% ------------VLV-------ELANGK------K---------------------------------YYPKDQIELFSQL-------------EEMKPFAKEAVE---------NSFAP 28 enthi-q51cz6 24.7% ------------LVR-------IKSNGK------T---------------------------------YTAKQLREVYKQI-------------PELKDKTDYILD---------TEMTP 29 plaba-q4z5z8 20.7% ------------IV--------VIINMD------EFPIDEKLAQSIVTECGIYNESCYTDREDVNLKTYTLSNWYELLSN--------------DMREKYENY------------IQYTD 30 playo-q7rh25 21.8% ------------IV--------VIINMG------KLPIDEKLVQSIVTECGIYNERCYTDREDVNLKTYTLSNWHELLSD--------------DIREKYENY------------IQYTD 31 plafa-MAL6P1.135 24.2% ------------VV--------ILINMS------NTPIDEDHVQYLVTLCGIYKPECYRNRADVNLKVYTLKNWHELLDD--------------KLKAKYENY------------KLYRE 32 ashgo-q755k2 19.2% -VLHNNTDTYGNFIRFN-KPQ-GPLSSR------N---------------------------------LTMEDAIDYIFEL--APGWLGRRATDQYSFGYATSPEQMQLNERHHAHWSNP 33 klula-q6cl20 18.7% -TANNNTDTYGNFIRFA-DVD-GNFLAKENSTWTN---------------------------------FTMSSAVQYVRDT--SPSWLQKRITDQYSFGYAKSEQEMKNNELYHSYWSNP 34 yeast-pdat 17.6% -ALNNNTDTYGNFIRFE-RNT-SDAFNK------N---------------------------------LTMKDAINMTLSI--SPEWLQRRVHEQYSFGYSKNEEELRKNELHHKHWSNP 35 canal-q5abf2 18.2% EDIGEKKRSFGSFIQYK-T---ANDSSR------E---------------------------------VTIDQSIEELLEN--SPDWYSKRVRENYSFGVAHTKEELEKNNHDQSKWSNP 36 debha-q6bsc3 18.3% LPEGPKGETFGTFIRLD-G-----TSKK------N---------------------------------LTMDESIDYLLER--SPDWFSNRVKEQYSFGIARTKKELKRNNQDHLKWSNP 37 aspor-q2ul81 18.1% --LPGQHTSYGNLLKFQ-QTN-SSLTAK------N---------------------------------LTVSESLAYLMNS--SDEWYRNQVQTSYSHGVAHTTAQVEANENDPRTWLNP 38 gibze-q4i8t3 18.5% --LPGQNRSYGSLLNFRVGSN-WTTPDR------N---------------------------------FTVEEGVSYLLNT--TEDWYQDQIKGSYSRGIAHSIDEVEANENDPKKWINP 39 neucr-q7s4e3 18.1% --QPGQGHSYGSLLNFRAGQNVSTTPDR------N---------------------------------FTIEDAMDYILDT--TDDWYRDQVKGSYSHGVAKTRAEVEANENDPRKWINP 40 schpo-pdat 18.1% --LNQTNFSNGAIIRYR--ED-IDKDHD------E---------------------------------FDIDDALQFLKNV--TDDDFKVMLAKNYSHGLAWTEKEVLKNNEMPSKWINP 41 leima-q4qhs0 18.5% ----------------------------------N------------------------------GTALGTRGTAELIRGG-------------CQRSGHEDCVRQIDSF-----LETID 42 tryb2-q382l4 18.9% ----------------------------------N------------------------------GTVLPPKEAIRLLTRR-------------LNESGHVAVVKQAREV-----LGRFG 43 trycr-q4dqa6 19.1% ----------------------------------N------------------------------RTRLTPKQVLKLTAQR-------------LRESGHEAQKEHVEEL-----LDHFD 44 arath-LCAT4 13.1% ------------------------SCGERKRAMME---------------------------------LEPLMLF------------------LSLTVAWRAL------------KFLRN 45 lyces-q71lx7 17.0% ------------VLEIW-KEK-SNSNGESSVVLES---------------------------------YSPLEAVSVYELALANNKVTYNGEKISLPFNLELL------------KWANK 46 orysa-q7xts6 15.8% ------------YLQIW-RQK-LDTNGKKSAMLES---------------------------------YEPDEAIKMIREALSKHEIISDGMHIPLPLDMDIL------------RWAKE consensus/100% ..................................p.................................h..............................h.................... consensus/90% .............h....................p.................................hs..ph.phh.p..............th..sh.................... consensus/80% ............hh..........tst.......s.................................aohpph.phhtph.............thp.Gh..h...............ts consensus/70% ............hh........h.osth......N.................................YThpshhchht-h.............tappGa.hh............pthps 1 human-PLA2G15 100.0% LVEATM---PP-GV-QLHCLYGT--GVPTPDSFYYE--S--F-----PDRDP---------------------KICFGDGDGTVNLKSAL-QCQA---WQSRQ-------EHQVLLQELP 2 canfa-q6xpz3 93.1% LVEAMV---PP-GV-PLHCLYGT--GVPTPDSFYYE--S--F-----PDRDP---------------------KICFGDGDGTVNLQSAL-QCQA---WRGHQ-------EHQVSLQALP 3 mouse-C87498 91.8% LVEAMT---PP-GV-ELHCLYGT--GVPTPNSFYYE--S--F-----PDRDP---------------------KICFGDGDGTVNLESVL-QCQA---WQSRQ-------EHRVSLQELP 4 ratno-q675a5 91.5% LVEALV---PP-GV-ELHCLYGT--GVPTPNSFYYE--N--F-----PDRDP---------------------KICFGDGDGTVNLESVL-QCQA---WQSRQ-------EHKVSLQELP 5 bovin-LPLA2 83.2% LVEATV---PP-GV-RLHCLYGT--GVPTPESFDYE--S--F-----PDRDP---------------------KIHYGTGDGTVNLQSAL-HCHT---WRGLQ-------KQEVSLQALP 6 xenla-q566i0 71.0% LVSSLN---PP-GV-DVHCLYGT--GVDTPDSFSYD--S--F-----PDKEP---------------------TTVYGAGDGTVNLESAL-QCGK---WRNRQ-------RQKVSLVELP 7 danre-q6nyh6 68.6% LVSALQ---PP-GV-PVHCLYGT--GIPTPQGYNYT--N--F-----PDTDP---------------------AVINGDGDGTVNLISAI-QCKR---WKGQQ-------KQAVEWLELP 8 tetng-q4t6m1 70.4% LVTDLA---PP-GV-AVHCLYGS--GLLTPEAFRYS--DK-F-----PDVDP---------------------TVVYGDGDGTVNLLSAK-QCGR---WVGRQ-------KQPVVLKELP 9 human-LCAT 48.4% LLAGLP---AP-GV-EVYCLYGV--GLPTPRTYIYD--HG-F-----PYTDP--------------------VGVLYEDGDDTVATRSTE-LCGL---WQGRQ-------PQPVHLLPLH 10 rabit-lcat 47.9% LLAGLP---AP-GV-EVYCLYGI--GLPTPHTYIYD--HG-F-----PYTDP--------------------VGVLYEDGDDTVATSSTD-LCGL---WRGRQ-------PQPVHLLPLH 11 bovin-lcat 49.7% LLAGLP---AP-GV-EVYCLYGI--GLPTPSTYIYD--HG-F-----PYTDP--------------------VDVLYEDGDDTVATRSTE-LCAR---WQGRQ-------KQPVHLLPLP 12 cavpo-lcat 47.6% LLAGLP---AP-GV-EVYCLYGV--GLSTPSTYIYD--HG-F-----PYSDP--------------------VNVLYEDGDDTVATRSTE-LCGL---WQGRQ-------PQPVHLLPLN 13 tupgl-lcat 47.1% LLAGLP---AP-GV-EVYCLYGV--GLPTPSTYIYD--HD-F-----PYTDP--------------------LDVLYEDGDNTVATRSME-LCSQ---WQGRQ-------PQPVHLLPLH 14 mouse-lcat 47.1% LLERLP---AP-GV-EVYCLYGV--GRPTPHTYIYD--HN-F-----PYKDP--------------------VAALYEDGDDTVATRSTE-LCGQ---WQGRQ-------SQPVHLLPMN 15 ratno-lcat 46.6% LLAGLP---AP-GV-EVYCLYGV--GMPTAHTYIYD--HN-F-----PYKDP--------------------VAALYEDGDDTVATRSTE-LCGQ---VQGRQ-------SQGVHLLRMN 16 anapl-lcat 52.6% LLKGLP---PP-GV-DTYCLYGT--GYPTVETYIYD--EH-F-----PYEDP--------------------VDMIYGDGDDTVNRRSSE-LCKR---WRNQQ-------KQKVHIQELR 17 chick-lcat 51.9% LLKGLP---PP-GV-DTYCLYGT--GYPTVETYIYD--EH-F-----PYEDP--------------------VDMIYGDGDDTVNKRSSE-LCKR---WRNQQ-------KQKVHVQELR 18 xenla-q66j38 52.9% LIEGLP---PP-GV-EVYCIYGT--GIPTAETYIYG--EG-F-----PNEPA--------------------IDIKYSDGDDTVHTRSME-LCKR---WINQQ-------KQKVHIHELA 19 caebr-A8Y168 45.8% LNGNLS---AP-GV-PVHCIYGT--GVPTPERFQWA--SGYF-----PDYPP---------------------TEFMGDGDGTVNKKSAT-VCSN---WIGNN------GGKKVTVHEVF 20 caeel-M05B5.4 44.8% LNGNLS---SP-GV-PVHCIYGT--GVPTPEKFSWA--PGYF-----PDYPP---------------------TEFMGDGDGTVNKKSAT-VCTN---WIGNN------NGYKVTVHEVF 21 drome-GH02384 38.3% YNRNFD---PP-NV-ELHCLYGE--GIDTVERLQYK--KSDI-----SGETP---------------------KLIMGLGDGTVNQRSLR-ACKY---WAGYS-------KAPINTLALQ 22 schja-Q86F58 35.4% LVDGLE---MPTGIDDIHCIHGS--NLSTTDKIAYA--APSFFYNGFPDQVP---------------------LLIPGNGDGTVSIRSLE-YCKN---WPGTK------------YYILP 23 arath-LCAT1 34.0% LTEELM---TP-GV-PVTCIYGR--GVDTPEVLMYG--KGGF------DKQP---------------------EIKYGDGDGTVNLASLA-ALKV----------------DSLNTVEID 24 medtr-q71ce5 33.2% LIAKID---AP-AV-AMTCIIGK--GVKTPEELFYR--NGDF------DEPP---------------------EFSYGDGDGTVNMVSLL-ALES--LWKDEK-------NQYLKVIKIG 25 orysa-Q851F0 32.5% LVEVLP---EP-GV-PVTCLVGT--GVDTVESLVYG--EGGF------EAGP--------------------EKVVYGDGDGTVNLDSLVGPIKA---WSDSP-------EQVVEVVELP 26 orysa-Q8S5X5 27.9% MWRALP---AP-MV-PVTSMYGV--GVRTPETFVYG--EAGF------EGTP---------------------EVVYGDGDGNMNIVSLM-AAEE---WSGVE-------GQILKVVRLP 27 enthi-c4m7v0 25.3% YLKKYNS-QVPHGV-EMHCGITS--GIETAHKITFK--GDTF------DSKS---------------------TIEFVDGDQEVTLNSLE-YCKK---MTE-------------NFTNLG 28 enthi-q51cz6 24.7% LYKKWNW-TIPNGV-KMDCVYSH--GKETPYSIEFD--TEDL------TKGY---------------------TVNYSDGDNLVNINSLE-SCKI---FTD-------------SVTNLG 29 plaba-q4z5z8 20.7% RFFSVDH-----GI-PTYCLYSTTKKKNTEYMLFYQ--DTHF------IQDP---------------------IIYYGIGDGTIPLESLE-ACKK---LQNVK-----------EAKHFE 30 playo-q7rh25 21.8% RFFSVDH-----GI-PTYCLYSTTRKRNTEYMLFYQ--DVHF------NHDP---------------------IIYYGIGDGTISLESLE-ACKK---LQNVK-----------EAKHFV 31 plafa-MAL6P1.135 24.2% RYYNKDH-----GV-PIYCLYSTINKKETEYLLYFE--TQNT------REEP---------------------TIYYGTGDGTVGTESLQ-ACSN---FYNTV-----------LTHHFS 32 ashgo-q755k2 19.2% LEVPLPR--AP-SM-KLYCLYGV--GNPTERAYVYK--E---------ERKI--SSLNVTIDYE------SDTPVFFSDGDGTVPVLTHA-MCHK---WAEGV-SPYNPAGINVTIVEMQ 33 klula-q6cl20 18.7% LDVPLPN--AP-NM-KIYCLYGI--NNPTERAYTYK--K---------DSES--SYLNMTIAYD------SPQPVFFADGDGTVPLMTHA-MCHK---WKQGV-SAYNPAGIEVKIVEMR 34 yeast-pdat 17.6% MEVPLPE--AP-HM-KIYCIYGV--NNPTERAYVYK--E---------EDDS--SALNLTIDYE------SKQPVFLTEGDGTVPLVAHS-MCHK---WAQGA-SPYNPAGINVTIVEMK 35 canal-q5abf2 18.2% LEAALPN--AT-SL-KVYCFYGV--GNPTERAYKYM--P---------ADKS--TKLDYVIDAD------SPDGVVLGDGDGTVSLLTHT-MCHE---WQKGDKSRYNPANVNVTIVEIK 36 debha-q6bsc3 18.3% LEAALPN--AP-DM-KMFCFYGI--GKPTERAYYYH--D---------ADPT--VKLDHTINSE------VENPVLLGDGDGTVSLLTHT-MCHE---WQKGSKSRYNPGNMSVTIVEIK 37 aspor-q2ul81 18.1% LEARLPL--AP-DM-KVYCFYGV--GKPTERSYYYQ--E---------ERDP-LVNLNVSIDTTVTNSDGVDHGVVMGEGDGTVNLLSTGYMCAK--GWNI---KRYNPAGVKIKVFEMP 38 gibze-q4i8t3 18.5% LETRLPL--AP-SL-KIYCFYGV--GKPTERGYFYK--P---------PDQPSLTNLNITIDTGYTEGD-VDHGVVMGEGDGTVNLLSTGYMCNH--GWNM---KRYNPAGVKVTVVEMP 39 neucr-q7s4e3 18.1% LETRLPL--AP-SL-KVYCFYGV--GKPTERAYFYR--A---------PDPGTTTHLKMTIDTTLTQGH-IDHGVILGEGDGTVNLMSLGYMCNK--GWKM---KRYNPAGSKITVVEMP 40 schpo-pdat 18.1% LETSLPY--AP-DM-KIYCVHGV--GKPTERGYYYT--NN-------PEGQP-------VIDSSVNDGTKVENGIVMDDGDGTLPILALGLVCNK--VWQT---KRFNPANTSITNYEIK 41 leima-q4qhs0 18.5% ELPSLPQ--AP-HT-TVVCLYGV--GLPAEAGYYLMWNPDEA-----NTETP-------YVGNSSVFNNNTSHGVRMSDGDDTVPLMSLAYMCRAVNGWGRNV--------GRVVTREFN 42 tryb2-q382l4 18.9% KRPNLPK--AP-NT-TVFCLYGV--DRKTEIGYVLG--EDEA------------------VDDTYNEGEHIVNGVINGDGDGTVPLLSLGYMCRAKNGWKRDV--------GRVITREHK 43 trycr-q4dqa6 19.1% ELPFLPR--SP-NL-TVVCLYGV--DRQTEVGYILG--DDDF------------------VNLTYHQFERATNGVILGNGDGTVPLMSLGYMCRAENGWKQNV--------GRVITREHK 44 arath-LCAT4 13.1% LFRI----------------------------IHYG--NEKM-----PVKDL--TNLRY-----------FQPTYICVDGDGTVPMESAM--------------------ADGLEAVARV 45 lyces-q71lx7 17.0% TREILCHAKVPDKV-KFYNIYGT--NYETPHSVCYG--SQNA-----PISDL--QQLPF-----------VQSNYISVDGDGTVPTESAK--------------------ADGLKAEARV 46 orysa-q7xts6 15.8% TQDVLCNAKLPKSV-KFYNIYGT--DYDTAHTVRYG--SEHH-----PISNL--SDLLY-----------TQGNYICVDGDGSVPVESAK--------------------ADGLDAVARV consensus/100% ................................h.h............................................GDt.h...s..............................h. consensus/90% h...h.....s.th..hhChau...s..T...h.at..t...................................hhhtpGDsTVsh.oh...ht....h................h..h. consensus/80% h.ttls...sP.sl..haClYGs..sh.T.pthhYt..p..h.......pts.....................thhhs-GDsTVsh.Sh...Ctt...a.t............lphhth. consensus/70% LhtsLs...sP.ul.plaClYGs..GhsT.psahYt..p..h.......pss.....................slhhuDGDGTVsh.Sht.hCpt...Wtt............lphhph. 1 human-PLA2G15 100.0% GS----------------EHIEMLANATTLAYLKRV 2 canfa-q6xpz3 93.1% GS----------------EHIEMLANATTLAYLKRV 3 mouse-C87498 91.8% GS----------------EHIEMLANATTLAYLKRV 4 ratno-q675a5 91.5% GS----------------EHIEMLANATTLAYLKRV 5 bovin-LPLA2 83.2% GN----------------EHIAMLANTTTLAYLKRV 6 xenla-q566i0 71.0% GN----------------EHIAMLSNISTISYVKKI 7 danre-q6nyh6 68.6% GN----------------EHVAMLLNSTTVDYIKKV 8 tetng-q4t6m1 70.4% GN----------------EHVNMLLNYTTVAYIKSV 9 human-LCAT 48.4% GI----------------QHLNMVFSNLTLEHINAI 10 rabit-lcat 47.9% ET----------------EHLNMVFSNQTLEHINAI 11 bovin-lcat 49.7% GT----------------QHLNMVFSNQTLEHINAI 12 cavpo-lcat 47.6% GT----------------QHLNMVFSNQTLEHINTI 13 tupgl-lcat 47.1% RI----------------QHLNMVFSNQTLEHINDI 14 mouse-lcat 47.1% ET----------------DHLNMVFSNKTMEHINAI 15 ratno-lcat 46.6% GT----------------DHLNMVFSNKTLEHINAI 16 anapl-lcat 52.6% GI----------------DHLNMVFSNLTLSSINEI 17 chick-lcat 51.9% GI----------------DHLNMVFSNLTLTL--HQ 18 xenla-q66j38 52.9% GI----------------QHLNMVFSNQTLTLINDI 19 caebr-A8Y168 45.8% QA----------------DHMAILKHPNAIELVRKA 20 caeel-M05B5.4 44.8% QA----------------DHMAILKHPNAIELVRKA 21 drome-GH02384 38.3% NV----------------DHLHILSNPDVLKYIRTV 22 schja-Q86F58 35.4% GA----------------EHVHILSDIRHINIILKF 23 arath-LCAT1 34.0% GV----------------SHTSILKDEIALKEIMKQ 24 medtr-q71ce5 33.2% GV----------------THTSILKDKVALDPIIGE 25 orysa-Q851F0 32.5% EV----------------SHSGILKDKSALDQILRI 26 orysa-Q8S5X5 27.9% GV----------------SHVGFFSDLALKKVVAEI 27 enthi-c4m7v0 25.3% KY----------------THQGMLLKKEVIEYVKNL 28 enthi-q51cz6 24.7% KH----------------GHLLILNSNDIWNYIKPK 29 plaba-q4z5z8 20.7% YY----------------KHIGILKNDIVSDYIYNI 30 playo-q7rh25 21.8% YY----------------KHIGILKSDIVSDYIYNI 31 plafa-MAL6P1.135 24.2% DT----------------SHVGILYTNETAKYIYDI 32 ashgo-q755k2 19.2% HQ---PDRFDIRGGAKSAEHVDVLGRAELNEYILRI 33 klula-q6cl20 18.7% HQ---PDRFDIRGGAKSAEHVDILGSAELNEYILKI 34 yeast-pdat 17.6% HQ---PDRFDIRGGAKSAEHVDILGSAELNDYILKI 35 canal-q5abf2 18.2% HE---PDRFDLRGGAKTAEHVDILGSAELNELVLTV 36 debha-q6bsc3 18.3% HE---PDRFDIRGGAKTADHVDILGSAELNELVLKV 37 aspor-q2ul81 18.1% HE---PDRFSPRGGPNTGDHVDILGRASLNELILRV 38 gibze-q4i8t3 18.5% HE---PDRFNPRGGPRTADHVDILGRYNLNELLLRV 39 neucr-q7s4e3 18.1% HE---PERFNPRGGPNTADHVDILGRQNLNEYILKV 40 schpo-pdat 18.1% HE---PAAFDLRGGPRSAEHVDILGHSELNEIILKV 41 leima-q4qhs0 18.5% HSVSGASSLKLRGGKLSAKHVDILGNYEMLEIILKI 42 tryb2-q382l4 18.9% HS--SGSSMNLRGGSSSGDHVDILGNHELVWTILKV 43 trycr-q4dqa6 19.1% HC--AGSLMELRGGTNSGDHVDILGNYDLIETILKI 44 arath-LCAT4 13.1% GV--------------PGEHRGILNDHRVFRMLKKW 45 lyces-q71lx7 17.0% GV--------------PGDHRGIVCDRHVFRVIKHW 46 orysa-q7xts6 15.8% GV--------------AADHRGIVCDRHVFRIIQHW consensus/100% ..................tH..hh.p..h....... consensus/90% t.................pHhthl.p..h.thl.th consensus/80% t.................pHlshlhs.ph.phl.ph consensus/70% t.................cHlshLhstphhchlhpl |
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