NP_000731sp|P20309|ACM3_HUMAN Muscarinic acetylcholine receptor M3 OS=Homo sapiens GN=CHRM3 PE=1 SV=1
NP_057232sp|Q9Y566|SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 OS=Homo sapiens GN=SHANK1 PE=1 SV=2
BAA24854sp|O43307|ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 OS=Homo sapiens GN=ARHGEF9 PE=1 SV=3
NP_004737sp|O14490|DLGP1_HUMAN Disks large-associated protein 1 OS=Homo sapiens GN=DLGAP1 PE=1 SV=1
NP_000656sp|P22303|ACES_HUMAN Acetylcholinesterase OS=Homo sapiens GN=ACHE PE=1 SV=1
NP_006530sp|O60359|CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit OS=Homo sapiens GN=CACNG3 PE=2 SV=1
NP_074056sp|Q9NQX3|GEPH_HUMAN Gephyrin OS=Homo sapiens GN=GPHN PE=1 SV=1
NP_068587sp|Q9GZV3|SC5A7_HUMAN High affinity choline transporter 1 OS=Homo sapiens GN=SLC5A7 PE=1 SV=1
XP_005244805sp|O00468|AGRIN_HUMAN Agrin OS=Homo sapiens GN=AGRN PE=1 SV=5
NP_000741sp|P30926|ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 OS=Homo sapiens GN=CHRNB4 PE=1 SV=2
XP_005256549sp|P78352|DLG4_HUMAN Disks large homolog 4 OS=Homo sapiens GN=DLG4 PE=1 SV=3
NP_619635sp|O60391|NMD3B_HUMAN Glutamate receptor ionotropic, NMDA 3B OS=Homo sapiens GN=GRIN3B PE=2 SV=2
NP_003046sp|Q16572|VACHT_HUMAN Vesicular acetylcholine transporter OS=Homo sapiens GN=SLC18A3 PE=1 SV=2
NP_076435sp|Q9BZG9|LYNX1_HUMAN Ly-6/neurotoxin-like protein 1 OS=Homo sapiens GN=LYNX1 PE=1 SV=3
NP_114102sp|P62955|CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit OS=Homo sapiens GN=CACNG7 PE=2 SV=1
NP_004792sp|Q9ULB1|NRX1A_HUMAN Neurexin-1 OS=Homo sapiens GN=NRXN1 PE=2 SV=1
NP_000802sp|Q16445|GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 OS=Homo sapiens GN=GABRA6 PE=2 SV=2
NP_005583sp|O15146|MUSK_HUMAN Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens GN=MUSK PE=1 SV=1
XP_004645627sp|O14936|CSKP_HUMAN Peripheral plasma membrane protein CASK OS=Homo sapiens GN=CASK PE=1 SV=3
NP_705691sp|Q8NFP4|MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 OS=Homo sapiens GN=MDGA1 PE=1 SV=1
NP_002325sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4
CAI65266sp|Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens GN=CAMK2A PE=1 SV=2
Q8N2Q7sp|Q8N2Q7|NLGN1_HUMAN Neuroligin-1 OS=Homo sapiens GN=NLGN1 PE=1 SV=2
P28329sp|P28329|CLAT_HUMAN Choline O-acetyltransferase OS=Homo sapiens GN=CHAT PE=1 SV=4
BAA24846sp|O43300|LRRT2_HUMAN Leucine-rich repeat transmembrane neuronal protein 2 OS=Homo sapiens GN=LRRTM2 PE=2 SV=3





Comparative Domain composition coded in tree node color
Some domain(s) are present only in blast hit Some domain(s) are present only in target
blast hit and target have different domains but could also have some in common. n.a.
similar domain composition in blast hit and target
For more details on domain composition just look at the table under the tree.

Up
Table S1: Best blast for NP_000731 in each species
Homo sapiensNP_000731 muscarinic acetylcholine receptor M3 [Homo sapiens] >gi|530365995|ref|XP_005273088.1| PREDICTED: muscarinic acetylcholine receptor M3 isoform X1 [Homo sapiens] >gi|530365997|ref|XP_005273089.1| PREDICTED: muscarinic acetylcholine receptor M3 isoform X2 [Homo sapiens] >gi|530365999|ref|XP_005273090.1| PREDICTED: muscarinic acetylcholine receptor M3 isoform X3 [Homo sapiens] >gi|530366001|ref|XP_005273091.1| PREDICTED: muscarinic acetylcholine receptor M3 isoform X4 [Homo sapiens] >gi|530366003|ref|XP_005273092.1| PREDICTED: muscarinic acetylcholine receptor M3 isoform X5 [Homo sapiens] >gi|113125|sp|P20309.1|ACM3_HUMAN RecName: Full=Muscarinic acetylcholine receptor M3 >gi|20302973|gb|AAM18940.1|AF498917_1 muscarinic acetylcholine receptor M3 [Homo sapiens] >gi|32324|emb|CAA33337.1| muscarinic acetylcholine receptor M3 [Homo sapiens] >gi|903979|gb|AAA70337.1| m3 muscarinic acetylcholine receptor [Homo sapiens] >gi|7592981|dbj|BAA94480.1| muscarinic acetylcholine receptor m3 [Homo sapiens] >gi|67678374|gb|AAH96844.1| CHRM3 protein, partial [Homo sapiens] >gi|111306506|gb|AAI21027.1| Cholinergic receptor, muscarinic 3 [Homo sapiens] >gi|119590482|gb|EAW70076.1| cholinergic receptor, muscarinic 3, isoform CRA_a [Homo sapiens] >gi|119590483|gb|EAW70077.1| cholinergic receptor, muscarinic 3, isoform CRA_a [Homo sapiens] >gi|119590484|gb|EAW70078.1| cholinergic receptor, muscarinic 3, isoform CRA_a [Homo sapiens] >gi|306921307|dbj|BAJ17733.1| cholinergic receptor, muscarinic 3 [synthetic construct]0
Pan troglodytesNP_001129093 muscarinic acetylcholine receptor M3 [Pan troglodytes] >gi|14194443|sp|Q9N2A4.1|ACM3_PANTR RecName: Full=Muscarinic acetylcholine receptor M3 >gi|194363484|dbj|BAA94481.2| muscarinic acetylcholine receptor m3 [Pan troglodytes]0
Danio rerioXP_700381 PREDICTED: muscarinic acetylcholine receptor M3 [Danio rerio]0
Drosophila melanogasterAAA28676 muscarinic acetylcholine receptor [Drosophila melanogaster]9.49382e-81
Caenorhabditis elegansNP_001024236 Protein GAR-3, isoform b [Caenorhabditis elegans] >gi|55977887|sp|Q9U7D5.2|ACM3_CAEEL RecName: Full=Muscarinic acetylcholine receptor gar-3; AltName: Full=G-protein-linked acetylcholine receptor 3 >gi|33186643|gb|AAP97492.1| muscarinic acetylcholine receptor large isoform [Caenorhabditis elegans] >gi|35210313|emb|CAE47471.1| Protein GAR-3, isoform b [Caenorhabditis elegans]4.80106e-75
Schistosoma mansoniXP_002575679 muscarinic acetylcholine (GAR) receptor [Schistosoma mansoni] >gi|353232037|emb|CCD79392.1| putative muscarinic acetylcholine (GAR) receptor [Schistosoma mansoni]1.10239e-42
Nematostella vectensisXP_001627311 predicted protein [Nematostella vectensis] >gi|156214217|gb|EDO35211.1| predicted protein [Nematostella vectensis]1.09034e-28
Trichoplax adhaerensXP_002112438 hypothetical protein TRIADDRAFT_26040 [Trichoplax adhaerens] >gi|190584479|gb|EDV24548.1| hypothetical protein TRIADDRAFT_26040 [Trichoplax adhaerens]9.47972e-22
Monosiga brevicollisXP_001751023 hypothetical protein [Monosiga brevicollis MX1] >gi|163770477|gb|EDQ84169.1| predicted protein [Monosiga brevicollis MX1]1.86308

Table S2: Target IDs for NP_000731

NP_000731 sp|P20309|ACM3_HUMAN Muscarinic acetylcholine receptor M3 OS=Homo sapiens GN=CHRM3 PE=1 SV=1
.......FromHomo sapiens
NP_000731
7tm_1
Pan troglodytes
NP_001129093
7tm_1
Danio rerio
XP_700381
7tm_1
Drosophila melanogaster
AAA28676
7tm_1
Caenorhabditis elegans
NP_001024236
7tm_1
Schistosoma mansoni
XP_002575679
7tm_1
Nematostella vectensis
XP_001627311
7tm_1
Trichoplax adhaerens
XP_002112438
7tm_1
Monosiga brevicollis
XP_001751023
PTPLA
Homo sapiensNP_000731NP_000731NP_000731AAG30036AAG30036AAH41805CAG46720NP_006574AAF21976
Pan troglodytesNP_001129093NP_001129093NP_001129093NP_001129093NP_001129093NP_001012444XP_001149473XP_001138878XP_001168034
Danio rerioXP_700381XP_700381XP_700381XP_700381XP_001919160XP_005160785NP_001129448XP_005157095XP_699783
Drosophila melanogasterAAA28676AAA28676AFJ23964AAA28676AFJ23964AGE13748AAA85716NP_001034064NP_609534
Caenorhabditis elegansNP_001024236NP_001024236NP_001024235NP_001024235NP_001024236NP_001022596NP_001024579AAN16459NP_504740
Schistosoma mansoniXP_002575679XP_002575679XP_002575679XP_002575679XP_002575679XP_002575679XP_002576181XP_002576181XP_002573701
Nematostella vectensisXP_001627311XP_001627311XP_001627311XP_001627345XP_001620703XP_001639422XP_001627311XP_001629270XP_001622688
Trichoplax adhaerensXP_002112438XP_002112438XP_002112438XP_002115529XP_002112438XP_002114593XP_002118325XP_002112438XP_002114414
Monosiga brevicollisXP_001751023XP_001751023no hitno hitXP_001745782XP_001745200XP_001750587XP_001747170XP_001751023



Table S3: Target blast score for NP_000731

NP_000731 sp|P20309|ACM3_HUMAN Muscarinic acetylcholine receptor M3 OS=Homo sapiens GN=CHRM3 PE=1 SV=1
.......FromHomo sapiens
NP_000731
7tm_1
Pan troglodytes
NP_001129093
7tm_1
Danio rerio
XP_700381
7tm_1
Drosophila melanogaster
AAA28676
7tm_1
Caenorhabditis elegans
NP_001024236
7tm_1
Schistosoma mansoni
XP_002575679
7tm_1
Nematostella vectensis
XP_001627311
7tm_1
Trichoplax adhaerens
XP_002112438
7tm_1
Monosiga brevicollis
XP_001751023
PTPLA
Homo sapiens0002.57699e-811.57217e-657.12254e-441.21201e-446.32762e-298.73616e-26
Pan troglodytes0004.46556e-803.02918e-646.65265e-452.11229e-451.05864e-296.89055e-29
Danio rerio0004.57676e-785.46665e-583.72872e-435.12807e-429.96261e-332.24774e-29
Drosophila melanogaster9.49382e-816.06167e-814.35944e-7905.70922e-663.17351e-694.62367e-432.43347e-295.07589e-22
Caenorhabditis elegans4.80106e-754.19966e-754.35987e-691.90838e-8102.75445e-567.08823e-412.32871e-182.07416e-26
Schistosoma mansoni1.10239e-429.96567e-431.04553e-424.93012e-362.99508e-2503.86784e-375.93192e-269.55412e-22
Nematostella vectensis1.09034e-281.15557e-282.42835e-271.94083e-231.79121e-211.84931e-2101.97712e-628.24494e-35
Trichoplax adhaerens9.47972e-229.5694e-225.17372e-191.51826e-193.57988e-163.03681e-145.73225e-304.19878e-1531.30622e-34
Monosiga brevicollis1.863081.83152no hitno hit1.333565.760541.099093.181880


Table S4: Comparative domain composition for NP_000731

NP_000731 sp|P20309|ACM3_HUMAN Muscarinic acetylcholine receptor M3 OS=Homo sapiens GN=CHRM3 PE=1 SV=1
7tm_1 (1)
.......FromHomo sapiens
NP_000731
7tm_1 (1)
Pan troglodytes
NP_001129093
7tm_1 (1)
Danio rerio
XP_700381
7tm_1 (1)
Drosophila melanogaster
AAA28676
7tm_1 (2)
Caenorhabditis elegans
NP_001024236
7tm_1 (1)
Schistosoma mansoni
XP_002575679
7tm_1 (1)
Nematostella vectensis
XP_001627311
7tm_1 (1)
Trichoplax adhaerens
XP_002112438
7tm_1 (1)
Monosiga brevicollis
XP_001751023
PTPLA (1)
Homo sapiens
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (-1)PTPLA (1)
Pan troglodytes
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (-1)PTPLA (1)
Danio rerio
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)
n.a.n.a.
7tm_1 (0)
n.a.n.a.
Drosophila melanogaster
7tm_1 (1)

7tm_1 (1)
n.a.
7tm_1 (1)
n.a.n.a.
7tm_1 (0)

7tm_1 (0)

7tm_1 (-1)PTPLA (1)
Caenorhabditis elegans
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (-1)PTPLA (1)
Schistosoma mansoni
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)
n.a.n.a.
7tm_1 (-1)PTPLA (1)
Nematostella vectensis
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (-1)PTPLA (1)
Trichoplax adhaerens
7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (0)

7tm_1 (-1)PTPLA (1)
Monosiga brevicollis
7tm_1 (-1)PTPLA (1)

7tm_1 (-1)PTPLA (1)
no hitno hitn.a.
7tm_1 (-1)DEP (1), Mem_trans (2)

7tm_1 (-1)Ank_2 (1), Pkinase (1)

7tm_1 (-1)DEP (1), Mem_trans (2)

7tm_1 (-1)PTPLA (1)



Tree S1: Tree for NP_000731

NP_000731 7tm_1NP 000731 HS Pt Dr AAG30036 7tm_1AAG30036 HS Dm Ce NP_001129093 7tm_1NP 001129093 PT Hs Dr Dm Ce XP_001919160 n.a.XP 001919160 DR Ce XP_700381 7tm_1XP 700381 DR Hs Pt Dm AAH41805 7tm_1AAH41805 HS Sm XP_005160785 n.a.XP 005160785 DR Sm NP_001012444 7tm_1NP 001012444 PT Sm NP_001024236 7tm_1NP 001024236 CE Hs Pt NP_001024235 7tm_1NP 001024235 CE Dr Dm AAA28676 7tm_1AAA28676 DM Hs Pt AFJ23964 n.a.AFJ23964 DM Dr Ce XP_699783 n.a.XP 699783 DR Mb AAF21976 PTPLAAAF21976 HS Mb XP_001168034 PTPLAXP 001168034 PT Mb XP_001622688 PTPLAXP 001622688 NV Mb XP_002573701 PTPLAXP 002573701 SM Mb NP_504740 PTPLANP 504740 CE Mb XP_002114414 PTPLAXP 002114414 TA Mb NP_609534 PTPLANP 609534 DM Mb XP_001751023 PTPLAXP 001751023 MB Hs Pt XP_001745200 DEP, Mem_transXP 001745200 MB Sm XP_002575679 7tm_1XP 002575679 SM Hs Pt Dr Dm Ce AGE13748 n.a.AGE13748 DM Sm NP_001022596 7tm_1NP 001022596 CE Sm XP_001745782 n.a.XP 001745782 MB Ce AAN16459 7tm_1AAN16459 CE Ta XP_002576181 n.a.XP 002576181 SM Nv Ta NP_006574 7tm_1NP 006574 HS Ta XP_001138878 7tm_1XP 001138878 PT Ta XP_002114593 7tm_1XP 002114593 TA Sm XP_002115529 7tm_1XP 002115529 TA Dm XP_002112438 7tm_1XP 002112438 TA Hs Pt Dr Ce XP_001747170 DEP, Mem_transXP 001747170 MB Ta XP_001629270 7tm_1XP 001629270 NV Ta XP_005157095 n.a.XP 005157095 DR Ta XP_001627345 7tm_1XP 001627345 NV Dm XP_001627311 7tm_1XP 001627311 NV Hs Pt Dr XP_001750587 Ank_2, PkinaseXP 001750587 MB Nv XP_001639422 7tm_1XP 001639422 NV Sm XP_001620703 7tm_1XP 001620703 NV Ce XP_002118325 7tm_1XP 002118325 TA Nv NP_001034064 7tm_1NP 001034064 DM Ta CAG46720 7tm_1CAG46720 HS Nv XP_001149473 7tm_1XP 001149473 PT Nv NP_001129448 7tm_1NP 001129448 DR Nv NP_001024579 7tm_1NP 001024579 CE Nv AAA85716 7tm_1AAA85716 DM Nv
((NP_001129448_DR_Nv:0.16944,(XP_001149473_PT_Nv:0.0,CAG46720_HS_Nv:0.0):0.03312):0.39280,(AAA85716_DM_Nv:0.42691,NP_001024579_CE_Nv:0.59158):0.34788,(NP_001034064_DM_Ta:0.66823,(((XP_002576181_SM_Nv_Ta:0.47810,AAN16459_CE_Ta:0.64088):0.06048,((((XP_001751023_MB_Hs_Pt:0.12573,(NP_609534_DM_Mb:0.55470,(((NP_504740_CE_Mb:0.45375,XP_002573701_SM_Mb:0.61330):0.14746,(XP_001622688_NV_Mb:0.34280,(XP_001168034_PT_Mb:0.14618,(AAF21976_HS_Mb:0.09930,XP_699783_DR_Mb:0.16163):0.19270):0.25645):0.09181):0.07448,XP_002114414_TA_Mb:0.33945):0.17860):1.04973):2.27188,(((NP_001012444_PT_Sm:0.00014,(XP_005160785_DR_Sm:0.13426,AAH41805_HS_Sm:0.00014):0.00512):0.11916,((NP_001129093_PT_Hs_Dr_Dm_Ce:0.00181,(AAG30036_HS_Dm_Ce:0.00014,NP_000731_HS_Pt_Dr:0.00134):0.00020):0.12290,(XP_700381_DR_Hs_Pt_Dm:0.18742,XP_001919160_DR_Ce:0.10012):0.13633):0.06055):0.15552,((NP_001024235_CE_Dr_Dm:0.00014,NP_001024236_CE_Hs_Pt:0.00014):0.39764,(AFJ23964_DM_Dr_Ce:0.00014,AAA28676_DM_Hs_Pt:0.00014):0.19713):0.19772):0.06087):0.00912,XP_001745200_MB_Sm:4.22199):0.22027,((NP_001022596_CE_Sm:0.48970,(AGE13748_DM_Sm:0.29775,XP_002575679_SM_Hs_Pt_Dr_Dm_Ce:0.38304):0.16110):0.24083,XP_001745782_MB_Ce:3.99105):0.18187):0.61153):0.08799,((XP_002118325_TA_Nv:1.01158,((XP_001750587_MB_Nv:2.40745,XP_001627311_NV_Hs_Pt_Dr:0.00010):0.65223,(XP_001620703_NV_Ce:0.53500,XP_001639422_NV_Sm:0.49437):0.26952):0.18134):0.14806,((XP_005157095_DR_Ta:0.85802,((XP_001629270_NV_Ta:0.38215,(XP_001747170_MB_Ta:1.12414,XP_002112438_TA_Hs_Pt_Dr_Ce:0.13049):0.36471):0.20932,(XP_002115529_TA_Dm:1.00305,(XP_002114593_TA_Sm:0.90300,(XP_001138878_PT_Ta:0.0,NP_006574_HS_Ta:0.0):0.74254):0.16664):0.14807):0.17141):0.11729,XP_001627345_NV_Dm:0.81179):0.25600):0.14176):0.11475):0.09480);

Up
Table S1: Best blast for NP_057232 in each species
Homo sapiensNP_057232 SH3 and multiple ankyrin repeat domains protein 1 [Homo sapiens] >gi|229462779|sp|Q9Y566.2|SHAN1_HUMAN RecName: Full=SH3 and multiple ankyrin repeat domains protein 1; Short=Shank1; AltName: Full=Somatostatin receptor-interacting protein; Short=SSTR-interacting protein; Short=SSTRIP0
Pan troglodytesXP_003954514 PREDICTED: LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 1 [Pan troglodytes]0
Danio rerioXP_003198170 PREDICTED: SH3 and multiple ankyrin repeat domains protein 1-like isoform X1 [Danio rerio]0
Drosophila melanogasterNP_610925 prosap, isoform A [Drosophila melanogaster] >gi|386767927|ref|NP_001246315.1| prosap, isoform B [Drosophila melanogaster] >gi|201066247|gb|ACH92532.1| LD13733p [Drosophila melanogaster] >gi|220902213|gb|AAF58298.3| prosap, isoform A [Drosophila melanogaster] >gi|383302470|gb|AFH08069.1| prosap, isoform B [Drosophila melanogaster]1.10277e-102
Caenorhabditis elegansNP_001022007 Protein SHN-1, isoform b [Caenorhabditis elegans] >gi|38422245|emb|CAE54886.1| Protein SHN-1, isoform b [Caenorhabditis elegans]4.35343e-91
Schistosoma mansoniXP_002575029 sh3 and multiple ankyrin repeat domains protein 12 (shank12) [Schistosoma mansoni]3.52311e-90
Nematostella vectensisXP_001634679 predicted protein [Nematostella vectensis] >gi|156221765|gb|EDO42616.1| predicted protein [Nematostella vectensis]1.53148e-103
Trichoplax adhaerensXP_002108424 hypothetical protein TRIADDRAFT_51290 [Trichoplax adhaerens] >gi|190589200|gb|EDV29222.1| hypothetical protein TRIADDRAFT_51290 [Trichoplax adhaerens]5.54865e-10
Monosiga brevicollisXP_001748613 hypothetical protein [Monosiga brevicollis MX1] >gi|163772854|gb|EDQ86500.1| predicted protein [Monosiga brevicollis MX1]4.90103e-75

Table S2: Target IDs for NP_057232

NP_057232 sp|Q9Y566|SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 OS=Homo sapiens GN=SHANK1 PE=1 SV=2
.......FromHomo sapiens
NP_057232
PDZ, Ank_2, SAM_1, SH3_2
Pan troglodytes
XP_003954514
Danio rerio
XP_003198170
Drosophila melanogaster
NP_610925
PDZ, Ank_2, SH3_2
Caenorhabditis elegans
NP_001022007
PDZ, Ank_2
Schistosoma mansoni
XP_002575029
Nematostella vectensis
XP_001634679
PDZ, Ank_2, SH3_2, Ank
Trichoplax adhaerens
XP_002108424
Ank_2
Monosiga brevicollis
XP_001748613
SH3_1, PDZ, SAM_1, Ank_2
Homo sapiensNP_057232EAW71894EAW71894AAZ77790AAZ77790EAW73584AAZ77790XP_005274026EAW73584
Pan troglodytesXP_003954514XP_003954514XP_001158535XP_001158535XP_001158535XP_001158535XP_001158535NP_001266962XP_001158535
Danio rerioXP_003198170XP_003198170XP_003198170AAI54836AAI54836AAI54836XP_003198290XP_693039AAI54836
Drosophila melanogasterNP_610925NP_610925NP_610925AAK77286NP_610925NP_610925NP_610925NP_787123NP_610925
Caenorhabditis elegansNP_001022007NP_001022007NP_001022007NP_001022007NP_001022007NP_001022007NP_001022007AAA85854NP_001022007
Schistosoma mansoniXP_002575029XP_002575029XP_002575029XP_002575029XP_002575029CCD81496XP_002575029XP_002579067XP_002575029
Nematostella vectensisXP_001634679XP_001634679XP_001634679XP_001634679XP_001634679XP_001634679XP_001634679XP_001641548XP_001634679
Trichoplax adhaerensXP_002108424XP_002108424XP_002112605XP_002110491XP_002109164XP_002109164XP_002108424XP_002108424XP_002108769
Monosiga brevicollisXP_001748613XP_001748613XP_001748613XP_001748613XP_001748613XP_001748613XP_001748613XP_001745253XP_001748613



Table S3: Target blast score for NP_057232

NP_057232 sp|Q9Y566|SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 OS=Homo sapiens GN=SHANK1 PE=1 SV=2
.......FromHomo sapiens
NP_057232
PDZ, Ank_2, SAM_1, SH3_2
Pan troglodytes
XP_003954514
Danio rerio
XP_003198170
Drosophila melanogaster
NP_610925
PDZ, Ank_2, SH3_2
Caenorhabditis elegans
NP_001022007
PDZ, Ank_2
Schistosoma mansoni
XP_002575029
Nematostella vectensis
XP_001634679
PDZ, Ank_2, SH3_2, Ank
Trichoplax adhaerens
XP_002108424
Ank_2
Monosiga brevicollis
XP_001748613
SH3_1, PDZ, SAM_1, Ank_2
Homo sapiens001.82046e-1795.65139e-1171.61643e-891.1525e-982.04161e-1182.14152e-1174.08083e-84
Pan troglodytes003.3628e-1372.66332e-1051.27142e-864.20785e-881.94557e-1088.76561e-1181.48688e-80
Danio rerio05.77975e-13201.15001e-1242.34393e-931.9318e-958.82546e-1572.23542e-281.80024e-83
Drosophila melanogaster1.10277e-1023.94044e-813.78166e-9804.417e-1031.11129e-986.28967e-1021.75177e-242.91979e-77
Caenorhabditis elegans4.35343e-915.51239e-721.98408e-824.31913e-11004.81861e-775.06956e-903.82635e-207.19498e-81
Schistosoma mansoni3.52311e-901.69543e-752.30473e-771.94288e-982.88666e-7601.07123e-945.69159e-1046.90258e-62
Nematostella vectensis8.3476e-1061.49934e-878.45578e-963.09879e-1024.70524e-856.80087e-9507.2314e-207.73418e-81
Trichoplax adhaerens4.20864e-122.02181e-121.49121e-113.44118e-107.13193e-141.60259e-158.97321e-1006.96983e-12
Monosiga brevicollis4.90103e-751.12034e-606.44874e-651.21215e-761.10629e-616.79187e-631.68218e-784.83094e-150


Table S4: Comparative domain composition for NP_057232

NP_057232 sp|Q9Y566|SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 OS=Homo sapiens GN=SHANK1 PE=1 SV=2
PDZ (1), Ank_2 (2), SAM_1 (1), SH3_2 (1)
.......FromHomo sapiens
NP_057232
PDZ (1), Ank_2 (2), SAM_1 (1), SH3_2 (1)
Pan troglodytes
XP_003954514
Danio rerio
XP_003198170
Drosophila melanogaster
NP_610925
PDZ (1), Ank_2 (2), SH3_2 (1)
Caenorhabditis elegans
NP_001022007
PDZ (1), Ank_2 (2)
Schistosoma mansoni
XP_002575029
Nematostella vectensis
XP_001634679
PDZ (1), Ank_2 (1), SH3_2 (1), Ank (1)
Trichoplax adhaerens
XP_002108424
Ank_2 (3)
Monosiga brevicollis
XP_001748613
SH3_1 (1), PDZ (1), SAM_1 (1), Ank_2 (2)
Homo sapiens
PDZ (0), Ank_2 (0), SAM_1 (0), SH3_2 (0)
n.a.n.a.
PDZ (0), SAM_1 (0), SH3_2 (0)Ank_2 (-2)

PDZ (0), SAM_1 (0), SH3_2 (0)Ank_2 (-2)
n.a.
PDZ (0), SAM_1 (0), SH3_2 (0)Ank_2 (-2)
n.a.n.a.
Pan troglodytesn.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.
Danio rerion.a.n.a.n.a.
Ank_2 (0), SH3_2 (0)PDZ (-1), SAM_1 (-1)

Ank_2 (0), SH3_2 (0)PDZ (-1), SAM_1 (-1)

Ank_2 (0), SH3_2 (0)PDZ (-1), SAM_1 (-1)
n.a.n.a.
Ank_2 (0), SH3_2 (0)PDZ (-1), SAM_1 (-1)
Drosophila melanogaster
PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)

PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)

PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)

PDZ (0), SH3_2 (0)SAM_1 (-1), Ank_2 (-2)

PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)

PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)

PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)

Ank_2 (6)PDZ (-1), SAM_1 (-1), SH3_2 (-1)Death (1), Ank (3), ZU5 (1), Ank_3 (1)

PDZ (0), Ank_2 (0), SH3_2 (0)SAM_1 (-1)
Caenorhabditis elegans
PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)

Ank_2 (5)PDZ (-1), SAM_1 (-1), SH3_2 (-1)Death (1), Ank (4), ZU5 (1)

PDZ (0), Ank_2 (0)SAM_1 (-1), SH3_2 (-1)
Schistosoma mansonin.a.n.a.n.a.n.a.n.a.
Ank_2 (0)PDZ (-1), SAM_1 (-1), SH3_2 (-1)
n.a.
Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)
n.a.
Nematostella vectensis
PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)

Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)

PDZ (0), Ank_2 (-1), SH3_2 (0)SAM_1 (-1)Ank (1)
Trichoplax adhaerens
Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)

Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)

Ank_2 (-1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)Ank (1)

PDZ (0)SAM_1 (-1), Ank_2 (-2), SH3_2 (-1)RA (1)

SAM_1 (0), Ank_2 (0)PDZ (-1), SH3_2 (-1)Ank (1), SAM_2 (1)

SAM_1 (0), Ank_2 (0)PDZ (-1), SH3_2 (-1)Ank (1), SAM_2 (1)

Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)

Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)

PDZ (3)SAM_1 (-1), Ank_2 (-2), SH3_2 (-1)
Monosiga brevicollis
PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)

Ank_2 (1)PDZ (-1), SAM_1 (-1), SH3_2 (-1)

PDZ (0), SAM_1 (0), Ank_2 (0)SH3_2 (-1)SH3_1 (1)



Tree S1: Tree for NP_057232

NP_001266962 n.a.NP 001266962 PT Ta XP_005274026 n.a.XP 005274026 HS Ta XP_002579067 Ank_2XP 002579067 SM Ta XP_002108424 Ank_2XP 002108424 TA Hs Pt Nv XP_693039 n.a.XP 693039 DR Ta XP_002112605 Ank_2, AnkXP 002112605 TA Dr NP_787123 Death, Ank_2, Ank, ZU5, Ank_3NP 787123 DM Ta AAA85854 Death, Ank_2, Ank, ZU5AAA85854 CE Ta XP_002109164 SAM_1, Ank_2, Ank, SAM_2XP 002109164 TA Ce Sm XP_001641548 Ank_2XP 001641548 NV Ta XP_001745253 Ank_2XP 001745253 MB Ta XP_002110491 PDZ, RAXP 002110491 TA Dm XP_002108769 PDZXP 002108769 TA Mb XP_001748613 SH3_1, PDZ, SAM_1, Ank_2XP 001748613 MB Hs Pt Dr Dm Ce Sm Nv XP_001634679 PDZ, Ank_2, SH3_2, AnkXP 001634679 NV Hs Pt Dr Dm Ce Sm Mb XP_003198290 n.a.XP 003198290 DR Nv AAI54836 Ank_2, SH3_2AAI54836 DR Dm Ce Sm Mb EAW73584 n.a.EAW73584 HS Sm Mb XP_001158535 n.a.XP 001158535 PT Dr Dm Ce Sm Nv Mb AAZ77790 PDZ, SAM_1, SH3_2AAZ77790 HS Dm Ce Nv EAW71894 n.a.EAW71894 HS Pt Dr XP_003954514 n.a.XP 003954514 PT Hs NP_057232 PDZ, Ank_2, SAM_1, SH3_2NP 057232 XP_003198170 n.a.XP 003198170 DR Hs Pt NP_001022007 PDZ, Ank_2NP 001022007 CE Hs Pt Dr Dm Sm Nv Mb NP_610925 PDZ, Ank_2, SH3_2NP 610925 DM Hs Pt Dr Ce Sm Nv Mb XP_002575029 n.a.XP 002575029 SM Hs Pt Dr Dm Ce Nv Mb
(XP_002575029_SM_Hs_Pt_Dr_Dm_Ce_Nv_Mb:0.47673,(NP_610925_DM_Hs_Pt_Dr_Ce_Sm_Nv_Mb:0.24267,NP_001022007_CE_Hs_Pt_Dr_Dm_Sm_Nv_Mb:0.44014):0.11435,(((XP_003198170_DR_Hs_Pt:0.16378,(NP_057232:0.00014,(XP_003954514_PT_Hs:0.09615,EAW71894_HS_Pt_Dr:0.00014):0.00015):0.11923):0.13134,((AAZ77790_HS_Dm_Ce_Nv:0.00014,XP_001158535_PT_Dr_Dm_Ce_Sm_Nv_Mb:0.00249):0.11217,(EAW73584_HS_Sm_Mb:0.13854,(AAI54836_DR_Dm_Ce_Sm_Mb:0.08579,XP_003198290_DR_Nv:0.09394):0.04600):0.05632):0.03721):0.16142,(XP_001634679_NV_Hs_Pt_Dr_Dm_Ce_Sm_Mb:0.32265,(XP_001748613_MB_Hs_Pt_Dr_Dm_Ce_Sm_Nv:0.52416,((XP_002108769_TA_Mb:0.38074,XP_002110491_TA_Dm:0.50210):1.17321,(((((XP_002108424_TA_Hs_Pt_Nv:0.27050,(XP_002579067_SM_Ta:0.56513,(XP_005274026_HS_Ta:0.00014,NP_001266962_PT_Ta:0.00160):0.34047):0.17877):0.52372,(XP_002112605_TA_Dr:0.81962,XP_693039_DR_Ta:0.63545):0.07707):0.10764,(AAA85854_CE_Ta:0.22287,NP_787123_DM_Ta:0.24040):0.34407):0.15179,(XP_001641548_NV_Ta:0.66619,XP_002109164_TA_Ce_Sm:0.96079):0.05507):0.23920,XP_001745253_MB_Ta:0.72089):0.14324):0.84390):0.11213):0.09287):0.05662);

Up
Table S1: Best blast for BAA24854 in each species
Homo sapiensBAA24854 KIAA0424 [Homo sapiens]0
Pan troglodytesXP_003317541 PREDICTED: rho guanine nucleotide exchange factor 9 isoform 1 [Pan troglodytes] >gi|397492115|ref|XP_003816975.1| PREDICTED: rho guanine nucleotide exchange factor 9 isoform 1 [Pan paniscus]0
Danio rerioXP_001923441 PREDICTED: rho guanine nucleotide exchange factor 9-like isoform X1 [Danio rerio]0
Drosophila melanogasterAAR96206 AT18471p [Drosophila melanogaster]1.12281e-47
Caenorhabditis elegansNP_001256492 Protein UIG-1, isoform e [Caenorhabditis elegans] >gi|293321431|emb|CBL43435.1| Protein UIG-1, isoform e [Caenorhabditis elegans]4.48971e-16
Schistosoma mansoniXP_002573950 dynamin-associated protein [Schistosoma mansoni]4.7818e-17
Nematostella vectensisXP_001637264 predicted protein [Nematostella vectensis] >gi|156224375|gb|EDO45201.1| predicted protein [Nematostella vectensis]2.12923e-143
Trichoplax adhaerensXP_002107606 hypothetical protein TRIADDRAFT_19156 [Trichoplax adhaerens] >gi|190588382|gb|EDV28404.1| hypothetical protein TRIADDRAFT_19156, partial [Trichoplax adhaerens]4.31218e-100
Monosiga brevicollisXP_001744370 hypothetical protein [Monosiga brevicollis MX1] >gi|163777456|gb|EDQ91073.1| predicted protein [Monosiga brevicollis MX1]4.09883e-30

Table S2: Target IDs for BAA24854

BAA24854 sp|O43307|ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 OS=Homo sapiens GN=ARHGEF9 PE=1 SV=3
.......FromHomo sapiens
BAA24854
SH3_1, PH, RhoGEF
Pan troglodytes
XP_003317541
SH3_1, RhoGEF, PH
Danio rerio
XP_001923441
Drosophila melanogaster
AAR96206
SH3_1, RhoGEF
Caenorhabditis elegans
NP_001256492
RhoGEF
Schistosoma mansoni
XP_002573950
Nematostella vectensis
XP_001637264
SH3_1, RhoGEF, PH
Trichoplax adhaerens
XP_002107606
SH3_1, RhoGEF
Monosiga brevicollis
XP_001744370
DEP, RhoGEF
Homo sapiensBAA24854BAA24854BAA24854XP_005266349BAG56812XP_0052610832PZ1_A2PZ1_AXP_005251369
Pan troglodytesXP_003317541XP_003317541XP_003317541XP_001152732XP_001135739XP_001166935XP_525919XP_525919XP_003311791
Danio rerioXP_005157206NP_001155135XP_001923441XP_005162799XP_005174146XP_005160634XP_687404XP_005162799XP_001923357
Drosophila melanogasterAAR96206AAR96206AAR96206NP_001261202NP_001261075NP_001260664AAR96206NP_573372AAR96206
Caenorhabditis elegansNP_001256492NP_001256492NP_001256492NP_001023039NP_001256491NP_001255927NP_001256492NP_001256492NP_001256492
Schistosoma mansoniXP_002573950XP_002573950CCD83010CCD59040CCD83010XP_002573950XP_002573950CCD61011XP_002579229
Nematostella vectensisXP_001637264XP_001637264XP_001637264XP_001637264XP_001635622XP_001621844XP_001637264XP_001637264XP_001619564
Trichoplax adhaerensXP_002107606XP_002107606XP_002107606XP_002107606XP_002107606XP_002112796XP_002107606XP_002107606XP_002114352
Monosiga brevicollisXP_001744370XP_001744370XP_001744370XP_001744370XP_001743474XP_001750319XP_001744370XP_001743474XP_001744370



Table S3: Target blast score for BAA24854

BAA24854 sp|O43307|ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 OS=Homo sapiens GN=ARHGEF9 PE=1 SV=3
.......FromHomo sapiens
BAA24854
SH3_1, PH, RhoGEF
Pan troglodytes
XP_003317541
SH3_1, RhoGEF, PH
Danio rerio
XP_001923441
Drosophila melanogaster
AAR96206
SH3_1, RhoGEF
Caenorhabditis elegans
NP_001256492
RhoGEF
Schistosoma mansoni
XP_002573950
Nematostella vectensis
XP_001637264
SH3_1, RhoGEF, PH
Trichoplax adhaerens
XP_002107606
SH3_1, RhoGEF
Monosiga brevicollis
XP_001744370
DEP, RhoGEF
Homo sapiens0006.63872e-535.55244e-783.33482e-734.35943e-1531.61031e-993.91476e-66
Pan troglodytes0002.96197e-533.30051e-756.06574e-741.06073e-1502.36925e-999.67435e-67
Danio rerio0002.15086e-451.45186e-651.84173e-681.07495e-1493.06487e-913.15381e-63
Drosophila melanogaster1.10724e-486.49159e-492.57126e-5708.22447e-579.89784e-483.12386e-522.34276e-196.60085e-19
Caenorhabditis elegans3.50785e-144.66963e-145.00153e-153.57036e-1103.54085e-162.48288e-193.32792e-197.89787e-09
Schistosoma mansoni4.90307e-175.26161e-174.47746e-169.94312e-111.75471e-1602.95371e-179.12876e-204.86198e-13
Nematostella vectensis6.73661e-1432.24764e-1431.55933e-1343.00718e-514.02346e-232.4681e-3803.87937e-1011.1901e-39
Trichoplax adhaerens5.45275e-1011.57936e-1014.68481e-992.63362e-249.73325e-242.70793e-283.80858e-10602.25234e-37
Monosiga brevicollis2.30005e-311.42442e-312.75218e-305.72134e-201.21021e-238.3882e-203.30658e-408.21605e-260


Table S4: Comparative domain composition for BAA24854

BAA24854 sp|O43307|ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 OS=Homo sapiens GN=ARHGEF9 PE=1 SV=3
SH3_1 (1), PH (1), RhoGEF (1)
.......FromHomo sapiens
BAA24854
SH3_1 (1), PH (1), RhoGEF (1)
Pan troglodytes
XP_003317541
SH3_1 (1), RhoGEF (1), PH (1)
Danio rerio
XP_001923441
Drosophila melanogaster
AAR96206
SH3_1 (1), RhoGEF (1)
Caenorhabditis elegans
NP_001256492
RhoGEF (1)
Schistosoma mansoni
XP_002573950
Nematostella vectensis
XP_001637264
SH3_1 (1), RhoGEF (1), PH (1)
Trichoplax adhaerens
XP_002107606
SH3_1 (1), RhoGEF (1)
Monosiga brevicollis
XP_001744370
DEP (1), RhoGEF (1)
Homo sapiens
SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)
n.a.
RhoGEF (0)SH3_1 (-1), PH (-1)

SH3_1 (-1), RhoGEF (-1), PH (-1)
n.a.n.a.n.a.
Pan troglodytes
SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)
n.a.
SH3_1 (2), RhoGEF (0), PH (0)SH3_2 (2), C2 (1)
n.a.n.a.n.a.
Danio rerio
SH3_1 (-1), RhoGEF (-1), PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)
n.a.n.a.n.a.n.a.
SH3_1 (0), RhoGEF (0), PH (0)
n.a.
RhoGEF (0), PH (0)SH3_1 (-1)DEP (2)
Drosophila melanogaster
SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (-1), RhoGEF (-1), PH (-1)
n.a.
SH3_1 (-1), RhoGEF (-1), PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)C1_1 (1), CH (1), SH2 (1)

SH3_1 (0), RhoGEF (0)PH (-1)
Caenorhabditis elegans
RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0), PH (0)SH3_1 (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)

SH3_1 (2)RhoGEF (-1), PH (-1)SH3_2 (2)

RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)
Schistosoma mansonin.a.n.a.
RhoGEF (0)SH3_1 (-1), PH (-1)Spectrin (2)

RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)Spectrin (2)
n.a.n.a.
SH3_1 (2), RhoGEF (0)PH (-1)SH3_2 (1), Renin_r (1)

SH3_1 (-1), RhoGEF (-1), PH (-1)
Nematostella vectensis
SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)
n.a.
SH3_1 (1), RhoGEF (0)PH (-1)SH3_2 (1)

SH3_1 (0), RhoGEF (0), PH (0)

SH3_1 (0), RhoGEF (0), PH (0)

RhoGEF (0), PH (0)SH3_1 (-1)
Trichoplax adhaerens
SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (-1), RhoGEF (-1), PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

SH3_1 (0), RhoGEF (0)PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)DEP (2)
Monosiga brevicollis
RhoGEF (0)SH3_1 (-1), PH (-1)DEP (1)

RhoGEF (0)SH3_1 (-1), PH (-1)DEP (1)

RhoGEF (0)SH3_1 (-1), PH (-1)DEP (1)

RhoGEF (0)SH3_1 (-1), PH (-1)DEP (1)

RhoGEF (0)SH3_1 (-1), PH (-1)

SH3_1 (-1), RhoGEF (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)DEP (1)

RhoGEF (0)SH3_1 (-1), PH (-1)

RhoGEF (0)SH3_1 (-1), PH (-1)DEP (1)



Tree S1: Tree for BAA24854

XP_005157206 XP 005157206 DR Hs NP_001155135 SH3_1, RhoGEFNP 001155135 DR Pt BAA24854 SH3_1, PH, RhoGEFBAA24854 HS Pt Dr XP_003317541 SH3_1, RhoGEF, PHXP 003317541 PT Hs Dr XP_001152732 SH3_1, RhoGEF, PHXP 001152732 PT Dm XP_005266349 n.a.XP 005266349 HS Dm XP_005162799 n.a.XP 005162799 DR Dm Ta 2PZ1_A n.a.2PZ1 A HS Nv Ta XP_525919 n.a.XP 525919 PT Nv Ta XP_687404 SH3_1, RhoGEF, PHXP 687404 DR Nv XP_001637264 SH3_1, RhoGEF, PHXP 001637264 NV Hs Pt Dr Dm Ta XP_001619564 RhoGEF, PHXP 001619564 NV Mb XP_002107606 SH3_1, RhoGEFXP 002107606 TA Hs Pt Dr Dm Ce Nv AAR96206 SH3_1, RhoGEFAAR96206 DM Hs Pt Dr Nv Mb XP_005251369 n.a.XP 005251369 HS Mb XP_003311791 n.a.XP 003311791 PT Mb XP_001923357 DEP, RhoGEF, PHXP 001923357 DR Mb XP_002114352 DEP, RhoGEFXP 002114352 TA Mb XP_001744370 DEP, RhoGEFXP 001744370 MB Hs Pt Dr Dm Nv XP_001743474 RhoGEFXP 001743474 MB Ce Ta XP_005261083 XP 005261083 HS Sm XP_001166935 SH3_1, PH, RhoGEF, SH3_2, C2XP 001166935 PT Sm XP_005160634 n.a.XP 005160634 DR Sm XP_001621844 SH3_1, RhoGEF, SH3_2XP 001621844 NV Sm XP_002573950 n.a.XP 002573950 SM Hs Pt Nv CCD61011 SH3_1, RhoGEF, SH3_2, Renin_rCCD61011 SM Ta XP_002579229 XP 002579229 SM Mb CCD59040 RhoGEFCCD59040 SM Dm NP_001023039 RhoGEF, PHNP 001023039 CE Dm NP_573372 SH3_1, RhoGEF, C1_1, SH2, CHNP 573372 DM Ta BAG56812 RhoGEFBAG56812 HS Ce XP_001135739 n.a.XP 001135739 PT Ce XP_005174146 n.a.XP 005174146 DR Ce XP_001635622 n.a.XP 001635622 NV Ce NP_001261075 n.a.NP 001261075 DM Ce NP_001256492 RhoGEFNP 001256492 CE Hs Pt Dr Nv Ta Mb CCD83010 Spectrin, RhoGEFCCD83010 SM Dr Ce XP_002112796 XP 002112796 TA Sm NP_001260664 NP 001260664 DM Sm NP_001255927 SH3_1, SH3_2NP 001255927 CE Sm XP_001750319 XP 001750319 MB Sm
(((((XP_001635622_NV_Ce:0.46393,(XP_005174146_DR_Ce:0.09126,(XP_001135739_PT_Ce:0.00258,BAG56812_HS_Ce:0.00015):0.04910):0.15711):0.34833,(NP_001256492_CE_Hs_Pt_Dr_Nv_Ta_Mb:0.61632,NP_001261075_DM_Ce:0.79854):0.13822):0.30769,(NP_573372_DM_Ta:0.97948,((NP_001023039_CE_Dm:0.88513,CCD59040_SM_Dm:1.07625):0.19660,(((CCD61011_SM_Ta:0.00015,XP_002573950_SM_Hs_Pt_Nv:0.00014):0.78046,(XP_001621844_NV_Sm:0.37650,(XP_005160634_DR_Sm:0.35537,(XP_001166935_PT_Sm:0.00014,XP_005261083_HS_Sm:0.00014):0.21429):0.19562):0.44315):0.32400,XP_002579229_SM_Mb:3.10218):0.07899):0.18514):0.19429):0.06324,CCD83010_SM_Dr_Ce:1.28002):0.04151,(XP_001750319_MB_Sm:1.04947,(NP_001255927_CE_Sm:0.55303,(NP_001260664_DM_Sm:0.31179,XP_002112796_TA_Sm:0.57258):0.59241):1.14556):2.42940,(XP_001743474_MB_Ce_Ta:0.95758,((XP_001744370_MB_Hs_Pt_Dr_Dm_Nv:0.67738,(XP_002114352_TA_Mb:0.88726,(XP_001923357_DR_Mb:0.09683,(XP_003311791_PT_Mb:0.0,XP_005251369_HS_Mb:0.0):0.06140):0.27967):0.19993):0.28312,(AAR96206_DM_Hs_Pt_Dr_Nv_Mb:0.94589,(XP_002107606_TA_Hs_Pt_Dr_Dm_Ce_Nv:0.58943,((XP_001619564_NV_Mb:0.00014,XP_001637264_NV_Hs_Pt_Dr_Dm_Ta:0.00016):0.35964,((XP_687404_DR_Nv:0.09149,(XP_525919_PT_Nv_Ta:0.00611,2PZ1_A_HS_Nv_Ta:0.00015):0.13623):0.10153,(((NP_001155135_DR_Pt:0.00014,XP_005157206_DR_Hs:0.00015):0.07030,(XP_003317541_PT_Hs_Dr:0.00162,BAA24854_HS_Pt_Dr:0.00015):0.07262):0.21535,((XP_005266349_HS_Dm:0.0,XP_001152732_PT_Dm:0.0):0.11607,XP_005162799_DR_Dm_Ta:0.25526):0.08861):0.04369):0.21009):0.08274):0.18808):0.12685):0.33056):0.05776);

Up
Table S1: Best blast for NP_004737 in each species
Homo sapiensNP_004737 disks large-associated protein 1 isoform 1 [Homo sapiens] >gi|18201963|sp|O14490.1|DLGP1_HUMAN RecName: Full=Disks large-associated protein 1; Short=DAP-1; AltName: Full=Guanylate kinase-associated protein; Short=hGKAP; AltName: Full=PSD-95/SAP90-binding protein 1; AltName: Full=SAP90/PSD-95-associated protein 1; Short=SAPAP1 >gi|2588978|dbj|BAA23258.1| DAP-1 alpha [Homo sapiens] >gi|119622063|gb|EAX01658.1| discs, large (Drosophila) homolog-associated protein 1, isoform CRA_g [Homo sapiens] >gi|187950351|gb|AAI36454.1| Discs, large (Drosophila) homolog-associated protein 1 [Homo sapiens] >gi|223460484|gb|AAI36455.1| Discs, large (Drosophila) homolog-associated protein 1 [Homo sapiens]0
Pan troglodytesXP_512038 PREDICTED: disks large-associated protein 1 [Pan troglodytes]0
Danio rerioXP_005163496 PREDICTED: disks large-associated protein 1 isoform X1 [Danio rerio]0
Drosophila melanogasterNP_724427 vulcan, isoform B [Drosophila melanogaster] >gi|21626827|gb|AAM68356.1| vulcan, isoform B [Drosophila melanogaster] >gi|261490729|gb|ACX83593.1| RE52822p [Drosophila melanogaster]1.82595e-17
Caenorhabditis elegansNP_498156 Protein W03A5.4 [Caenorhabditis elegans] >gi|373220520|emb|CCD73956.1| Protein W03A5.4 [Caenorhabditis elegans]6.71052e-11
Schistosoma mansoniCCD75025 putative hepatoma up-regulated protein [Schistosoma mansoni]4.29203e-15
Nematostella vectensisXP_001634969 predicted protein [Nematostella vectensis] >gi|156222058|gb|EDO42906.1| predicted protein [Nematostella vectensis]2.85806e-23
Trichoplax adhaerensXP_002116625 hypothetical protein TRIADDRAFT_60595 [Trichoplax adhaerens] >gi|190580901|gb|EDV20981.1| hypothetical protein TRIADDRAFT_60595 [Trichoplax adhaerens]1.50814e-16
Monosiga brevicollisNo Hit

Table S2: Target IDs for NP_004737

NP_004737 sp|O14490|DLGP1_HUMAN Disks large-associated protein 1 OS=Homo sapiens GN=DLGAP1 PE=1 SV=1
.......FromHomo sapiens
NP_004737
GKAP
Pan troglodytes
XP_512038
Danio rerio
XP_005163496
Drosophila melanogaster
NP_724427
GKAP
Caenorhabditis elegans
NP_498156
GKAP
Schistosoma mansoni
CCD75025
GKAP
Nematostella vectensis
XP_001634969
GKAP
Trichoplax adhaerens
XP_002116625
GKAP
Monosiga brevicollis
No Hit
Homo sapiensNP_004737NP_004737NP_001229690XP_005260389EAX01652NP_001035951NP_001035951BAG57994no hit
Pan troglodytesXP_512038XP_512038XP_512038XP_519583XP_001143838XP_003316971XP_003316971XP_003316971no hit
Danio rerioXP_005163496XP_005163496XP_005163496XP_005168764XP_005163497XP_697562AAI60618XP_005158597no hit
Drosophila melanogasterNP_724427no hitNP_724427NP_724427NP_524868NP_524868NP_524868NP_524868no hit
Caenorhabditis elegansNP_498156no hitNP_498156NP_498156NP_498156NP_498156NP_498156NP_498156no hit
Schistosoma mansoniCCD75025XP_002580291CCD75025CCD75025CCD75025CCD75027CCD75025XP_002582102no hit
Nematostella vectensisXP_001634969no hitXP_001634969XP_001634969XP_001627379XP_001634969XP_001634969XP_001634969no hit
Trichoplax adhaerensXP_002116625XP_002117726XP_002116625XP_002116625XP_002116625XP_002116625XP_002116625XP_002116625no hit
Monosiga brevicollisno hitno hitXP_001743490XP_001746231XP_001746231XP_001746231XP_001746231XP_001746231no hit



Table S3: Target blast score for NP_004737

NP_004737 sp|O14490|DLGP1_HUMAN Disks large-associated protein 1 OS=Homo sapiens GN=DLGAP1 PE=1 SV=1
.......FromHomo sapiens
NP_004737
GKAP
Pan troglodytes
XP_512038
Danio rerio
XP_005163496
Drosophila melanogaster
NP_724427
GKAP
Caenorhabditis elegans
NP_498156
GKAP
Schistosoma mansoni
CCD75025
GKAP
Nematostella vectensis
XP_001634969
GKAP
Trichoplax adhaerens
XP_002116625
GKAP
Monosiga brevicollis
No Hit
Homo sapiens0004.60068e-182.49963e-112.80662e-153.34281e-205.08359e-16no hit
Pan troglodytes0004.0725e-191.41427e-114.69558e-165.59265e-213.32001e-15no hit
Danio rerio0004.65468e-249.03106e-133.03199e-199.04061e-232.51843e-20no hit
Drosophila melanogaster1.82595e-17no hit3.01536e-1503.28467e-099.74694e-209.92983e-149.69502e-14no hit
Caenorhabditis elegans6.71052e-11no hit9.38242e-112.55363e-0902.83904e-110.9742492.72486e-06no hit
Schistosoma mansoni4.29203e-150.2110972.80321e-142.3921e-201.28186e-1104.29773e-123.90813e-13no hit
Nematostella vectensis2.85806e-23no hit2.79888e-241.41081e-208.99438e-079.14143e-191.24252e-1798.72238e-21no hit
Trichoplax adhaerens7.79564e-180.5879721.01279e-181.80766e-155.75655e-085.5385e-154.58162e-155.02199e-134no hit
Monosiga brevicollisno hitno hit1.574965.74978e-090.001028278.24851e-100.000505411.7802e-13no hit


Table S4: Comparative domain composition for NP_004737

NP_004737 sp|O14490|DLGP1_HUMAN Disks large-associated protein 1 OS=Homo sapiens GN=DLGAP1 PE=1 SV=1
GKAP (1)
.......FromHomo sapiens
NP_004737
GKAP (1)
Pan troglodytes
XP_512038
Danio rerio
XP_005163496
Drosophila melanogaster
NP_724427
GKAP (1)
Caenorhabditis elegans
NP_498156
GKAP (1)
Schistosoma mansoni
CCD75025
GKAP (1)
Nematostella vectensis
XP_001634969
GKAP (1)
Trichoplax adhaerens
XP_002116625
GKAP (1)
Monosiga brevicollis
No Hit
Homo sapiens
GKAP (0)

GKAP (0)

GKAP (0)
n.a.
GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
no hit
Pan troglodytesn.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.no hit
Danio rerion.a.n.a.n.a.n.a.n.a.n.a.
GKAP (1)
n.a.no hit
Drosophila melanogaster
GKAP (0)
no hit
GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
no hit
Caenorhabditis elegans
GKAP (0)
no hit
GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
no hit
Schistosoma mansoni
GKAP (0)

GKAP (-1)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
n.a.no hit
Nematostella vectensis
GKAP (0)
no hit
GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
no hit
Trichoplax adhaerens
GKAP (0)

GKAP (-1)Dynactin (1), CAP_GLY (1)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
no hit
Monosiga brevicollisno hitno hitn.a.
GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)

GKAP (0)
no hit



Tree S1: Tree for NP_004737

XP_002580291 XP 002580291 SM Pt XP_001743490 n.a.XP 001743490 MB Dr NP_724427 GKAPNP 724427 DM Hs Dr NP_524868 GKAPNP 524868 DM Ce Sm Nv Ta XP_002582102 n.a.XP 002582102 SM Ta CCD75025 GKAPCCD75025 SM Hs Dr Dm Ce Nv XP_001746231 GKAPXP 001746231 MB Dm Ce Sm Nv Ta NP_498156 GKAPNP 498156 CE Hs Dr Dm Sm Nv Ta XP_002116625 GKAPXP 002116625 TA Hs Dr Dm Ce Sm Nv XP_001627379 GKAPXP 001627379 NV Ce XP_001634969 GKAPXP 001634969 NV Hs Dr Dm Sm Ta XP_003316971 n.a.XP 003316971 PT Sm Nv Ta NP_001035951 GKAPNP 001035951 HS Sm Nv XP_005260389 n.a.XP 005260389 HS Dm XP_005168764 n.a.XP 005168764 DR Dm XP_697562 n.a.XP 697562 DR Sm AAI60618 GKAPAAI60618 DR Nv XP_005158597 n.a.XP 005158597 DR Ta XP_519583 n.a.XP 519583 PT Dm BAG57994 GKAPBAG57994 HS Ta XP_005163496 n.a.XP 005163496 DR Hs Pt XP_005163497 n.a.XP 005163497 DR Ce XP_002117726 Dynactin, CAP_GLYXP 002117726 TA Pt XP_001143838 n.a.XP 001143838 PT Ce EAX01652 GKAPEAX01652 HS Ce XP_512038 n.a.XP 512038 PT Hs Dr NP_001229690 GKAPNP 001229690 HS Dr NP_004737 GKAPNP 004737 HS Pt
(NP_004737_HS_Pt:0.00014,NP_001229690_HS_Dr:0.00016,(XP_512038_PT_Hs_Dr:0.00115,(EAX01652_HS_Ce:0.00014,(XP_001143838_PT_Ce:0.00014,(XP_002117726_TA_Pt:1.14487,((XP_005163497_DR_Ce:0.00016,XP_005163496_DR_Hs_Pt:0.00014):0.13418,((BAG57994_HS_Ta:0.28876,(XP_519583_PT_Dm:0.04342,XP_005158597_DR_Ta:0.11553):0.04877):0.13959,((XP_001634969_NV_Hs_Dr_Dm_Sm_Ta:0.53284,(XP_001627379_NV_Ce:0.43032,((XP_002116625_TA_Hs_Dr_Dm_Ce_Sm_Nv:0.63029,(NP_498156_CE_Hs_Dr_Dm_Sm_Nv_Ta:0.91585,XP_001746231_MB_Dm_Ce_Sm_Nv_Ta:0.93651):0.20837):0.15554,((CCD75025_SM_Hs_Dr_Dm_Ce_Nv:0.00014,XP_002582102_SM_Ta:0.00014):0.43992,((XP_001743490_MB_Dr:1.16651,XP_002580291_SM_Pt:1.42062):0.91878,(NP_524868_DM_Ce_Sm_Nv_Ta:0.00014,NP_724427_DM_Hs_Dr:0.00014):0.02075):0.41298):0.18699):0.05377):0.14753):0.40692,(((NP_001035951_HS_Sm_Nv:0.0,XP_003316971_PT_Sm_Nv_Ta:0.0):0.00016,XP_005260389_HS_Dm:0.00014):0.08703,(AAI60618_DR_Nv:0.20112,(XP_697562_DR_Sm:0.00015,XP_005168764_DR_Dm:0.00014):0.09888):0.07401):0.04254):0.04207):0.08515):0.15606):0.00058):0.00016):0.00016):0.00016);

Up
Table S1: Best blast for NP_000656 in each species
Homo sapiensNP_000656 acetylcholinesterase isoform E4-E6 precursor [Homo sapiens] >gi|332867618|ref|XP_003318708.1| PREDICTED: acetylcholinesterase isoform 1 [Pan troglodytes] >gi|410059401|ref|XP_003951139.1| PREDICTED: acetylcholinesterase [Pan troglodytes] >gi|426357289|ref|XP_004045977.1| PREDICTED: acetylcholinesterase isoform 1 [Gorilla gorilla gorilla] >gi|530385929|ref|XP_005250415.1| PREDICTED: acetylcholinesterase isoform X2 [Homo sapiens] >gi|113037|sp|P22303.1|ACES_HUMAN RecName: Full=Acetylcholinesterase; Short=AChE; Flags: Precursor >gi|177975|gb|AAA68151.1| acetylcholinesterase [Homo sapiens] >gi|30172726|gb|AAP22365.1| unknown [Homo sapiens] >gi|51094560|gb|EAL23812.1| acetylcholinesterase (YT blood group) [Homo sapiens] >gi|119596867|gb|EAW76461.1| acetylcholinesterase (Yt blood group), isoform CRA_b [Homo sapiens] >gi|119596868|gb|EAW76462.1| acetylcholinesterase (Yt blood group), isoform CRA_b [Homo sapiens] >gi|158256078|dbj|BAF84010.1| unnamed protein product [Homo sapiens] >gi|208965774|dbj|BAG72901.1| acetylcholinesterase [synthetic construct]0
Pan troglodytesXP_003318708 acetylcholinesterase isoform E4-E6 precursor [Homo sapiens] >gi|332867618|ref|XP_003318708.1| PREDICTED: acetylcholinesterase isoform 1 [Pan troglodytes] >gi|410059401|ref|XP_003951139.1| PREDICTED: acetylcholinesterase [Pan troglodytes] >gi|426357289|ref|XP_004045977.1| PREDICTED: acetylcholinesterase isoform 1 [Gorilla gorilla gorilla] >gi|530385929|ref|XP_005250415.1| PREDICTED: acetylcholinesterase isoform X2 [Homo sapiens] >gi|113037|sp|P22303.1|ACES_HUMAN RecName: Full=Acetylcholinesterase; Short=AChE; Flags: Precursor >gi|177975|gb|AAA68151.1| acetylcholinesterase [Homo sapiens] >gi|30172726|gb|AAP22365.1| unknown [Homo sapiens] >gi|51094560|gb|EAL23812.1| acetylcholinesterase (YT blood group) [Homo sapiens] >gi|119596867|gb|EAW76461.1| acetylcholinesterase (Yt blood group), isoform CRA_b [Homo sapiens] >gi|119596868|gb|EAW76462.1| acetylcholinesterase (Yt blood group), isoform CRA_b [Homo sapiens] >gi|158256078|dbj|BAF84010.1| unnamed protein product [Homo sapiens] >gi|208965774|dbj|BAG72901.1| acetylcholinesterase [synthetic construct]0
Danio rerioNP_571921 acetylcholinesterase precursor [Danio rerio] >gi|14916524|sp|Q9DDE3.1|ACES_DANRE RecName: Full=Acetylcholinesterase; Short=AChE; Flags: Precursor >gi|12043531|emb|CAC19790.1| acetylcholinesterase [Danio rerio] >gi|190337767|gb|AAI63891.1| Acetylcholinesterase [Danio rerio] >gi|190337773|gb|AAI63898.1| Acetylcholinesterase [Danio rerio]0
Drosophila melanogaster1DX4_A Chain A, Ache From Drosophila Melanogaster Complex With Tacrine Derivative 9-(3-Phenylmethylamino)-1,2,3,4-Tetrahydroacridine >gi|157879803|pdb|1QO9|A Chain A, Native Acetylcholinesterase From Drosophila Melanogaster >gi|157879804|pdb|1QON|A Chain A, Ache From Drosophila Melanogaster Complex With Tacrine Derivative 9-(3-Iodobenzylamino)-1,2,3,4-Tetrahydroacridine6.28022e-118
Caenorhabditis elegansNP_510660 Protein ACE-1 [Caenorhabditis elegans] >gi|584715|sp|P38433.1|ACE1_CAEEL RecName: Full=Acetylcholinesterase 1; Short=AChE 1; Flags: Precursor >gi|671831|emb|CAA53080.1| acetylcholinesterase [Caenorhabditis elegans] >gi|351061160|emb|CCD68912.1| Protein ACE-1 [Caenorhabditis elegans]3.55742e-142
Schistosoma mansoniAAQ14321 acetylcholinesterase [Schistosoma mansoni] >gi|350646637|emb|CCD58664.1| acetylcholinesterase, putative [Schistosoma mansoni]5.28902e-93
Nematostella vectensisXP_001627490 predicted protein [Nematostella vectensis] >gi|156214401|gb|EDO35390.1| predicted protein [Nematostella vectensis]3.00826e-98
Trichoplax adhaerensXP_002117133 hypothetical protein TRIADDRAFT_1836 [Trichoplax adhaerens] >gi|190580355|gb|EDV20439.1| hypothetical protein TRIADDRAFT_1836 [Trichoplax adhaerens]1.22823e-97
Monosiga brevicollisXP_001749350 hypothetical protein [Monosiga brevicollis MX1] >gi|163772216|gb|EDQ85871.1| predicted protein [Monosiga brevicollis MX1]2.12043e-67

Table S2: Target IDs for NP_000656

NP_000656 sp|P22303|ACES_HUMAN Acetylcholinesterase OS=Homo sapiens GN=ACHE PE=1 SV=1
.......FromHomo sapiens
NP_000656
COesterase, AChE_tetra
Pan troglodytes
XP_003318708
Danio rerio
NP_571921
COesterase, AChE_tetra
Drosophila melanogaster
1DX4_A
Caenorhabditis elegans
NP_510660
COesterase
Schistosoma mansoni
AAQ14321
COesterase
Nematostella vectensis
XP_001627490
COesterase
Trichoplax adhaerens
XP_002117133
COesterase
Monosiga brevicollis
XP_001749350
COesterase
Homo sapiensNP_000656NP_0006563O9M_A2PM8_A4BDT_A2WSL_A3BE8_A4BDT_ABAD97163
Pan troglodytesXP_003318708XP_003318708XP_516857XP_516857XP_003318708XP_516857XP_001139129XP_003318709XP_003318709
Danio rerioNP_571921NP_571921NP_571921NP_571921NP_571921NP_571921NP_001159803NP_001159804XP_002661384
Drosophila melanogaster1DX4_A1DX4_A1DX4_AP071401DX4_A1DX4_AAAC41579NP_723931NP_001163662
Caenorhabditis elegansNP_510660NP_510660NP_510660NP_510660NP_510660NP_510660NP_510660NP_510660NP_510660
Schistosoma mansoniAAQ14321AAQ14321AAQ14321AAQ14321AAQ14321AAQ14321XP_002574124AAQ14321XP_002574406
Nematostella vectensisXP_001627490XP_001627490XP_001639145XP_001629673XP_001627490XP_001627490XP_001627490XP_001639304XP_001627490
Trichoplax adhaerensXP_002117133XP_002117133XP_002117133XP_002117137XP_002117900XP_002117134XP_002117145XP_002117133XP_002117130
Monosiga brevicollisXP_001749350XP_001749350XP_001743880XP_001750804XP_001743880XP_001743880XP_001750804XP_001750804XP_001749350



Table S3: Target blast score for NP_000656

NP_000656 sp|P22303|ACES_HUMAN Acetylcholinesterase OS=Homo sapiens GN=ACHE PE=1 SV=1
.......FromHomo sapiens
NP_000656
COesterase, AChE_tetra
Pan troglodytes
XP_003318708
Danio rerio
NP_571921
COesterase, AChE_tetra
Drosophila melanogaster
1DX4_A
Caenorhabditis elegans
NP_510660
COesterase
Schistosoma mansoni
AAQ14321
COesterase
Nematostella vectensis
XP_001627490
COesterase
Trichoplax adhaerens
XP_002117133
COesterase
Monosiga brevicollis
XP_001749350
COesterase
Homo sapiens0003.46063e-1292.96816e-1456.9958e-1011.55563e-1021.65574e-912.92091e-57
Pan troglodytes0001.76957e-1281.12524e-1452.00842e-1001.31313e-1003.51059e-921.26051e-57
Danio rerio0005.15296e-1121.07917e-1315.68067e-947.92643e-972.20752e-792.18354e-53
Drosophila melanogaster6.28022e-1186.28022e-1181.76275e-10204.23819e-1135.21518e-772.02336e-555.2539e-506.20372e-40
Caenorhabditis elegans3.55742e-1423.55742e-1424.19497e-1232.11734e-11301.15867e-1005.65617e-828.56938e-672.21072e-41
Schistosoma mansoni5.28902e-935.28902e-933.08066e-901.44408e-822.16196e-10501.03413e-642.32565e-562.81266e-32
Nematostella vectensis9.4082e-969.4082e-961.87376e-744.82486e-734.56455e-837.46354e-5905.82766e-822.91381e-48
Trichoplax adhaerens1.22823e-971.22823e-973.04907e-811.25597e-738.54395e-746.55749e-583.00566e-8702.99519e-45
Monosiga brevicollis2.12043e-672.12043e-672.69223e-491.0673e-502.86577e-633.67559e-481.61332e-601.46607e-530


Table S4: Comparative domain composition for NP_000656

NP_000656 sp|P22303|ACES_HUMAN Acetylcholinesterase OS=Homo sapiens GN=ACHE PE=1 SV=1
COesterase (1), AChE_tetra (1)
.......FromHomo sapiens
NP_000656
COesterase (1), AChE_tetra (1)
Pan troglodytes
XP_003318708
Danio rerio
NP_571921
COesterase (2), AChE_tetra (1)
Drosophila melanogaster
1DX4_A
Caenorhabditis elegans
NP_510660
COesterase (1)
Schistosoma mansoni
AAQ14321
COesterase (1)
Nematostella vectensis
XP_001627490
COesterase (1)
Trichoplax adhaerens
XP_002117133
COesterase (1)
Monosiga brevicollis
XP_001749350
COesterase (1)
Homo sapiens
COesterase (0), AChE_tetra (0)

COesterase (0), AChE_tetra (0)
n.a.n.a.n.a.n.a.n.a.n.a.
COesterase (0), AChE_tetra (0)
Pan troglodytesn.a.n.a.n.a.n.a.n.a.n.a.
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)
Danio rerio
COesterase (1), AChE_tetra (0)

COesterase (1), AChE_tetra (0)

COesterase (1), AChE_tetra (0)

COesterase (1), AChE_tetra (0)

COesterase (1), AChE_tetra (0)

COesterase (1), AChE_tetra (0)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)
Drosophila melanogastern.a.n.a.n.a.
COesterase (0)AChE_tetra (-1)
n.a.n.a.
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (2)AChE_tetra (-1)
Caenorhabditis elegans
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)
Schistosoma mansoni
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)
n.a.
Nematostella vectensis
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)
Trichoplax adhaerens
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)
Monosiga brevicollis
COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)

COesterase (0)AChE_tetra (-1)



Tree S1: Tree for NP_000656

XP_003318708 n.a.XP 003318708 PT Hs Ce NP_000656 COesterase, AChE_tetraNP 000656 HS Pt 4BDT_A n.a.4BDT A HS Ce Ta XP_003318709 COesteraseXP 003318709 PT Ta Mb BAD97163 COesterase, AChE_tetraBAD97163 HS Mb NP_571921 COesterase, AChE_tetraNP 571921 DR Hs Pt Dm Ce Sm 2WSL_A n.a.2WSL A HS Sm 2PM8_A n.a.2PM8 A HS Dm 3O9M_A n.a.3O9M A HS Dr XP_516857 n.a.XP 516857 PT Dr Dm Sm XP_002574124 COesteraseXP 002574124 SM Nv AAQ14321 COesteraseAAQ14321 SM Hs Pt Dr Dm Ce Ta NP_510660 COesteraseNP 510660 CE Hs Pt Dr Dm Sm Nv Ta Mb 1DX4_A n.a.1DX4 A DM Hs Pt Dr Ce Sm XP_001743880 COesteraseXP 001743880 MB Dr Ce Sm XP_001750804 COesteraseXP 001750804 MB Dm Nv Ta XP_002661384 COesteraseXP 002661384 DR Mb XP_001749350 COesteraseXP 001749350 MB Hs Pt XP_002117900 COesteraseXP 002117900 TA Ce XP_002117133 COesteraseXP 002117133 TA Hs Pt Dr XP_002117137 COesteraseXP 002117137 TA Dm XP_002117134 COesteraseXP 002117134 TA Sm XP_002117130 COesteraseXP 002117130 TA Mb XP_002117145 COesteraseXP 002117145 TA Nv XP_001139129 COesteraseXP 001139129 PT Nv 3BE8_A n.a.3BE8 A HS Nv NP_001159803 COesteraseNP 001159803 DR Nv NP_001159804 COesteraseNP 001159804 DR Ta NP_001163662 COesteraseNP 001163662 DM Mb NP_723931 COesteraseNP 723931 DM Ta AAC41579 COesteraseAAC41579 DM Nv XP_002574406 n.a.XP 002574406 SM Mb XP_001629673 COesteraseXP 001629673 NV Dm XP_001639145 COesteraseXP 001639145 NV Dr XP_001627490 COesteraseXP 001627490 NV Hs Pt Ce Sm Mb XP_001639304 COesteraseXP 001639304 NV Ta
(XP_001639304_NV_Ta:0.78012,((XP_002117145_TA_Nv:0.81589,(XP_002117130_TA_Mb:0.59742,(XP_002117134_TA_Sm:0.70246,(XP_002117137_TA_Dm:0.33257,(XP_002117133_TA_Hs_Pt_Dr:0.12779,XP_002117900_TA_Ce:0.10950):0.23155):0.19525):0.08606):0.16934):0.36115,((XP_001749350_MB_Hs_Pt:0.96351,(XP_002661384_DR_Mb:0.73489,XP_001750804_MB_Dm_Nv_Ta:0.68481):0.45809):0.29362,(XP_001743880_MB_Dr_Ce_Sm:0.75510,(((XP_516857_PT_Dr_Dm_Sm:0.00216,(3O9M_A_HS_Dr:0.00014,(2PM8_A_HS_Dm:0.00015,2WSL_A_HS_Sm:0.00014):0.00703):0.00611):0.37017,(NP_571921_DR_Hs_Pt_Dm_Ce_Sm:0.20588,((((NP_000656_HS_Pt:0.0,XP_003318708_PT_Hs_Ce:0.0):0.00014,4BDT_A_HS_Ce_Ta:0.00014):0.00014,XP_003318709_PT_Ta_Mb:0.00877):0.00131,BAD97163_HS_Mb:0.00221):0.32714):0.15358):0.10102,(1DX4_A_DM_Hs_Pt_Dr_Ce_Sm:0.84927,(NP_510660_CE_Hs_Pt_Dr_Dm_Sm_Nv_Ta_Mb:0.70980,(AAQ14321_SM_Hs_Pt_Dr_Dm_Ce_Ta:0.78328,XP_002574124_SM_Nv:0.95426):0.16298):0.13937):0.10155):0.25692):0.09549):0.11655):0.12169,(((XP_001629673_NV_Dm:0.84671,XP_002574406_SM_Mb:0.69940):0.24646,((AAC41579_DM_Nv:0.00015,NP_723931_DM_Ta:0.00361):1.03674,(NP_001163662_DM_Mb:0.84357,(NP_001159804_DR_Ta:0.09703,(NP_001159803_DR_Nv:0.05310,(3BE8_A_HS_Nv:0.00177,XP_001139129_PT_Nv:0.00014):0.04416):0.05796):0.33984):0.24912):0.14032):0.10389,(XP_001627490_NV_Hs_Pt_Ce_Sm_Mb:0.61499,XP_001639145_NV_Dr:0.68228):0.27334):0.00020);

Up
Table S1: Best blast for NP_006530 in each species
Homo sapiensNP_006530 voltage-dependent calcium channel gamma-3 subunit [Homo sapiens] >gi|197099598|ref|NP_001126660.1| voltage-dependent calcium channel gamma-3 subunit [Pongo abelii] >gi|387763162|ref|NP_001248473.1| voltage-dependent calcium channel gamma-3 subunit [Macaca mulatta] >gi|296219788|ref|XP_002756048.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Callithrix jacchus] >gi|332225100|ref|XP_003261715.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Nomascus leucogenys] >gi|395846168|ref|XP_003795784.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Otolemur garnettii] >gi|397485204|ref|XP_003813747.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Pan paniscus] >gi|402907971|ref|XP_003916733.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Papio anubis] >gi|403277182|ref|XP_003930255.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Saimiri boliviensis boliviensis] >gi|426381578|ref|XP_004057414.1| PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Gorilla gorilla gorilla] >gi|6685277|sp|O60359.1|CCG3_HUMAN RecName: Full=Voltage-dependent calcium channel gamma-3 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-3; Short=TARP gamma-3 >gi|75061665|sp|Q5R5X2.1|CCG3_PONAB RecName: Full=Voltage-dependent calcium channel gamma-3 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-3; Short=TARP gamma-3 >gi|75075953|sp|Q4R589.1|CCG3_MACFA RecName: Full=Voltage-dependent calcium channel gamma-3 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-3; Short=TARP gamma-3 >gi|4558766|gb|AAD22739.1|AF100346_1 neuronal voltage gated calcium channel gamma-3 subunit [Homo sapiens] >gi|7230381|gb|AAF42975.1|AF134640_1 calcium channel gamma subunit 3 [Homo sapiens] >gi|33150706|gb|AAP97231.1|AF114832_1 voltage-gated calcium channel gamma subunit [Homo sapiens] >gi|3093433|gb|AAC15246.1| Unknown gene product [Homo sapiens] >gi|25058364|gb|AAH40005.1| Calcium channel, voltage-dependent, gamma subunit 3 [Homo sapiens] >gi|54673645|gb|AAH37899.1| Calcium channel, voltage-dependent, gamma subunit 3 [Homo sapiens] >gi|55732281|emb|CAH92844.1| hypothetical protein [Pongo abelii] >gi|67970788|dbj|BAE01736.1| unnamed protein product [Macaca fascicularis] >gi|119576198|gb|EAW55794.1| calcium channel, voltage-dependent, gamma subunit 3, isoform CRA_b [Homo sapiens] >gi|312151880|gb|ADQ32452.1| calcium channel, voltage-dependent, gamma subunit 3 [synthetic construct] >gi|355710056|gb|EHH31520.1| Neuronal voltage-gated calcium channel gamma-3 subunit [Macaca mulatta] >gi|355756643|gb|EHH60251.1| Neuronal voltage-gated calcium channel gamma-3 subunit [Macaca fascicularis]0
Pan troglodytesXP_001154641 PREDICTED: voltage-dependent calcium channel gamma-3 subunit [Pan troglodytes]5.29574e-159
Danio rerioXP_693299 PREDICTED: voltage-dependent calcium channel gamma-3 subunit-like [Danio rerio]1.1345e-170
Drosophila melanogasterNP_001027082 stargazin-like protein [Drosophila melanogaster] >gi|71854527|gb|AAF50855.3| stargazin-like protein [Drosophila melanogaster] >gi|484399606|gb|AGK45224.1| GH12419p1 [Drosophila melanogaster]3.23865e-11
Caenorhabditis elegansNP_001021976 Protein STG-1 [Caenorhabditis elegans] >gi|33300013|emb|CAE17720.1| Protein STG-1 [Caenorhabditis elegans] >gi|67773313|gb|AAY81925.1| stargazin related protein STG-1 [Caenorhabditis elegans]2.18488e-07
Schistosoma mansoniXP_002575164 importin beta-1 [Schistosoma mansoni] >gi|353232539|emb|CCD79894.1| putative importin beta-1 [Schistosoma mansoni]2.43565
Nematostella vectensisXP_001642058 predicted protein [Nematostella vectensis] >gi|156229199|gb|EDO49995.1| predicted protein [Nematostella vectensis]0.204132
Trichoplax adhaerensXP_002108365 hypothetical protein TRIADDRAFT_52765 [Trichoplax adhaerens] >gi|190589141|gb|EDV29163.1| hypothetical protein TRIADDRAFT_52765 [Trichoplax adhaerens]4.95788
Monosiga brevicollisXP_001743015 hypothetical protein [Monosiga brevicollis MX1] >gi|163778114|gb|EDQ91729.1| predicted protein [Monosiga brevicollis MX1]2.64837

Table S2: Target IDs for NP_006530

NP_006530 sp|O60359|CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit OS=Homo sapiens GN=CACNG3 PE=2 SV=1
.......FromHomo sapiens
NP_006530
PMP22_Claudin
Pan troglodytes
XP_001154641
Danio rerio
XP_693299
PMP22_Claudin
Drosophila melanogaster
NP_001027082
Caenorhabditis elegans
NP_001021976
Schistosoma mansoni
XP_002575164
IBN_N
Nematostella vectensis
XP_001642058
Trichoplax adhaerens
XP_002108365
TPR_1, TPR_8, TPR_2
Monosiga brevicollis
XP_001743015
zf-C2HC5, ASCH
Homo sapiensNP_006530NP_006530NP_006530NP_114102NP_665810NP_002256NP_689566AAH01248NP_057297
Pan troglodytesXP_001154641XP_001154641XP_001154641XP_001174727XP_003315735NP_001266762XP_001174180XP_001164860XP_510472
Danio rerioXP_693299XP_693299XP_693299XP_005166293XP_001337872NP_001032791AAZ29457NP_775392AAI24324
Drosophila melanogasterNP_001027082NP_001027082NP_001027082NP_001027082NP_001027082NP_477496no hitNP_649026NP_608393
Caenorhabditis elegansNP_001021976NP_001021976NP_001021976NP_001021976NP_001021976NP_491477NP_001022363NP_498636NP_497100
Schistosoma mansoniXP_002575164CCD80408XP_002578732XP_002579718XP_002570020XP_002575164XP_002570794CCD75652CCD75843
Nematostella vectensisXP_001642058XP_001642058XP_001627385XP_001629312ABF61776XP_001636221XP_001642058XP_001638862XP_001638454
Trichoplax adhaerensXP_002108365XP_002108365no hitXP_002116050XP_002117335XP_002110849no hitXP_002108365XP_002114380
Monosiga brevicollisXP_001743015XP_001742128XP_001749803no hitno hitXP_001747343XP_001751067XP_001742844XP_001743015



Table S3: Target blast score for NP_006530

NP_006530 sp|O60359|CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit OS=Homo sapiens GN=CACNG3 PE=2 SV=1
.......FromHomo sapiens
NP_006530
PMP22_Claudin
Pan troglodytes
XP_001154641
Danio rerio
XP_693299
PMP22_Claudin
Drosophila melanogaster
NP_001027082
Caenorhabditis elegans
NP_001021976
Schistosoma mansoni
XP_002575164
IBN_N
Nematostella vectensis
XP_001642058
Trichoplax adhaerens
XP_002108365
TPR_1, TPR_8, TPR_2
Monosiga brevicollis
XP_001743015
zf-C2HC5, ASCH
Homo sapiens04.44466e-1607.36827e-1702.6519e-090.0018983500.0001226476.71443e-1621.30053e-70
Pan troglodytes1.53801e-16005.80661e-1431.28853e-119.22391e-0605.95931e-076.09541e-1511.91662e-73
Danio rerio1.1345e-1703.34111e-14306.01234e-124.76685e-0500.0002956142.98721e-1718.09247e-54
Drosophila melanogaster3.23865e-119.04746e-081.20321e-1101.44855e-070no hit1.57365e-674.10506e-48
Caenorhabditis elegans2.18488e-074.76265e-051.78962e-071.02553e-10000.1260391.43598e-696.20886e-20
Schistosoma mansoni2.435651.883851.03771.581441.6808105.372232.85135e-996.88011e-47
Nematostella vectensis0.005449280.01133710.02090890.04721250.10225401.08548e-1265.97368e-1582.65713e-104
Trichoplax adhaerens4.957887.70629no hit7.433551.240360no hit02.33768e-58
Monosiga brevicollis2.648372.293522.48498no hitno hit6.50473e-1740.06585761.25865e-880


Table S4: Comparative domain composition for NP_006530

NP_006530 sp|O60359|CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit OS=Homo sapiens GN=CACNG3 PE=2 SV=1
PMP22_Claudin (1)
.......FromHomo sapiens
NP_006530
PMP22_Claudin (1)
Pan troglodytes
XP_001154641
Danio rerio
XP_693299
PMP22_Claudin (1)
Drosophila melanogaster
NP_001027082
Caenorhabditis elegans
NP_001021976
Schistosoma mansoni
XP_002575164
IBN_N (1)
Nematostella vectensis
XP_001642058
Trichoplax adhaerens
XP_002108365
TPR_1 (1), TPR_8 (1), TPR_2 (1)
Monosiga brevicollis
XP_001743015
zf-C2HC5 (1), ASCH (1)
Homo sapiens
PMP22_Claudin (0)

PMP22_Claudin (0)

PMP22_Claudin (0)

PMP22_Claudin (-1)

PMP22_Claudin (0)

PMP22_Claudin (-1)IBN_N (1), Arm (1)

PMP22_Claudin (0)

PMP22_Claudin (-1)TPR_1 (1)

PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)
Pan troglodytesn.a.n.a.n.a.n.a.
PMP22_Claudin (0)
n.a.
PMP22_Claudin (0)
n.a.
PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)
Danio rerio
PMP22_Claudin (0)

PMP22_Claudin (0)

PMP22_Claudin (0)
n.a.n.a.n.a.
PMP22_Claudin (0)
n.a.n.a.
Drosophila melanogastern.a.n.a.n.a.n.a.n.a.
PMP22_Claudin (-1)IBN_N (1)
no hit
PMP22_Claudin (-1)TPR_2 (1)

PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)
Caenorhabditis elegansn.a.n.a.n.a.n.a.n.a.
PMP22_Claudin (-1)IBN_N (1), HEAT (1)

PMP22_Claudin (-1)Cache_1 (1), VWA_N (1)

PMP22_Claudin (-1)TPR_1 (1), PPR (1)

PMP22_Claudin (-1)zf-C2HC5 (1)
Schistosoma mansoni
PMP22_Claudin (-1)IBN_N (1)

PMP22_Claudin (-1)Peptidase_A22B (1)
n.a.
PMP22_Claudin (-1)MFS_1 (1)
n.a.
PMP22_Claudin (-1)IBN_N (1)
n.a.
PMP22_Claudin (-1)TPR_1 (1)

PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)
Nematostella vectensisn.a.n.a.n.a.
PMP22_Claudin (-1)RINGv (1)

PMP22_Claudin (-1)Noggin (1)

PMP22_Claudin (-1)IBN_N (1)
n.a.n.a.
PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)
Trichoplax adhaerens
PMP22_Claudin (-1)TPR_1 (1), TPR_8 (1), TPR_2 (1)

PMP22_Claudin (-1)TPR_1 (1), TPR_8 (1), TPR_2 (1)
no hit
PMP22_Claudin (-1)I-set (2), fn3 (4)

PMP22_Claudin (-1)Ribosomal_L28 (1)

PMP22_Claudin (-1)IBN_N (1)
no hit
PMP22_Claudin (-1)TPR_1 (1), TPR_8 (1), TPR_2 (1)

PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)
Monosiga brevicollis
PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)

PMP22_Claudin (-1)DNA_ligase_A_C (1), DNA_ligase_A_M (1), DNA_ligase_A_N (1)
n.a.no hitno hit
PMP22_Claudin (-1)IBN_N (1)
n.a.
PMP22_Claudin (-1)TPR_1 (1)

PMP22_Claudin (-1)ASCH (1), zf-C2HC5 (1)



Tree S1: Tree for NP_006530

XP_001164860 n.a.XP 001164860 PT Ta AAH01248 TPR_1AAH01248 HS Ta NP_775392 n.a.NP 775392 DR Ta XP_001638862 n.a.XP 001638862 NV Ta CCD75652 TPR_1CCD75652 SM Ta XP_001742844 TPR_1XP 001742844 MB Ta NP_649026 TPR_2NP 649026 DM Ta NP_498636 TPR_1, PPRNP 498636 CE Ta XP_001174180 PMP22_ClaudinXP 001174180 PT Nv NP_689566 PMP22_ClaudinNP 689566 HS Nv XP_002570794 n.a.XP 002570794 SM Nv XP_001642058 n.a.XP 001642058 NV Hs Pt XP_001749803 n.a.XP 001749803 MB Dr XP_001743015 zf-C2HC5, ASCHXP 001743015 MB Hs NP_608393 zf-C2HC5, ASCHNP 608393 DM Mb CCD75843 zf-C2HC5, ASCHCCD75843 SM Mb XP_002114380 zf-C2HC5, ASCHXP 002114380 TA Mb XP_001638454 zf-C2HC5, ASCHXP 001638454 NV Mb AAI24324 n.a.AAI24324 DR Mb NP_057297 zf-C2HC5, ASCHNP 057297 HS Mb XP_510472 zf-C2HC5, ASCHXP 510472 PT Mb NP_497100 zf-C2HC5NP 497100 CE Mb XP_002116050 I-set, fn3XP 002116050 TA Dm NP_001022363 Cache_1, VWA_NNP 001022363 CE Nv NP_006530 PMP22_ClaudinNP 006530 HS Pt Dr XP_001154641 n.a.XP 001154641 PT Hs Dr XP_693299 PMP22_ClaudinXP 693299 DR Hs Pt XP_002578732 n.a.XP 002578732 SM Dr XP_002108365 TPR_1, TPR_8, TPR_2XP 002108365 TA Hs Pt NP_001021976 n.a.NP 001021976 CE Hs Pt Dr Dm XP_002570020 n.a.XP 002570020 SM Ce XP_001629312 RINGvXP 001629312 NV Dm NP_001027082 n.a.NP 001027082 DM Hs Pt Dr Ce NP_665810 PMP22_ClaudinNP 665810 HS Ce XP_003315735 PMP22_ClaudinXP 003315735 PT Ce XP_001337872 n.a.XP 001337872 DR Ce XP_005166293 n.a.XP 005166293 DR Dm CCD80408 Peptidase_A22BCCD80408 SM Pt NP_114102 NP 114102 HS Dm XP_001174727 n.a.XP 001174727 PT Dm AAZ29457 PMP22_ClaudinAAZ29457 DR Nv XP_001751067 n.a.XP 001751067 MB Nv XP_001627385 n.a.XP 001627385 NV Dr XP_002117335 Ribosomal_L28XP 002117335 TA Ce XP_002579718 MFS_1XP 002579718 SM Dm XP_001747343 IBN_NXP 001747343 MB Sm XP_002575164 IBN_NXP 002575164 SM Hs ABF61776 NogginABF61776 NV Ce NP_491477 IBN_N, HEATNP 491477 CE Sm XP_001742128 DNA_ligase_A_C, DNA_ligase_A_N, DNA_ligase_A_MXP 001742128 MB Pt XP_002110849 IBN_NXP 002110849 TA Sm NP_001266762 n.a.NP 001266762 PT Sm NP_002256 Arm, IBN_NNP 002256 HS Sm NP_001032791 n.a.NP 001032791 DR Sm XP_001636221 IBN_NXP 001636221 NV Sm NP_477496 IBN_NNP 477496 DM Sm
(((NP_001032791_DR_Sm:0.04135,(NP_002256_HS_Sm:0.00014,NP_001266762_PT_Sm:0.00230):0.04108):0.14246,XP_001636221_NV_Sm:0.36097):0.04785,NP_477496_DM_Sm:0.38489,(((XP_001742128_MB_Pt:3.73838,(NP_491477_CE_Sm:0.44032,ABF61776_NV_Ce:3.11018):0.07302):0.08145,((XP_001747343_MB_Sm:0.73610,(((((XP_001751067_MB_Nv:0.18737,AAZ29457_DR_Nv:1.49019):1.55682,XP_001627385_NV_Dr:3.14058):0.52315,((((XP_002570020_SM_Ce:1.26990,NP_001021976_CE_Hs_Pt_Dr_Dm:0.00016):1.45324,((XP_693299_DR_Hs_Pt:0.09521,(XP_001154641_PT_Hs_Dr:0.02208,NP_006530_HS_Pt_Dr:0.00015):0.10335):0.38518,(XP_002108365_TA_Hs_Pt:0.33337,XP_002578732_SM_Dr:1.69392):0.55723):1.28640):0.81180,(NP_001027082_DM_Hs_Pt_Dr_Ce:0.73486,XP_001629312_NV_Dm:2.54273):0.08070):1.05520,((XP_001174727_PT_Dm:0.0,NP_114102_HS_Dm:0.0):0.17824,(CCD80408_SM_Pt:3.27519,((XP_003315735_PT_Ce:0.0,NP_665810_HS_Ce:0.0):0.05963,(XP_005166293_DR_Dm:0.00016,XP_001337872_DR_Ce:0.00014):0.06083):0.00021):0.15647):0.09214):0.70109):1.42230,(((NP_001022363_CE_Nv:2.94612,XP_002116050_TA_Dm:1.60148):0.22099,(NP_497100_CE_Mb:0.50685,((AAI24324_DR_Mb:0.18788,(XP_001638454_NV_Mb:0.36434,(XP_002114380_TA_Mb:0.35100,(CCD75843_SM_Mb:0.57373,NP_608393_DM_Mb:0.52309):0.01978):0.08541):0.15739):0.14980,(XP_510472_PT_Mb:0.00224,NP_057297_HS_Mb:0.00014):0.16467):0.46157):2.14316):1.15684,(((NP_498636_CE_Ta:0.77993,(NP_649026_DM_Ta:1.04809,(XP_001742844_MB_Ta:0.84159,(CCD75652_SM_Ta:0.93829,(XP_001638862_NV_Ta:0.61394,(NP_775392_DR_Ta:0.27497,(AAH01248_HS_Ta:0.00279,XP_001164860_PT_Ta:0.02132):0.24617):0.33991):0.08822):0.10037):0.16865):0.28619):0.59057,((NP_689566_HS_Nv:0.0,XP_001174180_PT_Nv:0.0):0.44361,(XP_001642058_NV_Hs_Pt:0.00014,XP_002570794_SM_Nv:0.99360):1.23153):2.21010):0.80410,(XP_001743015_MB_Hs:2.71718,XP_001749803_MB_Dr:1.15364):0.62185):0.04263):0.40600):0.14007,(XP_002579718_SM_Dm:2.30383,XP_002117335_TA_Ce:1.86521):0.64167):1.65880):0.02550,XP_002575164_SM_Hs:0.32240):0.13399):0.10006,XP_002110849_TA_Sm:0.31805):0.07448);

Up
Table S1: Best blast for NP_074056 in each species
Homo sapiensBAA92623 KIAA1385 protein [Homo sapiens]0
Pan troglodytesXP_001135627 gephyrin isoform 2 [Homo sapiens] >gi|383873350|ref|NP_001244744.1| gephyrin [Macaca mulatta] >gi|126282625|ref|XP_001369878.1| PREDICTED: gephyrin isoform 3 [Monodelphis domestica] >gi|296215296|ref|XP_002754065.1| PREDICTED: gephyrin isoform 3 [Callithrix jacchus] >gi|332842525|ref|XP_001135627.2| PREDICTED: gephyrin isoform 7 [Pan troglodytes] >gi|345803567|ref|XP_003435080.1| PREDICTED: gephyrin isoform 2 [Canis lupus familiaris] >gi|359069727|ref|XP_003586639.1| PREDICTED: gephyrin isoformX2 [Bos taurus] >gi|397507229|ref|XP_003824107.1| PREDICTED: gephyrin isoform 2 [Pan paniscus] >gi|403264446|ref|XP_003924493.1| PREDICTED: gephyrin isoform 2 [Saimiri boliviensis boliviensis] >gi|426233544|ref|XP_004010776.1| PREDICTED: gephyrin isoform 2 [Ovis aries] >gi|441595085|ref|XP_004087211.1| PREDICTED: gephyrin isoform 2 [Nomascus leucogenys] >gi|465963161|ref|XP_004262187.1| PREDICTED: gephyrin isoform 2 [Orcinus orca] >gi|471360899|ref|XP_004371017.1| PREDICTED: gephyrin isoform 2 [Trichechus manatus latirostris] >gi|472355971|ref|XP_004397631.1| PREDICTED: gephyrin isoform 4 [Odobenus rosmarus divergens] >gi|478504024|ref|XP_004426313.1| PREDICTED: gephyrin isoform 2 [Ceratotherium simum simum] >gi|504144191|ref|XP_004584526.1| PREDICTED: gephyrin isoform X4 [Ochotona princeps] >gi|505837682|ref|XP_004612405.1| PREDICTED: gephyrin isoform X5 [Sorex araneus] >gi|507945258|ref|XP_004681829.1| PREDICTED: gephyrin isoform X5 [Condylura cristata] >gi|511828593|ref|XP_004739023.1| PREDICTED: gephyrin isoform X7 [Mustela putorius furo] >gi|511957995|ref|XP_004797269.1| PREDICTED: gephyrin isoform X6 [Mustela putorius furo] >gi|512949988|ref|XP_004837435.1| PREDICTED: gephyrin isoform X4 [Heterocephalus glaber] >gi|531997498|ref|XP_005343306.1| PREDICTED: gephyrin isoform X6 [Microtus ochrogaster] >gi|533171333|ref|XP_005399157.1| PREDICTED: gephyrin-like isoform X8 [Chinchilla lanigera] >gi|13431554|sp|Q9NQX3.1|GEPH_HUMAN RecName: Full=Gephyrin; Includes: RecName: Full=Molybdopterin adenylyltransferase; Short=MPT adenylyltransferase; AltName: Full=Domain G; Includes: RecName: Full=Molybdopterin molybdenumtransferase; Short=MPT Mo-transferase; AltName: Full=Domain E >gi|8926308|gb|AAF81785.1|AF272663_1 gephyrin [Homo sapiens] >gi|168278877|dbj|BAG11318.1| gephyrin [synthetic construct]0
Danio rerioBAI68425 gephyrin2 [Danio rerio]0
Drosophila melanogasterADQ74796 MIP27737p [Drosophila melanogaster]1.13481e-70
Caenorhabditis elegansNP_509700 Protein MOC-1 [Caenorhabditis elegans] >gi|22265937|emb|CAA90069.2| Protein MOC-1 [Caenorhabditis elegans]2.42687e-77
Schistosoma mansoniXP_002577975 molybdopterin biosynthesis protein [Schistosoma mansoni]1.10136e-27
Nematostella vectensisXP_001627768 predicted protein [Nematostella vectensis] >gi|156214688|gb|EDO35668.1| predicted protein [Nematostella vectensis]1.24011e-161
Trichoplax adhaerensXP_002117252 hypothetical protein TRIADDRAFT_61235 [Trichoplax adhaerens] >gi|190580217|gb|EDV20302.1| hypothetical protein TRIADDRAFT_61235 [Trichoplax adhaerens]2.56724e-158
Monosiga brevicollisXP_001749995 hypothetical protein [Monosiga brevicollis MX1] >gi|163771505|gb|EDQ85170.1| predicted protein [Monosiga brevicollis MX1]5.41056e-47

Table S2: Target IDs for NP_074056

NP_074056 sp|Q9NQX3|GEPH_HUMAN Gephyrin OS=Homo sapiens GN=GPHN PE=1 SV=1
.......FromHomo sapiens
BAA92623
MoeA_C, MoeA_N, MoCF_biosynth
Pan troglodytes
XP_001135627
Danio rerio
BAI68425
MoeA_C, MoeA_N, MoCF_biosynth
Drosophila melanogaster
ADQ74796
MoeA_C, MoeA_N, MoCF_biosynth
Caenorhabditis elegans
NP_509700
MoeA_C, MoeA_N, MoCF_biosynth
Schistosoma mansoni
XP_002577975
Nematostella vectensis
XP_001627768
MoeA_C, MoeA_N, MoCF_biosynth
Trichoplax adhaerens
XP_002117252
MoeA_C, MoeA_N, MoCF_biosynth
Monosiga brevicollis
XP_001749995
MoeA_N, MoCF_biosynth
Homo sapiensBAA92623BAA92623BAA92623XP_005267312BAH12110BAH12110BAH12110BAH12110BAH12110
Pan troglodytesXP_001135627XP_001135627XP_001135627XP_003314447XP_003314447XP_003314447XP_003314447XP_003314447XP_003314447
Danio rerioBAI68425BAI68425BAI68425BAI68421BAI68425BAI68421BAI68421BAI68421BAI68422
Drosophila melanogasterADQ74796ADQ74796ADQ74796ADQ74796ADQ74796ADQ74796NP_477030NP_477030AAQ67536
Caenorhabditis elegansNP_509700NP_509700NP_509700NP_509700NP_509700NP_509700NP_509700NP_509700NP_509700
Schistosoma mansoniXP_002577975XP_002577975XP_002577975XP_002577975XP_002577975XP_002577975XP_002577974XP_002577975CCD60209
Nematostella vectensisXP_001627768XP_001627768XP_001627768XP_001627768XP_001627768XP_001627768XP_001627768XP_001627768XP_001627768
Trichoplax adhaerensXP_002117252XP_002117252XP_002117252XP_002117252XP_002117252XP_002117252XP_002117252XP_002117252XP_002117252
Monosiga brevicollisXP_001749995XP_001749995XP_001749995XP_001749995XP_001749995XP_001749995XP_001749995XP_001749995XP_001749995



Table S3: Target blast score for NP_074056

NP_074056 sp|Q9NQX3|GEPH_HUMAN Gephyrin OS=Homo sapiens GN=GPHN PE=1 SV=1
.......FromHomo sapiens
BAA92623
MoeA_C, MoeA_N, MoCF_biosynth
Pan troglodytes
XP_001135627
Danio rerio
BAI68425
MoeA_C, MoeA_N, MoCF_biosynth
Drosophila melanogaster
ADQ74796
MoeA_C, MoeA_N, MoCF_biosynth
Caenorhabditis elegans
NP_509700
MoeA_C, MoeA_N, MoCF_biosynth
Schistosoma mansoni
XP_002577975
Nematostella vectensis
XP_001627768
MoeA_C, MoeA_N, MoCF_biosynth
Trichoplax adhaerens
XP_002117252
MoeA_C, MoeA_N, MoCF_biosynth
Monosiga brevicollis
XP_001749995
MoeA_N, MoCF_biosynth
Homo sapiens0005.66289e-681.1982e-774.00955e-191.82206e-1515.50174e-1584.32134e-36
Pan troglodytes0009.47424e-699.92777e-783.22106e-194.92908e-1522.07894e-1589.86834e-37
Danio rerio0001.73429e-699.48981e-772.22424e-192.52829e-1515.47995e-1592.12141e-35
Drosophila melanogaster1.12145e-675.86894e-688.49247e-6905.6896e-614.49203e-152.27015e-1178.71672e-1233.62152e-28
Caenorhabditis elegans1.4983e-788.1976e-793.1604e-788.74886e-6301.93865e-157.78823e-712.41038e-831.41032e-31
Schistosoma mansoni1.12932e-271.10136e-273.52647e-272.53666e-191.2123e-212.32456e-1188.94674e-529.57817e-333.37679e-32
Nematostella vectensis5.04931e-1611.24011e-1611.84571e-1612.91018e-668.76093e-751.79642e-25001.62453e-58
Trichoplax adhaerens4.53831e-1582.56724e-1585.47235e-1591.35297e-701.89557e-822.37094e-25005.94424e-76
Monosiga brevicollis6.34199e-475.41056e-475.18627e-465.13658e-245.57751e-370.2139981.20015e-673.0746e-890


Table S4: Comparative domain composition for NP_074056

NP_074056 sp|Q9NQX3|GEPH_HUMAN Gephyrin OS=Homo sapiens GN=GPHN PE=1 SV=1
MoeA_C (1), MoeA_N (1), MoCF_biosynth (2)
.......FromHomo sapiens
BAA92623
MoeA_C (1), MoeA_N (1), MoCF_biosynth (2)
Pan troglodytes
XP_001135627
Danio rerio
BAI68425
MoeA_C (1), MoeA_N (1), MoCF_biosynth (2)
Drosophila melanogaster
ADQ74796
MoeA_C (1), MoeA_N (1), MoCF_biosynth (1)
Caenorhabditis elegans
NP_509700
MoeA_C (1), MoeA_N (1), MoCF_biosynth (1)
Schistosoma mansoni
XP_002577975
Nematostella vectensis
XP_001627768
MoeA_C (1), MoeA_N (1), MoCF_biosynth (2)
Trichoplax adhaerens
XP_002117252
MoeA_C (1), MoeA_N (1), MoCF_biosynth (2)
Monosiga brevicollis
XP_001749995
MoeA_N (1), MoCF_biosynth (2)
Homo sapiens
MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)
n.a.
MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)
Pan troglodytesn.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.
Danio rerio
MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)
Drosophila melanogaster
MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_N (0), MoCF_biosynth (-1)MoeA_C (-1)
Caenorhabditis elegans
MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (-1)
Schistosoma mansonin.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.
MoeA_N (0), MoCF_biosynth (-1)MoeA_C (-1)
Nematostella vectensis
MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)
Trichoplax adhaerens
MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)

MoeA_C (0), MoeA_N (0), MoCF_biosynth (0)
Monosiga brevicollis
MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)

MoeA_N (0), MoCF_biosynth (0)MoeA_C (-1)



Tree S1: Tree for NP_074056

NP_477030 MoeA_C, MoeA_N, MoCF_biosynthNP 477030 DM Nv Ta ADQ74796 MoeA_C, MoeA_N, MoCF_biosynthADQ74796 DM Hs Pt Dr Ce Sm AAQ67536 MoeA_N, MoCF_biosynthAAQ67536 DM Mb XP_002577974 n.a.XP 002577974 SM Nv CCD60209 MoeA_N, MoCF_biosynthCCD60209 SM Mb XP_001749995 MoeA_N, MoCF_biosynthXP 001749995 MB Hs Pt Dr Dm Ce Sm Nv Ta NP_509700 MoeA_C, MoeA_N, MoCF_biosynthNP 509700 CE Hs Pt Dr Dm Sm Nv Ta Mb XP_002577975 n.a.XP 002577975 SM Hs Pt Dr Dm Ce Ta XP_001627768 MoeA_C, MoeA_N, MoCF_biosynthXP 001627768 NV Hs Pt Dr Dm Ce Sm Ta Mb XP_002117252 MoeA_C, MoeA_N, MoCF_biosynthXP 002117252 TA Hs Pt Dr Dm Ce Sm Nv Mb XP_005267312 n.a.XP 005267312 HS Dm XP_003314447 n.a.XP 003314447 PT Dm Ce Sm Nv Ta Mb BAA92623 MoeA_C, MoeA_N, MoCF_biosynthBAA92623 HS Pt Dr XP_001135627 n.a.XP 001135627 PT Hs Dr BAH12110 MoeA_C, MoeA_N, MoCF_biosynthBAH12110 HS Ce Sm Nv Ta Mb BAI68425 MoeA_C, MoeA_N, MoCF_biosynthBAI68425 DR Hs Pt Ce BAI68421 MoeA_C, MoeA_N, MoCF_biosynthBAI68421 DR Dm Sm Nv Ta BAI68422 MoeA_C, MoeA_N, MoCF_biosynthBAI68422 DR Mb
(BAI68422_DR_Mb:0.00015,BAI68421_DR_Dm_Sm_Nv_Ta:0.00014,(BAI68425_DR_Hs_Pt_Ce:0.02022,((BAH12110_HS_Ce_Sm_Nv_Ta_Mb:0.00247,((XP_003314447_PT_Dm_Ce_Sm_Nv_Ta_Mb:0.0,XP_005267312_HS_Dm:0.0):0.00014,(XP_001135627_PT_Hs_Dr:0.0,BAA92623_HS_Pt_Dr:0.0):0.00014):0.00015):0.01155,((((NP_509700_CE_Hs_Pt_Dr_Dm_Sm_Nv_Ta_Mb:0.67897,XP_001749995_MB_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Ta:0.67852):0.10549,((CCD60209_SM_Mb:0.00014,XP_002577974_SM_Nv:0.00014):1.03772,(AAQ67536_DM_Mb:0.00016,(ADQ74796_DM_Hs_Pt_Dr_Ce_Sm:0.00014,NP_477030_DM_Nv_Ta:0.00016):0.00521):0.65141):0.15103):0.19141,XP_002577975_SM_Hs_Pt_Dr_Dm_Ce_Ta:0.94160):0.07799,(XP_002117252_TA_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Mb:0.39361,XP_001627768_NV_Hs_Pt_Dr_Dm_Ce_Sm_Ta_Mb:0.33446):0.10178):0.31304):0.01116):0.00030);

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Table S1: Best blast for NP_068587 in each species
Homo sapiensNP_068587 high affinity choline transporter 1 [Homo sapiens] >gi|530368780|ref|XP_005264065.1| PREDICTED: high affinity choline transporter 1 isoform X1 [Homo sapiens] >gi|56404957|sp|Q9GZV3.1|SC5A7_HUMAN RecName: Full=High affinity choline transporter 1; AltName: Full=Hemicholinium-3-sensitive choline transporter; Short=CHT; AltName: Full=Solute carrier family 5 member 7 >gi|9843754|emb|CAC03717.1| high affinity choline transporter [Homo sapiens] >gi|10998442|gb|AAG25940.1| high affinity choline transporter [Homo sapiens] >gi|11231081|dbj|BAB18161.1| high-affinity choline transporter CHT1 [Homo sapiens] >gi|18375494|emb|CAC88115.1| high affinity choline transporter [Homo sapiens] >gi|62822378|gb|AAY14927.1| unknown [Homo sapiens] >gi|84105437|gb|AAI11526.1| Solute carrier family 5 (choline transporter), member 7 [Homo sapiens] >gi|119574278|gb|EAW53893.1| solute carrier family 5 (choline transporter), member 7 [Homo sapiens]0
Pan troglodytesXP_001165105 PREDICTED: high affinity choline transporter 1 [Pan troglodytes]0
Danio rerioXP_001344597 PREDICTED: high affinity choline transporter 1 isoform X1 [Danio rerio] >gi|528468398|ref|XP_005159988.1| PREDICTED: high affinity choline transporter 1 isoform X2 [Danio rerio]0
Drosophila melanogasterNP_650743 CG7708, isoform A [Drosophila melanogaster] >gi|24648033|ref|NP_732369.1| CG7708, isoform B [Drosophila melanogaster] >gi|195569843|ref|XP_002102918.1| GD19244 [Drosophila simulans] >gi|56404981|sp|Q9VE46.2|SC5A7_DROME RecName: Full=High-affinity choline transporter 1 >gi|15010410|gb|AAK77253.1| GH02984p [Drosophila melanogaster] >gi|23171668|gb|AAF55583.2| CG7708, isoform A [Drosophila melanogaster] >gi|23171669|gb|AAN13786.1| CG7708, isoform B [Drosophila melanogaster] >gi|194198845|gb|EDX12421.1| GD19244 [Drosophila simulans] >gi|220947076|gb|ACL86081.1| CG7708-PA [synthetic construct]8.70162e-176
Caenorhabditis elegansNP_502539 Protein CHO-1 [Caenorhabditis elegans] >gi|56404693|sp|O02228.2|SC5A7_CAEEL RecName: Full=High-affinity choline transporter 1 >gi|6863032|dbj|BAA90483.1| high-affinity choline transporter CHO-1 [Caenorhabditis elegans] >gi|14530376|emb|CAB02847.2| Protein CHO-1 [Caenorhabditis elegans]7.02188e-162
Schistosoma mansoniXP_002576589 high-affinity choline transporter [Schistosoma mansoni] >gi|353232654|emb|CCD80009.1| putative high-affinity choline transporter [Schistosoma mansoni]3.86656e-123
Nematostella vectensisXP_001636363 predicted protein [Nematostella vectensis] >gi|156223465|gb|EDO44300.1| predicted protein [Nematostella vectensis]3.78825e-156
Trichoplax adhaerensXP_002110789 hypothetical protein TRIADDRAFT_54064 [Trichoplax adhaerens] >gi|190586740|gb|EDV26793.1| hypothetical protein TRIADDRAFT_54064 [Trichoplax adhaerens]0.639311
Monosiga brevicollisXP_001745129 hypothetical protein [Monosiga brevicollis MX1] >gi|163776743|gb|EDQ90362.1| predicted protein [Monosiga brevicollis MX1]0.708303

Table S2: Target IDs for NP_068587

NP_068587 sp|Q9GZV3|SC5A7_HUMAN High affinity choline transporter 1 OS=Homo sapiens GN=SLC5A7 PE=1 SV=1
.......FromHomo sapiens
NP_068587
SSF
Pan troglodytes
XP_001165105
SSF
Danio rerio
XP_001344597
SSF
Drosophila melanogaster
NP_650743
SSF
Caenorhabditis elegans
NP_502539
SSF
Schistosoma mansoni
XP_002576589
SSF
Nematostella vectensis
XP_001636363
SSF
Trichoplax adhaerens
XP_002110789
5-FTHF_cyc-lig
Monosiga brevicollis
XP_001745129
Mito_carr, EF_hand_4
Homo sapiensNP_068587NP_068587NP_068587NP_068587NP_068587NP_068587NP_068587NP_006432NP_443133
Pan troglodytesXP_001165105XP_001165105XP_001165105XP_001165105XP_001165105XP_001165105XP_001165105XP_001154891XP_001153366
Danio rerioXP_001344597XP_001344597XP_001344597XP_001339635XP_001339635XP_001344597XP_001344597XP_002662791XP_005160736
Drosophila melanogasterNP_650743NP_650743NP_650743NP_650743NP_650743NP_650743NP_650743NP_001097432NP_729802
Caenorhabditis elegansNP_502539NP_502539NP_502539NP_502539NP_502539NP_502539NP_502539NP_492692NP_510081
Schistosoma mansoniXP_002576589XP_002576589XP_002576589XP_002576589XP_002576589XP_002576589XP_002576589XP_002569909XP_002581376
Nematostella vectensisXP_001636363XP_001636363XP_001636363XP_001638621XP_001636363XP_001638621XP_001636363XP_001629681XP_001624285
Trichoplax adhaerensXP_002110789XP_002110789XP_002115769XP_002110861XP_002117545no hitno hitXP_002110789XP_002110012
Monosiga brevicollisXP_001745129XP_001745129no hitXP_001749946no hitno hitno hitXP_001742699XP_001745129



Table S3: Target blast score for NP_068587

NP_068587 sp|Q9GZV3|SC5A7_HUMAN High affinity choline transporter 1 OS=Homo sapiens GN=SLC5A7 PE=1 SV=1
.......FromHomo sapiens
NP_068587
SSF
Pan troglodytes
XP_001165105
SSF
Danio rerio
XP_001344597
SSF
Drosophila melanogaster
NP_650743
SSF
Caenorhabditis elegans
NP_502539
SSF
Schistosoma mansoni
XP_002576589
SSF
Nematostella vectensis
XP_001636363
SSF
Trichoplax adhaerens
XP_002110789
5-FTHF_cyc-lig
Monosiga brevicollis
XP_001745129
Mito_carr, EF_hand_4
Homo sapiens00002.18669e-1723.09942e-1366.16528e-1681.00225e-608.71639e-109
Pan troglodytes00002.32178e-1737.31503e-1376.47342e-1692.97332e-611.26636e-110
Danio rerio00008.58516e-1741.32752e-1491.46331e-1712.77503e-647.38614e-116
Drosophila melanogaster5.83767e-1732.6791e-1730007.65925e-1546.50972e-1741.50257e-451.11496e-100
Caenorhabditis elegans7.02188e-1624.60702e-1622.55449e-173007.01538e-1395.32165e-1702.97785e-331.61124e-100
Schistosoma mansoni3.86656e-1235.8701e-1234.65283e-1502.63069e-1589.50262e-14001.07072e-1243.3877e-282.31222e-89
Nematostella vectensis3.78825e-1562.35411e-1565.69633e-1701.97485e-1801.63384e-1721.59796e-12508.37065e-711.02639e-115
Trichoplax adhaerens0.6393110.633620.06752689.017221.94555no hitno hit1.45209e-1502.28249e-99
Monosiga brevicollis0.7083030.684212no hit0.86462no hitno hitno hit6.39332e-470


Table S4: Comparative domain composition for NP_068587

NP_068587 sp|Q9GZV3|SC5A7_HUMAN High affinity choline transporter 1 OS=Homo sapiens GN=SLC5A7 PE=1 SV=1
SSF (1)
.......FromHomo sapiens
NP_068587
SSF (1)
Pan troglodytes
XP_001165105
SSF (1)
Danio rerio
XP_001344597
SSF (1)
Drosophila melanogaster
NP_650743
SSF (1)
Caenorhabditis elegans
NP_502539
SSF (1)
Schistosoma mansoni
XP_002576589
SSF (1)
Nematostella vectensis
XP_001636363
SSF (1)
Trichoplax adhaerens
XP_002110789
5-FTHF_cyc-lig (1)
Monosiga brevicollis
XP_001745129
Mito_carr (3), EF_hand_4 (1)
Homo sapiens
SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (1), Mito_carr (3)
Pan troglodytes
SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (1), Mito_carr (3)
Danio rerio
SSF (0)

SSF (0)

SSF (0)
n.a.n.a.
SSF (0)

SSF (0)
n.a.n.a.
Drosophila melanogaster
SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (2), Mito_carr (3)
Caenorhabditis elegans
SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (1), EF_hand_4 (1), Mito_carr (3)
Schistosoma mansoni
SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (2), Mito_carr (3)
Nematostella vectensis
SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (0)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (2), Mito_carr (3)
Trichoplax adhaerens
SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)FtsJ (1), Spb1_C (1), DUF3381 (1)

SSF (-1)TFIID_90kDa (1), WD40 (5)

SSF (-1)Acetyltransf_7 (1)
no hitno hit
SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_5 (1), Mito_carr (3)
Monosiga brevicollis
SSF (-1)EF_hand_4 (1), Mito_carr (3)

SSF (-1)EF_hand_4 (1), Mito_carr (3)
no hitn.a.no hitno hitno hit
SSF (-1)5-FTHF_cyc-lig (1)

SSF (-1)EF_hand_4 (1), Mito_carr (3)



Tree S1: Tree for NP_068587

XP_001154891 5-FTHF_cyc-ligXP 001154891 PT Ta NP_006432 5-FTHF_cyc-ligNP 006432 HS Ta XP_002662791 n.a.XP 002662791 DR Ta XP_001629681 5-FTHF_cyc-ligXP 001629681 NV Ta XP_002110789 5-FTHF_cyc-ligXP 002110789 TA Hs Pt XP_001742699 5-FTHF_cyc-ligXP 001742699 MB Ta XP_002569909 5-FTHF_cyc-ligXP 002569909 SM Ta NP_001097432 5-FTHF_cyc-ligNP 001097432 DM Ta NP_492692 5-FTHF_cyc-ligNP 492692 CE Ta XP_002115769 Spb1_C, FtsJ, DUF3381XP 002115769 TA Dr XP_002110861 TFIID_90kDa, WD40XP 002110861 TA Dm XP_001153366 EF_hand_5, Mito_carrXP 001153366 PT Mb NP_443133 EF_hand_5, Mito_carrNP 443133 HS Mb XP_005160736 n.a.XP 005160736 DR Mb XP_002581376 EF_hand_5, Mito_carrXP 002581376 SM Mb NP_729802 EF_hand_5, Mito_carrNP 729802 DM Mb NP_510081 EF_hand_5, Mito_carr, EF_hand_4NP 510081 CE Mb XP_002110012 EF_hand_5, Mito_carrXP 002110012 TA Mb XP_001624285 EF_hand_5, Mito_carrXP 001624285 NV Mb XP_001745129 Mito_carr, EF_hand_4XP 001745129 MB Hs Pt XP_002117545 Acetyltransf_7XP 002117545 TA Ce XP_001344597 SSFXP 001344597 DR Hs Pt Sm Nv XP_001749946 n.a.XP 001749946 MB Dm XP_001339635 n.a.XP 001339635 DR Dm Ce XP_001165105 SSFXP 001165105 PT Hs Dr Dm Ce Sm Nv NP_068587 SSFNP 068587 HS Pt Dr Dm Ce Sm Nv XP_002576589 SSFXP 002576589 SM Hs Pt Dr Dm Ce Nv NP_650743 SSFNP 650743 DM Hs Pt Dr Ce Sm Nv NP_502539 SSFNP 502539 CE Hs Pt Dr Dm Sm Nv XP_001638621 SSFXP 001638621 NV Dm Sm XP_001636363 SSFXP 001636363 NV Hs Pt Dr Ce
(XP_001636363_NV_Hs_Pt_Dr_Ce:0.28472,XP_001638621_NV_Dm_Sm:0.35992,((XP_002576589_SM_Hs_Pt_Dr_Dm_Ce_Nv:0.37130,((NP_068587_HS_Pt_Dr_Dm_Ce_Sm_Nv:0.00165,XP_001165105_PT_Hs_Dr_Dm_Ce_Sm_Nv:0.00015):0.15496,((XP_001749946_MB_Dm:3.05675,(XP_001344597_DR_Hs_Pt_Sm_Nv:0.03521,(XP_002117545_TA_Ce:4.34720,(((((NP_001097432_DM_Ta:0.49964,((XP_001742699_MB_Ta:0.50800,(XP_002110789_TA_Hs_Pt:0.28730,(XP_001629681_NV_Ta:0.45708,(XP_002662791_DR_Ta:0.25043,(NP_006432_HS_Ta:0.00965,XP_001154891_PT_Ta:0.00015):0.30118):0.15039):0.09272):0.15075):0.06829,XP_002569909_SM_Ta:1.01443):0.21209):0.26174,NP_492692_CE_Ta:0.57927):1.86259,(XP_002110861_TA_Dm:2.27748,XP_002115769_TA_Dr:2.78488):1.13807):1.27141,((XP_001624285_NV_Mb:0.23543,XP_002110012_TA_Mb:0.41819):0.07154,((XP_002581376_SM_Mb:0.54878,(XP_005160736_DR_Mb:0.20962,(NP_443133_HS_Mb:0.00014,XP_001153366_PT_Mb:0.00232):0.14684):0.09064):0.04683,(NP_510081_CE_Mb:0.35572,NP_729802_DM_Mb:0.27987):0.13390):0.05596):0.15467):0.22223,XP_001745129_MB_Hs_Pt:0.17557):1.62060):1.41208):0.01239):0.03314,XP_001339635_DR_Dm_Ce:0.11893):0.12314):0.30428):0.07760,(NP_502539_CE_Hs_Pt_Dr_Dm_Sm_Nv:0.43395,NP_650743_DM_Hs_Pt_Dr_Ce_Sm_Nv:0.23557):0.05708):0.16627);

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Table S1: Best blast for XP_005244805 in each species
Homo sapiensXP_005244805 PREDICTED: agrin isoform X1 [Homo sapiens]0
Pan troglodytesXP_003319002 PREDICTED: agrin-like [Pan troglodytes]0
Danio rerioNP_001170923 agrin precursor [Danio rerio] >gi|189397234|gb|ACD93413.1| NtA agrin [Danio rerio]0
Drosophila melanogasterCAB72284 EG:BACR25B3.11 [Drosophila melanogaster]2.40487e-63
Caenorhabditis elegansT16859 hypothetical protein T13C2.5 - Caenorhabditis elegans3.34974e-106
Schistosoma mansoniXP_002577398 agrin [Schistosoma mansoni]1.3814e-63
Nematostella vectensisXP_001627394 predicted protein [Nematostella vectensis] >gi|156214303|gb|EDO35294.1| predicted protein [Nematostella vectensis]4.71374e-71
Trichoplax adhaerensXP_002113830 hypothetical protein TRIADDRAFT_57635 [Trichoplax adhaerens] >gi|190584234|gb|EDV24304.1| hypothetical protein TRIADDRAFT_57635 [Trichoplax adhaerens]3.85292e-95
Monosiga brevicollisXP_001748540 hypothetical protein [Monosiga brevicollis MX1] >gi|163773059|gb|EDQ86704.1| predicted protein [Monosiga brevicollis MX1]0.000112213

Table S2: Target IDs for XP_005244805

XP_005244805 sp|O00468|AGRIN_HUMAN Agrin OS=Homo sapiens GN=AGRN PE=1 SV=5
.......FromHomo sapiens
XP_005244805
Pan troglodytes
XP_003319002
Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGF
Danio rerio
NP_001170923
Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGF
Drosophila melanogaster
CAB72284
Laminin_G_2, I-set, EGF, Ldl_recept_a, Laminin_G_1
Caenorhabditis elegans
T16859
Schistosoma mansoni
XP_002577398
Nematostella vectensis
XP_001627394
Laminin_G_2, I-set, hEGF, EGF, Laminin_G_1
Trichoplax adhaerens
XP_002113830
Laminin_G_2, Kazal_2, Laminin_G_1
Monosiga brevicollis
XP_001748540
hEGF, EGF_3, CUB, Laminin_EGF
Homo sapiensXP_005244805XP_005244805XP_005244806BAD93088AAC39776EAW56293BAD93088NP_940978EAW88241
Pan troglodytesXP_003319002XP_003319002XP_003319002XP_003319002XP_003319002XP_003319002XP_003949370XP_003319002XP_003314768
Danio rerioNP_001170923NP_001170923NP_001170923DAA06181NP_001170923NP_001170923DAA06181NP_001170923XP_005158088
Drosophila melanogasterCAB72284CAB72284CAB70094CAB72284NP_729380NP_729380CAB72284AAF63502ADK20128
Caenorhabditis elegansT16859T16859T16859NP_497044T16859NP_001022152NP_497044NP_001254438T27283
Schistosoma mansoniXP_002577398CCD59852XP_002577398XP_002572665CCD59852XP_002577398CCD81767XP_002572665XP_002575252
Nematostella vectensisXP_001627394XP_001627394XP_001627394XP_001627394XP_001632449XP_001632449XP_001627394XP_001638936XP_001635521
Trichoplax adhaerensXP_002113830XP_002113830XP_002113830XP_002113830XP_002110589XP_002110589XP_002113830XP_002113830XP_002110968
Monosiga brevicollisXP_001748540XP_001748540XP_001745303XP_001750093XP_001750851XP_001743515XP_001750093XP_001744965XP_001748540



Table S3: Target blast score for XP_005244805

XP_005244805 sp|O00468|AGRIN_HUMAN Agrin OS=Homo sapiens GN=AGRN PE=1 SV=5
.......FromHomo sapiens
XP_005244805
Pan troglodytes
XP_003319002
Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGF
Danio rerio
NP_001170923
Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGF
Drosophila melanogaster
CAB72284
Laminin_G_2, I-set, EGF, Ldl_recept_a, Laminin_G_1
Caenorhabditis elegans
T16859
Schistosoma mansoni
XP_002577398
Nematostella vectensis
XP_001627394
Laminin_G_2, I-set, hEGF, EGF, Laminin_G_1
Trichoplax adhaerens
XP_002113830
Laminin_G_2, Kazal_2, Laminin_G_1
Monosiga brevicollis
XP_001748540
hEGF, EGF_3, CUB, Laminin_EGF
Homo sapiens0003.95072e-1051.08195e-1023.55071e-597.05076e-1437.48601e-991.63245e-15
Pan troglodytes0001.26921e-613.22516e-1013.26742e-633.47454e-753.51847e-1001.55651e-17
Danio rerio0007.23821e-1066.60065e-1019.36677e-561.70962e-1468.30356e-1014.26141e-60
Drosophila melanogaster6.35631e-649.46874e-668.40694e-5409.57986e-229.26996e-185.37604e-1015.57419e-633.89373e-44
Caenorhabditis elegans3.32907e-1066.77238e-1052.00373e-1031.088e-2801.32867e-788.49454e-311.90961e-228.3075e-13
Schistosoma mansoni1.3946e-632.32225e-632.22726e-565.07416e-275.80119e-6705.30929e-315.93937e-438.87542e-22
Nematostella vectensis7.30293e-729.45553e-732.62103e-766.81401e-1005.01599e-601.73124e-4104.7895e-671.61458e-58
Trichoplax adhaerens5.72479e-952.13717e-1003.08793e-1011.55368e-533.84912e-221.80499e-152.39627e-6005.58269e-20
Monosiga brevicollis3.77036e-063.6625e-067.78652e-091.2835e-052.36439e-147.87909e-071.15833e-082.76223e-150


Table S4: Comparative domain composition for XP_005244805

XP_005244805 sp|O00468|AGRIN_HUMAN Agrin OS=Homo sapiens GN=AGRN PE=1 SV=5
.......FromHomo sapiens
XP_005244805
Pan troglodytes
XP_003319002
Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_G_1 (3), Laminin_EGF (2)
Danio rerio
NP_001170923
Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), SEA (1), Laminin_G_1 (3), Laminin_EGF (2)
Drosophila melanogaster
CAB72284
Laminin_G_2 (2), I-set (1), EGF (1), Ldl_recept_a (1), Laminin_G_1 (1)
Caenorhabditis elegans
T16859
Schistosoma mansoni
XP_002577398
Nematostella vectensis
XP_001627394
Laminin_G_2 (2), I-set (1), hEGF (1), EGF (3), Laminin_G_1 (1)
Trichoplax adhaerens
XP_002113830
Laminin_G_2 (5), Kazal_2 (2), Laminin_G_1 (1)
Monosiga brevicollis
XP_001748540
hEGF (1), EGF_3 (1), CUB (2), Laminin_EGF (3)
Homo sapiens



Laminin_G_2 (1), EGF (1), hEGF (2), I-set (15), Laminin_G_1 (2)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)


Laminin_G_2 (1), EGF (1), hEGF (2), I-set (15), Laminin_G_1 (2)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Pan troglodytes
Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)


Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Danio rerio
Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), SEA (1), Laminin_EGF (2), Laminin_G_1 (3)

Laminin_G_2 (1), EGF (2), hEGF (1), I-set (12), Laminin_B (3), Ldl_recept_a (4), Laminin_EGF (9), Laminin_G_1 (2)

Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), Laminin_EGF (2), Laminin_G_1 (3), SEA (1)

Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), Laminin_EGF (2), Laminin_G_1 (3), SEA (1)

Laminin_G_2 (1), EGF (2), hEGF (1), I-set (12), Laminin_B (3), Ldl_recept_a (4), Laminin_EGF (9), Laminin_G_1 (2)

Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), Laminin_EGF (2), Laminin_G_1 (3), SEA (1)

Drosophila melanogaster
Laminin_G_2 (2), EGF (1), I-set (1), Ldl_recept_a (1), Laminin_G_1 (1)

Laminin_G_2 (2), EGF (1), I-set (1), Ldl_recept_a (1), Laminin_G_1 (1)

Laminin_G_2 (2), EGF (1), Laminin_G_1 (1)

Laminin_G_2 (2), EGF (1), I-set (1), Ldl_recept_a (1), Laminin_G_1 (1)

Kazal_2 (6), Kazal_1 (3)

Kazal_2 (6), Kazal_1 (3)

Laminin_G_2 (2), EGF (1), I-set (1), Ldl_recept_a (1), Laminin_G_1 (1)

Laminin_G_2 (3), EGF (1)

C_tripleX (26)
Caenorhabditis elegans



Laminin_G_2 (3), I-set (4), Laminin_B (2), Ldl_recept_a (3), Laminin_EGF (7)


Kazal_2 (5), Laminin_G_2 (2), Kazal_1 (3), Laminin_EGF (2)

Laminin_G_2 (3), I-set (4), Laminin_B (2), Ldl_recept_a (3), Laminin_EGF (7)

Laminin_G_2 (3)

Schistosoma mansoni

Kazal_2 (8), Laminin_G_2 (2), Laminin_EGF (2)



Kazal_2 (8), Laminin_G_2 (2), Laminin_EGF (2)


Laminin_G_2 (2), EGF (2)


hEGF (2), EGF_CA (8)
Nematostella vectensis
Laminin_G_2 (2), EGF (3), hEGF (1), I-set (1), Laminin_G_1 (1)

Laminin_G_2 (2), EGF (3), hEGF (1), I-set (1), Laminin_G_1 (1)

Laminin_G_2 (2), EGF (3), hEGF (1), I-set (1), Laminin_G_1 (1)

Laminin_G_2 (2), EGF (3), hEGF (1), I-set (1), Laminin_G_1 (1)

Kazal_2 (7), Kazal_1 (2)

Kazal_2 (7), Kazal_1 (2)

Laminin_G_2 (2), EGF (3), hEGF (1), I-set (1), Laminin_G_1 (1)

Laminin_G_2 (3)

PSI (1), CUB (1), Laminin_EGF (3), EGF_CA (1)
Trichoplax adhaerens
Kazal_2 (2), Laminin_G_2 (5), Laminin_G_1 (1)

Kazal_2 (2), Laminin_G_2 (5), Laminin_G_1 (1)

Kazal_2 (2), Laminin_G_2 (5), Laminin_G_1 (1)

Kazal_2 (2), Laminin_G_2 (5), Laminin_G_1 (1)

Kazal_2 (3)

Kazal_2 (3)

Kazal_2 (2), Laminin_G_2 (5), Laminin_G_1 (1)

Kazal_2 (2), Laminin_G_2 (5), Laminin_G_1 (1)

EGF_3 (6), cEGF (1), EGF_CA (11)
Monosiga brevicollis
EGF_3 (1), hEGF (1), CUB (2), Laminin_EGF (3)

EGF_3 (1), hEGF (1), CUB (2), Laminin_EGF (3)

hEGF (1), CUB (2), Laminin_EGF (3)

EGF (6), hEGF (1), Y_phosphatase (1)

Cadherin (20), Laminin_EGF (4), Y_phosphatase (1)

Laminin_N (1), Laminin_EGF (3)

EGF (6), hEGF (1), Y_phosphatase (1)

Laminin_G_2 (1), Laminin_G_1 (1), Lectin_C (1)

EGF_3 (1), hEGF (1), CUB (2), Laminin_EGF (3)



Tree S1: Tree for XP_005244805

XP_001750851 Cadherin, Y_phosphatase, Laminin_EGFXP 001750851 MB Ce XP_001743515 Laminin_N, Laminin_EGFXP 001743515 MB Sm XP_001748540 hEGF, EGF_3, CUB, Laminin_EGFXP 001748540 MB Hs Pt XP_001745303 hEGF, CUB, Laminin_EGFXP 001745303 MB Dr T27283 T27283 CE Mb XP_003314768 XP 003314768 PT Mb ADK20128 C_tripleXADK20128 DM Mb XP_001750093 hEGF, EGF, Y_phosphataseXP 001750093 MB Dm Nv EAW88241 EAW88241 HS Mb XP_002575252 hEGF, EGF_CAXP 002575252 SM Mb XP_002110968 cEGF, EGF_3, EGF_CAXP 002110968 TA Mb XP_001635521 PSI, CUB, Laminin_EGF, EGF_CAXP 001635521 NV Mb XP_005158088 XP 005158088 DR Mb XP_002572665 XP 002572665 SM Dm Ta CCD81767 Laminin_G_2, EGFCCD81767 SM Nv XP_001638936 Laminin_G_2XP 001638936 NV Ta AAF63502 Laminin_G_2, EGFAAF63502 DM Ta XP_002113830 Laminin_G_2, Kazal_2, Laminin_G_1XP 002113830 TA Hs Pt Dr Dm Nv XP_003949370 XP 003949370 PT Nv BAD93088 Laminin_G_2, I-set, hEGF, EGF, Laminin_G_1BAD93088 HS Dm Nv DAA06181 Laminin_G_2, I-set, hEGF, EGF, Ldl_recept_a, Laminin_B, Laminin_G_1, Laminin_EGFDAA06181 DR Dm Nv XP_001627394 Laminin_G_2, I-set, hEGF, EGF, Laminin_G_1XP 001627394 NV Hs Pt Dr Dm NP_497044 Laminin_G_2, I-set, Ldl_recept_a, Laminin_B, Laminin_EGFNP 497044 CE Dm Nv CAB70094 Laminin_G_2, EGF, Laminin_G_1CAB70094 DM Dr CAB72284 Laminin_G_2, I-set, EGF, Ldl_recept_a, Laminin_G_1CAB72284 DM Hs Pt Nv NP_001254438 Laminin_G_2NP 001254438 CE Ta XP_001744965 Lectin_C, Laminin_G_2, Laminin_G_1XP 001744965 MB Ta XP_005244805 XP 005244805 HS Pt XP_005244806 XP 005244806 HS Dr NP_940978 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFNP 940978 HS Ta AAC39776 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFAAC39776 HS Ce EAW56293 EAW56293 HS Sm XP_003319002 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFXP 003319002 PT Hs Dr Dm Ce Sm Ta NP_001170923 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFNP 001170923 DR Hs Pt Ce Sm Ta XP_002110589 Kazal_2XP 002110589 TA Ce Sm NP_729380 Kazal_2, Kazal_1NP 729380 DM Ce Sm CCD59852 Laminin_G_2, Kazal_2, Laminin_EGFCCD59852 SM Pt Ce XP_002577398 XP 002577398 SM Hs Dr XP_001632449 Kazal_2, Kazal_1XP 001632449 NV Ce Sm NP_001022152 Laminin_G_2, Kazal_2, Kazal_1, Laminin_EGFNP 001022152 CE Sm T16859 T16859 CE Hs Pt Dr
((NP_729380_DM_Ce_Sm:1.18485,((NP_001170923_DR_Hs_Pt_Ce_Sm_Ta:0.29193,(((((XP_005244806_HS_Dr:0.00014,XP_005244805_HS_Pt:0.00014):0.00014,NP_940978_HS_Ta:0.00016):0.01193,((((XP_002113830_TA_Hs_Pt_Dr_Dm_Nv:0.86090,((CCD81767_SM_Nv:0.00015,XP_002572665_SM_Dm_Ta:0.00014):0.86316,(AAF63502_DM_Ta:0.80399,XP_001638936_NV_Ta:0.63237):0.15574):0.15051):0.19214,((XP_002110968_TA_Mb:0.54197,((XP_002575252_SM_Mb:1.02860,(EAW88241_HS_Mb:0.49265,XP_001750093_MB_Dm_Nv:0.43325):0.22282):0.39756,((ADK20128_DM_Mb:1.00675,(XP_003314768_PT_Mb:0.61202,T27283_CE_Mb:0.70374):0.18474):0.27612,((XP_001743515_MB_Sm:0.57434,XP_001750851_MB_Ce:0.70117):0.62523,(XP_001745303_MB_Dr:0.81361,XP_001748540_MB_Hs_Pt:0.20375):0.11180):0.84623):0.30697):0.45227):0.68690,(XP_005158088_DR_Mb:0.80338,XP_001635521_NV_Mb:0.35627):2.22242):0.56125):0.06091,((((DAA06181_DR_Dm_Nv:0.31749,(BAD93088_HS_Dm_Nv:0.00014,XP_003949370_PT_Nv:0.00391):0.26512):0.38418,(NP_497044_CE_Dm_Nv:1.61698,XP_001627394_NV_Hs_Pt_Dr_Dm:0.76336):0.05412):0.18861,(CAB72284_DM_Hs_Pt_Nv:0.00016,CAB70094_DM_Dr:0.00014):0.91701):0.16380,NP_001254438_CE_Ta:1.24144):0.09526):0.20927,XP_001744965_MB_Ta:1.33900):0.60682):0.03131,(EAW56293_HS_Sm:0.00014,AAC39776_HS_Ce:0.00014):0.00101):0.00014,XP_003319002_PT_Hs_Dr_Dm_Ce_Sm_Ta:0.00426):0.36025):0.48176,XP_002110589_TA_Ce_Sm:1.13476):0.11682):0.24694,(T16859_CE_Hs_Pt_Dr:0.00014,NP_001022152_CE_Sm:0.00014):0.74309,((XP_002577398_SM_Hs_Dr:0.0,CCD59852_SM_Pt_Ce:0.0):0.92885,XP_001632449_NV_Ce_Sm:0.78292):0.24757);

Up
Table S1: Best blast for NP_000741 in each species
Homo sapiensNP_000741 neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor [Homo sapiens] >gi|2506129|sp|P30926.2|ACHB4_HUMAN RecName: Full=Neuronal acetylcholine receptor subunit beta-4; Flags: Precursor >gi|1224054|gb|AAA92123.1| beta 4 nicotinic acetylcholine receptor subunit [Homo sapiens] >gi|1458126|gb|AAB40117.1| nicotinic acetylcholine receptor beta4 subunit precursor [Homo sapiens] >gi|1702920|emb|CAA69693.1| nicotinic acetylcholine receptor beta4 subunit precursor [Homo sapiens] >gi|15558965|gb|AAL02062.1| neuronal nicotinic acetylcholine receptor beta 4 subunit [Homo sapiens] >gi|64654089|gb|AAH96082.1| Cholinergic receptor, nicotinic, beta 4 [Homo sapiens] >gi|64654633|gb|AAH96080.1| Cholinergic receptor, nicotinic, beta 4 [Homo sapiens]0
Pan troglodytesXP_510529 PREDICTED: neuronal acetylcholine receptor subunit beta-4 [Pan troglodytes]0
Danio rerioXP_696993 PREDICTED: neuronal acetylcholine receptor subunit beta-4-like [Danio rerio]0
Drosophila melanogasterNP_524481 nicotinic acetylcholine receptor alpha 96Aa, isoform A [Drosophila melanogaster] >gi|442620902|ref|NP_001262917.1| nicotinic acetylcholine receptor alpha 96Aa, isoform C [Drosophila melanogaster] >gi|30581035|sp|P09478.2|ACH1_DROME RecName: Full=Acetylcholine receptor subunit alpha-like 1; Flags: Precursor >gi|23172169|gb|AAF56301.2| nicotinic acetylcholine receptor alpha 96Aa, isoform A [Drosophila melanogaster] >gi|440217843|gb|AGB96297.1| nicotinic acetylcholine receptor alpha 96Aa, isoform C [Drosophila melanogaster]2.84989e-106
Caenorhabditis elegansNP_491472 Protein UNC-38 [Caenorhabditis elegans] >gi|2492621|sp|Q23022.1|ACH5_CAEEL RecName: Full=Acetylcholine receptor subunit alpha-type unc-38; AltName: Full=Uncoordinated protein 38; Flags: Precursor >gi|1731934|emb|CAA67197.1| alpha nicotinic acetylcholine receptor subunit [Caenorhabditis elegans] >gi|1731963|emb|CAA67196.1| alpha nicotinic acetylcholine receptor subunit [Caenorhabditis elegans] >gi|351061944|emb|CCD69819.1| Protein UNC-38 [Caenorhabditis elegans]1.91244e-104
Schistosoma mansoniCCD81092 nAChR subunit (ShAR1-alpha-like) [Schistosoma mansoni]3.61069e-62
Nematostella vectensisXP_001634117 predicted protein [Nematostella vectensis] >gi|156221196|gb|EDO42054.1| predicted protein [Nematostella vectensis]1.0901e-76
Trichoplax adhaerensXP_002115855 hypothetical protein TRIADDRAFT_59701 [Trichoplax adhaerens] >gi|190581631|gb|EDV21707.1| hypothetical protein TRIADDRAFT_59701 [Trichoplax adhaerens]1.91465
Monosiga brevicollisXP_001744686 hypothetical protein [Monosiga brevicollis MX1] >gi|163777017|gb|EDQ90635.1| predicted protein [Monosiga brevicollis MX1]2.36582e-07

Table S2: Target IDs for NP_000741

NP_000741 sp|P30926|ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 OS=Homo sapiens GN=CHRNB4 PE=1 SV=2
.......FromHomo sapiens
NP_000741
Neur_chan_memb, Neur_chan_LBD
Pan troglodytes
XP_510529
Danio rerio
XP_696993
Neur_chan_memb, Neur_chan_LBD
Drosophila melanogaster
NP_524481
Neur_chan_memb, Neur_chan_LBD
Caenorhabditis elegans
NP_491472
Neur_chan_memb, Neur_chan_LBD
Schistosoma mansoni
CCD81092
Neur_chan_memb, Neur_chan_LBD
Nematostella vectensis
XP_001634117
Neur_chan_memb, Neur_chan_LBD
Trichoplax adhaerens
XP_002115855
Tetraspannin
Monosiga brevicollis
XP_001744686
Neur_chan_LBD
Homo sapiensNP_000741NP_000741NP_000739NP_000733AAC84176NP_000737CAA49778XP_005253318CAA05108
Pan troglodytesXP_510529XP_510529XP_001152392NP_001029107XP_003314857XP_001164138XP_001164138XP_001137973XP_003313358
Danio rerioXP_696993XP_001343044XP_696993XP_005160540NP_001035417CAE49579AAI62599NP_001006041XP_700338
Drosophila melanogasterNP_524481NP_524483NP_524481NP_524481NP_524481NP_723494CAD86936NP_511054NP_001262234
Caenorhabditis elegansNP_491472NP_491472NP_491533NP_491533NP_491472NP_001023847NP_001023847NP_492636NP_501715
Schistosoma mansoniCCD81092CCD82321CCD81092XP_002577842XP_002577842CCD81092CCD81092XP_002572809XP_002570554
Nematostella vectensisXP_001634117XP_001634117XP_001634102XP_001634101XP_001634135XP_001634117XP_001634117XP_001639760XP_001630277
Trichoplax adhaerensXP_002115855XP_002111826XP_002116376XP_002110503XP_002110143no hitXP_002112951XP_002115855no hit
Monosiga brevicollisXP_001744686XP_001744686XP_001744686XP_001744686XP_001744686XP_001744686XP_001750950XP_001742944XP_001744686



Table S3: Target blast score for NP_000741

NP_000741 sp|P30926|ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 OS=Homo sapiens GN=CHRNB4 PE=1 SV=2
.......FromHomo sapiens
NP_000741
Neur_chan_memb, Neur_chan_LBD
Pan troglodytes
XP_510529
Danio rerio
XP_696993
Neur_chan_memb, Neur_chan_LBD
Drosophila melanogaster
NP_524481
Neur_chan_memb, Neur_chan_LBD
Caenorhabditis elegans
NP_491472
Neur_chan_memb, Neur_chan_LBD
Schistosoma mansoni
CCD81092
Neur_chan_memb, Neur_chan_LBD
Nematostella vectensis
XP_001634117
Neur_chan_memb, Neur_chan_LBD
Trichoplax adhaerens
XP_002115855
Tetraspannin
Monosiga brevicollis
XP_001744686
Neur_chan_LBD
Homo sapiens0003.3561e-1083.72268e-1121.05724e-1068.67306e-1073.25391e-221.58565e-09
Pan troglodytes0007.09847e-1101.41538e-1123.35113e-1091.21715e-1092.07023e-237.87952e-14
Danio rerio0001.0716e-1082.19327e-991.12371e-1032.74394e-1052.48588e-237.11468e-13
Drosophila melanogaster2.84989e-1064.0122e-1114.64867e-11301.07624e-1231.15346e-1121.62245e-1102.41753e-144.53051e-10
Caenorhabditis elegans1.91244e-1045.41686e-975.75907e-1191.60437e-14408.4811e-1035.15284e-883.00229e-121.36822e-14
Schistosoma mansoni1.45873e-632.69479e-591.76335e-741.42718e-701.25667e-6501.92012e-891.10142e-191.27038e-15
Nematostella vectensis1.0901e-761.60138e-701.4071e-772.24819e-752.60332e-716.23316e-8807.18395e-214.29018e-14
Trichoplax adhaerens1.914654.970280.4341271.089670.850368no hit4.334611.84811e-167no hit
Monosiga brevicollis2.36582e-077.11558e-073.22673e-080.008528980.01352511.84399e-081.71637e-055.662180


Table S4: Comparative domain composition for NP_000741

NP_000741 sp|P30926|ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 OS=Homo sapiens GN=CHRNB4 PE=1 SV=2
Neur_chan_memb (1), Neur_chan_LBD (1)
.......FromHomo sapiens
NP_000741
Neur_chan_memb (1), Neur_chan_LBD (1)
Pan troglodytes
XP_510529
Danio rerio
XP_696993
Neur_chan_memb (1), Neur_chan_LBD (1)
Drosophila melanogaster
NP_524481
Neur_chan_memb (1), Neur_chan_LBD (1)
Caenorhabditis elegans
NP_491472
Neur_chan_memb (1), Neur_chan_LBD (1)
Schistosoma mansoni
CCD81092
Neur_chan_memb (1), Neur_chan_LBD (1)
Nematostella vectensis
XP_001634117
Neur_chan_memb (2), Neur_chan_LBD (1)
Trichoplax adhaerens
XP_002115855
Tetraspannin (1)
Monosiga brevicollis
XP_001744686
Neur_chan_LBD (1)
Homo sapiens
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
n.a.
Neur_chan_LBD (0), Neur_chan_memb (0)
Pan troglodytesn.a.n.a.
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
n.a.n.a.n.a.n.a.n.a.
Danio rerio
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_LBD (0), Neur_chan_memb (0)
n.a.
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Tetraspannin (1)
n.a.
Drosophila melanogaster
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Tetraspannin (1)
n.a.
Caenorhabditis elegans
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Tetraspannin (1)

Neur_chan_LBD (0), Neur_chan_memb (0)
Schistosoma mansoni
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
n.a.n.a.
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
n.a.
Neur_chan_LBD (0), Neur_chan_memb (0)
Nematostella vectensis
Neur_chan_LBD (0), Neur_chan_memb (1)

Neur_chan_LBD (0), Neur_chan_memb (1)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (1)

Neur_chan_LBD (0), Neur_chan_memb (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Tetraspannin (1)

Neur_chan_LBD (0), Neur_chan_memb (0)
Trichoplax adhaerens
Neur_chan_memb (-1), Neur_chan_LBD (-1)Tetraspannin (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)7tm_3 (1), ANF_receptor (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)PRT_C (1), C2 (3)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Peptidase_M14 (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)NUC194 (1), FAT (1), PI3_PI4_kinase (1), FATC (1)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)Cadherin (21)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Tetraspannin (1)
no hit
Monosiga brevicollis
Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Ank_2 (2)

Neur_chan_LBD (0)Neur_chan_memb (-1)



Tree S1: Tree for NP_000741

XP_696993 Neur_chan_memb, Neur_chan_LBDXP 696993 DR Hs XP_002116376 PRT_C, C2XP 002116376 TA Dr XP_002111826 7tm_3, ANF_receptorXP 002111826 TA Pt XP_510529 n.a.XP 510529 PT Hs NP_000741 Neur_chan_memb, Neur_chan_LBDNP 000741 HS Pt XP_001152392 Neur_chan_memb, Neur_chan_LBDXP 001152392 PT Dr NP_000739 Neur_chan_memb, Neur_chan_LBDNP 000739 HS Dr CAA05108 Neur_chan_memb, Neur_chan_LBDCAA05108 HS Mb XP_001343044 XP 001343044 DR Pt XP_002110143 PI3_PI4_kinase, NUC194, FATC, FATXP 002110143 TA Ce NP_000733 Neur_chan_memb, Neur_chan_LBDNP 000733 HS Dm NP_001029107 Neur_chan_memb, Neur_chan_LBDNP 001029107 PT Dm XP_005160540 n.a.XP 005160540 DR Dm NP_001035417 Neur_chan_memb, Neur_chan_LBDNP 001035417 DR Ce XP_003314857 n.a.XP 003314857 PT Ce AAC84176 Neur_chan_memb, Neur_chan_LBDAAC84176 HS Ce NP_524483 Neur_chan_memb, Neur_chan_LBDNP 524483 DM Pt NP_001262234 n.a.NP 001262234 DM Mb NP_524481 Neur_chan_memb, Neur_chan_LBDNP 524481 DM Hs Dr Ce NP_491472 Neur_chan_memb, Neur_chan_LBDNP 491472 CE Hs Pt NP_491533 Neur_chan_memb, Neur_chan_LBDNP 491533 CE Dr Dm CCD82321 Neur_chan_memb, Neur_chan_LBDCCD82321 SM Pt XP_002577842 n.a.XP 002577842 SM Dm Ce XP_002112951 CadherinXP 002112951 TA Nv XP_002110503 Peptidase_M14XP 002110503 TA Dm XP_001137973 n.a.XP 001137973 PT Ta XP_005253318 n.a.XP 005253318 HS Ta NP_001006041 TetraspanninNP 001006041 DR Ta NP_492636 TetraspanninNP 492636 CE Ta NP_511054 TetraspanninNP 511054 DM Ta XP_002115855 TetraspanninXP 002115855 TA Hs XP_002572809 n.a.XP 002572809 SM Ta XP_001639760 TetraspanninXP 001639760 NV Ta XP_700338 n.a.XP 700338 DR Mb XP_003313358 n.a.XP 003313358 PT Mb NP_501715 Neur_chan_memb, Neur_chan_LBDNP 501715 CE Mb XP_002570554 Neur_chan_memb, Neur_chan_LBDXP 002570554 SM Mb XP_001630277 Neur_chan_memb, Neur_chan_LBDXP 001630277 NV Mb XP_001750950 SAM_1, Neur_chan_LBDXP 001750950 MB Nv XP_001744686 Neur_chan_LBDXP 001744686 MB Hs Pt Dr Dm Ce Sm XP_001742944 Ank_2XP 001742944 MB Ta XP_001634101 Neur_chan_memb, Neur_chan_LBDXP 001634101 NV Dm XP_001634135 Neur_chan_memb, Neur_chan_LBDXP 001634135 NV Ce XP_001634102 Neur_chan_memb, Neur_chan_LBDXP 001634102 NV Dr XP_001634117 Neur_chan_memb, Neur_chan_LBDXP 001634117 NV Hs Pt Sm NP_001023847 Neur_chan_memb, Neur_chan_LBDNP 001023847 CE Sm Nv NP_000737 Neur_chan_memb, Neur_chan_LBDNP 000737 HS Sm XP_001164138 n.a.XP 001164138 PT Sm Nv CAA49778 Neur_chan_memb, Neur_chan_LBDCAA49778 HS Nv CAE49579 Neur_chan_memb, Neur_chan_LBDCAE49579 DR Sm AAI62599 Neur_chan_memb, Neur_chan_LBDAAI62599 DR Nv NP_723494 Neur_chan_memb, Neur_chan_LBDNP 723494 DM Sm CAD86936 Neur_chan_memb, Neur_chan_LBDCAD86936 DM Nv CCD81092 Neur_chan_memb, Neur_chan_LBDCCD81092 SM Hs Dr Nv
(((((XP_001634117_NV_Hs_Pt_Sm:0.58972,((XP_001634101_NV_Dm:0.41075,XP_001742944_MB_Ta:3.21580):0.19679,(XP_001634102_NV_Dr:0.67339,XP_001634135_NV_Ce:0.37888):0.08428):0.21836):0.18992,(((XP_001639760_NV_Ta:0.58856,((XP_002572809_SM_Ta:0.65079,XP_002115855_TA_Hs:0.22102):0.42204,((NP_511054_DM_Ta:0.81190,NP_492636_CE_Ta:1.08370):0.46321,(NP_001006041_DR_Ta:0.12168,(XP_005253318_HS_Ta:0.20171,XP_001137973_PT_Ta:0.32329):0.15808):0.24746):0.12672):0.05989):3.64049,(XP_003313358_PT_Mb:0.16304,XP_700338_DR_Mb:0.12492):0.73861):0.26328,((XP_001630277_NV_Mb:0.83011,(XP_002570554_SM_Mb:1.05192,NP_501715_CE_Mb:1.07854):0.31101):0.85686,(XP_001744686_MB_Hs_Pt_Dr_Dm_Ce_Sm:1.13952,XP_001750950_MB_Nv:1.54777):0.36976):0.67121):0.39233):0.17565,(((XP_002577842_SM_Dm_Ce:0.00014,CCD82321_SM_Pt:0.00014):0.32074,(XP_002110503_TA_Dm:1.07056,XP_002112951_TA_Nv:2.19200):0.97648):0.64947,(((NP_524481_DM_Hs_Dr_Ce:0.14283,(NP_001262234_DM_Mb:0.21676,NP_524483_DM_Pt:0.28603):0.09962):0.09770,(NP_491533_CE_Dr_Dm:0.33144,NP_491472_CE_Hs_Pt:0.44128):0.15692):0.18625,(((AAC84176_HS_Ce:0.00936,XP_003314857_PT_Ce:0.00332):0.31597,((NP_001029107_PT_Dm:0.00915,NP_000733_HS_Dm:0.00385):0.08870,(NP_001035417_DR_Ce:0.03124,XP_005160540_DR_Dm:0.02507):0.03666):0.14140):0.21267,((((CAA05108_HS_Mb:0.00014,(NP_000739_HS_Dr:0.0,XP_001152392_PT_Dr:0.0):0.00014):0.18173,(((XP_002116376_TA_Dr:2.52845,XP_696993_DR_Hs:0.05298):0.13849,XP_002111826_TA_Pt:1.89696):0.02750,(NP_000741_HS_Pt:0.01108,XP_510529_PT_Hs:0.00787):0.29552):0.04861):0.09306,XP_001343044_DR_Pt:0.14839):0.31014,XP_002110143_TA_Ce:2.78148):0.07888):0.07809):0.25100):0.11619):0.13353,NP_001023847_CE_Sm_Nv:0.47706):0.08581,((AAI62599_DR_Nv:0.00456,CAE49579_DR_Sm:0.00014):0.14716,((XP_001164138_PT_Sm_Nv:0.0,NP_000737_HS_Sm:0.0):0.00014,CAA49778_HS_Nv:0.00014):0.10307):0.40416,(CCD81092_SM_Hs_Dr_Nv:0.70357,(CAD86936_DM_Nv:0.15381,NP_723494_DM_Sm:0.14858):0.17092):0.08733);

Up
Table S1: Best blast for XP_005256549 in each species
Homo sapiensXP_005256549 PREDICTED: disks large homolog 4 isoform X4 [Homo sapiens] >gi|533172307|ref|XP_005399607.1| PREDICTED: disks large homolog 4 isoform X3 [Chinchilla lanigera] >gi|71658825|sp|P78352.3|DLG4_HUMAN RecName: Full=Disks large homolog 4; AltName: Full=Postsynaptic density protein 95; Short=PSD-95; AltName: Full=Synapse-associated protein 90; Short=SAP-90; Short=SAP90 >gi|168277798|dbj|BAG10877.1| discs large homolog 4 [synthetic construct] >gi|221039688|dbj|BAH11607.1| unnamed protein product [Homo sapiens]0
Pan troglodytesXP_523833 PREDICTED: disks large homolog 4 isoform 3 [Pan troglodytes]0
Danio rerioXP_001340947 PREDICTED: disks large homolog 4 [Danio rerio]0
Drosophila melanogasterNP_996404 discs large 1, isoform H [Drosophila melanogaster] >gi|45446906|gb|AAS65309.1| discs large 1, isoform H [Drosophila melanogaster]0
Caenorhabditis elegansNP_001024431 Protein DLG-1, isoform a [Caenorhabditis elegans] >gi|15529626|gb|AAL01376.1|AF406786_1 SAP97-like protein DLG-1 [Caenorhabditis elegans] >gi|13508723|emb|CAC35153.1| MAGUK protein DLG-1 [Caenorhabditis elegans] >gi|351058262|emb|CCD65680.1| Protein DLG-1, isoform a [Caenorhabditis elegans]2.29618e-156
Schistosoma mansoniXP_002579880 cell polarity protein [Schistosoma mansoni]6.39565e-97
Nematostella vectensisXP_001638123 predicted protein [Nematostella vectensis] >gi|156225241|gb|EDO46060.1| predicted protein [Nematostella vectensis]1.56687e-100
Trichoplax adhaerensXP_002108800 hypothetical protein TRIADDRAFT_63520 [Trichoplax adhaerens] >gi|190589576|gb|EDV29598.1| hypothetical protein TRIADDRAFT_63520 [Trichoplax adhaerens]0
Monosiga brevicollisXP_001743865 hypothetical protein [Monosiga brevicollis MX1] >gi|163777827|gb|EDQ91443.1| predicted protein [Monosiga brevicollis MX1]1.30897e-109

Table S2: Target IDs for XP_005256549

XP_005256549 sp|P78352|DLG4_HUMAN Disks large homolog 4 OS=Homo sapiens GN=DLG4 PE=1 SV=3
.......FromHomo sapiens
XP_005256549
Pan troglodytes
XP_523833
Danio rerio
XP_001340947
Drosophila melanogaster
NP_996404
SH3_1, PDZ, Guanylate_kin, L27_1
Caenorhabditis elegans
NP_001024431
PDZ, SH3_2, Guanylate_kin, L27_1
Schistosoma mansoni
XP_002579880
Nematostella vectensis
XP_001638123
SH3_2, Guanylate_kin
Trichoplax adhaerens
XP_002108800
SH3_1, PDZ, Guanylate_kin
Monosiga brevicollis
XP_001743865
SH3_1, PDZ, Guanylate_kin
Homo sapiensXP_005256549XP_005256549XP_005256546NP_001191315XP_005269359NP_066943XP_005269359XP_005273867BAG57959
Pan troglodytesXP_523833XP_523833XP_001168837XP_516979XP_516979XP_001175227XP_003313280XP_522127XP_001166132
Danio rerioXP_001340947XP_001340947XP_001340947XP_005163739XP_005163739XP_003199970XP_005165972XP_002663610XP_005163737
Drosophila melanogasterNP_996404NP_0010969553TVT_ANP_996404NP_9964043TVT_AAAL39553NP_001259448NP_001096955
Caenorhabditis elegansNP_001024431NP_001024431NP_001024431NP_001024431NP_001024431NP_001024431NP_001024431NP_001024431NP_001024431
Schistosoma mansoniXP_002579880XP_002579880XP_002579880CCD76115XP_002579880XP_002579880XP_002575789XP_002579880XP_002579880
Nematostella vectensisXP_001638123XP_001638123XP_001638123XP_001638123XP_001638123XP_001638123XP_001638123XP_001638123XP_001638123
Trichoplax adhaerensXP_002108800XP_002108800XP_002108800XP_002108800XP_002108800XP_002108800XP_002108800XP_002108800XP_002108800
Monosiga brevicollisXP_001743865XP_001743865XP_001743865XP_001743865XP_001743865XP_001743865XP_001743865XP_001743865XP_001743865



Table S3: Target blast score for XP_005256549

XP_005256549 sp|P78352|DLG4_HUMAN Disks large homolog 4 OS=Homo sapiens GN=DLG4 PE=1 SV=3
.......FromHomo sapiens
XP_005256549
Pan troglodytes
XP_523833
Danio rerio
XP_001340947
Drosophila melanogaster
NP_996404
SH3_1, PDZ, Guanylate_kin, L27_1
Caenorhabditis elegans
NP_001024431
PDZ, SH3_2, Guanylate_kin, L27_1
Schistosoma mansoni
XP_002579880
Nematostella vectensis
XP_001638123
SH3_2, Guanylate_kin
Trichoplax adhaerens
XP_002108800
SH3_1, PDZ, Guanylate_kin
Monosiga brevicollis
XP_001743865
SH3_1, PDZ, Guanylate_kin
Homo sapiens00005.40986e-1612.23634e-787.31078e-1573.23407e-1451.79315e-110
Pan troglodytes00002.38081e-1604.66248e-803.84301e-1611.08585e-1443.89928e-111
Danio rerio00006.66733e-1637.233e-767.13281e-1613.495e-1451.18585e-111
Drosophila melanogaster006.26351e-135001.01516e-526.54438e-1171.58221e-1341.21328e-93
Caenorhabditis elegans2.29618e-1561.16629e-1551.13558e-1453.95863e-16204.63452e-483.64244e-885.23715e-1121.60862e-97
Schistosoma mansoni6.39565e-973.02759e-966.69228e-901.16466e-596.75076e-5003.86497e-491.62691e-497.86273e-44
Nematostella vectensis1.01154e-1029.88065e-1039.56919e-1047.67364e-1628.37583e-935.84624e-5206.85965e-1201.95213e-54
Trichoplax adhaerens0001.11539e-1335.373e-1133.83307e-582.16809e-7204.96414e-85
Monosiga brevicollis1.30897e-1096.78532e-1091.3394e-1031.83275e-911.50636e-832.86945e-351.18312e-488.07332e-820


Table S4: Comparative domain composition for XP_005256549

XP_005256549 sp|P78352|DLG4_HUMAN Disks large homolog 4 OS=Homo sapiens GN=DLG4 PE=1 SV=3
.......FromHomo sapiens
XP_005256549
Pan troglodytes
XP_523833
Danio rerio
XP_001340947
Drosophila melanogaster
NP_996404
SH3_1 (1), PDZ (3), Guanylate_kin (1), L27_1 (1)
Caenorhabditis elegans
NP_001024431
PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)
Schistosoma mansoni
XP_002579880
Nematostella vectensis
XP_001638123
SH3_2 (1), Guanylate_kin (1)
Trichoplax adhaerens
XP_002108800
SH3_1 (1), PDZ (3), Guanylate_kin (2)
Monosiga brevicollis
XP_001743865
SH3_1 (1), PDZ (3), Guanylate_kin (1)
Homo sapiens

n.a.
PDZ (3), MAGUK_N_PEST (1), PDZ_assoc (1), SH3_2 (1), Guanylate_kin (1), L27_1 (1)
n.a.
PDZ (3), MAGUK_N_PEST (1), PDZ_assoc (1), SH3_1 (1), Guanylate_kin (1)
n.a.n.a.
PDZ (3), MAGUK_N_PEST (1), PDZ_assoc (1), SH3_2 (1), Guanylate_kin (1), L27_1 (1)
Pan troglodytesn.a.n.a.
n.a.n.a.
n.a.n.a.n.a.
Danio rerion.a.n.a.n.a.n.a.n.a.
n.a.n.a.n.a.
Drosophila melanogaster
PDZ (3), SH3_1 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1), L27_1 (1)
n.a.
PDZ (3), SH3_1 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1), L27_1 (1)
n.a.
PDZ (3), SH3_1 (1), Guanylate_kin (1), L27_1 (1)
n.a.
PDZ (3), SH3_1 (1), Guanylate_kin (1), L27_1 (1)
Caenorhabditis elegans
PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)

PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)
Schistosoma mansonin.a.n.a.n.a.
PDZ (3), SH3_2 (1), Guanylate_kin (1), L27_1 (1)
n.a.n.a.n.a.n.a.n.a.
Nematostella vectensis
SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)

SH3_2 (1), Guanylate_kin (1)
Trichoplax adhaerens
PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)

PDZ (3), SH3_1 (1), Guanylate_kin (2)
Monosiga brevicollis
PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)

PDZ (3), SH3_1 (1), Guanylate_kin (1)



Tree S1: Tree for XP_005256549

XP_002579880 n.a.XP 002579880 SM Hs Pt Dr Ce Ta Mb CCD76115 PDZ, SH3_2, Guanylate_kin, L27_1CCD76115 SM Dm XP_002575789 n.a.XP 002575789 SM Nv NP_001024431 PDZ, SH3_2, Guanylate_kin, L27_1NP 001024431 CE Hs Pt Dr Dm Sm Nv Ta Mb XP_001743865 SH3_1, PDZ, Guanylate_kinXP 001743865 MB Hs Pt Dr Dm Ce Sm Nv Ta XP_001638123 SH3_2, Guanylate_kinXP 001638123 NV Hs Pt Dr Dm Ce Sm Ta Mb XP_002108800 SH3_1, PDZ, Guanylate_kinXP 002108800 TA Hs Pt Dr Dm Ce Sm Nv Mb NP_001096955 SH3_1, PDZ, Guanylate_kin, L27_1NP 001096955 DM Pt Mb NP_996404 SH3_1, PDZ, Guanylate_kin, L27_1NP 996404 DM Hs Ce NP_001259448 n.a.NP 001259448 DM Ta 3TVT_A n.a.3TVT A DM Dr Sm AAL39553 SH3_1, PDZ, Guanylate_kin, L27_1AAL39553 DM Nv XP_522127 n.a.XP 522127 PT Ta XP_005273867 n.a.XP 005273867 HS Ta XP_003313280 n.a.XP 003313280 PT Nv XP_001175227 XP 001175227 PT Sm XP_002663610 n.a.XP 002663610 DR Ta NP_066943 SH3_1, PDZ, MAGUK_N_PEST, PDZ_assoc, Guanylate_kinNP 066943 HS Sm XP_003199970 XP 003199970 DR Sm XP_523833 n.a.XP 523833 PT Hs XP_005256549 XP 005256549 HS Pt XP_001168837 XP 001168837 PT Dr XP_005256546 n.a.XP 005256546 HS Dr XP_001340947 n.a.XP 001340947 DR Hs Pt XP_005163737 n.a.XP 005163737 DR Mb XP_005163739 n.a.XP 005163739 DR Dm Ce XP_005165972 n.a.XP 005165972 DR Nv NP_001191315 PDZ, MAGUK_N_PEST, SH3_2, PDZ_assoc, Guanylate_kin, L27_1NP 001191315 HS Dm XP_516979 n.a.XP 516979 PT Dm Ce BAG57959 PDZ, MAGUK_N_PEST, SH3_2, PDZ_assoc, Guanylate_kin, L27_1BAG57959 HS Mb XP_001166132 n.a.XP 001166132 PT Mb XP_005269359 n.a.XP 005269359 HS Ce Nv
((XP_001166132_PT_Mb:0.00013,BAG57959_HS_Mb:0.00141):0.01295,XP_005269359_HS_Ce_Nv:0.00014,((((XP_001340947_DR_Hs_Pt:0.12465,((XP_005256549_HS_Pt:0.00015,XP_523833_PT_Hs:0.00545):0.00374,(XP_005256546_HS_Dr:0.00015,XP_001168837_PT_Dr:0.00535):0.00735):0.06524):0.16604,(((AAL39553_DM_Nv:0.00014,(3TVT_A_DM_Dr_Sm:0.00014,(NP_001259448_DM_Ta:0.00014,(NP_996404_DM_Hs_Ce:0.00014,NP_001096955_DM_Pt_Mb:0.00014):0.00016):0.00015):0.00015):0.39225,(((XP_002575789_SM_Nv:0.91419,(CCD76115_SM_Dm:0.01951,XP_002579880_SM_Hs_Pt_Dr_Ce_Ta_Mb:0.02042):0.89333):0.24463,(XP_001743865_MB_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Ta:1.24994,NP_001024431_CE_Hs_Pt_Dr_Dm_Sm_Nv_Ta_Mb:0.51338):0.14107):0.10010,(XP_002108800_TA_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Mb:0.62525,XP_001638123_NV_Hs_Pt_Dr_Dm_Ce_Sm_Ta_Mb:0.11454):0.03198):0.03680):0.16789,((XP_003199970_DR_Sm:0.06110,NP_066943_HS_Sm:0.02290):0.16321,(XP_002663610_DR_Ta:0.04718,((XP_005273867_HS_Ta:0.0,XP_522127_PT_Ta:0.0):0.00014,(XP_001175227_PT_Sm:0.00016,XP_003313280_PT_Nv:0.00014):0.00677):0.06530):0.04956):0.05499):0.03813):0.02283,(XP_005165972_DR_Nv:0.08909,(XP_005163739_DR_Dm_Ce:0.00014,XP_005163737_DR_Mb:0.01463):0.05720):0.02636):0.04961,(XP_516979_PT_Dm_Ce:0.00131,NP_001191315_HS_Dm:0.00014):0.00140):0.00134);

Up
Table S1: Best blast for NP_619635 in each species
Homo sapiensNP_619635 glutamate receptor ionotropic, NMDA 3B precursor [Homo sapiens] >gi|71153527|sp|O60391.2|NMD3B_HUMAN RecName: Full=Glutamate receptor ionotropic, NMDA 3B; Short=GluN3B; AltName: Full=N-methyl-D-aspartate receptor subtype 3B; Short=NMDAR3B; Short=NR3B; Flags: Precursor >gi|59891574|tpg|DAA04570.1| TPA_exp: NMDA receptor 3B subunit [Homo sapiens] >gi|162317684|gb|AAI56391.1| Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B [synthetic construct]0
Pan troglodytesBAI22785 glutamate receptor, ionotropic, N-methyl D-aspartate 3B [Pan troglodytes]0
Danio rerioXP_002663775 PREDICTED: glutamate receptor ionotropic, NMDA 3A-like [Danio rerio]0
Drosophila melanogasterAAM46167 NMDA receptor 2 [Drosophila melanogaster]5.75605e-74
Caenorhabditis elegansNP_001256640 Protein NMR-2, isoform a [Caenorhabditis elegans] >gi|327415444|gb|AAK01102.2|AF318614_1 NMDA-type ionotropic glutamate receptor NMR-2 [Caenorhabditis elegans] >gi|339730652|emb|CAB01667.4| Protein NMR-2, isoform a [Caenorhabditis elegans]2.82873e-75
Schistosoma mansoniXP_002576025 glutamate receptor NMDA [Schistosoma mansoni] >gi|360044590|emb|CCD82138.1| putative glutamate receptor, NMDA [Schistosoma mansoni]1.18493e-63
Nematostella vectensisXP_001627645 predicted protein [Nematostella vectensis] >gi|156214561|gb|EDO35545.1| predicted protein [Nematostella vectensis]1.15526e-59
Trichoplax adhaerensXP_002112772 hypothetical protein TRIADDRAFT_25027 [Trichoplax adhaerens] >gi|190584813|gb|EDV24882.1| hypothetical protein TRIADDRAFT_25027 [Trichoplax adhaerens]1.92293e-35
Monosiga brevicollisXP_001749281 hypothetical protein [Monosiga brevicollis MX1] >gi|163772147|gb|EDQ85802.1| predicted protein [Monosiga brevicollis MX1]3.47968

Table S2: Target IDs for NP_619635

NP_619635 sp|O60391|NMD3B_HUMAN Glutamate receptor ionotropic, NMDA 3B OS=Homo sapiens GN=GRIN3B PE=2 SV=2
.......FromHomo sapiens
NP_619635
Lig_chan, SBP_bac_3
Pan troglodytes
BAI22785
Lig_chan, SBP_bac_3
Danio rerio
XP_002663775
Drosophila melanogaster
AAM46167
Lig_chan, SBP_bac_3, ANF_receptor
Caenorhabditis elegans
NP_001256640
Lig_chan, SBP_bac_3, ANF_receptor
Schistosoma mansoni
XP_002576025
Lig_chan, SBP_bac_3
Nematostella vectensis
XP_001627645
Lig_chan, CaM_bdg_C0, Lig_chan-Glu_bd, ANF_receptor
Trichoplax adhaerens
XP_002112772
Lig_chan, Lig_chan-Glu_bd
Monosiga brevicollis
XP_001749281
Homo sapiensNP_619635EAW69576NP_597702AAB60368NP_001127880XP_005255326XP_005266128EAW67066BAG56841
Pan troglodytesBAI22785BAI22785BAI22784XP_528744NP_001029361BAI22781BAI22780XP_522168XP_511872
Danio rerioXP_002663775XP_002663775XP_002663775XP_691754NP_001121809XP_691754XP_005161124NP_997917AAV66421
Drosophila melanogasterAAM46167AAM46167AAM46167NP_001014714NP_001162636AAM46167NP_730940NP_650925NP_723199
Caenorhabditis elegansNP_001256640NP_001256640NP_001256640NP_001256640NP_001256640NP_001256640NP_495033AAK01095NP_494258
Schistosoma mansoniXP_002576025XP_002576025XP_002576025XP_002576025XP_002576025XP_002576025XP_002572261XP_002576035XP_002572218
Nematostella vectensisXP_001627645XP_001627645XP_001627645XP_001627645XP_001627645XP_001627645XP_001627645XP_001633354XP_001641047
Trichoplax adhaerensXP_002112772XP_002112772XP_002112772XP_002111317XP_002107780XP_002108131XP_002111317XP_002112772XP_002111224
Monosiga brevicollisXP_001749281XP_001749281XP_001746747XP_001743319XP_001743426XP_001742357XP_001750905XP_001745980XP_001749281



Table S3: Target blast score for NP_619635

NP_619635 sp|O60391|NMD3B_HUMAN Glutamate receptor ionotropic, NMDA 3B OS=Homo sapiens GN=GRIN3B PE=2 SV=2
.......FromHomo sapiens
NP_619635
Lig_chan, SBP_bac_3
Pan troglodytes
BAI22785
Lig_chan, SBP_bac_3
Danio rerio
XP_002663775
Drosophila melanogaster
AAM46167
Lig_chan, SBP_bac_3, ANF_receptor
Caenorhabditis elegans
NP_001256640
Lig_chan, SBP_bac_3, ANF_receptor
Schistosoma mansoni
XP_002576025
Lig_chan, SBP_bac_3
Nematostella vectensis
XP_001627645
Lig_chan, CaM_bdg_C0, Lig_chan-Glu_bd, ANF_receptor
Trichoplax adhaerens
XP_002112772
Lig_chan, Lig_chan-Glu_bd
Monosiga brevicollis
XP_001749281
Homo sapiens0006.0781e-1303.37556e-1246.84017e-10307.89175e-764.2771
Pan troglodytes0001.24348e-1304.46836e-1241.37155e-10201.3441e-760.882106
Danio rerio0007.89857e-1293.36185e-1175.21684e-10204.2054e-735.95413
Drosophila melanogaster5.13819e-722.40065e-736.84813e-80005.68725e-14405.6014e-701.36438
Caenorhabditis elegans2.82873e-753.32161e-754.4938e-82007.73189e-1391.70878e-1431.8084e-721.72816
Schistosoma mansoni4.7501e-652.00619e-652.7132e-827.96809e-1435.20344e-141006.53891e-640.0265918
Nematostella vectensis1.15526e-596.87289e-621.44857e-723.2688e-871.98258e-841.75928e-6001.48896e-640.0601816
Trichoplax adhaerens6.29489e-371.33593e-364.94835e-477.29851e-427.60948e-421.067e-339.45888e-6800.0417629
Monosiga brevicollis0.2373130.1225420.04612550.1717360.185960.0170960.0003502160.4944860


Table S4: Comparative domain composition for NP_619635

NP_619635 sp|O60391|NMD3B_HUMAN Glutamate receptor ionotropic, NMDA 3B OS=Homo sapiens GN=GRIN3B PE=2 SV=2
Lig_chan (1), SBP_bac_3 (1)
.......FromHomo sapiens
NP_619635
Lig_chan (1), SBP_bac_3 (1)
Pan troglodytes
BAI22785
Lig_chan (1), SBP_bac_3 (1)
Danio rerio
XP_002663775
Drosophila melanogaster
AAM46167
Lig_chan (1), SBP_bac_3 (1), ANF_receptor (1)
Caenorhabditis elegans
NP_001256640
Lig_chan (1), SBP_bac_3 (1), ANF_receptor (1)
Schistosoma mansoni
XP_002576025
Lig_chan (1), SBP_bac_3 (1)
Nematostella vectensis
XP_001627645
Lig_chan (1), CaM_bdg_C0 (1), Lig_chan-Glu_bd (1), ANF_receptor (1)
Trichoplax adhaerens
XP_002112772
Lig_chan (1), Lig_chan-Glu_bd (1)
Monosiga brevicollis
XP_001749281
Homo sapiens
Lig_chan (0), SBP_bac_3 (0)
n.a.
Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1), NMDAR2_C (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1), NMDAR2_C (1)
n.a.n.a.
Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1)
n.a.
Pan troglodytes
Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1), NMDAR2_C (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1), NMDAR2_C (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1), NMDAR2_C (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1), CaM_bdg_C0 (1)
n.a.n.a.
Danio rerion.a.n.a.n.a.n.a.
Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), NMDAR2_C (1)
n.a.
Lig_chan (-1), SBP_bac_3 (-1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1)

Lig_chan (-1), SBP_bac_3 (-1)Integrin_alpha2 (1), Integrin_alpha (1)
Drosophila melanogaster
Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (2), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1)
n.a.
Caenorhabditis elegans
Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)zf-LITAF-like (1), ANF_receptor (1)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (-1), SBP_bac_3 (-1)TRA-1_regulated (1)
Schistosoma mansoni
Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)
n.a.
Lig_chan (0), SBP_bac_3 (0)

Lig_chan (-1), SBP_bac_3 (-1)FG-GAP (2), Integrin_alpha2 (2)
Nematostella vectensis
Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)ANF_receptor (1), Lig_chan-Glu_bd (1), CaM_bdg_C0 (1)

Lig_chan (0)SBP_bac_3 (-1)Lig_chan-Glu_bd (1)

Lig_chan (-1), SBP_bac_3 (-1)Integrin_alpha2 (2)
Trichoplax adhaerens
Lig_chan (0)SBP_bac_3 (-1)Lig_chan-Glu_bd (1)

Lig_chan (0)SBP_bac_3 (-1)Lig_chan-Glu_bd (1)

Lig_chan (0)SBP_bac_3 (-1)Lig_chan-Glu_bd (1)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0)SBP_bac_3 (-1)Lig_chan-Glu_bd (1)

Lig_chan (0), SBP_bac_3 (0)

Lig_chan (0), SBP_bac_3 (0)ANF_receptor (1)

Lig_chan (0)SBP_bac_3 (-1)Lig_chan-Glu_bd (1)

Lig_chan (-1), SBP_bac_3 (-1)FG-GAP (2), Integrin_alpha2 (1)
Monosiga brevicollisn.a.n.a.
Lig_chan (-1), SBP_bac_3 (-1)GST_C (1), GST_N (1), Striatin (1), WD40 (3)

Lig_chan (-1), SBP_bac_3 (-1)GHL (1)

Lig_chan (-1), SBP_bac_3 (-1)CNH (1), Vps39_2 (1)
n.a.
Lig_chan (-1), SBP_bac_3 (-1)ANF_receptor (1), Pkinase_Tyr (1)

Lig_chan (-1), SBP_bac_3 (-1)Phospholip_B (1)
n.a.



Tree S1: Tree for NP_619635

XP_005255326 n.a.XP 005255326 HS Sm BAI22781 Lig_chan, SBP_bac_3, ANF_receptor, NMDAR2_CBAI22781 PT Sm NP_001029361 Lig_chan, SBP_bac_3, ANF_receptor, NMDAR2_CNP 001029361 PT Ce NP_001127880 Lig_chan, SBP_bac_3, ANF_receptor, NMDAR2_CNP 001127880 HS Ce XP_691754 n.a.XP 691754 DR Dm Sm XP_528744 Lig_chan, SBP_bac_3, ANF_receptor, NMDAR2_CXP 528744 PT Dm AAB60368 Lig_chan, SBP_bac_3, ANF_receptor, NMDAR2_CAAB60368 HS Dm NP_001121809 Lig_chan, Lig_chan-Glu_bd, ANF_receptor, NMDAR2_CNP 001121809 DR Ce XP_001750905 Pkinase_Tyr, ANF_receptorXP 001750905 MB Nv XP_001743426 Vps39_2, CNHXP 001743426 MB Ce BAG56841 n.a.BAG56841 HS Mb XP_511872 n.a.XP 511872 PT Mb XP_002111224 Integrin_alpha2, FG-GAPXP 002111224 TA Mb AAV66421 Integrin_alpha2, Integrin_alphaAAV66421 DR Mb XP_002572218 Integrin_alpha2, FG-GAPXP 002572218 SM Mb XP_001641047 Integrin_alpha2XP 001641047 NV Mb AAM46167 Lig_chan, SBP_bac_3, ANF_receptorAAM46167 DM Hs Pt Dr Sm NP_001162636 Lig_chan, SBP_bac_3, ANF_receptorNP 001162636 DM Ce NP_001256640 Lig_chan, SBP_bac_3, ANF_receptorNP 001256640 CE Hs Pt Dr Dm Sm NP_494258 TRA-1_regulatedNP 494258 CE Mb XP_002576025 Lig_chan, SBP_bac_3XP 002576025 SM Hs Pt Dr Dm Ce NP_619635 Lig_chan, SBP_bac_3NP 619635 EAW69576 n.a.EAW69576 HS Pt XP_001746747 GST_N, GST_C, Striatin, WD40XP 001746747 MB Dr XP_001749281 n.a.XP 001749281 MB Hs Pt BAI22785 Lig_chan, SBP_bac_3BAI22785 PT Hs NP_723199 n.a.NP 723199 DM Mb XP_002663775 n.a.XP 002663775 DR Hs Pt BAI22784 Lig_chan, SBP_bac_3BAI22784 PT Dr NP_597702 Lig_chan, SBP_bac_3NP 597702 HS Dr XP_001743319 GHLXP 001743319 MB Dm XP_001742357 n.a.XP 001742357 MB Sm BAI22780 Lig_chan, CaM_bdg_C0, SBP_bac_3, ANF_receptorBAI22780 PT Nv XP_005266128 n.a.XP 005266128 HS Nv XP_005161124 XP 005161124 DR Nv XP_001627645 Lig_chan, CaM_bdg_C0, Lig_chan-Glu_bd, ANF_receptorXP 001627645 NV Hs Pt Dr Dm Ce Sm NP_730940 Lig_chan, CaM_bdg_C0, SBP_bac_3, ANF_receptorNP 730940 DM Nv XP_002572261 n.a.XP 002572261 SM Nv NP_495033 Lig_chan, zf-LITAF-like, SBP_bac_3, ANF_receptorNP 495033 CE Nv AAK01095 Lig_chan, SBP_bac_3AAK01095 CE Ta XP_002576035 Lig_chan, SBP_bac_3XP 002576035 SM Ta NP_650925 Lig_chan, Lig_chan-Glu_bd, ANF_receptorNP 650925 DM Ta EAW67066 Lig_chan, Lig_chan-Glu_bd, ANF_receptorEAW67066 HS Ta XP_522168 n.a.XP 522168 PT Ta NP_997917 Lig_chan, Lig_chan-Glu_bd, ANF_receptorNP 997917 DR Ta XP_001633354 Lig_chan, Lig_chan-Glu_bdXP 001633354 NV Ta XP_002112772 Lig_chan, Lig_chan-Glu_bdXP 002112772 TA Hs Pt Dr XP_001745980 Phospholip_BXP 001745980 MB Ta XP_002107780 Lig_chan, Lig_chan-Glu_bdXP 002107780 TA Ce XP_002111317 Lig_chan, SBP_bac_3, ANF_receptorXP 002111317 TA Dm Nv XP_002108131 Lig_chan, SBP_bac_3XP 002108131 TA Sm
(((((((XP_001641047_NV_Mb:1.07768,XP_002572218_SM_Mb:0.00015):1.73709,(AAV66421_DR_Mb:1.24411,(XP_002111224_TA_Mb:0.20189,(XP_511872_PT_Mb:0.00014,BAG56841_HS_Mb:0.00016):0.60927):1.76988):0.00014):1.79004,((XP_001743426_MB_Ce:2.03124,XP_001750905_MB_Nv:1.04018):2.87935,(((AAB60368_HS_Dm:0.0,XP_528744_PT_Dm:0.0):0.07155,NP_001121809_DR_Ce:0.09270):0.11904,(XP_691754_DR_Dm_Sm:0.11920,(NP_001127880_HS_Ce:0.00014,((BAI22781_PT_Sm:0.0,XP_005255326_HS_Sm:0.0):0.00014,NP_001029361_PT_Ce:0.00198):0.00020):0.12144):0.04979):0.30836):0.19309):0.14847,(XP_002576025_SM_Hs_Pt_Dr_Dm_Ce:0.67701,(NP_494258_CE_Mb:2.41236,(NP_001256640_CE_Hs_Pt_Dr_Dm_Sm:0.59884,(NP_001162636_DM_Ce:0.00015,AAM46167_DM_Hs_Pt_Dr_Sm:0.00014):0.61506):0.07140):0.00027):0.31655):0.25489,((XP_001742357_MB_Sm:1.20023,XP_001743319_MB_Dm:4.39938):1.75452,((NP_597702_HS_Dr:0.00431,BAI22784_PT_Dr:0.00014):0.30925,(((XP_001746747_MB_Dr:2.80569,(EAW69576_HS_Pt:0.00014,NP_619635:0.00122):0.00959):0.00105,((BAI22785_PT_Hs:0.00441,XP_001749281_MB_Hs_Pt:0.92858):0.00025,NP_723199_DM_Mb:2.42303):0.00038):0.41035,XP_002663775_DR_Hs_Pt:0.27138):0.12051):0.73490):0.32104):0.33418,(NP_495033_CE_Nv:0.90938,(XP_002572261_SM_Nv:0.60779,(NP_730940_DM_Nv:0.43204,(XP_001627645_NV_Hs_Pt_Dr_Dm_Ce_Sm:0.43268,((XP_005266128_HS_Nv:0.0,BAI22780_PT_Nv:0.0):0.04497,XP_005161124_DR_Nv:0.07665):0.33376):0.11046):0.04297):0.12093):0.41632):0.47312,(XP_002108131_TA_Sm:0.79678,XP_002111317_TA_Dm_Nv:0.77548):0.24489,((XP_002107780_TA_Ce:0.87259,(XP_001745980_MB_Ta:2.40033,XP_002112772_TA_Hs_Pt_Dr:0.72529):0.38054):0.10137,(((NP_650925_DM_Ta:0.36569,(XP_002576035_SM_Ta:0.51596,AAK01095_CE_Ta:0.52812):0.14362):0.12586,((XP_522168_PT_Ta:0.0,EAW67066_HS_Ta:0.0):0.02021,NP_997917_DR_Ta:0.05628):0.49009):0.22747,XP_001633354_NV_Ta:1.01053):0.10983):0.12274);

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Table S1: Best blast for NP_003046 in each species
Homo sapiensNP_003046 vesicular acetylcholine transporter [Homo sapiens] >gi|313104043|sp|Q16572.2|VACHT_HUMAN RecName: Full=Vesicular acetylcholine transporter; Short=VAChT; AltName: Full=Solute carrier family 18 member 30
Pan troglodytesXP_001138996 PREDICTED: vesicular acetylcholine transporter isoform 1 [Pan troglodytes]0
Danio rerioNP_001071018 probable vesicular acetylcholine transporter-A [Danio rerio] >gi|123884384|sp|Q08C75.1|VACHA_DANRE RecName: Full=Probable vesicular acetylcholine transporter-A; Short=VAChT-A; AltName: Full=Solute carrier family 18 member 3-A >gi|115313351|gb|AAI24355.1| Zgc:153442 [Danio rerio] >gi|182890228|gb|AAI65388.1| Zgc:153442 protein [Danio rerio]0
Drosophila melanogasterNP_477138 VAChT [Drosophila melanogaster] >gi|34924873|sp|O17444.2|VACHT_DROME RecName: Full=Vesicular acetylcholine transporter; Short=VAChT >gi|23171672|gb|AAF55587.2| VAChT [Drosophila melanogaster] >gi|283436232|gb|ADB13439.1| MIP14469p [Drosophila melanogaster]3.01101e-147
Caenorhabditis elegansCCA65517 UNC-17 protein [Caenorhabditis elegans]8.07232e-124
Schistosoma mansoniXP_002575938 vesicular acetylcholine transporter [Schistosoma mansoni] >gi|360044888|emb|CCD82436.1| putative vesicular acetylcholine transporter [Schistosoma mansoni]7.41438e-149
Nematostella vectensisXP_001627861 predicted protein [Nematostella vectensis] >gi|156214822|gb|EDO35798.1| predicted protein [Nematostella vectensis]8.38888e-14
Trichoplax adhaerensXP_002115127 hypothetical protein TRIADDRAFT_58958 [Trichoplax adhaerens] >gi|190582510|gb|EDV22583.1| hypothetical protein TRIADDRAFT_58958 [Trichoplax adhaerens]9.3463e-13
Monosiga brevicollisXP_001748493 hypothetical protein [Monosiga brevicollis MX1] >gi|163773012|gb|EDQ86657.1| predicted protein [Monosiga brevicollis MX1]7.71481e-07

Table S2: Target IDs for NP_003046

NP_003046 sp|Q16572|VACHT_HUMAN Vesicular acetylcholine transporter OS=Homo sapiens GN=SLC18A3 PE=1 SV=2
.......FromHomo sapiens
NP_003046
MFS_1
Pan troglodytes
XP_001138996
MFS_1
Danio rerio
NP_001071018
MFS_1
Drosophila melanogaster
NP_477138
MFS_1
Caenorhabditis elegans
CCA65517
MFS_1
Schistosoma mansoni
XP_002575938
MFS_1
Nematostella vectensis
XP_001627861
MFS_1
Trichoplax adhaerens
XP_002115127
MFS_1
Monosiga brevicollis
XP_001748493
MFS_1
Homo sapiensNP_003046AAA20497AAA20497NP_003046NP_003046AAA20497NP_439896NP_439896NP_001135922
Pan troglodytesXP_001138996XP_001138996XP_001138996XP_001138996XP_001138996XP_001138996XP_001169507XP_001169507XP_001147131
Danio rerioNP_001071018NP_001071018NP_001071018NP_001071018NP_001071018NP_001071018XP_005158657XP_005158657A2SWM2
Drosophila melanogasterNP_477138AAB86609NP_477138NP_477138NP_477138NP_477138AAB86609AAN71386AAK93216
Caenorhabditis elegansCCA65517CCA65517CCA65517CCA65518CCA65517NP_001023602NP_741717NP_741717NP_502513
Schistosoma mansoniXP_002575938XP_002575938XP_002575938XP_002575938XP_002575938XP_002575938XP_002575938XP_002571409XP_002577628
Nematostella vectensisXP_001627861XP_001627861XP_001627861XP_001627861XP_001627861XP_001627861XP_001627861XP_001627861XP_001631496
Trichoplax adhaerensXP_002115127XP_002115127XP_002116032XP_002116032XP_002115132XP_002116032XP_002115127XP_002115127XP_002108329
Monosiga brevicollisXP_001748493XP_001748493XP_001748493XP_001748493XP_001748493XP_001748493XP_001748493XP_001748493XP_001748493



Table S3: Target blast score for NP_003046

NP_003046 sp|Q16572|VACHT_HUMAN Vesicular acetylcholine transporter OS=Homo sapiens GN=SLC18A3 PE=1 SV=2
.......FromHomo sapiens
NP_003046
MFS_1
Pan troglodytes
XP_001138996
MFS_1
Danio rerio
NP_001071018
MFS_1
Drosophila melanogaster
NP_477138
MFS_1
Caenorhabditis elegans
CCA65517
MFS_1
Schistosoma mansoni
XP_002575938
MFS_1
Nematostella vectensis
XP_001627861
MFS_1
Trichoplax adhaerens
XP_002115127
MFS_1
Monosiga brevicollis
XP_001748493
MFS_1
Homo sapiens0005.74078e-1358.50253e-1343.13225e-1606.44424e-761.69072e-521.30175e-89
Pan troglodytes0004.87501e-1351.85701e-1353.09309e-1605.40493e-761.11437e-522.40286e-89
Danio rerio0008.2056e-1485.92074e-1504.22304e-1714.27861e-745.77285e-575.50743e-75
Drosophila melanogaster3.01101e-1472.21533e-1461.86807e-16504.59127e-1711.20606e-1755.53763e-101.03073e-192.45715e-82
Caenorhabditis elegans1.85073e-1251.91919e-1262.66021e-1453.66456e-14802.47737e-1601.32275e-834.76795e-531.1688e-65
Schistosoma mansoni7.41438e-1493.32778e-1487.74674e-1644.90857e-1533.62103e-15804.31894e-121.0053e-163.79441e-69
Nematostella vectensis3.07026e-115.69788e-128.1756e-132.25518e-094.55239e-084.44894e-1203.02538e-673.21268e-88
Trichoplax adhaerens9.3463e-131.94799e-132.08437e-152.25618e-111.59294e-081.2261e-162.0898e-6703.67481e-96
Monosiga brevicollis7.71481e-078.27058e-079.24036e-060.02792350.0001993750.0001995520.01785773.526150


Table S4: Comparative domain composition for NP_003046

NP_003046 sp|Q16572|VACHT_HUMAN Vesicular acetylcholine transporter OS=Homo sapiens GN=SLC18A3 PE=1 SV=2
MFS_1 (1)
.......FromHomo sapiens
NP_003046
MFS_1 (1)
Pan troglodytes
XP_001138996
MFS_1 (1)
Danio rerio
NP_001071018
MFS_1 (1)
Drosophila melanogaster
NP_477138
MFS_1 (1)
Caenorhabditis elegans
CCA65517
MFS_1 (1)
Schistosoma mansoni
XP_002575938
MFS_1 (1)
Nematostella vectensis
XP_001627861
MFS_1 (1)
Trichoplax adhaerens
XP_002115127
MFS_1 (2)
Monosiga brevicollis
XP_001748493
MFS_1 (1)
Homo sapiens
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
Pan troglodytes
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
n.a.
Danio rerio
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
n.a.n.a.
MFS_1 (0)
Drosophila melanogaster
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
Caenorhabditis elegans
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
Schistosoma mansoni
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
n.a.
MFS_1 (0)
Nematostella vectensis
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)
Trichoplax adhaerens
MFS_1 (1)

MFS_1 (1)

MFS_1 (1)

MFS_1 (1)

MFS_1 (0)

MFS_1 (1)

MFS_1 (1)

MFS_1 (1)

MFS_1 (0)
Monosiga brevicollis
MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)

MFS_1 (0)



Tree S1: Tree for NP_003046

CCA65518 MFS_1CCA65518 CE Dm NP_001023602 MFS_1NP 001023602 CE Sm CCA65517 MFS_1CCA65517 CE Hs Pt Dr AAB86609 MFS_1AAB86609 DM Pt Nv NP_477138 MFS_1NP 477138 DM Hs Dr Ce Sm NP_003046 MFS_1NP 003046 HS Dm Ce AAA20497 MFS_1AAA20497 HS Pt Dr Sm XP_001138996 MFS_1XP 001138996 PT Hs Dr Dm Ce Sm NP_001071018 MFS_1NP 001071018 DR Hs Pt Dm Ce Sm XP_002575938 MFS_1XP 002575938 SM Hs Pt Dr Dm Ce Nv AAN71386 MFS_1AAN71386 DM Ta XP_002571409 n.a.XP 002571409 SM Ta NP_439896 MFS_1NP 439896 HS Nv Ta XP_001169507 MFS_1XP 001169507 PT Nv Ta XP_005158657 n.a.XP 005158657 DR Nv Ta NP_741717 MFS_1NP 741717 CE Nv Ta XP_001627861 MFS_1XP 001627861 NV Hs Pt Dr Dm Ce Sm Ta XP_002115127 MFS_1XP 002115127 TA Hs Pt Nv XP_002116032 MFS_1XP 002116032 TA Dr Dm Sm XP_002115132 MFS_1XP 002115132 TA Ce NP_502513 MFS_1NP 502513 CE Mb XP_001748493 MFS_1XP 001748493 MB Hs Pt Dr Dm Ce Sm Nv Ta XP_002577628 MFS_1XP 002577628 SM Mb AAK93216 MFS_1AAK93216 DM Mb NP_001135922 MFS_1NP 001135922 HS Mb XP_001147131 n.a.XP 001147131 PT Mb A2SWM2 MFS_1A2SWM2 DR Mb XP_001631496 MFS_1XP 001631496 NV Mb XP_002108329 MFS_1XP 002108329 TA Mb
(XP_002108329_TA_Mb:0.46749,XP_001631496_NV_Mb:0.46900,((A2SWM2_DR_Mb:0.50578,(XP_001147131_PT_Mb:0.00015,NP_001135922_HS_Mb:0.00239):0.21200):0.20615,(AAK93216_DM_Mb:0.46709,((NP_502513_CE_Mb:0.60385,(((XP_002571409_SM_Ta:0.55152,AAN71386_DM_Ta:0.18705):0.33878,(((CCA65517_CE_Hs_Pt_Dr:0.00251,(NP_001023602_CE_Sm:0.00016,CCA65518_CE_Dm:0.00235):0.00016):0.58912,(NP_477138_DM_Hs_Dr_Ce_Sm:0.00189,AAB86609_DM_Pt_Nv:0.00455):0.24682):0.07496,(XP_002575938_SM_Hs_Pt_Dr_Dm_Ce_Nv:0.35765,(NP_001071018_DR_Hs_Pt_Dm_Ce_Sm:0.14434,(XP_001138996_PT_Hs_Dr_Dm_Ce_Sm:0.00952,(AAA20497_HS_Pt_Dr_Sm:0.00015,NP_003046_HS_Dm_Ce:0.00190):0.00014):0.20928):0.37733):0.05236):0.38621):0.50090,((XP_002115132_TA_Ce:0.59443,(XP_002116032_TA_Dr_Dm_Sm:0.21469,XP_002115127_TA_Hs_Pt_Nv:0.18538):0.21530):0.23353,(XP_001627861_NV_Hs_Pt_Dr_Dm_Ce_Sm_Ta:0.65639,(NP_741717_CE_Nv_Ta:0.99597,(XP_005158657_DR_Nv_Ta:0.46411,(XP_001169507_PT_Nv_Ta:0.00763,NP_439896_HS_Nv_Ta:0.00016):0.29566):0.34467):0.15732):0.24597):0.80108):1.73062):0.18887,(XP_002577628_SM_Mb:0.59629,XP_001748493_MB_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Ta:0.66396):0.09470):0.08948):0.06240):0.08903);

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Table S1: Best blast for NP_076435 in each species
Homo sapiensNP_076435 ly-6/neurotoxin-like protein 1 isoform a precursor [Homo sapiens] >gi|397497455|ref|XP_003819526.1| PREDICTED: secreted Ly-6/uPAR-related protein 2 [Pan paniscus] >gi|426360844|ref|XP_004047639.1| PREDICTED: ly-6/neurotoxin-like protein 1 isoform 1 [Gorilla gorilla gorilla] >gi|408360254|sp|Q9BZG9.3|LYNX1_HUMAN RecName: Full=Ly-6/neurotoxin-like protein 1; AltName: Full=Secreted Ly-6/uPAR domain-containing protein 2; AltName: Full=Secreted Ly-6/uPAR-related protein 2; Short=SLURP-2; Flags: Precursor >gi|119602705|gb|EAW82299.1| hCG2043033, isoform CRA_a [Homo sapiens]1.57991e-79
Pan troglodytesXP_003311986 ly-6/neurotoxin-like protein 1 isoform b precursor [Homo sapiens] >gi|332831263|ref|XP_003311986.1| PREDICTED: ly-6/neurotoxin-like protein 1-like [Pan troglodytes] >gi|28208164|dbj|BAC56859.1| secreted Ly6/uPAR related protein 2 [Homo sapiens] >gi|37181959|gb|AAQ88783.1| QLGT871 [Homo sapiens] >gi|46560057|gb|AAT00512.1| secreted Ly6/uPAR related-protein 2 [Homo sapiens] >gi|119602712|gb|EAW82306.1| hCG39313 [Homo sapiens]2.43416e-54
Danio rerioXP_706427 PREDICTED: prostate stem cell antigen [Danio rerio]3.67854
Drosophila melanogasterAEM92665 FI15222p1 [Drosophila melanogaster]0.1664
Caenorhabditis elegansT34290 hypothetical protein F49E10.5 - Caenorhabditis elegans0.0644428
Schistosoma mansoniXP_002573216 phospholipase A-2-activating protein [Schistosoma mansoni]7.35185
Nematostella vectensisNo Hit
Trichoplax adhaerensNo Hit
Monosiga brevicollisNo Hit

Table S2: Target IDs for NP_076435

NP_076435 sp|Q9BZG9|LYNX1_HUMAN Ly-6/neurotoxin-like protein 1 OS=Homo sapiens GN=LYNX1 PE=1 SV=3
.......FromHomo sapiens
NP_076435
UPAR_LY6
Pan troglodytes
XP_003311986
UPAR_LY6
Danio rerio
XP_706427
Drosophila melanogaster
AEM92665
Caenorhabditis elegans
T34290
Schistosoma mansoni
XP_002573216
Nematostella vectensis
No Hit
Trichoplax adhaerens
No Hit
Monosiga brevicollis
No Hit
Homo sapiensNP_076435NP_803253no hitno hitXP_005272319BAA92105no hitno hitno hit
Pan troglodytesXP_003311986XP_003311986no hitXP_510409XP_003950313XP_520517no hitno hitno hit
Danio rerioXP_706427XP_003200436XP_706427no hitXP_005173191NP_997855no hitno hitno hit
Drosophila melanogasterno hitno hitno hitAEM92665NP_001262520AAG21768no hitno hitno hit
Caenorhabditis elegansT34290NP_495882no hitT32115T34290NP_496147no hitno hitno hit
Schistosoma mansoniXP_002573216XP_002573216XP_002574805no hitCCD60514XP_002573216no hitno hitno hit
Nematostella vectensisno hitno hitXP_001638048no hitXP_001635086XP_001628574no hitno hitno hit
Trichoplax adhaerensXP_002113656XP_002110730XP_002108730XP_002107950XP_002110667XP_002109344no hitno hitno hit
Monosiga brevicollisno hitno hitXP_001745043XP_001750567XP_001742459XP_001747457no hitno hitno hit



Table S3: Target blast score for NP_076435

NP_076435 sp|Q9BZG9|LYNX1_HUMAN Ly-6/neurotoxin-like protein 1 OS=Homo sapiens GN=LYNX1 PE=1 SV=3
.......FromHomo sapiens
NP_076435
UPAR_LY6
Pan troglodytes
XP_003311986
UPAR_LY6
Danio rerio
XP_706427
Drosophila melanogaster
AEM92665
Caenorhabditis elegans
T34290
Schistosoma mansoni
XP_002573216
Nematostella vectensis
No Hit
Trichoplax adhaerens
No Hit
Monosiga brevicollis
No Hit
Homo sapiens1.57991e-791.75385e-52no hitno hit6.83389e-1304.65793e-129no hitno hitno hit
Pan troglodytes2.43416e-542.93425e-53no hit1.012981.1683e-1291.44618e-127no hitno hitno hit
Danio rerio3.678546.786593.81212e-56no hit1.00618e-1321.10343e-130no hitno hitno hit
Drosophila melanogasterno hitno hitno hit1.89341e-1021.78504e-1322.75923e-104no hitno hitno hit
Caenorhabditis elegans0.06444285.98207no hit0.591102.62129e-46no hitno hitno hit
Schistosoma mansoni0.2771950.1096760.0415586no hit6.33993e-1190no hitno hitno hit
Nematostella vectensisno hitno hit3.11695no hit5.80516e-366.25922e-62no hitno hitno hit
Trichoplax adhaerens0.9550370.3675490.05393820.8180551.78328e-362.33896e-106no hitno hitno hit
Monosiga brevicollisno hitno hit2.611630.9499491.16372e-154.40957e-32no hitno hitno hit


Table S4: Comparative domain composition for NP_076435

NP_076435 sp|Q9BZG9|LYNX1_HUMAN Ly-6/neurotoxin-like protein 1 OS=Homo sapiens GN=LYNX1 PE=1 SV=3
UPAR_LY6 (2)
.......FromHomo sapiens
NP_076435
UPAR_LY6 (2)
Pan troglodytes
XP_003311986
UPAR_LY6 (1)
Danio rerio
XP_706427
Drosophila melanogaster
AEM92665
Caenorhabditis elegans
T34290
Schistosoma mansoni
XP_002573216
Nematostella vectensis
No Hit
Trichoplax adhaerens
No Hit
Monosiga brevicollis
No Hit
Homo sapiens
UPAR_LY6 (0)

UPAR_LY6 (0)
no hitno hitn.a.
UPAR_LY6 (-2)PFU (1), PUL (1), WD40 (6)
no hitno hitno hit
Pan troglodytes
UPAR_LY6 (-1)

UPAR_LY6 (-1)
no hit
UPAR_LY6 (-2)Pkinase (1)
n.a.
UPAR_LY6 (-2)PFU (1), PUL (1), WD40 (6)
no hitno hitno hit
Danio rerion.a.
UPAR_LY6 (0)
n.a.no hitn.a.
UPAR_LY6 (-2)PFU (1), PUL (1), WD40 (6)
no hitno hitno hit
Drosophila melanogasterno hitno hitno hit
UPAR_LY6 (-2)

UPAR_LY6 (-2)2-Hacid_dh (1), 2-Hacid_dh_C (1)

UPAR_LY6 (-2)PFU (1), PUL (1), WD40 (6)
no hitno hitno hit
Caenorhabditis elegansn.a.n.a.no hit
UPAR_LY6 (-2)
n.a.
UPAR_LY6 (-2)PFU (2), PUL (1), WD40 (4)
no hitno hitno hit
Schistosoma mansonin.a.n.a.
UPAR_LY6 (-2)LIM (1)
no hit
UPAR_LY6 (-2)2-Hacid_dh (1), 2-Hacid_dh_C (1)
n.a.no hitno hitno hit
Nematostella vectensisno hitno hit
UPAR_LY6 (-2)DUF4206 (1)
no hit
UPAR_LY6 (-2)2-Hacid_dh (1), 2-Hacid_dh_C (1)

UPAR_LY6 (-2)WD40 (6)
no hitno hitno hit
Trichoplax adhaerens
UPAR_LY6 (-2)hEGF (2), EGF (26), EGF_CA (1)
n.a.
UPAR_LY6 (-2)Glucosamine_iso (1), G6PD_C (1), G6PD_N (1)

UPAR_LY6 (-2)F-box (1)

UPAR_LY6 (-2)2-Hacid_dh (1), 2-Hacid_dh_C (1)

UPAR_LY6 (-2)PFU (1), PUL (1), WD40 (5)
no hitno hitno hit
Monosiga brevicollisno hitno hit
UPAR_LY6 (-2)Ribosomal_L9_N (1), Disintegrin (1)

UPAR_LY6 (-2)Ank_2 (2), Mcp5_PH (1)

UPAR_LY6 (-2)2-Hacid_dh (1), 2-Hacid_dh_C (1)

UPAR_LY6 (-2)PFU (1), PUL (1), WD40 (1)
no hitno hitno hit



Tree S1: Tree for NP_076435

XP_005272319 n.a.XP 005272319 HS Ce XP_003950313 n.a.XP 003950313 PT Ce XP_005173191 n.a.XP 005173191 DR Ce NP_001262520 2-Hacid_dh, 2-Hacid_dh_CNP 001262520 DM Ce CCD60514 2-Hacid_dh, 2-Hacid_dh_CCCD60514 SM Ce T34290 n.a.T34290 CE Hs XP_001635086 2-Hacid_dh, 2-Hacid_dh_CXP 001635086 NV Ce XP_001742459 2-Hacid_dh, 2-Hacid_dh_CXP 001742459 MB Ce XP_001750567 Ank_2, Mcp5_PHXP 001750567 MB Dm XP_002110667 2-Hacid_dh, 2-Hacid_dh_CXP 002110667 TA Ce XP_002574805 LIMXP 002574805 SM Dr XP_001638048 DUF4206XP 001638048 NV Dr XP_706427 n.a.XP 706427 DR Hs XP_002108730 G6PD_C, G6PD_N, Glucosamine_isoXP 002108730 TA Dr T32115 T32115 CE Dm XP_003311986 UPAR_LY6XP 003311986 PT Hs NP_803253 UPAR_LY6NP 803253 HS Pt XP_002110730 n.a.XP 002110730 TA Pt NP_076435 UPAR_LY6NP 076435 NP_495882 n.a.NP 495882 CE Pt XP_003200436 UPAR_LY6XP 003200436 DR Pt XP_001745043 Ribosomal_L9_N, DisintegrinXP 001745043 MB Dr XP_002113656 EGF, hEGF, EGF_CAXP 002113656 TA Hs XP_002107950 F-boxXP 002107950 TA Dm XP_510409 PkinaseXP 510409 PT Dm AAG21768 PFU, PUL, WD40AAG21768 DM Sm XP_001747457 PFU, PUL, WD40XP 001747457 MB Sm NP_496147 PFU, PUL, WD40NP 496147 CE Sm XP_002109344 PFU, PUL, WD40XP 002109344 TA Sm XP_002573216 n.a.XP 002573216 SM Hs Pt XP_520517 PFU, PUL, WD40XP 520517 PT Sm BAA92105 PFU, PUL, WD40BAA92105 HS Sm NP_997855 PFU, PUL, WD40NP 997855 DR Sm XP_001628574 WD40XP 001628574 NV Sm
((((((XP_706427_DR_Hs:0.33155,(XP_001638048_NV_Dr:0.93127,XP_002574805_SM_Dr:0.86843):0.34197):0.43002,XP_002108730_TA_Dr:0.32209):1.61514,(XP_002110667_TA_Ce:0.33501,((T34290_CE_Hs:0.71544,((XP_005173191_DR_Ce:0.01599,(XP_003950313_PT_Ce:0.00269,XP_005272319_HS_Ce:0.00015):0.03412):0.09869,(CCD60514_SM_Ce:0.17152,NP_001262520_DM_Ce:0.12082):0.07558):0.26786):0.56112,((XP_001742459_MB_Ce:0.52623,XP_001635086_NV_Ce:0.41000):0.27257,XP_001750567_MB_Dm:2.88969):0.00016):0.42269):2.48037):0.14593,T32115_CE_Dm:2.73098):0.08164,(((XP_002113656_TA_Hs:0.03803,(((XP_003200436_DR_Pt:0.91928,NP_495882_CE_Pt:0.95931):1.00132,((NP_803253_HS_Pt:0.00015,XP_003311986_PT_Hs:0.00014):0.14607,(NP_076435:0.03199,XP_002110730_TA_Pt:1.01466):0.02304):0.00285):0.83634,XP_001745043_MB_Dr:3.30603):0.04499):0.71833,XP_002107950_TA_Dm:2.65541):0.63470,XP_510409_PT_Dm:1.65764):0.14452):0.88327,((XP_002573216_SM_Hs_Pt:0.86634,XP_002109344_TA_Sm:0.32515):0.20372,((XP_001747457_MB_Sm:1.03861,AAG21768_DM_Sm:0.40603):0.19258,NP_496147_CE_Sm:1.30664):0.13373):0.01670,(XP_001628574_NV_Sm:0.21532,(NP_997855_DR_Sm:0.14863,(BAA92105_HS_Sm:0.00154,XP_520517_PT_Sm:0.00237):0.15933):0.25633):0.05657);

Up
Table S1: Best blast for NP_114102 in each species
Homo sapiensNP_114102 voltage-dependent calcium channel gamma-7 subunit [Homo sapiens] >gi|21687016|ref|NP_542426.1| voltage-dependent calcium channel gamma-7 subunit [Rattus norvegicus] >gi|148540003|ref|NP_573452.3| voltage-dependent calcium channel gamma-7 subunit [Mus musculus] >gi|281182466|ref|NP_001162342.1| voltage-dependent calcium channel gamma-7 subunit [Papio anubis] >gi|284005020|ref|NP_001164860.1| voltage-dependent calcium channel gamma-7 subunit [Oryctolagus cuniculus] >gi|73947628|ref|XP_854277.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Canis lupus familiaris] >gi|114678973|ref|XP_001174727.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit isoform 2 [Pan troglodytes] >gi|338709928|ref|XP_001918181.2| PREDICTED: voltage-dependent calcium channel gamma-7 subunit-like [Equus caballus] >gi|348559400|ref|XP_003465504.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Cavia porcellus] >gi|358416978|ref|XP_003583530.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Bos taurus] >gi|359076119|ref|XP_003587382.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Bos taurus] >gi|395858547|ref|XP_003801629.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Otolemur garnettii] >gi|410982299|ref|XP_003997495.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Felis catus] >gi|470637539|ref|XP_004324081.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tursiops truncatus] >gi|471396348|ref|XP_004381796.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Trichechus manatus latirostris] >gi|472380392|ref|XP_004409599.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Odobenus rosmarus divergens] >gi|478529866|ref|XP_004439101.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Ceratotherium simum simum] >gi|504174876|ref|XP_004596998.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Ochotona princeps] >gi|505847095|ref|XP_004617017.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Sorex araneus] >gi|507576177|ref|XP_004671629.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Jaculus jaculus] >gi|507714773|ref|XP_004648414.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Octodon degus] >gi|507981764|ref|XP_004694364.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Condylura cristata] >gi|511921250|ref|XP_004779826.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Mustela putorius furo] >gi|512016412|ref|XP_004825505.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Mustela putorius furo] >gi|512942038|ref|XP_004909987.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Heterocephalus glaber] >gi|513010749|ref|XP_004866784.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Heterocephalus glaber] >gi|524968651|ref|XP_005084207.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Mesocricetus auratus] >gi|530416974|ref|XP_005259182.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit isoform X2 [Homo sapiens] >gi|532057510|ref|XP_005371457.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Microtus ochrogaster] >gi|532115312|ref|XP_005342318.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Ictidomys tridecemlineatus] >gi|533204886|ref|XP_005414927.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Chinchilla lanigera] >gi|51702228|sp|P62957.1|CCG7_RAT RecName: Full=Voltage-dependent calcium channel gamma-7 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-7; Short=TARP gamma-7 >gi|51702249|sp|P62955.1|CCG7_HUMAN RecName: Full=Voltage-dependent calcium channel gamma-7 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-7; Short=TARP gamma-7 >gi|51702250|sp|P62956.1|CCG7_MOUSE RecName: Full=Voltage-dependent calcium channel gamma-7 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-7; Short=TARP gamma-7 >gi|17974524|gb|AAL50040.1|AF361345_1 voltage-dependent calcium channel gamma-7 subunit [Rattus norvegicus] >gi|17974532|gb|AAL50044.1|AF361349_1 voltage-dependent calcium channel gamma-7 subunit [Mus musculus] >gi|17974540|gb|AAL50048.1|AF361353_1 voltage-dependent calcium channel gamma-7 subunit [Homo sapiens] >gi|19880955|gb|AAM00594.1|AF458897_1 voltage dependent calcium channel gamma 7 subunit [Homo sapiens] >gi|19880959|gb|AAM00596.1|AF458899_1 voltage dependent calcium channel gamma 7 subunit [Mus musculus] >gi|47480710|gb|AAH69332.1| Calcium channel, voltage-dependent, gamma subunit 7 [Homo sapiens] >gi|62740015|gb|AAH93869.1| Calcium channel, voltage-dependent, gamma subunit 7 [Homo sapiens] >gi|109730503|gb|AAI13504.1| Calcium channel, voltage-dependent, gamma subunit 7 [Homo sapiens] >gi|119592569|gb|EAW72163.1| calcium channel, voltage-dependent, gamma subunit 7, isoform CRA_b [Homo sapiens] >gi|148699229|gb|EDL31176.1| calcium channel, voltage-dependent, gamma subunit 7 [Mus musculus] >gi|149029815|gb|EDL84947.1| calcium channel, voltage-dependent, gamma subunit 7 [Rattus norvegicus] >gi|160904182|gb|ABX52167.1| calcium channel, voltage-dependent, gamma subunit 7 (predicted) [Papio anubis] >gi|167427238|gb|ABZ80218.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Callithrix jacchus] >gi|170649660|gb|ACB21246.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Callicebus moloch] >gi|184185522|gb|ACC68924.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Rhinolophus ferrumequinum] >gi|190576587|gb|ACE79076.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Sorex araneus] >gi|197215700|gb|ACH53088.1| calcium channel, voltage-dependent, gamma subunit 7 (predicted) [Otolemur garnettii] >gi|217418294|gb|ACK44297.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Oryctolagus cuniculus] >gi|223461224|gb|AAI41278.1| Calcium channel, voltage-dependent, gamma subunit 7 [Mus musculus] >gi|313883284|gb|ADR83128.1| calcium channel, voltage-dependent, gamma subunit 7 (CACNG7) [synthetic construct] >gi|351715944|gb|EHB18863.1| Voltage-dependent calcium channel gamma-7 subunit [Heterocephalus glaber] >gi|355703884|gb|EHH30375.1| hypothetical protein EGK_11027 [Macaca mulatta] >gi|355756133|gb|EHH59880.1| hypothetical protein EGM_10096 [Macaca fascicularis] >gi|431917246|gb|ELK16790.1| Voltage-dependent calcium channel gamma-7 subunit [Pteropus alecto] >gi|440913389|gb|ELR62843.1| Voltage-dependent calcium channel gamma-7 subunit [Bos grunniens mutus] >gi|444728665|gb|ELW69113.1| Voltage-dependent calcium channel gamma-7 subunit [Tupaia chinensis]0
Pan troglodytesXP_001174727 voltage-dependent calcium channel gamma-7 subunit [Homo sapiens] >gi|21687016|ref|NP_542426.1| voltage-dependent calcium channel gamma-7 subunit [Rattus norvegicus] >gi|148540003|ref|NP_573452.3| voltage-dependent calcium channel gamma-7 subunit [Mus musculus] >gi|281182466|ref|NP_001162342.1| voltage-dependent calcium channel gamma-7 subunit [Papio anubis] >gi|284005020|ref|NP_001164860.1| voltage-dependent calcium channel gamma-7 subunit [Oryctolagus cuniculus] >gi|73947628|ref|XP_854277.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Canis lupus familiaris] >gi|114678973|ref|XP_001174727.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit isoform 2 [Pan troglodytes] >gi|338709928|ref|XP_001918181.2| PREDICTED: voltage-dependent calcium channel gamma-7 subunit-like [Equus caballus] >gi|348559400|ref|XP_003465504.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Cavia porcellus] >gi|358416978|ref|XP_003583530.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Bos taurus] >gi|359076119|ref|XP_003587382.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Bos taurus] >gi|395858547|ref|XP_003801629.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Otolemur garnettii] >gi|410982299|ref|XP_003997495.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Felis catus] >gi|470637539|ref|XP_004324081.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tursiops truncatus] >gi|471396348|ref|XP_004381796.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Trichechus manatus latirostris] >gi|472380392|ref|XP_004409599.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Odobenus rosmarus divergens] >gi|478529866|ref|XP_004439101.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Ceratotherium simum simum] >gi|504174876|ref|XP_004596998.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Ochotona princeps] >gi|505847095|ref|XP_004617017.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Sorex araneus] >gi|507576177|ref|XP_004671629.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Jaculus jaculus] >gi|507714773|ref|XP_004648414.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Octodon degus] >gi|507981764|ref|XP_004694364.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Condylura cristata] >gi|511921250|ref|XP_004779826.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Mustela putorius furo] >gi|512016412|ref|XP_004825505.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Mustela putorius furo] >gi|512942038|ref|XP_004909987.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Heterocephalus glaber] >gi|513010749|ref|XP_004866784.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Heterocephalus glaber] >gi|524968651|ref|XP_005084207.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Mesocricetus auratus] >gi|530416974|ref|XP_005259182.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit isoform X2 [Homo sapiens] >gi|532057510|ref|XP_005371457.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Microtus ochrogaster] >gi|532115312|ref|XP_005342318.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Ictidomys tridecemlineatus] >gi|533204886|ref|XP_005414927.1| PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Chinchilla lanigera] >gi|51702228|sp|P62957.1|CCG7_RAT RecName: Full=Voltage-dependent calcium channel gamma-7 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-7; Short=TARP gamma-7 >gi|51702249|sp|P62955.1|CCG7_HUMAN RecName: Full=Voltage-dependent calcium channel gamma-7 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-7; Short=TARP gamma-7 >gi|51702250|sp|P62956.1|CCG7_MOUSE RecName: Full=Voltage-dependent calcium channel gamma-7 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-7; Short=TARP gamma-7 >gi|17974524|gb|AAL50040.1|AF361345_1 voltage-dependent calcium channel gamma-7 subunit [Rattus norvegicus] >gi|17974532|gb|AAL50044.1|AF361349_1 voltage-dependent calcium channel gamma-7 subunit [Mus musculus] >gi|17974540|gb|AAL50048.1|AF361353_1 voltage-dependent calcium channel gamma-7 subunit [Homo sapiens] >gi|19880955|gb|AAM00594.1|AF458897_1 voltage dependent calcium channel gamma 7 subunit [Homo sapiens] >gi|19880959|gb|AAM00596.1|AF458899_1 voltage dependent calcium channel gamma 7 subunit [Mus musculus] >gi|47480710|gb|AAH69332.1| Calcium channel, voltage-dependent, gamma subunit 7 [Homo sapiens] >gi|62740015|gb|AAH93869.1| Calcium channel, voltage-dependent, gamma subunit 7 [Homo sapiens] >gi|109730503|gb|AAI13504.1| Calcium channel, voltage-dependent, gamma subunit 7 [Homo sapiens] >gi|119592569|gb|EAW72163.1| calcium channel, voltage-dependent, gamma subunit 7, isoform CRA_b [Homo sapiens] >gi|148699229|gb|EDL31176.1| calcium channel, voltage-dependent, gamma subunit 7 [Mus musculus] >gi|149029815|gb|EDL84947.1| calcium channel, voltage-dependent, gamma subunit 7 [Rattus norvegicus] >gi|160904182|gb|ABX52167.1| calcium channel, voltage-dependent, gamma subunit 7 (predicted) [Papio anubis] >gi|167427238|gb|ABZ80218.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Callithrix jacchus] >gi|170649660|gb|ACB21246.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Callicebus moloch] >gi|184185522|gb|ACC68924.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Rhinolophus ferrumequinum] >gi|190576587|gb|ACE79076.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Sorex araneus] >gi|197215700|gb|ACH53088.1| calcium channel, voltage-dependent, gamma subunit 7 (predicted) [Otolemur garnettii] >gi|217418294|gb|ACK44297.1| voltage-dependent calcium channel gamma-7 subunit (predicted) [Oryctolagus cuniculus] >gi|223461224|gb|AAI41278.1| Calcium channel, voltage-dependent, gamma subunit 7 [Mus musculus] >gi|313883284|gb|ADR83128.1| calcium channel, voltage-dependent, gamma subunit 7 (CACNG7) [synthetic construct] >gi|351715944|gb|EHB18863.1| Voltage-dependent calcium channel gamma-7 subunit [Heterocephalus glaber] >gi|355703884|gb|EHH30375.1| hypothetical protein EGK_11027 [Macaca mulatta] >gi|355756133|gb|EHH59880.1| hypothetical protein EGM_10096 [Macaca fascicularis] >gi|431917246|gb|ELK16790.1| Voltage-dependent calcium channel gamma-7 subunit [Pteropus alecto] >gi|440913389|gb|ELR62843.1| Voltage-dependent calcium channel gamma-7 subunit [Bos grunniens mutus] >gi|444728665|gb|ELW69113.1| Voltage-dependent calcium channel gamma-7 subunit [Tupaia chinensis]0
Danio rerioNP_001076553 calcium channel, voltage-dependent, gamma subunit 7a [Danio rerio]1.63781e-148
Drosophila melanogasterNP_001027082 stargazin-like protein [Drosophila melanogaster] >gi|71854527|gb|AAF50855.3| stargazin-like protein [Drosophila melanogaster] >gi|484399606|gb|AGK45224.1| GH12419p1 [Drosophila melanogaster]0.00224479
Caenorhabditis elegansNP_001024993 Protein CLC-3, isoform a [Caenorhabditis elegans] >gi|373218761|emb|CCD63043.1| Protein CLC-3, isoform a [Caenorhabditis elegans]0.0350587
Schistosoma mansoniXP_002579108 Rac guanyl-nucleotide exchange factor [Schistosoma mansoni] >gi|360044425|emb|CCD81973.1| putative rac guanyl-nucleotide exchange factor [Schistosoma mansoni]9.94988
Nematostella vectensisXP_001622435 hypothetical protein NEMVEDRAFT_v1g141205 [Nematostella vectensis] >gi|156208974|gb|EDO30335.1| predicted protein [Nematostella vectensis]0.00312764
Trichoplax adhaerensXP_002110478 hypothetical protein TRIADDRAFT_54528 [Trichoplax adhaerens] >gi|190586429|gb|EDV26482.1| hypothetical protein TRIADDRAFT_54528 [Trichoplax adhaerens]3.19589
Monosiga brevicollisXP_001742726 hypothetical protein [Monosiga brevicollis MX1] >gi|163779350|gb|EDQ92964.1| predicted protein [Monosiga brevicollis MX1]0.0326552

Table S2: Target IDs for NP_114102

NP_114102 sp|P62955|CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit OS=Homo sapiens GN=CACNG7 PE=2 SV=1
.......FromHomo sapiens
NP_114102
Pan troglodytes
XP_001174727
Danio rerio
NP_001076553
Drosophila melanogaster
NP_001027082
Caenorhabditis elegans
NP_001024993
Schistosoma mansoni
XP_002579108
Nematostella vectensis
XP_001622435
zf-C3H1, NRDE-2
Trichoplax adhaerens
XP_002110478
Zip
Monosiga brevicollis
XP_001742726
Homo sapiensNP_114102NP_114102NP_114102NP_114102AAK20030no hitBAC86028BAG60292EAW72166
Pan troglodytesXP_001174727XP_001174727XP_001174727XP_001174727XP_001174727no hitXP_509222XP_001148498XP_001174727
Danio rerioNP_001076553NP_001076553NP_001076553XP_005166293XP_001337872no hitAAH66556P59889XP_001342879
Drosophila melanogasterNP_001027082NP_001027082NP_611254NP_001027082NP_649052no hitNP_649073NP_610231NP_723472
Caenorhabditis elegansNP_001024993NP_001024993NP_001021976NP_001021976NP_001024993no hitNP_504547NP_493626T23638
Schistosoma mansoniXP_002579108XP_002579108CCD79545XP_002579718XP_002575046XP_002579108CCD59863XP_002575391no hit
Nematostella vectensisXP_001622435XP_001622435XP_001628749XP_001629312XP_001641484no hitXP_001622435XP_001626411XP_001624231
Trichoplax adhaerensXP_002110478XP_002110478XP_002111100XP_002116050XP_002112801no hitXP_002117760XP_002110478no hit
Monosiga brevicollisXP_001742726XP_001742726XP_001742726no hitno hitXP_001745309XP_001743870XP_001746384XP_001742726



Table S3: Target blast score for NP_114102

NP_114102 sp|P62955|CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit OS=Homo sapiens GN=CACNG7 PE=2 SV=1
.......FromHomo sapiens
NP_114102
Pan troglodytes
XP_001174727
Danio rerio
NP_001076553
Drosophila melanogaster
NP_001027082
Caenorhabditis elegans
NP_001024993
Schistosoma mansoni
XP_002579108
Nematostella vectensis
XP_001622435
zf-C3H1, NRDE-2
Trichoplax adhaerens
XP_002110478
Zip
Monosiga brevicollis
XP_001742726
Homo sapiens002.39048e-1342.6519e-090.005778no hit2.75727e-1155.72188e-270.0315496
Pan troglodytes003.99937e-1354.43673e-100.00476399no hit2.49764e-1128.83564e-280.00821461
Danio rerio1.63781e-1481.63781e-1481.70022e-1716.01234e-120.0440635no hit0.06565713.91723e-260.00281971
Drosophila melanogaster0.002244790.002244790.0061195601.99637no hit0.06979341.40255e-141.28694
Caenorhabditis elegans0.03505870.03505871.800421.02553e-101.06728e-166no hit3.836895.07262e-270.208214
Schistosoma mansoni9.949889.949882.140891.581440.2520500.1745435.3048e-09no hit
Nematostella vectensis2.303432.303430.7254511.76860.118947no hit01.10179e-240.349002
Trichoplax adhaerens3.195893.195891.097267.433556.80255no hit5.49738e-560no hit
Monosiga brevicollis0.03265520.03265520.550981no hitno hit2.491832.50718e-050.0003166082.50467e-160


Table S4: Comparative domain composition for NP_114102

NP_114102 sp|P62955|CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit OS=Homo sapiens GN=CACNG7 PE=2 SV=1
.......FromHomo sapiens
NP_114102
Pan troglodytes
XP_001174727
Danio rerio
NP_001076553
Drosophila melanogaster
NP_001027082
Caenorhabditis elegans
NP_001024993
Schistosoma mansoni
XP_002579108
Nematostella vectensis
XP_001622435
zf-C3H1 (1), NRDE-2 (1)
Trichoplax adhaerens
XP_002110478
Zip (1)
Monosiga brevicollis
XP_001742726
Homo sapiens



n.a.no hit
zf-C3H1 (1)

Zip (1)
n.a.
Pan troglodytesn.a.n.a.n.a.n.a.n.a.no hit
zf-C3H1 (1)

Zip (1)
n.a.
Danio rerion.a.n.a.n.a.n.a.n.a.no hit
PRP1_N (1)

Zip (1)

PMP22_Claudin (1)
Drosophila melanogastern.a.n.a.n.a.n.a.
p450 (1)
no hit
PRP1_N (1)

Zip (1)
n.a.
Caenorhabditis elegansn.a.n.a.n.a.n.a.n.a.no hit
HAT (1)

Zip (1)
n.a.
Schistosoma mansonin.a.n.a.
RA (1)

MFS_1 (1)
n.a.n.a.n.a.
Zip (1)
no hit
Nematostella vectensis
NRDE-2 (1), zf-C3H1 (1)

NRDE-2 (1), zf-C3H1 (1)

7tm_1 (1)

RINGv (1)
n.a.no hit
NRDE-2 (1), zf-C3H1 (1)

Zip (1)

Kinesin (1)
Trichoplax adhaerens
Zip (1)

Zip (1)

TM2 (1)

I-set (2), fn3 (4)

TPR_1 (1)
no hit
zf-C3H1 (1)

Zip (1)
no hit
Monosiga brevicollisn.a.n.a.n.a.no hitno hitn.a.
TPR_8 (1), PRP1_N (1)

Zip (1)
n.a.



Tree S1: Tree for NP_114102

AAH66556 PRP1_NAAH66556 DR Nv XP_001743870 TPR_8, PRP1_NXP 001743870 MB Nv NP_649073 PRP1_NNP 649073 DM Nv NP_504547 HATNP 504547 CE Nv CCD59863 n.a.CCD59863 SM Nv XP_509222 zf-C3H1XP 509222 PT Nv BAC86028 zf-C3H1BAC86028 HS Nv XP_002117760 zf-C3H1XP 002117760 TA Nv XP_001622435 zf-C3H1, NRDE-2XP 001622435 NV Hs Pt NP_001024993 n.a.NP 001024993 CE Hs Pt NP_649052 p450NP 649052 DM Ce XP_002112801 TPR_1XP 002112801 TA Ce XP_002575046 n.a.XP 002575046 SM Ce CCD79545 RACCD79545 SM Dr AAK20030 n.a.AAK20030 HS Ce EAW72166 n.a.EAW72166 HS Mb NP_114102 NP 114102 HS Pt Dr Dm XP_001174727 n.a.XP 001174727 PT Hs Dr Dm Ce Mb XP_002579108 n.a.XP 002579108 SM Hs Pt XP_001337872 n.a.XP 001337872 DR Ce XP_005166293 n.a.XP 005166293 DR Dm XP_001342879 PMP22_ClaudinXP 001342879 DR Mb NP_001076553 n.a.NP 001076553 DR Hs Pt NP_611254 n.a.NP 611254 DM Dr XP_001745309 n.a.XP 001745309 MB Sm XP_001742726 n.a.XP 001742726 MB Hs Pt Dr NP_723472 n.a.NP 723472 DM Mb T23638 n.a.T23638 CE Mb XP_001624231 KinesinXP 001624231 NV Mb XP_002579718 MFS_1XP 002579718 SM Dm XP_002116050 I-set, fn3XP 002116050 TA Dm NP_001027082 n.a.NP 001027082 DM Hs Pt NP_001021976 n.a.NP 001021976 CE Dr Dm XP_001628749 7tm_1XP 001628749 NV Dr XP_001629312 RINGvXP 001629312 NV Dm XP_002111100 TM2XP 002111100 TA Dr XP_001626411 ZipXP 001626411 NV Ta NP_610231 ZipNP 610231 DM Ta XP_002575391 ZipXP 002575391 SM Ta XP_001148498 ZipXP 001148498 PT Ta BAG60292 ZipBAG60292 HS Ta XP_001641484 n.a.XP 001641484 NV Ce P59889 ZipP59889 DR Ta XP_001746384 ZipXP 001746384 MB Ta NP_493626 ZipNP 493626 CE Ta XP_002110478 ZipXP 002110478 TA Hs Pt
((XP_002575391_SM_Ta:0.89972,((NP_610231_DM_Ta:1.12280,XP_001626411_NV_Ta:0.46836):0.05704,(XP_002111100_TA_Dr:0.00016,((XP_001745309_MB_Sm:2.93468,(((XP_002575046_SM_Ce:0.91583,(XP_002112801_TA_Ce:0.96137,(NP_649052_DM_Ce:0.98325,NP_001024993_CE_Hs_Pt:0.00014):0.47990):0.12149):0.65894,(((XP_002117760_TA_Nv:0.97693,(BAC86028_HS_Nv:0.00135,XP_509222_PT_Nv:0.00015):0.83122):0.54200,((NP_649073_DM_Nv:0.60251,(XP_001743870_MB_Nv:0.41024,AAH66556_DR_Nv:0.47251):0.24731):0.37905,(CCD59863_SM_Nv:1.02831,NP_504547_CE_Nv:0.77076):0.61686):0.54359):0.66856,XP_001622435_NV_Hs_Pt:0.07515):0.76713):0.57488,(((XP_002579108_SM_Hs_Pt:1.34598,((XP_001174727_PT_Hs_Dr_Dm_Ce_Mb:0.0,NP_114102_HS_Pt_Dr_Dm:0.0):0.00014,(EAW72166_HS_Mb:0.00014,(AAK20030_HS_Ce:0.00014,CCD79545_SM_Dr:1.61888):0.02641):0.00015):0.03150):0.07236,(XP_005166293_DR_Dm:0.00014,XP_001337872_DR_Ce:0.00016):0.29293):0.03916,((NP_001076553_DR_Hs_Pt:0.00961,XP_001342879_DR_Mb:0.04318):0.00016,NP_611254_DM_Dr:1.38746):0.04707):0.18947):0.08116):0.00013,((((T23638_CE_Mb:2.62222,(NP_723472_DM_Mb:1.02566,XP_001742726_MB_Hs_Pt_Dr:0.00014):0.26072):0.35168,XP_001624231_NV_Mb:1.79592):0.94161,(NP_001021976_CE_Dr_Dm:0.91082,(NP_001027082_DM_Hs_Pt:0.23616,(XP_002116050_TA_Dm:1.48951,XP_002579718_SM_Dm:1.94077):0.19020):0.94035):0.33087):0.16302,(XP_001629312_NV_Dm:2.70921,XP_001628749_NV_Dr:0.29631):1.27406):0.00016):1.20476):0.87752):0.04344):0.08602,(XP_002110478_TA_Hs_Pt:0.71244,(NP_493626_CE_Ta:0.39188,XP_001746384_MB_Ta:0.81399):0.01626):0.40945,(((BAG60292_HS_Ta:0.00016,XP_001148498_PT_Ta:0.00347):0.00939,XP_001641484_NV_Ce:1.71409):0.44343,P59889_DR_Ta:0.36146):0.14260);

Up
Table S1: Best blast for NP_004792 in each species
Homo sapiensNP_004792 neurexin-1-beta isoform alpha1 precursor [Homo sapiens] >gi|17369704|sp|Q9ULB1.1|NRX1A_HUMAN RecName: Full=Neurexin-1; AltName: Full=Neurexin I-alpha; AltName: Full=Neurexin-1-alpha; Flags: Precursor >gi|6498407|dbj|BAA87821.1| neurexin I-alpha protein [Homo sapiens]0
Pan troglodytesXP_003309055 PREDICTED: neurexin-1-alpha isoform 1 [Pan troglodytes]0
Danio rerioXP_005156273 PREDICTED: neurexin 1a isoform X8 [Danio rerio]0
Drosophila melanogasterNP_001262841 neurexin 1, isoform G [Drosophila melanogaster] >gi|440217754|gb|AGB96221.1| neurexin 1, isoform G [Drosophila melanogaster]0
Caenorhabditis elegansNP_001263860 Protein NRX-1, isoform l [Caenorhabditis elegans] >gi|393793244|emb|CCH63925.1| Protein NRX-1, isoform l [Caenorhabditis elegans]8.02545e-152
Schistosoma mansoniCCD76014 chondroitin sulfate proteoglycan-related [Schistosoma mansoni]1.31229e-61
Nematostella vectensisXP_001638936 predicted protein [Nematostella vectensis] >gi|156226061|gb|EDO46873.1| predicted protein [Nematostella vectensis]1.30022e-31
Trichoplax adhaerensXP_002113830 hypothetical protein TRIADDRAFT_57635 [Trichoplax adhaerens] >gi|190584234|gb|EDV24304.1| hypothetical protein TRIADDRAFT_57635 [Trichoplax adhaerens]3.46591e-31
Monosiga brevicollisXP_001750740 hypothetical protein [Monosiga brevicollis MX1] >gi|163770764|gb|EDQ84445.1| predicted protein [Monosiga brevicollis MX1]4.19825e-17

Table S2: Target IDs for NP_004792

NP_004792 sp|Q9ULB1|NRX1A_HUMAN Neurexin-1 OS=Homo sapiens GN=NRXN1 PE=2 SV=1
.......FromHomo sapiens
NP_004792
Laminin_G_2
Pan troglodytes
XP_003309055
Danio rerio
XP_005156273
Drosophila melanogaster
NP_001262841
Caenorhabditis elegans
NP_001263860
Laminin_G_2
Schistosoma mansoni
CCD76014
Laminin_G_2
Nematostella vectensis
XP_001638936
Laminin_G_2
Trichoplax adhaerens
XP_002113830
Laminin_G_2, Kazal_2, Laminin_G_1
Monosiga brevicollis
XP_001750740
Laminin_G_2
Homo sapiensNP_004792NP_004792NP_004792Q9Y4C0NP_004792BAA76765NP_877950NP_940978BAA34463
Pan troglodytesXP_003309055XP_003309055XP_003309055XP_001166116XP_003309055XP_003313158XP_001142294XP_003319002XP_001165864
Danio rerioXP_005156273XP_005156273XP_005156273NP_001073478XP_005156272XP_005156271XP_001339765NP_001170923NP_001073453
Drosophila melanogasterNP_001262841NP_001262841NP_001262841NP_001262841NP_001262841NP_001262839AAF63502AAF63502AAL39876
Caenorhabditis elegansNP_001263860NP_001263860NP_001263860NP_001263860NP_001263860NP_001256262AAD25092NP_001254438NP_001256262
Schistosoma mansoniCCD76014CCD76014CCD76014XP_002570557XP_002570557CCD76014CCD81767XP_002572665XP_002571785
Nematostella vectensisXP_001638936XP_001638936XP_001638936XP_001638936XP_001631324XP_001638936XP_001638936XP_001638936XP_001638823
Trichoplax adhaerensXP_002113830XP_002113830XP_002113830XP_002113830XP_002113830XP_002113830XP_002113830XP_002113830XP_002113830
Monosiga brevicollisXP_001750740XP_001750740XP_001744965XP_001744965XP_001750740XP_001749516XP_001744965XP_001744965XP_001750740



Table S3: Target blast score for NP_004792

NP_004792 sp|Q9ULB1|NRX1A_HUMAN Neurexin-1 OS=Homo sapiens GN=NRXN1 PE=2 SV=1
.......FromHomo sapiens
NP_004792
Laminin_G_2
Pan troglodytes
XP_003309055
Danio rerio
XP_005156273
Drosophila melanogaster
NP_001262841
Caenorhabditis elegans
NP_001263860
Laminin_G_2
Schistosoma mansoni
CCD76014
Laminin_G_2
Nematostella vectensis
XP_001638936
Laminin_G_2
Trichoplax adhaerens
XP_002113830
Laminin_G_2, Kazal_2, Laminin_G_1
Monosiga brevicollis
XP_001750740
Laminin_G_2
Homo sapiens00007.27424e-1583.34049e-621.2187e-1037.48601e-996.47388e-16
Pan troglodytes00001.53287e-1583.68283e-621.26493e-1033.51847e-1001.6586e-16
Danio rerio00008.20675e-1572.40057e-601.08565e-1128.30356e-1014.04153e-14
Drosophila melanogaster00005.90832e-1521.22762e-475.93902e-735.57419e-633.67815e-14
Caenorhabditis elegans8.02545e-1521.64348e-1511.3767e-1487.60405e-15201.89231e-474.73731e-288.98381e-211.6147e-16
Schistosoma mansoni1.31229e-611.20432e-613.56382e-564.04807e-541.66227e-5002.07182e-395.93937e-436.00202e-08
Nematostella vectensis1.57475e-311.05178e-311.10342e-316.80115e-321.38719e-272.42875e-1102.02413e-691.77564e-10
Trichoplax adhaerens3.46591e-312.97577e-315.92541e-291.51066e-334.79815e-211.02591e-091.32694e-6705.68133e-13
Monosiga brevicollis4.19825e-174.3071e-174.56377e-158.03724e-152.7708e-163.38726e-062.10216e-112.76223e-150


Table S4: Comparative domain composition for NP_004792

NP_004792 sp|Q9ULB1|NRX1A_HUMAN Neurexin-1 OS=Homo sapiens GN=NRXN1 PE=2 SV=1
Laminin_G_2 (6)
.......FromHomo sapiens
NP_004792
Laminin_G_2 (6)
Pan troglodytes
XP_003309055
Danio rerio
XP_005156273
Drosophila melanogaster
NP_001262841
Caenorhabditis elegans
NP_001263860
Laminin_G_2 (6)
Schistosoma mansoni
CCD76014
Laminin_G_2 (4)
Nematostella vectensis
XP_001638936
Laminin_G_2 (3)
Trichoplax adhaerens
XP_002113830
Laminin_G_2 (5), Kazal_2 (2), Laminin_G_1 (1)
Monosiga brevicollis
XP_001750740
Laminin_G_2 (2)
Homo sapiens
Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (-4)EGF (1), Laminin_G_1 (1), fn3 (2)

Laminin_G_2 (-6)Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), Laminin_EGF (2), Laminin_G_1 (3), SEA (1)

Laminin_G_2 (0)
Pan troglodytesn.a.n.a.n.a.
Laminin_G_2 (-6)
n.a.n.a.n.a.
Laminin_G_2 (-6)Kazal_2 (6), NtA (1), EGF (3), Kazal_1 (3), Laminin_EGF (2), Laminin_G_1 (3), SEA (1)
n.a.
Danio rerion.a.n.a.n.a.
Laminin_G_2 (0)
n.a.n.a.n.a.
Laminin_G_2 (-6)Kazal_2 (8), NtA (1), EGF (3), Kazal_1 (1), Laminin_EGF (2), Laminin_G_1 (3), SEA (1)

Laminin_G_2 (-1)
Drosophila melanogastern.a.n.a.n.a.n.a.n.a.
Laminin_G_2 (-6)

Laminin_G_2 (-3)EGF (1)

Laminin_G_2 (-3)EGF (1)

Laminin_G_2 (-4)
Caenorhabditis elegans
Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (0)

Laminin_G_2 (-3)I-set (4), Laminin_B (2), Ldl_recept_a (3), Laminin_EGF (7)

Laminin_G_2 (-3)

Laminin_G_2 (0)
Schistosoma mansoni
Laminin_G_2 (-2)

Laminin_G_2 (-2)

Laminin_G_2 (-2)
n.a.n.a.
Laminin_G_2 (-2)

Laminin_G_2 (-4)EGF (2)

Laminin_G_2 (-6)
n.a.
Nematostella vectensis
Laminin_G_2 (-3)

Laminin_G_2 (-3)

Laminin_G_2 (-3)

Laminin_G_2 (-3)

Laminin_G_2 (-4)EGF (1)

Laminin_G_2 (-3)

Laminin_G_2 (-3)

Laminin_G_2 (-3)

Laminin_G_2 (-4)Laminin_N (1), Laminin_EGF (9), fn3 (10)
Trichoplax adhaerens
Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)

Laminin_G_2 (-1)Kazal_2 (2), Laminin_G_1 (1)
Monosiga brevicollis
Laminin_G_2 (-4)

Laminin_G_2 (-4)

Laminin_G_2 (-5)Laminin_G_1 (1), Lectin_C (1)

Laminin_G_2 (-5)Laminin_G_1 (1), Lectin_C (1)

Laminin_G_2 (-4)

Laminin_G_2 (-6)EGF (2), Cadherin (1)

Laminin_G_2 (-5)Laminin_G_1 (1), Lectin_C (1)

Laminin_G_2 (-5)Laminin_G_1 (1), Lectin_C (1)

Laminin_G_2 (-4)



Tree S1: Tree for NP_004792

NP_001254438 Laminin_G_2NP 001254438 CE Ta AAD25092 Laminin_G_2, I-set, Ldl_recept_a, Laminin_B, Laminin_EGFAAD25092 CE Nv AAF63502 Laminin_G_2, EGFAAF63502 DM Nv Ta XP_001142294 n.a.XP 001142294 PT Nv NP_877950 Laminin_G_2, EGF, fn3, Laminin_G_1NP 877950 HS Nv XP_001339765 n.a.XP 001339765 DR Nv XP_001638936 Laminin_G_2XP 001638936 NV Hs Pt Dr Dm Sm Ta XP_003319002 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFXP 003319002 PT Ta NP_940978 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFNP 940978 HS Ta NP_001170923 Kazal_2, NtA, EGF, Kazal_1, SEA, Laminin_G_1, Laminin_EGFNP 001170923 DR Ta XP_002572665 XP 002572665 SM Ta CCD81767 Laminin_G_2, EGFCCD81767 SM Nv XP_002113830 Laminin_G_2, Kazal_2, Laminin_G_1XP 002113830 TA Hs Pt Dr Dm Ce Sm Nv Mb XP_001638823 Laminin_G_2, Laminin_N, fn3, Laminin_EGFXP 001638823 NV Mb XP_001750740 Laminin_G_2XP 001750740 MB Hs Pt Ce XP_001744965 Lectin_C, Laminin_G_2, Laminin_G_1XP 001744965 MB Dr Dm Nv Ta XP_002571785 n.a.XP 002571785 SM Mb XP_002570557 n.a.XP 002570557 SM Dm Ce CCD76014 Laminin_G_2CCD76014 SM Hs Pt Dr XP_001749516 EGF, CadherinXP 001749516 MB Sm NP_001256262 Laminin_G_2NP 001256262 CE Sm Mb NP_001263860 Laminin_G_2NP 001263860 CE Hs Pt Dr Dm XP_001631324 Laminin_G_2, EGFXP 001631324 NV Ce NP_001262841 n.a.NP 001262841 DM Hs Pt Dr Ce NP_001262839 NP 001262839 DM Sm AAL39876 Laminin_G_2AAL39876 DM Mb XP_001165864 n.a.XP 001165864 PT Mb XP_001166116 XP 001166116 PT Dm BAA34463 Laminin_G_2BAA34463 HS Mb Q9Y4C0 Laminin_G_2Q9Y4C0 HS Dm NP_001073478 Laminin_G_2NP 001073478 DR Dm XP_005156272 n.a.XP 005156272 DR Ce XP_005156273 n.a.XP 005156273 DR Hs Pt XP_005156271 n.a.XP 005156271 DR Sm NP_004792 Laminin_G_2NP 004792 HS Pt Dr Ce XP_003309055 n.a.XP 003309055 PT Hs Dr Ce XP_003313158 n.a.XP 003313158 PT Sm BAA76765 Laminin_G_2BAA76765 HS Sm NP_001073453 Laminin_G_2NP 001073453 DR Mb
(NP_001073453_DR_Mb:0.09507,(BAA76765_HS_Sm:0.00316,XP_003313158_PT_Sm:0.00014):0.11010,(((XP_005156271_DR_Sm:0.00104,(XP_005156273_DR_Hs_Pt:0.00016,XP_005156272_DR_Ce:0.00014):0.00015):0.16944,(XP_003309055_PT_Hs_Dr_Ce:0.00014,NP_004792_HS_Pt_Dr_Ce:0.00065):0.09466):0.09186,(((AAL39876_DM_Mb:0.00014,(NP_001262839_DM_Sm:0.00014,NP_001262841_DM_Hs_Pt_Dr_Ce:0.00014):0.00015):0.78449,(((XP_002571785_SM_Mb:0.82450,(((XP_001750740_MB_Hs_Pt_Ce:1.01683,XP_001638823_NV_Mb:1.55582):0.63075,(((CCD81767_SM_Nv:0.00274,XP_002572665_SM_Ta:0.00014):1.06142,((XP_001638936_NV_Hs_Pt_Dr_Dm_Sm_Ta:0.73865,(((AAD25092_CE_Nv:0.00014,NP_001254438_CE_Ta:0.00016):0.87082,AAF63502_DM_Nv_Ta:0.65400):0.12399,(XP_001339765_DR_Nv:0.18250,(NP_877950_HS_Nv:0.00124,XP_001142294_PT_Nv:0.00175):0.17916):0.53125):0.16745):0.07019,(NP_001170923_DR_Ta:0.31765,(NP_940978_HS_Ta:0.01118,XP_003319002_PT_Ta:0.00014):0.31268):0.60312):0.11208):0.40839,XP_002113830_TA_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Mb:1.13610):0.01999):0.17408,XP_001744965_MB_Dr_Dm_Nv_Ta:1.32858):0.21310):0.07114,(XP_001749516_MB_Sm:0.69609,(CCD76014_SM_Hs_Pt_Dr:0.00013,XP_002570557_SM_Dm_Ce:0.00082):0.88387):0.64956):0.26131,(XP_001631324_NV_Ce:1.51222,(NP_001263860_CE_Hs_Pt_Dr_Dm:0.00014,NP_001256262_CE_Sm_Mb:0.00016):1.08567):0.21084):0.07732):0.42162,(NP_001073478_DR_Dm:0.10321,(((XP_001166116_PT_Dm:0.00240,XP_001165864_PT_Mb:0.00014):0.00019,BAA34463_HS_Mb:0.00221):0.00016,Q9Y4C0_HS_Dm:0.00024):0.08626):0.08962):0.03816):0.09099);

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Table S1: Best blast for NP_000802 in each species
Homo sapiensNP_000802 gamma-aminobutyric acid receptor subunit alpha-6 precursor [Homo sapiens] >gi|126302548|sp|Q16445.2|GBRA6_HUMAN RecName: Full=Gamma-aminobutyric acid receptor subunit alpha-6; AltName: Full=GABA(A) receptor subunit alpha-6; Flags: Precursor >gi|64654354|gb|AAH96242.1| Gamma-aminobutyric acid (GABA) A receptor, alpha 6 [Homo sapiens] >gi|64654801|gb|AAH96241.1| Gamma-aminobutyric acid (GABA) A receptor, alpha 6 [Homo sapiens] >gi|68563331|gb|AAH99641.1| Gamma-aminobutyric acid (GABA) A receptor, alpha 6 [Homo sapiens] >gi|68563375|gb|AAH99640.1| Gamma-aminobutyric acid (GABA) A receptor, alpha 6 [Homo sapiens] >gi|119581946|gb|EAW61542.1| gamma-aminobutyric acid (GABA) A receptor, alpha 6 [Homo sapiens] >gi|158259945|dbj|BAF82150.1| unnamed protein product [Homo sapiens]0
Pan troglodytesXP_001144345 PREDICTED: gamma-aminobutyric acid receptor subunit alpha-6 isoform 2 [Pan troglodytes]0
Danio rerioXP_002667403 PREDICTED: gamma-aminobutyric acid receptor subunit alpha-4 [Danio rerio]0
Drosophila melanogasterNP_001162770 CG8916, isoform C [Drosophila melanogaster] >gi|272506127|gb|ACZ95305.1| CG8916, isoform C [Drosophila melanogaster]1.06361e-96
Caenorhabditis elegansNP_498532 Protein LGC-38 [Caenorhabditis elegans] >gi|373218821|emb|CCD63396.1| Protein LGC-38 [Caenorhabditis elegans]3.117e-82
Schistosoma mansoniXP_002580535 Cys-loop ligand gated ion channel subunit [Schistosoma mansoni] >gi|360044035|emb|CCD81582.1| putative cys-loop ligand gated ion channel subunit [Schistosoma mansoni]6.65235e-55
Nematostella vectensisXP_001627510 predicted protein [Nematostella vectensis] >gi|156214422|gb|EDO35410.1| predicted protein [Nematostella vectensis]3.20377e-78
Trichoplax adhaerensNo Hit
Monosiga brevicollisXP_001750950 hypothetical protein [Monosiga brevicollis MX1] >gi|163770538|gb|EDQ84226.1| predicted protein [Monosiga brevicollis MX1]2.15797e-16

Table S2: Target IDs for NP_000802

NP_000802 sp|Q16445|GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 OS=Homo sapiens GN=GABRA6 PE=2 SV=2
.......FromHomo sapiens
NP_000802
Neur_chan_memb, Neur_chan_LBD
Pan troglodytes
XP_001144345
Neur_chan_memb, Neur_chan_LBD
Danio rerio
XP_002667403
Drosophila melanogaster
NP_001162770
Neur_chan_memb, Neur_chan_LBD
Caenorhabditis elegans
NP_498532
Neur_chan_memb, Neur_chan_LBD
Schistosoma mansoni
XP_002580535
Neur_chan_memb, Neur_chan_LBD
Nematostella vectensis
XP_001627510
Neur_chan_memb, Neur_chan_LBD
Trichoplax adhaerens
No Hit
Monosiga brevicollis
XP_001750950
SAM_1, Neur_chan_LBD
Homo sapiensNP_000802NP_000802NP_000802AAH22488BAH12535XP_005263292AAB38273no hitXP_005274717
Pan troglodytesXP_001144345XP_001144345XP_001144345XP_001144345XP_001136822XP_003310621XP_001169235no hitXP_001136822
Danio rerioXP_002667403XP_002667403XP_002667403XP_001920091NP_571857NP_571477XP_694878no hitACR83582
Drosophila melanogasterNP_001162770NP_001162770NP_001162770NP_573090AAK92842NP_001034061AAA28559no hitNP_001163655
Caenorhabditis elegansNP_498532NP_498532NP_498532NP_001023766NP_498532NP_001020962NP_499661no hit3RHW_A
Schistosoma mansoniXP_002580535XP_002580535XP_002570554XP_002570554XP_002580535XP_002580535XP_002570554no hitXP_002573816
Nematostella vectensisXP_001627510XP_001627510XP_001627510XP_001627510XP_001627510XP_001627510XP_001627510no hitXP_001635153
Trichoplax adhaerensno hitno hitXP_002112422XP_002116563XP_002114242no hitXP_002114333no hitXP_002108155
Monosiga brevicollisXP_001750950XP_001750950XP_001750950XP_001750950XP_001750950XP_001744686XP_001750950no hitXP_001750950



Table S3: Target blast score for NP_000802

NP_000802 sp|Q16445|GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 OS=Homo sapiens GN=GABRA6 PE=2 SV=2
.......FromHomo sapiens
NP_000802
Neur_chan_memb, Neur_chan_LBD
Pan troglodytes
XP_001144345
Neur_chan_memb, Neur_chan_LBD
Danio rerio
XP_002667403
Drosophila melanogaster
NP_001162770
Neur_chan_memb, Neur_chan_LBD
Caenorhabditis elegans
NP_498532
Neur_chan_memb, Neur_chan_LBD
Schistosoma mansoni
XP_002580535
Neur_chan_memb, Neur_chan_LBD
Nematostella vectensis
XP_001627510
Neur_chan_memb, Neur_chan_LBD
Trichoplax adhaerens
No Hit
Monosiga brevicollis
XP_001750950
SAM_1, Neur_chan_LBD
Homo sapiens0003.21909e-912.41596e-969.31783e-676.98954e-73no hit8.99605e-15
Pan troglodytes0001.38793e-984.59081e-965.61845e-671.73299e-73no hit1.57474e-15
Danio rerio0003.07642e-881.17527e-922.3298e-662.05474e-74no hit6.43278e-15
Drosophila melanogaster1.06361e-969.16028e-978.68659e-9308.16678e-1168.14853e-668.24032e-78no hit1.73195e-10
Caenorhabditis elegans3.117e-822.41638e-823.28325e-795.1991e-8805.93774e-622.26839e-69no hit4.31869e-11
Schistosoma mansoni6.65235e-556.57145e-522.39731e-552.27967e-547.22751e-5503.6064e-47no hit1.635e-08
Nematostella vectensis3.20377e-782.87976e-781.01836e-772.76463e-696.7272e-795.40982e-560no hit4.13311e-14
Trichoplax adhaerensno hitno hit6.415922.264212.57696no hit8.74381no hit1.04018
Monosiga brevicollis2.15797e-162.42369e-169.88552e-162.78303e-102.80746e-108.25205e-066.60442e-09no hit0


Table S4: Comparative domain composition for NP_000802

NP_000802 sp|Q16445|GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 OS=Homo sapiens GN=GABRA6 PE=2 SV=2
Neur_chan_memb (1), Neur_chan_LBD (1)
.......FromHomo sapiens
NP_000802
Neur_chan_memb (1), Neur_chan_LBD (1)
Pan troglodytes
XP_001144345
Neur_chan_memb (1), Neur_chan_LBD (1)
Danio rerio
XP_002667403
Drosophila melanogaster
NP_001162770
Neur_chan_memb (1), Neur_chan_LBD (1)
Caenorhabditis elegans
NP_498532
Neur_chan_memb (1), Neur_chan_LBD (1)
Schistosoma mansoni
XP_002580535
Neur_chan_memb (1), Neur_chan_LBD (1)
Nematostella vectensis
XP_001627510
Neur_chan_memb (1), Neur_chan_LBD (1)
Trichoplax adhaerens
No Hit
Monosiga brevicollis
XP_001750950
SAM_1 (1), Neur_chan_LBD (1)
Homo sapiens
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_LBD (0), Neur_chan_memb (0)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)
Pan troglodytes
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)
Danio rerio
Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)
no hit
Neur_chan_LBD (0), Neur_chan_memb (0)
Drosophila melanogaster
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
no hit
Neur_chan_LBD (0), Neur_chan_memb (0)
Caenorhabditis elegans
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)
Schistosoma mansoni
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)
Nematostella vectensis
Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)

Neur_chan_LBD (0), Neur_chan_memb (0)
no hit
Neur_chan_LBD (0), Neur_chan_memb (0)
Trichoplax adhaerensno hitno hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)AMP-binding (1), adh_short (1), NAD_binding_4 (1), PP-binding (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)Pyridoxal_deC (1)

Neur_chan_memb (-1), Neur_chan_LBD (-1)ASC (1)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)Mif2 (1)
no hit
Neur_chan_memb (-1), Neur_chan_LBD (-1)His_Phos_2 (1)
Monosiga brevicollis
Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)

Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)

Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)

Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)

Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)

Neur_chan_LBD (0)Neur_chan_memb (-1)

Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)
no hit
Neur_chan_LBD (0)Neur_chan_memb (-1)SAM_1 (1)



Tree S1: Tree for NP_000802

NP_000802 Neur_chan_memb, Neur_chan_LBDNP 000802 HS Pt Dr XP_002108155 His_Phos_2XP 002108155 TA Mb XP_001144345 Neur_chan_memb, Neur_chan_LBDXP 001144345 PT Hs Dr Dm XP_002667403 XP 002667403 DR Hs Pt XP_001920091 XP 001920091 DR Dm AAH22488 Neur_chan_memb, Neur_chan_LBDAAH22488 HS Dm ACR83582 Neur_chan_memb, Neur_chan_LBDACR83582 DR Mb XP_005274717 XP 005274717 HS Mb XP_002112422 NAD_binding_4, AMP-binding, adh_short, PP-bindingXP 002112422 TA Dr NP_001162770 Neur_chan_memb, Neur_chan_LBDNP 001162770 DM Hs Pt Dr XP_002116563 Pyridoxal_deCXP 002116563 TA Dm NP_001023766 Neur_chan_memb, Neur_chan_LBDNP 001023766 CE Dm XP_002114242 ASCXP 002114242 TA Ce NP_498532 Neur_chan_memb, Neur_chan_LBDNP 498532 CE Hs Pt Dr AAK92842 Neur_chan_memb, Neur_chan_LBDAAK92842 DM Ce XP_002114333 Mif2XP 002114333 TA Nv XP_001627510 Neur_chan_memb, Neur_chan_LBDXP 001627510 NV Hs Pt Dr Dm Ce Sm NP_499661 Neur_chan_memb, Neur_chan_LBDNP 499661 CE Nv AAA28559 Neur_chan_memb, Neur_chan_LBDAAA28559 DM Nv XP_694878 XP 694878 DR Nv BAH12535 Neur_chan_memb, Neur_chan_LBDBAH12535 HS Ce XP_001136822 XP 001136822 PT Ce Mb AAB38273 Neur_chan_memb, Neur_chan_LBDAAB38273 HS Nv NP_571857 Neur_chan_memb, Neur_chan_LBDNP 571857 DR Ce XP_003310621 XP 003310621 PT Sm XP_005263292 XP 005263292 HS Sm NP_571477 Neur_chan_memb, Neur_chan_LBDNP 571477 DR Sm XP_001169235 XP 001169235 PT Nv NP_001034061 Neur_chan_memb, Neur_chan_LBDNP 001034061 DM Sm NP_001163655 Neur_chan_memb, Neur_chan_LBDNP 001163655 DM Mb 3RHW_A 3RHW A CE Mb NP_001020962 Neur_chan_memb, Neur_chan_LBDNP 001020962 CE Sm XP_002580535 Neur_chan_memb, Neur_chan_LBDXP 002580535 SM Hs Pt Ce XP_002570554 Neur_chan_memb, Neur_chan_LBDXP 002570554 SM Dr Dm Nv XP_001744686 Neur_chan_LBDXP 001744686 MB Sm XP_002573816 XP 002573816 SM Mb XP_001750950 SAM_1, Neur_chan_LBDXP 001750950 MB Hs Pt Dr Dm Ce Nv XP_001635153 Neur_chan_memb, Neur_chan_LBDXP 001635153 NV Mb
((XP_001635153_NV_Mb:0.68135,((XP_002573816_SM_Mb:1.57808,XP_001744686_MB_Sm:1.16701):0.32916,XP_001750950_MB_Hs_Pt_Dr_Dm_Ce_Nv:1.15530):1.03873):0.33035,(((NP_571477_DR_Sm:0.00959,((XP_005263292_HS_Sm:0.0,XP_003310621_PT_Sm:0.0):0.01478,((AAB38273_HS_Nv:0.00014,(XP_001136822_PT_Ce_Mb:0.00235,BAH12535_HS_Ce:0.00247):0.01103):0.04561,NP_571857_DR_Ce:0.08229):0.03026):0.03710):0.02373,XP_001169235_PT_Nv:0.00178):0.41155,((XP_002570554_SM_Dr_Dm_Nv:0.57505,XP_002580535_SM_Hs_Pt_Ce:0.65377):0.32147,((NP_001163655_DM_Mb:0.00014,NP_001034061_DM_Sm:0.00016):0.27905,(NP_001020962_CE_Sm:0.16475,3RHW_A_CE_Mb:0.30406):0.25455):0.34078):0.15934):0.17499,((((XP_002116563_TA_Dm:1.62499,NP_001162770_DM_Hs_Pt_Dr:0.06590):0.20458,NP_001023766_CE_Dm:0.86749):0.32002,(((XP_002667403_DR_Hs_Pt:0.15943,((XP_002108155_TA_Mb:2.06944,NP_000802_HS_Pt_Dr:0.00279):0.00026,XP_001144345_PT_Hs_Dr_Dm:0.00316):0.12190):0.10021,(XP_005274717_HS_Mb:0.07674,(ACR83582_DR_Mb:0.08139,(AAH22488_HS_Dm:0.05760,XP_001920091_DR_Dm:0.02737):0.03648):0.02303):0.10858):0.19966,XP_002112422_TA_Dr:2.35417):0.22905):0.28147,((XP_694878_DR_Nv:0.29131,(AAA28559_DM_Nv:0.11309,NP_499661_CE_Nv:0.26086):0.21699):0.29338,((AAK92842_DM_Ce:0.33575,(NP_498532_CE_Hs_Pt_Dr:0.14540,XP_002114242_TA_Ce:0.98240):0.21986):0.26736,(XP_001627510_NV_Hs_Pt_Dr_Dm_Ce_Sm:0.24715,XP_002114333_TA_Nv:0.64429):0.28751):0.06319):0.07621):0.09691);

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Table S1: Best blast for NP_005583 in each species
Homo sapiensNP_005583 muscle, skeletal receptor tyrosine-protein kinase isoform 1 [Homo sapiens] >gi|50400806|sp|O15146.1|MUSK_HUMAN RecName: Full=Muscle, skeletal receptor tyrosine-protein kinase; AltName: Full=Muscle-specific tyrosine-protein kinase receptor; Short=MuSK; Short=Muscle-specific kinase receptor; Flags: Precursor >gi|2253312|gb|AAB63044.1| muscle specific tyrosine kinase receptor [Homo sapiens]0
Pan troglodytesXP_001146498 PREDICTED: muscle, skeletal receptor tyrosine-protein kinase isoform 6 [Pan troglodytes]0
Danio rerioNP_001004503 muscle, skeletal receptor tyrosine-protein kinase isoform 1 precursor [Danio rerio] >gi|46981406|gb|AAT07679.1| unplugged isoform FL [Danio rerio]0
Drosophila melanogasterNP_477255 neurospecific receptor kinase [Drosophila melanogaster] >gi|27923847|sp|Q9V6K3.2|ROR2_DROME RecName: Full=Tyrosine-protein kinase transmembrane receptor Ror2; Short=dRor2; AltName: Full=Neurospecific receptor tyrosine kinase; Flags: Precursor >gi|21627258|gb|AAF58420.2| neurospecific receptor kinase [Drosophila melanogaster] >gi|190684754|gb|ACE82588.1| RE55360p [Drosophila melanogaster]2.95728e-118
Caenorhabditis elegansNP_001033327 Protein CAM-1, isoform c [Caenorhabditis elegans] >gi|77799257|emb|CAJ34992.1| Protein CAM-1, isoform c [Caenorhabditis elegans]1.87522e-64
Schistosoma mansoniXP_002570256 tyrosine kinase [Schistosoma mansoni] >gi|360044794|emb|CCD82342.1| tyrosine kinase [Schistosoma mansoni]8.60691e-64
Nematostella vectensisXP_001639715 predicted protein [Nematostella vectensis] >gi|156226845|gb|EDO47652.1| predicted protein [Nematostella vectensis]3.11364e-78
Trichoplax adhaerensXP_002111141 hypothetical protein TRIADDRAFT_4397 [Trichoplax adhaerens] >gi|190587092|gb|EDV27145.1| hypothetical protein TRIADDRAFT_4397, partial [Trichoplax adhaerens]3.81815e-69
Monosiga brevicollisXP_001747477 hypothetical protein [Monosiga brevicollis MX1] >gi|163773923|gb|EDQ87557.1| predicted protein [Monosiga brevicollis MX1]1.88006e-61

Table S2: Target IDs for NP_005583

NP_005583 sp|O15146|MUSK_HUMAN Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens GN=MUSK PE=1 SV=1
.......FromHomo sapiens
NP_005583
Fz, Pkinase_Tyr, I-set
Pan troglodytes
XP_001146498
Danio rerio
NP_001004503
Pkinase_Tyr, Fz, I-set, Kringle
Drosophila melanogaster
NP_477255
Pkinase_Tyr, Fz, Kringle
Caenorhabditis elegans
NP_001033327
Pkinase_Tyr, Fz, Kringle
Schistosoma mansoni
XP_002570256
Pkinase_Tyr
Nematostella vectensis
XP_001639715
Pkinase_Tyr
Trichoplax adhaerens
XP_002111141
Pkinase_Tyr
Monosiga brevicollis
XP_001747477
Pkinase_Tyr
Homo sapiensNP_005583NP_005583EAW59065EAW590653ZZW_ANP_0050031IRK_A1IRK_A3O23_A
Pan troglodytesXP_001146498XP_001146498XP_520183XP_520183XP_520126XP_513458XP_512323XP_512323XP_512323
Danio rerioNP_001004503NP_001004503NP_001004503NP_001108364XP_005165942XP_696695AAM89520AAM89520AAM89520
Drosophila melanogasterNP_477255NP_477255AAD02091NP_477255NP_476962NP_476962AER38488AER38488AER38488
Caenorhabditis elegansNP_001033327NP_001033327AAA28129NP_001033327NP_001021908NP_001021908NP_497650NP_497650AAP44084
Schistosoma mansoniXP_002570256XP_002570256XP_002570256XP_002570256XP_002570256XP_002570256AAN39120XP_002577756CBH50761
Nematostella vectensisXP_001639715XP_001639715XP_001639715XP_001639715ABN70838XP_001637553XP_001639715XP_001639715XP_001639715
Trichoplax adhaerensXP_002111141XP_002111141XP_002111141XP_002111141XP_002112653XP_002114313XP_002111144XP_002111141XP_002111144
Monosiga brevicollisXP_001747477XP_001747477XP_001747477XP_001747477XP_001750062XP_001743419XP_001747477XP_001747477XP_001747477



Table S3: Target blast score for NP_005583

NP_005583 sp|O15146|MUSK_HUMAN Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens GN=MUSK PE=1 SV=1
.......FromHomo sapiens
NP_005583
Fz, Pkinase_Tyr, I-set
Pan troglodytes
XP_001146498
Danio rerio
NP_001004503
Pkinase_Tyr, Fz, I-set, Kringle
Drosophila melanogaster
NP_477255
Pkinase_Tyr, Fz, Kringle
Caenorhabditis elegans
NP_001033327
Pkinase_Tyr, Fz, Kringle
Schistosoma mansoni
XP_002570256
Pkinase_Tyr
Nematostella vectensis
XP_001639715
Pkinase_Tyr
Trichoplax adhaerens
XP_002111141
Pkinase_Tyr
Monosiga brevicollis
XP_001747477
Pkinase_Tyr
Homo sapiens002.3547e-1771.71616e-1224.0832e-791.09077e-704.88415e-1635.22981e-1225.96931e-76
Pan troglodytes001.50434e-1756.4128e-1201.69745e-751.75298e-716.53606e-1603.01361e-1176.99737e-71
Danio rerio0004.90502e-1741.46687e-721.19367e-745.85271e-1535.92398e-1167.08807e-74
Drosophila melanogaster2.95728e-1183.21542e-1184.00031e-11302.07591e-762.90791e-791.44791e-1298.3163e-971.67683e-66
Caenorhabditis elegans1.87522e-641.74054e-643.06677e-572.18805e-7503.1918e-577.64469e-863.28189e-665.09659e-57
Schistosoma mansoni8.60691e-647.37454e-641.04319e-612.59834e-553.22137e-5702.93449e-715.37327e-591.24583e-59
Nematostella vectensis3.11364e-783.85439e-782.39564e-784.6461e-722.53672e-603.5818e-5504.21311e-1194.6207e-78
Trichoplax adhaerens3.81815e-693.81815e-691.00297e-677.78471e-675.88406e-571.34846e-463.73459e-14001.15916e-72
Monosiga brevicollis1.88006e-611.63646e-615.91931e-613.86611e-571.45223e-531.14165e-441.19148e-786.42276e-710


Table S4: Comparative domain composition for NP_005583

NP_005583 sp|O15146|MUSK_HUMAN Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens GN=MUSK PE=1 SV=1
Fz (1), Pkinase_Tyr (1), I-set (2)
.......FromHomo sapiens
NP_005583
Fz (1), Pkinase_Tyr (1), I-set (2)
Pan troglodytes
XP_001146498
Danio rerio
NP_001004503
Pkinase_Tyr (1), Fz (1), I-set (3), Kringle (1)
Drosophila melanogaster
NP_477255
Pkinase_Tyr (1), Fz (1), Kringle (1)
Caenorhabditis elegans
NP_001033327
Pkinase_Tyr (1), Fz (1), Kringle (1)
Schistosoma mansoni
XP_002570256
Pkinase_Tyr (1)
Nematostella vectensis
XP_001639715
Pkinase_Tyr (1)
Trichoplax adhaerens
XP_002111141
Pkinase_Tyr (1)
Monosiga brevicollis
XP_001747477
Pkinase_Tyr (1)
Homo sapiens
Fz (0), I-set (0), Pkinase_Tyr (0)

Fz (0), I-set (0), Pkinase_Tyr (0)
n.a.n.a.n.a.
Fz (0), I-set (-1), Pkinase_Tyr (0)Kringle (1)
n.a.n.a.
Pkinase_Tyr (-1), Fz (-1), I-set (-2)
Pan troglodytesn.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.
Danio rerio
Fz (0), I-set (1), Pkinase_Tyr (0)Kringle (1)

Fz (0), I-set (1), Pkinase_Tyr (0)Kringle (1)

Fz (0), I-set (1), Pkinase_Tyr (0)Kringle (1)

Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)
n.a.n.a.
Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)
Drosophila melanogaster
Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)Kringle (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)Kringle (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)
Caenorhabditis elegans
Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)SH3_1 (1), SH2 (1)

Fz (0), Pkinase_Tyr (0)I-set (-2)Kringle (1)

Fz (0), I-set (-1), Pkinase_Tyr (0)Kringle (1)

Fz (0), I-set (-1), Pkinase_Tyr (0)Kringle (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)Furin-like (1), Recep_L_domain (2), fn3 (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)Furin-like (1), Recep_L_domain (2), fn3 (1)

I-set (1), Pkinase_Tyr (0)Fz (-1)
Schistosoma mansoni
Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)Furin-like (1), Recep_L_domain (2)
n.a.
Pkinase_Tyr (0)Fz (-1), I-set (-2)SH2 (1)
Nematostella vectensis
Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)
Trichoplax adhaerens
Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)
Monosiga brevicollis
Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)Recep_L_domain (1)

Pkinase_Tyr (1)Fz (-1), I-set (-2)PH (1), SH2 (1)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)

Pkinase_Tyr (0)Fz (-1), I-set (-2)



Tree S1: Tree for NP_005583

XP_520183 n.a.XP 520183 PT Dr Dm NP_005583 Fz, Pkinase_Tyr, I-setNP 005583 HS Pt XP_001146498 n.a.XP 001146498 PT Hs EAW59065 n.a.EAW59065 HS Dr Dm NP_001004503 Pkinase_Tyr, Fz, I-set, KringleNP 001004503 DR Hs Pt NP_001108364 Pkinase_Tyr, Fz, KringleNP 001108364 DR Dm NP_477255 Pkinase_Tyr, Fz, KringleNP 477255 DM Hs Pt AAD02091 Fz, Pkinase_Tyr, KringleAAD02091 DM Dr XP_001637553 Pkinase_TyrXP 001637553 NV Sm XP_513458 n.a.XP 513458 PT Sm NP_005003 Pkinase_Tyr, Fz, I-set, KringleNP 005003 HS Sm XP_696695 n.a.XP 696695 DR Sm XP_005165942 n.a.XP 005165942 DR Ce XP_520126 n.a.XP 520126 PT Ce 3ZZW_A n.a.3ZZW A HS Ce XP_002570256 Pkinase_TyrXP 002570256 SM Hs Pt Dr Dm Ce NP_476962 Pkinase_Tyr, KringleNP 476962 DM Ce Sm NP_001021908 Pkinase_Tyr, Fz, I-set, KringleNP 001021908 CE Sm NP_001033327 Pkinase_Tyr, Fz, KringleNP 001033327 CE Hs Pt Dm XP_001743419 Pkinase_Tyr, PH, SH2XP 001743419 MB Sm XP_001750062 Pkinase_Tyr, Recep_L_domainXP 001750062 MB Ce XP_512323 n.a.XP 512323 PT Nv Ta Mb 1IRK_A n.a.1IRK A HS Nv Ta AAM89520 Pkinase_TyrAAM89520 DR Nv Ta Mb 3O23_A 3O23 A HS Mb NP_497650 Pkinase_Tyr, fn3, Recep_L_domain, Furin-likeNP 497650 CE Nv Ta AER38488 Pkinase_TyrAER38488 DM Nv Ta Mb XP_001639715 Pkinase_TyrXP 001639715 NV Hs Pt Dr Dm Ta Mb XP_002111144 Pkinase_TyrXP 002111144 TA Nv Mb XP_002111141 Pkinase_TyrXP 002111141 TA Hs Pt Dr Dm AAN39120 Pkinase_Tyr, Recep_L_domain, Furin-likeAAN39120 SM Nv XP_001747477 Pkinase_TyrXP 001747477 MB Hs Pt Dr Dm Nv Ta AAP44084 Pkinase_Tyr, I-setAAP44084 CE Mb ABN70838 Pkinase_TyrABN70838 NV Ce XP_002112653 Pkinase_TyrXP 002112653 TA Ce XP_002577756 n.a.XP 002577756 SM Ta CBH50761 Pkinase_Tyr, SH2CBH50761 SM Mb AAA28129 SH3_1, Pkinase_Tyr, SH2AAA28129 CE Dr XP_002114313 Pkinase_TyrXP 002114313 TA Sm
(((XP_002577756_SM_Ta:0.59606,(XP_002112653_TA_Ce:0.59357,(ABN70838_NV_Ce:0.30539,AAP44084_CE_Mb:0.46265):0.18192):0.06804):0.16784,(XP_002114313_TA_Sm:0.53077,(AAA28129_CE_Dr:0.26318,CBH50761_SM_Mb:0.23391):0.31533):0.22127):0.14131,(XP_001747477_MB_Hs_Pt_Dr_Dm_Nv_Ta:0.64304,(AAN39120_SM_Nv:0.74368,((XP_002111141_TA_Hs_Pt_Dr_Dm:0.20761,XP_002111144_TA_Nv_Mb:0.04835):0.23680,((XP_001639715_NV_Hs_Pt_Dr_Dm_Ta_Mb:0.15235,(AER38488_DM_Nv_Ta_Mb:0.23038,NP_497650_CE_Nv_Ta:0.73228):0.11901):0.06426,((1IRK_A_HS_Nv_Ta:0.00845,XP_512323_PT_Nv_Ta_Mb:0.00015):0.07168,(3O23_A_HS_Mb:0.02028,AAM89520_DR_Nv_Ta_Mb:0.04932):0.11224):0.07589):0.06312):0.17142):0.26339):0.07089,(XP_001750062_MB_Ce:0.60720,(XP_001743419_MB_Sm:0.87742,((NP_001033327_CE_Hs_Pt_Dm:0.00014,NP_001021908_CE_Sm:0.00015):0.60193,((NP_476962_DM_Ce_Sm:0.32696,(((3ZZW_A_HS_Ce:0.00243,XP_520126_PT_Ce:0.00383):0.26396,((NP_005003_HS_Sm:0.0,XP_513458_PT_Sm:0.0):0.05614,(XP_005165942_DR_Ce:0.00016,XP_696695_DR_Sm:0.00014):0.08720):0.09188):0.14849,XP_002570256_SM_Hs_Pt_Dr_Dm_Ce:0.67977):0.02947):0.11752,(XP_001637553_NV_Sm:0.51238,((AAD02091_DM_Dr:0.00014,NP_477255_DM_Hs_Pt:0.00329):0.35533,((EAW59065_HS_Dr_Dm:0.00014,(XP_001146498_PT_Hs:0.00014,(NP_005583_HS_Pt:0.00200,XP_520183_PT_Dr_Dm:0.00014):0.00019):0.00581):0.19059,(NP_001108364_DR_Dm:0.00014,NP_001004503_DR_Hs_Pt:0.00016):0.31392):0.13603):0.31888):0.07072):0.13371):0.12273):0.14729):0.05244);

Up
Table S1: Best blast for XP_004645627 in each species
Homo sapiensXP_005272742 PREDICTED: peripheral plasma membrane protein CASK isoform X1 [Octodon degus] >gi|511866943|ref|XP_004754976.1| PREDICTED: peripheral plasma membrane protein CASK isoform X1 [Mustela putorius furo] >gi|511974482|ref|XP_004805207.1| PREDICTED: peripheral plasma membrane protein CASK isoform X1 [Mustela putorius furo] >gi|512975978|ref|XP_004850059.1| PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Heterocephalus glaber] >gi|530421614|ref|XP_005272742.1| PREDICTED: peripheral plasma membrane protein CASK isoform X1 [Homo sapiens] >gi|145559462|sp|O14936.3|CSKP_HUMAN RecName: Full=Peripheral plasma membrane protein CASK; Short=hCASK; AltName: Full=Calcium/calmodulin-dependent serine protein kinase; AltName: Full=Protein lin-2 homolog >gi|119579797|gb|EAW59393.1| calcium/calmodulin-dependent serine protein kinase (MAGUK family), isoform CRA_d [Homo sapiens]0
Pan troglodytesXP_003317477 PREDICTED: peripheral plasma membrane protein CASK [Pan troglodytes]0
Danio rerioAAI62667 Cask protein [Danio rerio]0
Drosophila melanogasterNP_524441 CASK ortholog, isoform B [Drosophila melanogaster] >gi|34223738|sp|Q24210.4|CSKP_DROME RecName: Full=Peripheral plasma membrane protein CASK; Short=dCASK; AltName: Full=Calcium/calmodulin-dependent protein kinase; Short=CAKI; Short=Camguk >gi|23171917|gb|AAF55922.2| CASK ortholog, isoform B [Drosophila melanogaster] >gi|209529753|gb|ACI49771.1| FI02017p [Drosophila melanogaster]0
Caenorhabditis elegansNP_001024587 Protein LIN-2, isoform a [Caenorhabditis elegans] >gi|1708832|sp|P54936.1|LIN2_CAEEL RecName: Full=Protein lin-2; AltName: Full=Abnormal cell lineage protein 2 >gi|1054692|emb|CAA63314.1| LIN-2A [Caenorhabditis elegans] >gi|13548307|emb|CAA90760.2| Protein LIN-2, isoform a [Caenorhabditis elegans]0
Schistosoma mansoniCCD78041 MAGUK homolog [Schistosoma mansoni]0
Nematostella vectensisXP_001631427 predicted protein [Nematostella vectensis] >gi|156218467|gb|EDO39364.1| predicted protein [Nematostella vectensis]0
Trichoplax adhaerensXP_002111823 hypothetical protein TRIADDRAFT_55243 [Trichoplax adhaerens] >gi|190585722|gb|EDV25790.1| hypothetical protein TRIADDRAFT_55243 [Trichoplax adhaerens]0
Monosiga brevicollisXP_001745863 hypothetical protein [Monosiga brevicollis MX1] >gi|163775664|gb|EDQ89287.1| predicted protein [Monosiga brevicollis MX1]6.02414e-80

Table S2: Target IDs for XP_004645627

XP_004645627 sp|O14936|CSKP_HUMAN Peripheral plasma membrane protein CASK OS=Homo sapiens GN=CASK PE=1 SV=3
.......FromHomo sapiens
XP_005272742
Pan troglodytes
XP_003317477
Danio rerio
AAI62667
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Drosophila melanogaster
NP_524441
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Caenorhabditis elegans
NP_001024587
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Schistosoma mansoni
CCD78041
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Nematostella vectensis
XP_001631427
PDZ, Pkinase, L27, Guanylate_kin
Trichoplax adhaerens
XP_002111823
PDZ, Pkinase, L27, Guanylate_kin
Monosiga brevicollis
XP_001745863
Pkinase, CaMKII_AD
Homo sapiensXP_005272742XP_005272742XP_005272743NP_001119527AAB88198AAB88198NP_001119527NP_001119527NP_741960
Pan troglodytesXP_003317477XP_003317477XP_003317477XP_003317477XP_001143527XP_003317477XP_003317477XP_003317477XP_001146325
Danio rerioAAI62667AAI62667AAI62667AAI62667NP_001135848AAI62667AAI62667AAI62667NP_001017741
Drosophila melanogasterNP_524441NP_524441NP_524441NP_524441NP_524441NP_524441NP_524441NP_524441NP_524635
Caenorhabditis elegansNP_001024587NP_001024587NP_001024587NP_001024587NP_001024587NP_001024587NP_001024587NP_001024587NP_001023296
Schistosoma mansoniCCD78041CCD78041CCD78041CCD78041CCD78041CCD78041CCD78041CCD78041XP_002572628
Nematostella vectensisXP_001631427XP_001631427XP_001631427XP_001631427XP_001631427XP_001631427XP_001631427XP_001631427XP_001641961
Trichoplax adhaerensXP_002111823XP_002111823XP_002111823XP_002111823XP_002111823XP_002111823XP_002111823XP_002111823XP_002115697
Monosiga brevicollisXP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863



Table S3: Target blast score for XP_004645627

XP_004645627 sp|O14936|CSKP_HUMAN Peripheral plasma membrane protein CASK OS=Homo sapiens GN=CASK PE=1 SV=3
.......FromHomo sapiens
XP_005272742
Pan troglodytes
XP_003317477
Danio rerio
AAI62667
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Drosophila melanogaster
NP_524441
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Caenorhabditis elegans
NP_001024587
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Schistosoma mansoni
CCD78041
PDZ, SH3_2, Pkinase, L27, Guanylate_kin
Nematostella vectensis
XP_001631427
PDZ, Pkinase, L27, Guanylate_kin
Trichoplax adhaerens
XP_002111823
PDZ, Pkinase, L27, Guanylate_kin
Monosiga brevicollis
XP_001745863
Pkinase, CaMKII_AD
Homo sapiens000000002.21463e-168
Pan troglodytes00004.24229e-1520004.54301e-163
Danio rerio000000007.16333e-163
Drosophila melanogaster000000002.57647e-167
Caenorhabditis elegans00000009.14489e-1563.18516e-156
Schistosoma mansoni00000001.04783e-1616.37544e-162
Nematostella vectensis00000004.43801e-1721.15042e-162
Trichoplax adhaerens00003.9656e-1575.33019e-1632.02415e-17405.40059e-151
Monosiga brevicollis9.11955e-781.4032e-742.66046e-784.73399e-699.22121e-441.2943e-531.28644e-671.2806e-460


Table S4: Comparative domain composition for XP_004645627

XP_004645627 sp|O14936|CSKP_HUMAN Peripheral plasma membrane protein CASK OS=Homo sapiens GN=CASK PE=1 SV=3
.......FromHomo sapiens
XP_005272742
Pan troglodytes
XP_003317477
Danio rerio
AAI62667
PDZ (1), SH3_2 (1), Pkinase (1), L27 (2), Guanylate_kin (1)
Drosophila melanogaster
NP_524441
PDZ (1), SH3_2 (1), Pkinase (1), L27 (2), Guanylate_kin (1)
Caenorhabditis elegans
NP_001024587
PDZ (1), SH3_2 (1), Pkinase (1), L27 (2), Guanylate_kin (1)
Schistosoma mansoni
CCD78041
PDZ (1), SH3_2 (1), Pkinase (1), L27 (1), Guanylate_kin (1)
Nematostella vectensis
XP_001631427
PDZ (1), Pkinase (1), L27 (1), Guanylate_kin (2)
Trichoplax adhaerens
XP_002111823
PDZ (1), Pkinase (1), L27 (1), Guanylate_kin (1)
Monosiga brevicollis
XP_001745863
Pkinase (1), CaMKII_AD (1)
Homo sapiens

n.a.
PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

Pkinase (1), CaMKII_AD (1)
Pan troglodytesn.a.n.a.n.a.n.a.
PDZ (1), SH3_2 (1), Guanylate_kin (1)
n.a.n.a.n.a.
Pkinase (1), CaMKII_AD (1)
Danio rerio
PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

Pkinase (1), CaMKII_AD (1)
Drosophila melanogaster
PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

Pkinase (1), CaMKII_AD (1)
Caenorhabditis elegans
PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (2)

Pkinase (1), CaMKII_AD (1)
Schistosoma mansoni
PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), SH3_2 (1), Guanylate_kin (1), L27 (1)
n.a.
Nematostella vectensis
PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (2), L27 (1)

Pkinase (1), CaMKII_AD (1)
Trichoplax adhaerens
PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

PDZ (1), Pkinase (1), Guanylate_kin (1), L27 (1)

Pkinase (1), CaMKII_AD (1)
Monosiga brevicollis
Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)

Pkinase (1), CaMKII_AD (1)



Tree S1: Tree for XP_004645627

NP_741960 Pkinase, CaMKII_ADNP 741960 HS Mb NP_001017741 Pkinase, CaMKII_ADNP 001017741 DR Mb XP_001146325 Pkinase, CaMKII_ADXP 001146325 PT Mb XP_002572628 n.a.XP 002572628 SM Mb NP_524635 Pkinase, CaMKII_ADNP 524635 DM Mb NP_001023296 Pkinase, CaMKII_ADNP 001023296 CE Mb XP_001641961 Pkinase, CaMKII_ADXP 001641961 NV Mb XP_002115697 Pkinase, CaMKII_ADXP 002115697 TA Mb XP_001745863 Pkinase, CaMKII_ADXP 001745863 MB Hs Pt Dr Dm Ce Sm Nv Ta XP_001631427 PDZ, Pkinase, L27, Guanylate_kinXP 001631427 NV Hs Pt Dr Dm Ce Sm Ta XP_002111823 PDZ, Pkinase, L27, Guanylate_kinXP 002111823 TA Hs Pt Dr Dm Ce Sm Nv NP_001024587 PDZ, SH3_2, Pkinase, L27, Guanylate_kinNP 001024587 CE Hs Pt Dr Dm Sm Nv Ta NP_524441 PDZ, SH3_2, Pkinase, L27, Guanylate_kinNP 524441 DM Hs Pt Dr Ce Sm Nv Ta CCD78041 PDZ, SH3_2, Pkinase, L27, Guanylate_kinCCD78041 SM Hs Pt Dr Dm Ce Nv Ta XP_001143527 PDZ, SH3_2, Guanylate_kinXP 001143527 PT Ce AAI62667 PDZ, SH3_2, Pkinase, L27, Guanylate_kinAAI62667 DR Hs Pt Dm Sm Nv Ta NP_001135848 PDZ, SH3_2, Pkinase, L27, Guanylate_kinNP 001135848 DR Ce NP_001119527 PDZ, SH3_2, Pkinase, L27, Guanylate_kinNP 001119527 HS Dm Nv Ta AAB88198 PDZ, SH3_2, Pkinase, L27, Guanylate_kinAAB88198 HS Ce Sm XP_003317477 n.a.XP 003317477 PT Hs Dr Dm Sm Nv Ta XP_005272742 XP 005272742 HS Pt XP_005272743 n.a.XP 005272743 HS Dr
(XP_005272743_HS_Dr:0.00014,XP_005272742_HS_Pt:0.00014,(XP_003317477_PT_Hs_Dr_Dm_Sm_Nv_Ta:0.00014,(AAB88198_HS_Ce_Sm:0.00110,(NP_001119527_HS_Dm_Nv_Ta:0.00014,((XP_001143527_PT_Ce:0.54197,((NP_524441_DM_Hs_Pt_Dr_Ce_Sm_Nv_Ta:0.37148,(((XP_001745863_MB_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Ta:0.36844,((NP_001023296_CE_Mb:0.19157,(NP_524635_DM_Mb:0.06430,(XP_002572628_SM_Mb:0.20296,(XP_001146325_PT_Mb:0.04190,(NP_001017741_DR_Mb:0.03301,NP_741960_HS_Mb:0.01803):0.06963):0.07574):0.03045):0.03577):0.06529,(XP_002115697_TA_Mb:0.30001,XP_001641961_NV_Mb:0.21779):0.04263):0.27268):0.72075,(XP_002111823_TA_Hs_Pt_Dr_Dm_Ce_Sm_Nv:1.02580,XP_001631427_NV_Hs_Pt_Dr_Dm_Ce_Sm_Ta:0.40215):0.01257):0.09337,NP_001024587_CE_Hs_Pt_Dr_Dm_Sm_Nv_Ta:0.66538):0.05046):0.04253,CCD78041_SM_Hs_Pt_Dr_Dm_Ce_Nv_Ta:0.39639):0.05917):0.08113,(NP_001135848_DR_Ce:0.03815,AAI62667_DR_Hs_Pt_Dm_Sm_Nv_Ta:0.01606):0.02308):0.00263):0.00015):0.00015):0.00011);

Up
Table S1: Best blast for NP_705691 in each species
Homo sapiensNP_705691 MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor [Homo sapiens] >gi|46396459|sp|Q8NFP4.1|MDGA1_HUMAN RecName: Full=MAM domain-containing glycosylphosphatidylinositol anchor protein 1; AltName: Full=GPI and MAM protein; Short=GPIM; AltName: Full=Glycosylphosphatidylinositol-MAM; AltName: Full=MAM domain-containing protein 3; Flags: Precursor >gi|21744725|gb|AAM77220.1|AF478693_1 glycosyl-phosphatidyl-inositol-MAM [Homo sapiens] >gi|119624357|gb|EAX03952.1| MAM domain containing glycosylphosphatidylinositol anchor 1, isoform CRA_c [Homo sapiens] >gi|157170240|gb|AAI52818.1| MAM domain containing glycosylphosphatidylinositol anchor 1 [synthetic construct] >gi|162319050|gb|AAI56660.1| MAM domain containing glycosylphosphatidylinositol anchor 1 [synthetic construct] >gi|261858058|dbj|BAI45551.1| MAM domain containing glycosylphosphatidylinositol anchor 1 [synthetic construct]0
Pan troglodytesXP_527378 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform 6 [Pan troglodytes]0
Danio rerioXP_002665249 PREDICTED: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1 [Danio rerio]0
Drosophila melanogasterNP_001014545 Unc-89, isoform B [Drosophila melanogaster] >gi|157400482|gb|AAX52680.2| Unc-89, isoform B [Drosophila melanogaster]5.64094e-25
Caenorhabditis elegansNP_001024582 Protein HIM-4, isoform b [Caenorhabditis elegans] >gi|3328186|gb|AAC26792.1| hemicentin precursor [Caenorhabditis elegans] >gi|3875956|emb|CAA87336.1| Protein HIM-4, isoform b [Caenorhabditis elegans]1.52783e-27
Schistosoma mansoniCCD83075 putative titin [Schistosoma mansoni]8.02018e-26
Nematostella vectensisXP_001639850 predicted protein [Nematostella vectensis] >gi|156226981|gb|EDO47787.1| predicted protein [Nematostella vectensis]1.07212e-37
Trichoplax adhaerensXP_002115593 hypothetical protein TRIADDRAFT_59472 [Trichoplax adhaerens] >gi|190581881|gb|EDV21956.1| hypothetical protein TRIADDRAFT_59472 [Trichoplax adhaerens]1.92981e-33
Monosiga brevicollisXP_001744426 hypothetical protein [Monosiga brevicollis MX1] >gi|163777512|gb|EDQ91129.1| predicted protein [Monosiga brevicollis MX1]7.18851e-16

Table S2: Target IDs for NP_705691

NP_705691 sp|Q8NFP4|MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 OS=Homo sapiens GN=MDGA1 PE=1 SV=1
.......FromHomo sapiens
NP_705691
I-set, MAM
Pan troglodytes
XP_527378
I-set, MAM
Danio rerio
XP_002665249
Drosophila melanogaster
NP_001014545
RhoGEF, I-set, Pkinase, fn3
Caenorhabditis elegans
NP_001024582
I-set, EGF_CA
Schistosoma mansoni
CCD83075
cEGF, TSP_1, I-set, EGF_CA
Nematostella vectensis
XP_001639850
WSC, fn2, MAM
Trichoplax adhaerens
XP_002115593
Ldl_recept_a, MAM, Kringle
Monosiga brevicollis
XP_001744426
Kazal_2, Kazal_1, MAM
Homo sapiensNP_705691NP_705691NP_001106970XP_005246886NP_114141EAW91198Q6UXC1XP_005276429EAW86187
Pan troglodytesXP_527378XP_527378XP_001151973XP_003309483XP_514061XP_514061XP_528464XP_528464XP_521422
Danio rerioXP_002665249XP_002665249XP_002665249NP_001177233XP_005160777XP_005160777XP_001919987XP_001919987XP_005163522
Drosophila melanogasterNP_001014545NP_001014545NP_001036495NP_001097440NP_001097440NP_001014545AGA18730NP_652600AGA18735
Caenorhabditis elegansNP_001024582NP_509635NP_001024582NP_001020988NP_001024582NP_509635NP_505857no hitno hit
Schistosoma mansoniCCD83075CCD83075CCD83075XP_002578919XP_002578919CCD83075XP_002578611CCD82477XP_002577398
Nematostella vectensisXP_001639850XP_001639850XP_001639850CCH23123XP_001641619XP_001631639XP_001639850XP_001639851XP_001639851
Trichoplax adhaerensXP_002115593XP_002115593XP_002115594XP_002110943XP_002112741no hitXP_002115594XP_002115593XP_002115593
Monosiga brevicollisXP_001744426XP_001744426XP_001744426XP_001744255XP_001747141XP_001748060XP_001744426XP_001744426XP_001744426



Table S3: Target blast score for NP_705691

NP_705691 sp|Q8NFP4|MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 OS=Homo sapiens GN=MDGA1 PE=1 SV=1
.......FromHomo sapiens
NP_705691
I-set, MAM
Pan troglodytes
XP_527378
I-set, MAM
Danio rerio
XP_002665249
Drosophila melanogaster
NP_001014545
RhoGEF, I-set, Pkinase, fn3
Caenorhabditis elegans
NP_001024582
I-set, EGF_CA
Schistosoma mansoni
CCD83075
cEGF, TSP_1, I-set, EGF_CA
Nematostella vectensis
XP_001639850
WSC, fn2, MAM
Trichoplax adhaerens
XP_002115593
Ldl_recept_a, MAM, Kringle
Monosiga brevicollis
XP_001744426
Kazal_2, Kazal_1, MAM
Homo sapiens0001.18098e-120001.29521e-7401.29683e-16
Pan troglodytes0006.19004e-114009.34307e-838.57175e-781.23371e-16
Danio rerio0001.80052e-11200005.52957e-17
Drosophila melanogaster1.75377e-231.43063e-237.45998e-2801.68955e-813.78025e-731.0552e-141.9991e-284.33339e-08
Caenorhabditis elegans1.52783e-271.31041e-271.28243e-301.16699e-160000.020525no hitno hit
Schistosoma mansoni8.02018e-268.51167e-264.75515e-251.15893e-81001.31076e-062.45185e-050.00124542
Nematostella vectensis1.07212e-371.04493e-376.6153e-361.92322e-642.06886e-561.75975e-56006.05918e-25
Trichoplax adhaerens1.9485e-311.86723e-311.03842e-292.55664e-561.2056e-39no hit001.27295e-20
Monosiga brevicollis1.61766e-151.21301e-154.4441e-155.72455e-354.06721e-078.4471e-363.31508e-187.35034e-200


Table S4: Comparative domain composition for NP_705691

NP_705691 sp|Q8NFP4|MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 OS=Homo sapiens GN=MDGA1 PE=1 SV=1
I-set (4), MAM (1)
.......FromHomo sapiens
NP_705691
I-set (4), MAM (1)
Pan troglodytes
XP_527378
I-set (4), MAM (1)
Danio rerio
XP_002665249
Drosophila melanogaster
NP_001014545
RhoGEF (1), I-set (21), Pkinase (2), fn3 (2)
Caenorhabditis elegans
NP_001024582
I-set (45), EGF_CA (1)
Schistosoma mansoni
CCD83075
cEGF (1), TSP_1 (5), I-set (18), EGF_CA (5)
Nematostella vectensis
XP_001639850
WSC (1), fn2 (1), MAM (26)
Trichoplax adhaerens
XP_002115593
Ldl_recept_a (9), MAM (27), Kringle (1)
Monosiga brevicollis
XP_001744426
Kazal_2 (1), Kazal_1 (1), MAM (3)
Homo sapiens
I-set (0), MAM (0)

I-set (0), MAM (0)

I-set (-1), MAM (0)

I-set (-4), MAM (-1)

I-set (39)MAM (-1)TSP_1 (6), cEGF (1), G2F (1), EGF_CA (6)

I-set (-4), MAM (-1)

MAM (5)I-set (-4)Ldl_recept_a (1)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)
Pan troglodytes
I-set (0), MAM (0)

I-set (0), MAM (0)

I-set (-1), MAM (0)

I-set (-4), MAM (-1)

I-set (39)MAM (-1)TSP_1 (6), cEGF (1), G2F (1), EGF_CA (6)

I-set (39)MAM (-1)TSP_1 (6), cEGF (1), G2F (1), EGF_CA (6)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)
Danio rerio
I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (39)MAM (-1)TSP_1 (6), cEGF (1), G2F (1), EGF_CA (5)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)
Drosophila melanogaster
I-set (17)MAM (-1)Pkinase (2), RhoGEF (1), fn3 (2)

I-set (17)MAM (-1)Pkinase (2), RhoGEF (1), fn3 (2)

I-set (4)MAM (-1)Dscam_C (1), fn3 (6)

I-set (17)MAM (-1)Pkinase (2), RhoGEF (1), fn3 (2)

I-set (17)MAM (-1)Pkinase (2), RhoGEF (1), fn3 (2)

I-set (17)MAM (-1)Pkinase (2), RhoGEF (1), fn3 (2)

MAM (0)I-set (-4)Somatomedin_B (1)

MAM (1)I-set (-4)Pkinase_Tyr (1)

MAM (0)I-set (-4)Somatomedin_B (1), Sushi (1)
Caenorhabditis elegans
I-set (41)MAM (-1)EGF_CA (1)

I-set (41)MAM (-1)EGF_CA (1)

I-set (41)MAM (-1)EGF_CA (1)

I-set (47)MAM (-1)RCSD (6), Pkinase (2), RhoGEF (1), fn3 (2)

I-set (41)MAM (-1)EGF_CA (1)

I-set (41)MAM (-1)EGF_CA (1)

MAM (0)I-set (-4)
no hitno hit
Schistosoma mansoni
I-set (14)MAM (-1)TSP_1 (5), cEGF (1), EGF_CA (5)

I-set (14)MAM (-1)TSP_1 (5), cEGF (1), EGF_CA (5)

I-set (14)MAM (-1)TSP_1 (5), cEGF (1), EGF_CA (5)

I-set (-4), MAM (-1)

I-set (-4), MAM (-1)

I-set (14)MAM (-1)TSP_1 (5), cEGF (1), EGF_CA (5)

I-set (-4), MAM (-1)

I-set (-3)MAM (-1)Ldl_recept_a (7)

I-set (-4), MAM (-1)
Nematostella vectensis
MAM (25)I-set (-4)fn2 (1), WSC (1)

MAM (25)I-set (-4)fn2 (1), WSC (1)

MAM (25)I-set (-4)fn2 (1), WSC (1)

I-set (-3)MAM (-1)Pkinase (1)

I-set (3)MAM (-1)

I-set (-4), MAM (-1)TSP_1 (6)

MAM (25)I-set (-4)fn2 (1), WSC (1)

MAM (20)I-set (-4)Ldl_recept_a (14), Trefoil (2)

MAM (20)I-set (-4)Ldl_recept_a (14), Trefoil (2)
Trichoplax adhaerens
MAM (26)I-set (-4)Ldl_recept_a (9), Kringle (1)

MAM (26)I-set (-4)Ldl_recept_a (9), Kringle (1)

MAM (12)I-set (-4)

I-set (-2)MAM (-1)Pkinase (1), fn3 (1)

I-set (-1)MAM (-1)
no hit
MAM (12)I-set (-4)

MAM (26)I-set (-4)Ldl_recept_a (9), Kringle (1)

MAM (26)I-set (-4)Ldl_recept_a (9), Kringle (1)
Monosiga brevicollis
MAM (2)I-set (-4)Kazal_2 (1), Kazal_1 (1)

MAM (2)I-set (-4)Kazal_2 (1), Kazal_1 (1)

MAM (2)I-set (-4)Kazal_2 (1), Kazal_1 (1)

I-set (-4), MAM (-1)Pkinase (1)

I-set (-4), MAM (-1)EGF_CA (1)

I-set (-4), MAM (-1)hEGF (1), EGF_3 (5), EGF (3), cEGF (2), EGF_CA (17)

MAM (2)I-set (-4)Kazal_2 (1), Kazal_1 (1)

MAM (2)I-set (-4)Kazal_2 (1), Kazal_1 (1)

MAM (2)I-set (-4)Kazal_2 (1), Kazal_1 (1)



Tree S1: Tree for NP_705691

NP_505857 MAMNP 505857 CE Nv XP_528464 XP 528464 PT Nv Ta Q6UXC1 Ldl_recept_a, MAMQ6UXC1 HS Nv XP_005163522 XP 005163522 DR Mb CCD82477 I-set, Ldl_recept_aCCD82477 SM Ta NP_652600 Pkinase_Tyr, MAMNP 652600 DM Ta AGA18735 Sushi, MAM, Somatomedin_BAGA18735 DM Mb AGA18730 MAM, Somatomedin_BAGA18730 DM Nv XP_001744426 Kazal_2, Kazal_1, MAMXP 001744426 MB Hs Pt Dr Nv Ta XP_521422 XP 521422 PT Mb EAW86187 EAW86187 HS Mb XP_005276429 XP 005276429 HS Ta XP_001639851 Ldl_recept_a, Trefoil, MAMXP 001639851 NV Ta Mb XP_002115594 MAMXP 002115594 TA Dr Nv XP_002115593 Ldl_recept_a, MAM, KringleXP 002115593 TA Hs Pt Mb XP_001919987 XP 001919987 DR Nv Ta XP_001639850 WSC, fn2, MAMXP 001639850 NV Hs Pt Dr XP_001151973 I-set, MAMXP 001151973 PT Dr NP_001106970 I-set, MAMNP 001106970 HS Dr XP_002665249 XP 002665249 DR Hs Pt NP_705691 I-set, MAMNP 705691 HS Pt XP_527378 I-set, MAMXP 527378 PT Hs XP_002578611 XP 002578611 SM Nv CCH23123 I-set, PkinaseCCH23123 NV Dm XP_002110943 I-set, Pkinase, fn3XP 002110943 TA Dm XP_002577398 XP 002577398 SM Mb XP_001744255 PkinaseXP 001744255 MB Dm NP_509635 I-set, EGF_CANP 509635 CE Pt Sm NP_001024582 I-set, EGF_CANP 001024582 CE Hs Dr XP_005246886 XP 005246886 HS Dm XP_003309483 XP 003309483 PT Dm NP_001036495 Dscam_C, I-set, fn3NP 001036495 DM Dr NP_001014545 RhoGEF, I-set, Pkinase, fn3NP 001014545 DM Hs Pt Sm NP_001097440 RhoGEF, I-set, Pkinase, fn3NP 001097440 DM Ce NP_001020988 RCSD, RhoGEF, I-set, Pkinase, fn3NP 001020988 CE Dm XP_001641619 I-setXP 001641619 NV Ce XP_002578919 XP 002578919 SM Dm Ce CCD83075 cEGF, TSP_1, I-set, EGF_CACCD83075 SM Hs Pt Dr XP_002112741 I-setXP 002112741 TA Ce XP_005160777 XP 005160777 DR Ce Sm NP_001177233 cEGF, TSP_1, I-set, G2F, EGF_CANP 001177233 DR Dm NP_114141 cEGF, TSP_1, I-set, G2F, EGF_CANP 114141 HS Ce XP_514061 cEGF, TSP_1, I-set, G2F, EGF_CAXP 514061 PT Ce Sm EAW91198 EAW91198 HS Sm XP_001747141 EGF_CAXP 001747141 MB Ce XP_001748060 cEGF, EGF, EGF_3, hEGF, EGF_CAXP 001748060 MB Sm XP_001631639 TSP_1XP 001631639 NV Sm
((EAW91198_HS_Sm:0.09705,(XP_514061_PT_Ce_Sm:0.00363,NP_114141_HS_Ce:0.00335):0.00961):0.02718,((NP_001177233_DR_Dm:0.00014,XP_005160777_DR_Ce_Sm:0.00014):0.22984,((((NP_001024582_CE_Hs_Dr:0.0,NP_509635_CE_Pt_Sm:0.0):0.59600,(((XP_002577398_SM_Mb:1.59579,(XP_002110943_TA_Dm:0.46640,CCH23123_NV_Dm:0.40350):0.00036):0.30443,XP_001744255_MB_Dm:0.67459):1.20448,(XP_002578611_SM_Nv:2.89416,(((XP_002665249_DR_Hs_Pt:0.10745,(NP_001106970_HS_Dr:0.00084,XP_001151973_PT_Dr:0.00014):0.10116):0.23004,(XP_527378_PT_Hs:0.00016,NP_705691_HS_Pt:0.00075):0.34063):0.02402,((XP_001744426_MB_Hs_Pt_Dr_Nv_Ta:0.88022,((NP_652600_DM_Ta:1.97526,(CCD82477_SM_Ta:0.30867,(XP_005163522_DR_Mb:0.31821,(Q6UXC1_HS_Nv:0.00623,(XP_528464_PT_Nv_Ta:0.00022,NP_505857_CE_Nv:0.00015):0.00803):1.31174):0.18421):0.00024):0.18848,(AGA18730_DM_Nv:0.00015,AGA18735_DM_Mb:0.01937):1.00271):0.22141):0.12133,(((XP_001639851_NV_Ta_Mb:0.42574,(XP_005276429_HS_Ta:0.00015,(EAW86187_HS_Mb:0.00014,XP_521422_PT_Mb:0.02348):0.01149):1.15377):0.15012,((XP_002115593_TA_Hs_Pt_Mb:0.53060,XP_002115594_TA_Dr_Nv:0.48699):0.00015,XP_001919987_DR_Nv_Ta:0.74205):0.14909):0.23107,XP_001639850_NV_Hs_Pt_Dr:0.15162):0.61559):0.63612):0.91666):0.46995):0.39544):0.30672,((XP_001641619_NV_Ce:0.88922,NP_001020988_CE_Dm:1.29178):0.20212,((NP_001097440_DM_Ce:0.00014,NP_001014545_DM_Hs_Pt_Sm:0.00014):1.20164,(NP_001036495_DM_Dr:0.81199,(XP_003309483_PT_Dm:0.50572,XP_005246886_HS_Dm:0.56327):0.30656):0.10163):0.14555):0.14059):0.15645,(XP_002112741_TA_Ce:0.88529,(CCD83075_SM_Hs_Pt_Dr:0.00014,XP_002578919_SM_Dm_Ce:0.00015):1.07112):0.18708):0.44416):0.18537,(XP_001631639_NV_Sm:1.00437,(XP_001748060_MB_Sm:0.51342,XP_001747141_MB_Ce:0.73521):2.37554):0.00024);

Up
Table S1: Best blast for NP_002325 in each species
Homo sapiensNP_002325 low-density lipoprotein receptor-related protein 4 precursor [Homo sapiens] >gi|269849756|sp|O75096.4|LRP4_HUMAN RecName: Full=Low-density lipoprotein receptor-related protein 4; Short=LRP-4; AltName: Full=Multiple epidermal growth factor-like domains 7; Flags: Precursor0
Pan troglodytesXP_508403 PREDICTED: low-density lipoprotein receptor-related protein 4 [Pan troglodytes]0
Danio rerioNP_001128156 low-density lipoprotein receptor-related protein 6 precursor [Danio rerio] >gi|170785927|gb|ACB38032.1| low density lipoprotein receptor-related protein 6 [Danio rerio]0
Drosophila melanogasterNP_001162769 CG8909, isoform C [Drosophila melanogaster] >gi|209418004|gb|ACI46540.1| IP21864p [Drosophila melanogaster] >gi|272506125|gb|ACZ95304.1| CG8909, isoform C [Drosophila melanogaster]0
Caenorhabditis elegansNP_492127 Protein LRP-1 [Caenorhabditis elegans] >gi|1708868|sp|Q04833.1|LRP_CAEEL RecName: Full=Low-density lipoprotein receptor-related protein; Short=LRP; Flags: Precursor >gi|156360|gb|AAA28105.1| LDL receptor-related protein [Caenorhabditis elegans] >gi|3876533|emb|CAA98124.1| Protein LRP-1 [Caenorhabditis elegans]0
Schistosoma mansoniXP_002578095 low-density lipoprotein receptor (ldl) [Schistosoma mansoni] >gi|360044928|emb|CCD82476.1| low-density lipoprotein receptor (ldl) [Schistosoma mansoni]2.28858e-13
Nematostella vectensisXP_001641196 predicted protein [Nematostella vectensis] >gi|156228334|gb|EDO49133.1| predicted protein [Nematostella vectensis]0
Trichoplax adhaerensXP_002107786 hypothetical protein TRIADDRAFT_19424 [Trichoplax adhaerens] >gi|190588562|gb|EDV28584.1| hypothetical protein TRIADDRAFT_19424, partial [Trichoplax adhaerens]0
Monosiga brevicollisXP_001749516 hypothetical protein [Monosiga brevicollis MX1] >gi|163771908|gb|EDQ85567.1| predicted protein [Monosiga brevicollis MX1]1.19248e-07

Table S2: Target IDs for NP_002325

NP_002325 sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4
.......FromHomo sapiens
NP_002325
cEGF, Ldl_recept_b, Ldl_recept_a
Pan troglodytes
XP_508403
Danio rerio
NP_001128156
Ldl_recept_b, Ldl_recept_a
Drosophila melanogaster
NP_001162769
Ldl_recept_b, Ldl_recept_a, EGF_CA
Caenorhabditis elegans
NP_492127
Ldl_recept_b, Ldl_recept_a
Schistosoma mansoni
XP_002578095
Ldl_recept_a
Nematostella vectensis
XP_001641196
Ldl_recept_b, Ldl_recept_a
Trichoplax adhaerens
XP_002107786
Ldl_recept_b, Ldl_recept_a
Monosiga brevicollis
XP_001749516
EGF, Cadherin
Homo sapiensNP_002325NP_002325AAC33006NP_002325AAB41649BAC03874AAC33006AAC33006XP_005259981
Pan troglodytesXP_508403XP_508403XP_001152103XP_508403XP_515882XP_520460XP_001152103XP_001152103XP_003309615
Danio rerioNP_001128156NP_001128156NP_001128156NP_001128156NP_001181916AAI28655NP_001128156NP_001128156NP_571516
Drosophila melanogasterNP_001162769NP_001162769AAF91072NP_001162769NP_001096924NP_001027034AAF91072AAF91072AAA28725
Caenorhabditis elegansNP_492127NP_492127NP_492127NP_492127NP_492127NP_492127NP_492127NP_492127NP_510822
Schistosoma mansoniXP_002578095XP_002578095XP_002578095XP_002578095XP_002578095XP_002578095XP_002578095XP_002578095CCD77998
Nematostella vectensisXP_001641196XP_001641196XP_001641196XP_001641196XP_001635789XP_001635789XP_001641196XP_001641196XP_001624536
Trichoplax adhaerensXP_002107786XP_002107786XP_002107786XP_002107786XP_002114326XP_002114326XP_002107786XP_002107786XP_002113653
Monosiga brevicollisXP_001749516XP_001749516XP_001743242XP_001750392XP_001748060XP_001750106XP_001743242XP_001743242XP_001749516



Table S3: Target blast score for NP_002325

NP_002325 sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4
.......FromHomo sapiens
NP_002325
cEGF, Ldl_recept_b, Ldl_recept_a
Pan troglodytes
XP_508403
Danio rerio
NP_001128156
Ldl_recept_b, Ldl_recept_a
Drosophila melanogaster
NP_001162769
Ldl_recept_b, Ldl_recept_a, EGF_CA
Caenorhabditis elegans
NP_492127
Ldl_recept_b, Ldl_recept_a
Schistosoma mansoni
XP_002578095
Ldl_recept_a
Nematostella vectensis
XP_001641196
Ldl_recept_b, Ldl_recept_a
Trichoplax adhaerens
XP_002107786
Ldl_recept_b, Ldl_recept_a
Monosiga brevicollis
XP_001749516
EGF, Cadherin
Homo sapiens000009.82563e-22004.70623e-22
Pan troglodytes000001.22228e-24003.41004e-24
Danio rerio000001.03126e-23005.45827e-22
Drosophila melanogaster000001.25323e-24006.1285e-19
Caenorhabditis elegans008.22665e-150001.09329e-202.49322e-1435.89487e-1165.17586e-20
Schistosoma mansoni2.28858e-131.30936e-134.94175e-206.24841e-181.84042e-2001.72151e-198.26767e-161.38465e-18
Nematostella vectensis00001.72173e-1382.30013e-27001.18712e-34
Trichoplax adhaerens0004.72605e-1774.91107e-1241.94022e-25004.93975e-29
Monosiga brevicollis4.03058e-091.64576e-080.0007571433.23311e-050.001263120.008385665.00889e-060.008665690


Table S4: Comparative domain composition for NP_002325

NP_002325 sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4
cEGF (1), Ldl_recept_b (16), Ldl_recept_a (8)
.......FromHomo sapiens
NP_002325
cEGF (1), Ldl_recept_b (16), Ldl_recept_a (8)
Pan troglodytes
XP_508403
Danio rerio
NP_001128156
Ldl_recept_b (12), Ldl_recept_a (3)
Drosophila melanogaster
NP_001162769
Ldl_recept_b (12), Ldl_recept_a (7), EGF_CA (1)
Caenorhabditis elegans
NP_492127
Ldl_recept_b (8), Ldl_recept_a (29)
Schistosoma mansoni
XP_002578095
Ldl_recept_a (4)
Nematostella vectensis
XP_001641196
Ldl_recept_b (12), Ldl_recept_a (3)
Trichoplax adhaerens
XP_002107786
Ldl_recept_b (9), Ldl_recept_a (2)
Monosiga brevicollis
XP_001749516
EGF (2), Cadherin (1)
Homo sapiens
Ldl_recept_a (0), cEGF (0), Ldl_recept_b (0)

Ldl_recept_a (0), cEGF (0), Ldl_recept_b (0)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (0), cEGF (0), Ldl_recept_b (0)

Ldl_recept_a (26), cEGF (0), Ldl_recept_b (-2)EGF_CA (2)

Ldl_recept_a (-3), Ldl_recept_b (-11)cEGF (-1)EGF_CA (1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)
Pan troglodytesn.a.n.a.
Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)
n.a.
Ldl_recept_a (26), cEGF (0), Ldl_recept_b (-3)EGF_CA (2)

Ldl_recept_a (0), Ldl_recept_b (-11)cEGF (-1)EGF_CA (1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)NIDO (1), hEGF (3), EGF (11), fn3 (3)
Danio rerio
Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (27), cEGF (2), Ldl_recept_b (1)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)CUB (2), Trypsin (1), SEA (1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)hEGF (3), EGF (22), Ank (5), NODP (1), NOD (1), Notch (3), DUF3454 (1), EGF_CA (4)
Drosophila melanogaster
Ldl_recept_a (-1), Ldl_recept_b (-4)cEGF (-1)EGF_CA (1)

Ldl_recept_a (-1), Ldl_recept_b (-4)cEGF (-1)EGF_CA (1)

Ldl_recept_a (-5), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (-1), Ldl_recept_b (-4)cEGF (-1)EGF_CA (1)

Ldl_recept_a (26), Ldl_recept_b (-8)cEGF (-1)EGF_CA (4)

Ldl_recept_a (12)cEGF (-1), Ldl_recept_b (-16)Laminin_G_2 (2), I-set (7), EGF (1), Laminin_B (3), Laminin_G_1 (1), Laminin_EGF (7)

Ldl_recept_a (-5), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-7)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)EGF (24), Ank (5), NODP (1), NOD (1), Notch (3), EGF_CA (4), DUF3454 (1)
Caenorhabditis elegans
Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

Ldl_recept_a (21), Ldl_recept_b (-8)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)Laminin_G_2 (2), hEGF (3), EGF (8), EGF_2 (1), EGF_CA (1)
Schistosoma mansoni
Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

Ldl_recept_a (-4)cEGF (-1), Ldl_recept_b (-16)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)EGF (3)
Nematostella vectensis
Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (0), Ldl_recept_b (-12)cEGF (-1)EGF_CA (1)

Ldl_recept_a (0), Ldl_recept_b (-12)cEGF (-1)EGF_CA (1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

Ldl_recept_a (-5), Ldl_recept_b (-4)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)TSP_1 (1), EGF (1), Cadherin (2)
Trichoplax adhaerens
Ldl_recept_a (-6), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (-6), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (-6), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (-6), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (0), cEGF (0), Ldl_recept_b (-13)

Ldl_recept_a (0), cEGF (0), Ldl_recept_b (-13)

Ldl_recept_a (-6), Ldl_recept_b (-7)cEGF (-1)

Ldl_recept_a (-6), Ldl_recept_b (-7)cEGF (-1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)hEGF (2), EGF (30), EGF_CA (1)
Monosiga brevicollis
cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)EGF (2), Cadherin (1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)EGF (2), Cadherin (1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)

cEGF (0)Ldl_recept_b (-16), Ldl_recept_a (-8)GPS (1), EGF_3 (1), 7tm_2 (1), EGF_CA (1)

cEGF (1)Ldl_recept_b (-16), Ldl_recept_a (-8)hEGF (1), EGF_3 (5), EGF (3), EGF_CA (17)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)Fibrinogen_C (2), Pkinase_Tyr (1)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)

cEGF (-1), Ldl_recept_b (-16), Ldl_recept_a (-8)EGF (2), Cadherin (1)



Tree S1: Tree for NP_002325

AAF91072 Ldl_recept_b, Ldl_recept_aAAF91072 DM Dr Nv Ta XP_001749516 EGF, CadherinXP 001749516 MB Hs Pt XP_001641196 Ldl_recept_b, Ldl_recept_aXP 001641196 NV Hs Pt Dr Dm Ta AAC33006 Ldl_recept_b, Ldl_recept_aAAC33006 HS Dr Nv Ta XP_001152103 Ldl_recept_b, Ldl_recept_aXP 001152103 PT Dr Nv Ta NP_001128156 Ldl_recept_b, Ldl_recept_aNP 001128156 DR Hs Pt Dm Nv Ta XP_002107786 Ldl_recept_b, Ldl_recept_aXP 002107786 TA Hs Pt Dr Dm Nv NP_002325 cEGF, Ldl_recept_b, Ldl_recept_aNP 002325 HS Pt Dm XP_508403 n.a.XP 508403 PT Hs Dm NP_001162769 Ldl_recept_b, Ldl_recept_a, EGF_CANP 001162769 DM Hs Pt AAI28655 Trypsin, Ldl_recept_a, SEA, CUBAAI28655 DR Sm XP_002114326 cEGF, Ldl_recept_b, Ldl_recept_aXP 002114326 TA Ce Sm XP_001635789 Ldl_recept_b, Ldl_recept_a, EGF_CAXP 001635789 NV Ce Sm NP_510822 Laminin_G_2, EGF, hEGF, EGF_2, EGF_CANP 510822 CE Mb CCD77998 EGFCCD77998 SM Mb AAA28725 Notch, Ank, EGF, NODP, DUF3454, EGF_CA, NODAAA28725 DM Mb XP_002113653 EGF, hEGF, EGF_CAXP 002113653 TA Mb XP_001748060 cEGF, EGF, EGF_3, hEGF, EGF_CAXP 001748060 MB Ce XP_001750392 cEGF, EGF_3, GPS, 7tm_2, EGF_CAXP 001750392 MB Dm XP_005259981 XP 005259981 HS Mb NP_571516 Ank, EGF, hEGF, NODP, NOD, Notch, EGF_CA, DUF3454NP 571516 DR Mb XP_003309615 NIDO, EGF, hEGF, fn3XP 003309615 PT Mb NP_001027034 Laminin_G_2, EGF, I-set, Laminin_B, Ldl_recept_a, Laminin_EGF, Laminin_G_1NP 001027034 DM Sm XP_002578095 Ldl_recept_aXP 002578095 SM Hs Pt Dr Dm Ce Nv Ta XP_001624536 TSP_1, EGF, CadherinXP 001624536 NV Mb BAC03874 Ldl_recept_b, Ldl_recept_a, EGF_CABAC03874 HS Sm XP_520460 Ldl_recept_b, Ldl_recept_a, EGF_CAXP 520460 PT Sm XP_515882 cEGF, Ldl_recept_b, Ldl_recept_a, EGF_CAXP 515882 PT Ce AAB41649 cEGF, Ldl_recept_b, Ldl_recept_a, EGF_CAAAB41649 HS Ce NP_001181916 cEGF, Ldl_recept_b, Ldl_recept_aNP 001181916 DR Ce XP_001743242 XP 001743242 MB Dr Nv Ta XP_001750106 Pkinase_Tyr, Fibrinogen_CXP 001750106 MB Sm NP_001096924 Ldl_recept_b, Ldl_recept_a, EGF_CANP 001096924 DM Ce NP_492127 Ldl_recept_b, Ldl_recept_aNP 492127 CE Hs Pt Dr Dm Sm Nv Ta
((((XP_001624536_NV_Mb:3.94856,(((((NP_001162769_DM_Hs_Pt:0.57874,(XP_508403_PT_Hs_Dm:0.00184,NP_002325_HS_Pt_Dm:0.00016):0.40283):0.16652,(XP_002107786_TA_Hs_Pt_Dr_Dm_Nv:0.91976,((XP_001641196_NV_Hs_Pt_Dr_Dm_Ta:0.42087,(XP_001749516_MB_Hs_Pt:0.83146,AAF91072_DM_Dr_Nv_Ta:0.58598):0.06471):0.06945,(NP_001128156_DR_Hs_Pt_Dm_Nv_Ta:0.09703,(XP_001152103_PT_Dr_Nv_Ta:0.00069,AAC33006_HS_Dr_Nv_Ta:0.00098):0.09036):0.25349):0.07165):0.26964):0.18305,(XP_002114326_TA_Ce_Sm:0.39791,AAI28655_DR_Sm:0.60712):0.13490):0.11627,XP_001635789_NV_Ce_Sm:0.50132):0.08854,((XP_003309615_PT_Mb:0.67710,(((AAA28725_DM_Mb:0.54257,(CCD77998_SM_Mb:0.82895,NP_510822_CE_Mb:0.73994):0.11395):0.16396,XP_002113653_TA_Mb:0.43547):0.12377,((XP_005259981_HS_Mb:0.18691,(XP_001750392_MB_Dm:0.43398,XP_001748060_MB_Ce:0.51605):0.60771):0.14594,NP_571516_DR_Mb:0.27913):0.10847):0.36828):1.87587,(XP_002578095_SM_Hs_Pt_Dr_Dm_Ce_Nv_Ta:0.54622,NP_001027034_DM_Sm:0.70225):0.18644):0.00018):0.02778):0.10698,(XP_520460_PT_Sm:0.00014,BAC03874_HS_Sm:0.00015):0.50976):0.31989,(NP_001181916_DR_Ce:0.21442,(AAB41649_HS_Ce:0.00318,XP_515882_PT_Ce:0.00216):0.25860):0.30320):0.12388,NP_492127_CE_Hs_Pt_Dr_Dm_Sm_Nv_Ta:0.76462,((XP_001750106_MB_Sm:1.30550,XP_001743242_MB_Dr_Nv_Ta:0.70408):0.65721,NP_001096924_DM_Ce:0.53515):0.03359);

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Table S1: Best blast for CAI65266 in each species
Homo sapiensNP_741960 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [Homo sapiens] >gi|397517760|ref|XP_003829074.1| PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [Pan paniscus] >gi|402873070|ref|XP_003900409.1| PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [Papio anubis] >gi|403285503|ref|XP_003934062.1| PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [Saimiri boliviensis boliviensis] >gi|426350596|ref|XP_004042856.1| PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 [Gorilla gorilla gorilla] >gi|68052312|sp|Q5RCC4.2|KCC2A_PONAB RecName: Full=Calcium/calmodulin-dependent protein kinase type II subunit alpha; Short=CaM kinase II subunit alpha; Short=CaMK-II subunit alpha >gi|296434552|sp|Q9UQM7.2|KCC2A_HUMAN RecName: Full=Calcium/calmodulin-dependent protein kinase type II subunit alpha; Short=CaM kinase II subunit alpha; Short=CaMK-II subunit alpha >gi|5915912|gb|AAD55815.1| calmodulin-dependent protein kinase II alpha [Homo sapiens] >gi|119582145|gb|EAW61741.1| calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_a [Homo sapiens] >gi|168278773|dbj|BAG11266.1| calcium/calmodulin-dependent protein kinase type II alpha chain [synthetic construct]0
Pan troglodytesXP_001165329 PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 16 [Pan troglodytes]0
Danio rerioNP_001017741 calcium/calmodulin-dependent protein kinase type II subunit alpha [Danio rerio] >gi|79158871|gb|AAI07972.1| Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha [Danio rerio]0
Drosophila melanogasterNP_524635 Calcium/calmodulin-dependent protein kinase II, isoform C [Drosophila melanogaster] >gi|45551188|ref|NP_726633.2| Calcium/calmodulin-dependent protein kinase II, isoform A [Drosophila melanogaster] >gi|281359585|ref|NP_001162831.1| Calcium/calmodulin-dependent protein kinase II, isoform H [Drosophila melanogaster] >gi|157178|gb|AAA51459.1| calmodulin-dependent protein kinase [Drosophila melanogaster] >gi|217322|dbj|BAA02593.1| Ca2+/calmodulin-dependent protein kinase II [Drosophila sp.] >gi|45444825|gb|AAF59388.3| Calcium/calmodulin-dependent protein kinase II, isoform A [Drosophila melanogaster] >gi|45444826|gb|AAF59389.3| Calcium/calmodulin-dependent protein kinase II, isoform C [Drosophila melanogaster] >gi|211938527|gb|ACJ13160.1| FI03620p [Drosophila melanogaster] >gi|272482450|gb|ACZ95100.1| Calcium/calmodulin-dependent protein kinase II, isoform H [Drosophila melanogaster]0
Caenorhabditis elegansNP_001023296 Protein UNC-43, isoform d [Caenorhabditis elegans] >gi|5834390|gb|AAD53949.1|AF180735_1 calcium/calmodulin dependent protein kinase II [Caenorhabditis elegans] >gi|14530502|emb|CAC42326.1| Protein UNC-43, isoform d [Caenorhabditis elegans]0
Schistosoma mansoniXP_002572628 protein kinase [Schistosoma mansoni]0
Nematostella vectensisXP_001622637 predicted protein [Nematostella vectensis] >gi|156209221|gb|EDO30537.1| predicted protein [Nematostella vectensis]0
Trichoplax adhaerensXP_002115697 hypothetical protein TRIADDRAFT_50756 [Trichoplax adhaerens] >gi|190581473|gb|EDV21549.1| hypothetical protein TRIADDRAFT_50756 [Trichoplax adhaerens]0
Monosiga brevicollisXP_001745863 hypothetical protein [Monosiga brevicollis MX1] >gi|163775664|gb|EDQ89287.1| predicted protein [Monosiga brevicollis MX1]7.08873e-166

Table S2: Target IDs for CAI65266

CAI65266 sp|Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens GN=CAMK2A PE=1 SV=2
.......FromHomo sapiens
NP_741960
Pkinase, CaMKII_AD
Pan troglodytes
XP_001165329
Danio rerio
NP_001017741
Pkinase, CaMKII_AD
Drosophila melanogaster
NP_524635
Pkinase, CaMKII_AD
Caenorhabditis elegans
NP_001023296
Pkinase, CaMKII_AD
Schistosoma mansoni
XP_002572628
Nematostella vectensis
XP_001622637
Pkinase, CaMKII_AD
Trichoplax adhaerens
XP_002115697
Pkinase, CaMKII_AD
Monosiga brevicollis
XP_001745863
Pkinase, CaMKII_AD
Homo sapiensNP_741960NP_057065BAA76812NP_742113NP_742126NP_742113NP_7421133SOA_ANP_741960
Pan troglodytesXP_001165329XP_001165329XP_001146392XP_001146392XP_001146325XP_001146392XP_001146392XP_001146325XP_001146325
Danio rerioNP_001017741NP_001017741NP_001017741XP_005156968XP_005159897XP_005159897XP_005159897XP_005159899NP_001017741
Drosophila melanogasterNP_524635NP_524635NP_524635NP_524635NP_001259082NP_726634NP_524635NP_001259082NP_524635
Caenorhabditis elegansNP_001023296NP_001023296NP_001023296NP_001023296NP_001023296NP_001023296NP_001023296NP_001023301NP_001023296
Schistosoma mansoniXP_002572628XP_002572628XP_002572628XP_002572628XP_002572628XP_002572628XP_002572628XP_002572628XP_002572628
Nematostella vectensisXP_001622637XP_001622637XP_001622637XP_001622637XP_001622637XP_001622637XP_001622637XP_001622637XP_001641961
Trichoplax adhaerensXP_002115697XP_002115697XP_002115697XP_002115697XP_002115697XP_002115697XP_002115697XP_002115697XP_002115697
Monosiga brevicollisXP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863XP_001745863



Table S3: Target blast score for CAI65266

CAI65266 sp|Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens GN=CAMK2A PE=1 SV=2
.......FromHomo sapiens
NP_741960
Pkinase, CaMKII_AD
Pan troglodytes
XP_001165329
Danio rerio
NP_001017741
Pkinase, CaMKII_AD
Drosophila melanogaster
NP_524635
Pkinase, CaMKII_AD
Caenorhabditis elegans
NP_001023296
Pkinase, CaMKII_AD
Schistosoma mansoni
XP_002572628
Nematostella vectensis
XP_001622637
Pkinase, CaMKII_AD
Trichoplax adhaerens
XP_002115697
Pkinase, CaMKII_AD
Monosiga brevicollis
XP_001745863
Pkinase, CaMKII_AD
Homo sapiens000000003.55008e-166
Pan troglodytes000000004.54301e-163
Danio rerio000000007.16333e-163
Drosophila melanogaster000000002.57647e-167
Caenorhabditis elegans00000001.54211e-1623.18516e-156
Schistosoma mansoni000000001.25214e-163
Nematostella vectensis000000001.15042e-162
Trichoplax adhaerens000000005.40059e-151
Monosiga brevicollis7.08873e-1669.64757e-1511.29611e-1632.39708e-1652.50198e-1541.14521e-1618.89543e-1603.48517e-1470


Table S4: Comparative domain composition for CAI65266

CAI65266 sp|Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens GN=CAMK2A PE=1 SV=2
Pkinase (1), CaMKII_AD (1)
.......FromHomo sapiens
NP_741960
Pkinase (1), CaMKII_AD (1)
Pan troglodytes
XP_001165329
Danio rerio
NP_001017741
Pkinase (1), CaMKII_AD (1)
Drosophila melanogaster
NP_524635
Pkinase (1), CaMKII_AD (1)
Caenorhabditis elegans
NP_001023296
Pkinase (1), CaMKII_AD (1)
Schistosoma mansoni
XP_002572628
Nematostella vectensis
XP_001622637
Pkinase (1), CaMKII_AD (1)
Trichoplax adhaerens
XP_002115697
Pkinase (1), CaMKII_AD (1)
Monosiga brevicollis
XP_001745863
Pkinase (1), CaMKII_AD (1)
Homo sapiens
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (0), CaMKII_AD (0)
Pan troglodytes
Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (0), CaMKII_AD (0)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)
Danio rerio
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (-1), CaMKII_AD (-1)

Pkinase (0), CaMKII_AD (0)
Drosophila melanogaster
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)
Caenorhabditis elegans
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)
Schistosoma mansonin.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.
Nematostella vectensis
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)
Trichoplax adhaerens
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)
Monosiga brevicollis
Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)

Pkinase (0), CaMKII_AD (0)



Tree S1: Tree for CAI65266

XP_001641961 Pkinase, CaMKII_ADXP 001641961 NV Mb XP_001622637 Pkinase, CaMKII_ADXP 001622637 NV Hs Pt Dr Dm Ce Sm Ta XP_002115697 Pkinase, CaMKII_ADXP 002115697 TA Hs Pt Dr Dm Ce Sm Nv Mb XP_001745863 Pkinase, CaMKII_ADXP 001745863 MB Hs Pt Dr Dm Ce Sm Nv Ta NP_001023301 Pkinase, CaMKII_ADNP 001023301 CE Ta NP_001023296 Pkinase, CaMKII_ADNP 001023296 CE Hs Pt Dr Dm Sm Nv Mb NP_524635 Pkinase, CaMKII_ADNP 524635 DM Hs Pt Dr Nv Mb NP_726634 Pkinase, CaMKII_ADNP 726634 DM Sm NP_001259082 Pkinase, CaMKII_ADNP 001259082 DM Ce Ta XP_002572628 n.a.XP 002572628 SM Hs Pt Dr Dm Ce Nv Ta Mb XP_005156968 XP 005156968 DR Dm NP_742126 Pkinase, CaMKII_ADNP 742126 HS Ce XP_001146325 Pkinase, CaMKII_ADXP 001146325 PT Ce Ta Mb NP_742113 Pkinase, CaMKII_ADNP 742113 HS Dm Sm Nv XP_001146392 XP 001146392 PT Dr Dm Sm Nv XP_005159897 XP 005159897 DR Ce Sm Nv XP_005159899 XP 005159899 DR Ta NP_001017741 Pkinase, CaMKII_ADNP 001017741 DR Hs Pt Mb XP_001165329 XP 001165329 PT Hs 3SOA_A 3SOA A HS Ta NP_057065 Pkinase, CaMKII_ADNP 057065 HS Pt NP_741960 Pkinase, CaMKII_ADNP 741960 HS Mb BAA76812 Pkinase, CaMKII_ADBAA76812 HS Dr
((NP_001017741_DR_Hs_Pt_Mb:0.04296,(((XP_005159899_DR_Ta:0.00014,XP_005159897_DR_Ce_Sm_Nv:0.00015):0.03840,((XP_001146325_PT_Ce_Ta_Mb:0.0,NP_742126_HS_Ce:0.0):0.00014,(XP_001146392_PT_Dr_Dm_Sm_Nv:0.00016,NP_742113_HS_Dm_Sm_Nv:0.00014):0.00016):0.03005):0.02347,(XP_005156968_DR_Dm:0.08017,(XP_002572628_SM_Hs_Pt_Dr_Dm_Ce_Nv_Ta_Mb:0.26961,(((NP_001023296_CE_Hs_Pt_Dr_Dm_Sm_Nv_Mb:0.00015,NP_001023301_CE_Ta:0.00014):0.23384,(XP_001745863_MB_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Ta:0.74337,(XP_002115697_TA_Hs_Pt_Dr_Dm_Ce_Sm_Nv_Mb:0.37429,(XP_001622637_NV_Hs_Pt_Dr_Dm_Ce_Sm_Ta:0.18613,XP_001641961_NV_Mb:0.23477):0.06056):0.04664):0.08625):0.05596,(NP_001259082_DM_Ce_Ta:0.00014,(NP_726634_DM_Sm:0.00014,NP_524635_DM_Hs_Pt_Dr_Nv_Mb:0.00014):0.00016):0.11379):0.01515):0.11113):0.01153):0.09669):0.01862,BAA76812_HS_Dr:0.00014,(NP_741960_HS_Mb:0.00014,(NP_057065_HS_Pt:0.00014,(3SOA_A_HS_Ta:0.00771,XP_001165329_PT_Hs:0.01727):0.00014):0.00015):0.00014);

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Table S1: Best blast for Q8N2Q7 in each species
Homo sapiensQ8N2Q7 RecName: Full=Neuroligin-1; Flags: Precursor0
Pan troglodytesXP_001166321 PREDICTED: neuroligin-1 isoform 6 [Pan troglodytes] >gi|114590434|ref|XP_001166397.1| PREDICTED: neuroligin-1 isoform 8 [Pan troglodytes] >gi|397523989|ref|XP_003831998.1| PREDICTED: neuroligin-1 isoform 1 [Pan paniscus]0
Danio rerioACX50608 neuroligin 1 [Danio rerio]0
Drosophila melanogasterNP_731172 neuroligin 1, isoform D [Drosophila melanogaster] >gi|386765277|ref|NP_001246966.1| neuroligin 1, isoform E [Drosophila melanogaster] >gi|28381150|gb|AAF53998.3| neuroligin 1, isoform D [Drosophila melanogaster] >gi|85857478|gb|ABC86275.1| RE29404p [Drosophila melanogaster] >gi|383292547|gb|AFH06285.1| neuroligin 1, isoform E [Drosophila melanogaster]8.77898e-82
Caenorhabditis elegansNP_510660 Protein ACE-1 [Caenorhabditis elegans] >gi|584715|sp|P38433.1|ACE1_CAEEL RecName: Full=Acetylcholinesterase 1; Short=AChE 1; Flags: Precursor >gi|671831|emb|CAA53080.1| acetylcholinesterase [Caenorhabditis elegans] >gi|351061160|emb|CCD68912.1| Protein ACE-1 [Caenorhabditis elegans]1.4919e-59
Schistosoma mansoniAAQ14321 acetylcholinesterase [Schistosoma mansoni] >gi|350646637|emb|CCD58664.1| acetylcholinesterase, putative [Schistosoma mansoni]1.47026e-57
Nematostella vectensisXP_001639145 predicted protein [Nematostella vectensis] >gi|156226271|gb|EDO47082.1| predicted protein [Nematostella vectensis]1.79542e-84
Trichoplax adhaerensXP_002117137 hypothetical protein TRIADDRAFT_2392 [Trichoplax adhaerens] >gi|190580359|gb|EDV20443.1| hypothetical protein TRIADDRAFT_2392 [Trichoplax adhaerens]3.65547e-76
Monosiga brevicollisXP_001749350 hypothetical protein [Monosiga brevicollis MX1] >gi|163772216|gb|EDQ85871.1| predicted protein [Monosiga brevicollis MX1]4.58971e-41

Table S2: Target IDs for Q8N2Q7

Q8N2Q7 sp|Q8N2Q7|NLGN1_HUMAN Neuroligin-1 OS=Homo sapiens GN=NLGN1 PE=1 SV=2
.......FromHomo sapiens
Q8N2Q7
COesterase
Pan troglodytes
XP_001166321
Danio rerio
ACX50608
COesterase
Drosophila melanogaster
NP_731172
COesterase
Caenorhabditis elegans
NP_510660
COesterase
Schistosoma mansoni
AAQ14321
COesterase
Nematostella vectensis
XP_001639145
COesterase
Trichoplax adhaerens
XP_002117137
COesterase
Monosiga brevicollis
XP_001749350
COesterase
Homo sapiensQ8N2Q7NP_055747XP_005247289XP_0052568014BDT_A2WSL_A3BE8_A3LII_ABAD97163
Pan troglodytesXP_001166321XP_001166321XP_001166321XP_001139129XP_003318708XP_516857XP_001139129XP_003318708XP_003318709
Danio rerioACX50608XP_005155787ACX50608XP_005172672NP_571921NP_571921NP_001159803NP_001159804XP_002661384
Drosophila melanogasterNP_731172NP_731172NP_731172NP_7311721DX4_A1DX4_ANP_7311721DX4_ANP_001163662
Caenorhabditis elegansNP_510660NP_510660NP_001257226NP_001257225NP_510660NP_510660NP_510660NP_496962NP_510660
Schistosoma mansoniAAQ14321AAQ14321AAQ14321AAQ14321AAQ14321AAQ14321AAQ14321AAQ14321XP_002574406
Nematostella vectensisXP_001639145XP_001639145XP_001639145XP_001635931XP_001627490XP_001627490XP_001639145XP_001639145XP_001627490
Trichoplax adhaerensXP_002117137XP_002117137XP_002117142XP_002117900XP_002117900XP_002117134XP_002117136XP_002117137XP_002117130
Monosiga brevicollisXP_001749350XP_001749350XP_001743880XP_001749350XP_001743880XP_001743880XP_001746821XP_001750804XP_001749350



Table S3: Target blast score for Q8N2Q7

Q8N2Q7 sp|Q8N2Q7|NLGN1_HUMAN Neuroligin-1 OS=Homo sapiens GN=NLGN1 PE=1 SV=2
.......FromHomo sapiens
Q8N2Q7
COesterase
Pan troglodytes
XP_001166321
Danio rerio
ACX50608
COesterase
Drosophila melanogaster
NP_731172
COesterase
Caenorhabditis elegans
NP_510660
COesterase
Schistosoma mansoni
AAQ14321
COesterase
Nematostella vectensis
XP_001639145
COesterase
Trichoplax adhaerens
XP_002117137
COesterase
Monosiga brevicollis
XP_001749350
COesterase
Homo sapiens0009.10487e-812.96817e-1456.99584e-1014.5996e-1022.53158e-932.92093e-57
Pan troglodytes0002.74842e-871.12524e-1452.00842e-1006.44856e-1002.07573e-931.26051e-57
Danio rerio0002.84925e-791.07917e-1315.68067e-941.17539e-974.44398e-832.18354e-53
Drosophila melanogaster8.77898e-824.78465e-831.98142e-8304.23819e-1135.21518e-779.808e-695.48524e-736.20372e-40
Caenorhabditis elegans1.4919e-592.20198e-611.04962e-731.70922e-7701.15867e-1004.3954e-742.9616e-672.21072e-41
Schistosoma mansoni1.47026e-579.29774e-601.26568e-571.57922e-442.16196e-10504.33389e-625.7397e-522.81266e-32
Nematostella vectensis1.79542e-847.75545e-874.87025e-894.32873e-624.56455e-837.46354e-5901.0592e-862.91381e-48
Trichoplax adhaerens3.65547e-764.85368e-793.23742e-736.66339e-508.54395e-746.55749e-589.67119e-8902.99519e-45
Monosiga brevicollis4.58971e-411.66292e-433.15138e-407.74199e-422.86577e-633.67559e-481.80178e-567.22812e-590


Table S4: Comparative domain composition for Q8N2Q7

Q8N2Q7 sp|Q8N2Q7|NLGN1_HUMAN Neuroligin-1 OS=Homo sapiens GN=NLGN1 PE=1 SV=2
COesterase (1)
.......FromHomo sapiens
Q8N2Q7
COesterase (1)
Pan troglodytes
XP_001166321
Danio rerio
ACX50608
COesterase (1)
Drosophila melanogaster
NP_731172
COesterase (1)
Caenorhabditis elegans
NP_510660
COesterase (1)
Schistosoma mansoni
AAQ14321
COesterase (1)
Nematostella vectensis
XP_001639145
COesterase (1)
Trichoplax adhaerens
XP_002117137
COesterase (1)
Monosiga brevicollis
XP_001749350
COesterase (1)
Homo sapiens
COesterase (0)

COesterase (0)
n.a.n.a.n.a.n.a.n.a.n.a.
COesterase (0)AChE_tetra (1)
Pan troglodytesn.a.n.a.n.a.
COesterase (0)
n.a.n.a.
COesterase (0)
n.a.
COesterase (0)
Danio rerio
COesterase (0)
n.a.
COesterase (0)
n.a.
COesterase (1)AChE_tetra (1)

COesterase (1)AChE_tetra (1)

COesterase (0)

COesterase (0)

COesterase (0)
Drosophila melanogaster
COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)
n.a.n.a.
COesterase (0)
n.a.
COesterase (2)
Caenorhabditis elegans
COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)
Schistosoma mansoni
COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)
n.a.
Nematostella vectensis
COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)
Trichoplax adhaerens
COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)
Monosiga brevicollis
COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)

COesterase (0)



Tree S1: Tree for Q8N2Q7

Q8N2Q7 COesteraseQ8N2Q7 NP_055747 COesteraseNP 055747 HS Pt XP_005247289 n.a.XP 005247289 HS Dr XP_001166321 n.a.XP 001166321 PT Hs Dr ACX50608 COesteraseACX50608 DR Hs XP_005155787 n.a.XP 005155787 DR Pt XP_005172672 n.a.XP 005172672 DR Dm XP_005256801 n.a.XP 005256801 HS Dm XP_001139129 COesteraseXP 001139129 PT Dm Nv 3BE8_A n.a.3BE8 A HS Nv NP_001159803 COesteraseNP 001159803 DR Nv NP_001159804 COesteraseNP 001159804 DR Ta NP_001257226 COesteraseNP 001257226 CE Dr NP_001257225 COesteraseNP 001257225 CE Dm NP_731172 COesteraseNP 731172 DM Hs Pt Dr Nv NP_001163662 COesteraseNP 001163662 DM Mb XP_001635931 COesteraseXP 001635931 NV Dm XP_002574406 n.a.XP 002574406 SM Mb XP_001639145 COesteraseXP 001639145 NV Hs Pt Dr Ta XP_001627490 COesteraseXP 001627490 NV Ce Sm Mb XP_001746821 COesteraseXP 001746821 MB Nv XP_001749350 COesteraseXP 001749350 MB Hs Pt Dm XP_001743880 COesteraseXP 001743880 MB Dr Ce Sm XP_001750804 COesteraseXP 001750804 MB Ta XP_002661384 COesteraseXP 002661384 DR Mb XP_002117136 COesteraseXP 002117136 TA Nv XP_002117137 COesteraseXP 002117137 TA Hs Pt XP_002117900 COesteraseXP 002117900 TA Dm Ce XP_002117134 COesteraseXP 002117134 TA Sm XP_002117130 COesteraseXP 002117130 TA Mb XP_002117142 COesteraseXP 002117142 TA Dr BAD97163 COesterase, AChE_tetraBAD97163 HS Mb XP_003318709 COesteraseXP 003318709 PT Mb 3LII_A n.a.3LII A HS Ta XP_003318708 n.a.XP 003318708 PT Ce Ta 4BDT_A n.a.4BDT A HS Ce NP_571921 COesterase, AChE_tetraNP 571921 DR Ce Sm 2WSL_A n.a.2WSL A HS Sm XP_516857 n.a.XP 516857 PT Sm AAQ14321 COesteraseAAQ14321 SM Hs Pt Dr Dm Ce Nv Ta NP_510660 COesteraseNP 510660 CE Hs Pt Sm Nv Mb NP_496962 COesteraseNP 496962 CE Ta 1DX4_A n.a.1DX4 A DM Ce Sm Ta
((((XP_516857_PT_Sm:0.00025,2WSL_A_HS_Sm:0.01450):0.36945,(NP_571921_DR_Ce_Sm:0.20137,(((XP_003318709_PT_Mb:0.00014,BAD97163_HS_Mb:0.00358):0.00015,3LII_A_HS_Ta:0.00014):0.00015,(4BDT_A_HS_Ce:0.0,XP_003318708_PT_Ce_Ta:0.0):0.00014):0.32555):0.16388):0.17728,(NP_510660_CE_Hs_Pt_Sm_Nv_Mb:0.66933,AAQ14321_SM_Hs_Pt_Dr_Dm_Ce_Nv_Ta:0.92865):0.12550):0.06284,((((XP_002661384_DR_Mb:0.91875,XP_001750804_MB_Ta:0.82203):0.34085,(XP_001743880_MB_Dr_Ce_Sm:0.94007,(XP_001749350_MB_Hs_Pt_Dm:0.84919,XP_001746821_MB_Nv:1.06339):0.11225):0.18868):0.09319,((XP_002574406_SM_Mb:0.95842,((((NP_001159804_DR_Ta:0.10090,(NP_001159803_DR_Nv:0.05283,(3BE8_A_HS_Nv:0.00181,XP_001139129_PT_Dm_Nv:0.00014):0.04188):0.06574):0.02538,(((XP_005155787_DR_Pt:0.00014,ACX50608_DR_Hs:0.00119):0.12206,((XP_005247289_HS_Dr:0.00162,(NP_055747_HS_Pt:0.00014,Q8N2Q7:0.00299):0.00749):0.00118,XP_001166321_PT_Hs_Dr:0.00015):0.05089):0.07556,(XP_005256801_HS_Dm:0.07339,XP_005172672_DR_Dm:0.07855):0.11908):0.01293):0.44132,((NP_001257225_CE_Dm:0.00014,NP_001257226_CE_Dr:0.00015):0.83631,(NP_001163662_DM_Mb:0.43711,NP_731172_DM_Hs_Pt_Dr_Nv:0.64604):0.21601):0.31776):0.20084,XP_001635931_NV_Dm:0.90854):0.07791):0.10141,(XP_001627490_NV_Ce_Sm_Mb:0.67169,XP_001639145_NV_Hs_Pt_Dr_Ta:0.63758):0.25060):0.14011):0.12430,(XP_002117142_TA_Dr:0.67561,(XP_002117130_TA_Mb:0.65839,(XP_002117134_TA_Sm:0.76018,(XP_002117900_TA_Dm_Ce:0.34318,(XP_002117137_TA_Hs_Pt:0.15735,XP_002117136_TA_Nv:0.17355):0.21427):0.17596):0.11054):0.13612):0.33470):0.29894,(1DX4_A_DM_Ce_Sm_Ta:0.77845,NP_496962_CE_Ta:0.83769):0.04751);

Up
Table S1: Best blast for P28329 in each species
Homo sapiensP28329 RecName: Full=Choline O-acetyltransferase; Short=CHOACTase; Short=ChAT; Short=Choline acetylase0
Pan troglodytesXP_003339420 PREDICTED: choline O-acetyltransferase [Pan troglodytes]0
Danio rerioNP_001124191 choline O-acetyltransferase [Danio rerio] >gi|528497806|ref|XP_005156786.1| PREDICTED: choline O-acetyltransferase isoform X1 [Danio rerio] >gi|209572788|sp|B2ZGJ1.1|CLAT_DANRE RecName: Full=Choline O-acetyltransferase; Short=CHOACTase; Short=ChAT; Short=Choline acetylase >gi|187942537|gb|ACD40042.1| choline acetyltransferase [Danio rerio]0
Drosophila melanogasterNP_996239 choline acetyltransferase, isoform B [Drosophila melanogaster] >gi|61679360|gb|AAS65177.2| choline acetyltransferase, isoform B [Drosophila melanogaster]1.26875e-156
Caenorhabditis elegansNP_510624 Protein B0395.3 [Caenorhabditis elegans] >gi|3873755|emb|CAA92218.1| Protein B0395.3 [Caenorhabditis elegans]5.54386e-109
Schistosoma mansoniXP_002575937 choline o-acyltransferase [Schistosoma mansoni] >gi|360044887|emb|CCD82435.1| putative choline o-acyltransferase [Schistosoma mansoni]1.59991e-149
Nematostella vectensisXP_001636274 predicted protein [Nematostella vectensis] >gi|156223376|gb|EDO44211.1| predicted protein [Nematostella vectensis]3.44919e-136
Trichoplax adhaerensXP_002109981 hypothetical protein TRIADDRAFT_20587 [Trichoplax adhaerens] >gi|190588105|gb|EDV28147.1| hypothetical protein TRIADDRAFT_20587 [Trichoplax adhaerens]5.63917e-123
Monosiga brevicollisXP_001750100 hypothetical protein [Monosiga brevicollis MX1] >gi|163771429|gb|EDQ85096.1| predicted protein [Monosiga brevicollis MX1]6.4108e-71

Table S2: Target IDs for P28329

P28329 sp|P28329|CLAT_HUMAN Choline O-acetyltransferase OS=Homo sapiens GN=CHAT PE=1 SV=4
.......FromHomo sapiens
P28329
Carn_acyltransf
Pan troglodytes
XP_003339420
Danio rerio
NP_001124191
Carn_acyltransf
Drosophila melanogaster
NP_996239
Carn_acyltransf
Caenorhabditis elegans
NP_510624
Carn_acyltransf
Schistosoma mansoni
XP_002575937
Carn_acyltransf
Nematostella vectensis
XP_001636274
Carn_acyltransf
Trichoplax adhaerens
XP_002109981
Carn_acyltransf
Monosiga brevicollis
XP_001750100
Dynamin_N, Carn_acyltransf, Dynamin_M
Homo sapiensP28329NP_001136405NP_0011364052FY2_AXP_005251765NP_066264NP_001244292NP_001244292NP_001867
Pan troglodytesXP_003339420XP_003339420XP_003339420XP_003339420XP_003312352XP_003339420XP_003312352XP_003312352XP_001173853
Danio rerioNP_001124191NP_001124191NP_001124191NP_001124191NP_001005587NP_001124191NP_001005587NP_001005587XP_005170764
Drosophila melanogasterNP_996239NP_996239NP_996239NP_996239NP_001036684NP_996239NP_996239NP_001036684NP_001163111
Caenorhabditis elegansNP_510624NP_510624NP_001023603NP_001023603NP_510624NP_001023603NP_510624NP_510624NP_496721
Schistosoma mansoniXP_002575937XP_002575937XP_002575937XP_002575937XP_002575937XP_002575937XP_002575937XP_002575937XP_002577959
Nematostella vectensisXP_001636274XP_001636274XP_001636274XP_001636274XP_001636274XP_001636274XP_001636274XP_001636274XP_001630518
Trichoplax adhaerensXP_002109981XP_002109981XP_002109981XP_002109981XP_002109981XP_002109981XP_002109981XP_002109981XP_002111483
Monosiga brevicollisXP_001750100XP_001750100XP_001750298XP_001750100XP_001750298XP_001750298XP_001750298XP_001750298XP_001750100



Table S3: Target blast score for P28329

P28329 sp|P28329|CLAT_HUMAN Choline O-acetyltransferase OS=Homo sapiens GN=CHAT PE=1 SV=4
.......FromHomo sapiens
P28329
Carn_acyltransf
Pan troglodytes
XP_003339420
Danio rerio
NP_001124191
Carn_acyltransf
Drosophila melanogaster
NP_996239
Carn_acyltransf
Caenorhabditis elegans
NP_510624
Carn_acyltransf
Schistosoma mansoni
XP_002575937
Carn_acyltransf
Nematostella vectensis
XP_001636274
Carn_acyltransf
Trichoplax adhaerens
XP_002109981
Carn_acyltransf
Monosiga brevicollis
XP_001750100
Dynamin_N, Carn_acyltransf, Dynamin_M
Homo sapiens0003.11621e-1552.45208e-1421.88744e-1421.74391e-1562.56093e-1700
Pan troglodytes0001.75987e-1508.98777e-1433.37237e-1403.39978e-1594.06137e-1720
Danio rerio0002.17278e-1471.6742e-1444.29189e-1348.47417e-1582.36399e-1670
Drosophila melanogaster1.10581e-1541.48204e-1501.77611e-14709.97825e-1233.09069e-1221.74819e-1182.27483e-1180
Caenorhabditis elegans5.54386e-1092.26061e-1072.22579e-1093.89301e-10306.28118e-933.45744e-1167.56539e-1253.99929e-176
Schistosoma mansoni1.59991e-1491.78719e-1481.67859e-1424.04985e-1275.22408e-8709.81806e-1085.04795e-1103.47763e-37
Nematostella vectensis2.51306e-1351.66438e-1321.63784e-1331.50621e-1205.49427e-1183.33629e-10302.77405e-1370
Trichoplax adhaerens5.63917e-1232.65072e-1207.47998e-1222.21341e-1072.95599e-1253.88183e-1046.82074e-13600
Monosiga brevicollis6.4108e-714.84302e-699.07042e-661.78971e-611.57956e-711.79718e-414.80981e-771.8413e-800


Table S4: Comparative domain composition for P28329

P28329 sp|P28329|CLAT_HUMAN Choline O-acetyltransferase OS=Homo sapiens GN=CHAT PE=1 SV=4
Carn_acyltransf (1)
.......FromHomo sapiens
P28329
Carn_acyltransf (1)
Pan troglodytes
XP_003339420
Danio rerio
NP_001124191
Carn_acyltransf (1)
Drosophila melanogaster
NP_996239
Carn_acyltransf (1)
Caenorhabditis elegans
NP_510624
Carn_acyltransf (1)
Schistosoma mansoni
XP_002575937
Carn_acyltransf (2)
Nematostella vectensis
XP_001636274
Carn_acyltransf (1)
Trichoplax adhaerens
XP_002109981
Carn_acyltransf (1)
Monosiga brevicollis
XP_001750100
Dynamin_N (1), Carn_acyltransf (1), Dynamin_M (1)
Homo sapiens
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)
n.a.n.a.
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)
Pan troglodytesn.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.n.a.
Danio rerio
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)
n.a.
Drosophila melanogaster
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)
Caenorhabditis elegans
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)
Schistosoma mansoni
Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (1)

Carn_acyltransf (-1)GED (1), Dynamin_M (1), Dynamin_N (1)
Nematostella vectensis
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (1)
Trichoplax adhaerens
Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)
Monosiga brevicollis
Carn_acyltransf (0)Dynamin_M (1), Dynamin_N (1)

Carn_acyltransf (0)Dynamin_M (1), Dynamin_N (1)

Carn_acyltransf (0)

Carn_acyltransf (0)Dynamin_M (1), Dynamin_N (1)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)

Carn_acyltransf (0)Dynamin_M (1), Dynamin_N (1)



Tree S1: Tree for P28329

XP_001173853 n.a.XP 001173853 PT Mb NP_001867 Carn_acyltransfNP 001867 HS Mb XP_005170764 n.a.XP 005170764 DR Mb NP_496721 Carn_acyltransfNP 496721 CE Mb NP_001163111 Carn_acyltransfNP 001163111 DM Mb XP_002111483 Carn_acyltransfXP 002111483 TA Mb XP_001750100 Dynamin_N, Carn_acyltransf, Dynamin_MXP 001750100 MB Hs Pt Dm XP_001630518 Carn_acyltransfXP 001630518 NV Mb XP_001750298 Carn_acyltransfXP 001750298 MB Dr Ce Sm Nv Ta NP_510624 Carn_acyltransfNP 510624 CE Hs Pt Nv Ta NP_001036684 Carn_acyltransfNP 001036684 DM Ce Ta XP_001636274 Carn_acyltransfXP 001636274 NV Hs Pt Dr Dm Ce Sm Ta XP_005251765 n.a.XP 005251765 HS Ce NP_001244292 Carn_acyltransfNP 001244292 HS Nv Ta XP_003312352 n.a.XP 003312352 PT Ce Nv Ta NP_001005587 Carn_acyltransfNP 001005587 DR Ce Nv Ta XP_002577959 Dynamin_N, GED, Dynamin_MXP 002577959 SM Mb XP_002109981 Carn_acyltransfXP 002109981 TA Hs Pt Dr Dm Ce Sm Nv P28329 Carn_acyltransfP28329 XP_003339420 n.a.XP 003339420 PT Hs Dr Dm Sm NP_066264 Carn_acyltransfNP 066264 HS Sm NP_001136405 Carn_acyltransfNP 001136405 HS Pt Dr 2FY2_A n.a.2FY2 A HS Dm NP_001124191 Carn_acyltransfNP 001124191 DR Hs Pt Dm Sm XP_002575937 Carn_acyltransfXP 002575937 SM Hs Pt Dr Dm Ce Nv Ta NP_001023603 Carn_acyltransfNP 001023603 CE Dr Dm Sm NP_996239 Carn_acyltransfNP 996239 DM Hs Pt Dr Sm Nv
(NP_996239_DM_Hs_Pt_Dr_Sm_Nv:0.66805,NP_001023603_CE_Dr_Dm_Sm:1.13222,(XP_002575937_SM_Hs_Pt_Dr_Dm_Ce_Nv_Ta:0.50559,((((XP_002577959_SM_Mb:4.31695,(NP_001005587_DR_Ce_Nv_Ta:0.17101,(XP_003312352_PT_Ce_Nv_Ta:0.00420,(NP_001244292_HS_Nv_Ta:0.00014,XP_005251765_HS_Ce:0.00171):0.00432):0.14757):0.23468):0.11631,XP_002109981_TA_Hs_Pt_Dr_Dm_Ce_Sm_Nv:0.77600):0.08428,(XP_001636274_NV_Hs_Pt_Dr_Dm_Ce_Sm_Ta:0.80089,((NP_001036684_DM_Ce_Ta:0.77286,NP_510624_CE_Hs_Pt_Nv_Ta:0.77135):0.16432,(XP_001750298_MB_Dr_Ce_Sm_Nv_Ta:1.02199,((((NP_001163111_DM_Mb:0.44954,NP_496721_CE_Mb:0.69521):0.08666,(XP_005170764_DR_Mb:0.20019,(NP_001867_HS_Mb:0.00308,XP_001173853_PT_Mb:0.00233):0.19476):0.23701):0.08641,XP_002111483_TA_Mb:0.66079):0.09608,(XP_001630518_NV_Mb:0.82703,XP_001750100_MB_Hs_Pt_Dm:0.42823):0.07108):0.71295):0.29481):0.11225):0.05932):0.31051,(NP_001124191_DR_Hs_Pt_Dm_Sm:0.23336,(2FY2_A_HS_Dm:0.02004,(NP_001136405_HS_Pt_Dr:0.00179,((XP_003339420_PT_Hs_Dr_Dm_Sm:0.01855,P28329:0.01829):0.00016,NP_066264_HS_Sm:0.00014):0.00016):0.00509):0.26337):0.36356):0.09584):0.19471);

Up
Table S1: Best blast for BAA24846 in each species
Homo sapiensBAA24846 KIAA0416 [Homo sapiens]0
Pan troglodytesXP_001172386 leucine-rich repeat transmembrane neuronal protein 2 precursor [Homo sapiens] >gi|388453549|ref|NP_001253533.1| leucine-rich repeat transmembrane neuronal protein 2 precursor [Macaca mulatta] >gi|114602047|ref|XP_001172386.1| PREDICTED: leucine-rich repeat transmembrane neuronal protein 2 isoform 2 [Pan troglodytes] >gi|332234600|ref|XP_003266493.1| PREDICTED: leucine-rich repeat transmembrane neuronal protein 2 [Nomascus leucogenys] >gi|397518157|ref|XP_003829262.1| PREDICTED: leucine-rich repeat transmembrane neuronal protein 2 [Pan paniscus] >gi|402872648|ref|XP_003900218.1| PREDICTED: leucine-rich repeat transmembrane neuronal protein 2 [Papio anubis] >gi|426350145|ref|XP_004042642.1| PREDICTED: leucine-rich repeat transmembrane neuronal protein 2 [Gorilla gorilla gorilla] >gi|50400808|sp|O43300.3|LRRT2_HUMAN RecName: Full=Leucine-rich repeat transmembrane neuronal protein 2; AltName: Full=Leucine-rich repeat neuronal 2 protein; Flags: Precursor >gi|29540620|gb|AAO67547.1| leucine-rich repeat transmembrane neuronal 2 protein [Homo sapiens] >gi|116496895|gb|AAI26409.1| Leucine rich repeat transmembrane neuronal 2 [Homo sapiens] >gi|116497219|gb|AAI26411.1| Leucine rich repeat transmembrane neuronal 2 [Homo sapiens] >gi|119582529|gb|EAW62125.1| leucine rich repeat transmembrane neuronal 2 [Homo sapiens] >gi|168267354|dbj|BAG09733.1| leucine-rich repeat transmembrane neuronal protein 2 precursor [synthetic construct] >gi|219518062|gb|AAI43927.1| Leucine rich repeat transmembrane neuronal 2 [Homo sapiens] >gi|313883124|gb|ADR83048.1| leucine rich repeat transmembrane neuronal 2 [synthetic construct]0
Danio rerioXP_003201382 PREDICTED: leucine-rich repeat transmembrane neuronal protein 2-like [Danio rerio] >gi|528520277|ref|XP_005157392.1| PREDICTED: leucine-rich repeat transmembrane neuronal protein 2-like [Danio rerio]0
Drosophila melanogasterNP_647931 CG7509 [Drosophila melanogaster] >gi|15010374|gb|AAK77235.1| GH01279p [Drosophila melanogaster] >gi|23093034|gb|AAF47941.2| CG7509 [Drosophila melanogaster] >gi|220954730|gb|ACL89908.1| CG7509-PA [synthetic construct]5.31325e-29
Caenorhabditis elegansNP_491035 Protein LRON-11 [Caenorhabditis elegans] >gi|12276052|gb|AAG50238.1|AF304125_1 1D304 [Caenorhabditis elegans] >gi|351062439|emb|CCD70416.1| Protein LRON-11 [Caenorhabditis elegans]9.40072e-25
Schistosoma mansoniCCD80354 putative peroxidasin [Schistosoma mansoni]3.89442e-15
Nematostella vectensisXP_001627507 predicted protein [Nematostella vectensis] >gi|156214419|gb|EDO35407.1| predicted protein [Nematostella vectensis]5.73376e-24
Trichoplax adhaerensXP_002110298 hypothetical protein TRIADDRAFT_54150 [Trichoplax adhaerens] >gi|190586249|gb|EDV26302.1| hypothetical protein TRIADDRAFT_54150 [Trichoplax adhaerens]2.3726e-26
Monosiga brevicollisXP_001749401 hypothetical protein [Monosiga brevicollis MX1] >gi|163772029|gb|EDQ85686.1| predicted protein [Monosiga brevicollis MX1]2.84239e-27

Table S2: Target IDs for BAA24846

BAA24846 sp|O43300|LRRT2_HUMAN Leucine-rich repeat transmembrane neuronal protein 2 OS=Homo sapiens GN=LRRTM2 PE=2 SV=3
.......FromHomo sapiens
BAA24846
LRR_4
Pan troglodytes
XP_001172386
LRR_4
Danio rerio
XP_003201382
Drosophila melanogaster
NP_647931
Caenorhabditis elegans
NP_491035
LRR_4, LRR_1
Schistosoma mansoni
CCD80354
I-set, An_peroxidase
Nematostella vectensis
XP_001627507
Trichoplax adhaerens
XP_002110298
LRR_1
Monosiga brevicollis
XP_001749401
Pkinase, LRR_5
Homo sapiensBAA24846BAA24846BAA24846XP_005269337AAH42334NP_0364253ZYJ_AAAH25681AAH42334
Pan troglodytesXP_001172386XP_001172386XP_001172386XP_001162714XP_001162714XP_519754XP_508374XP_003313024XP_001147414
Danio rerioXP_003201382XP_003201382XP_003201382XP_002664664NP_001074151AAH93131XP_692401XP_003198203XP_002664664
Drosophila melanogasterNP_647931NP_647931NP_647931NP_647931ADP07746AAK92960ADP69283ADP95695ABA86508
Caenorhabditis elegansNP_491035NP_491035NP_510437NP_491035NP_491035NP_505188NP_499897NP_499897NP_492348
Schistosoma mansoniCCD80354CCD80354XP_002573338XP_002573271CCD78880CCD80354CCD78880CCD78175XP_002572767
Nematostella vectensisXP_001627507XP_001627507XP_001627507XP_001638921XP_001640242XP_001631487XP_001627507XP_001640242XP_001631475
Trichoplax adhaerensXP_002110298XP_002110298XP_002116060XP_002117677XP_002109698XP_002114354XP_002112269XP_002110298XP_002109698
Monosiga brevicollisXP_001749401XP_001749401XP_001749401XP_001744945XP_001745932XP_001746607XP_001745932XP_001745897XP_001749401



Table S3: Target blast score for BAA24846

BAA24846 sp|O43300|LRRT2_HUMAN Leucine-rich repeat transmembrane neuronal protein 2 OS=Homo sapiens GN=LRRTM2 PE=2 SV=3
.......FromHomo sapiens
BAA24846
LRR_4
Pan troglodytes
XP_001172386
LRR_4
Danio rerio
XP_003201382
Drosophila melanogaster
NP_647931
Caenorhabditis elegans
NP_491035
LRR_4, LRR_1
Schistosoma mansoni
CCD80354
I-set, An_peroxidase
Nematostella vectensis
XP_001627507
Trichoplax adhaerens
XP_002110298
LRR_1
Monosiga brevicollis
XP_001749401
Pkinase, LRR_5
Homo sapiens0001.60668e-308.98169e-241.43107e-491.27237e-276.53688e-361.47e-38
Pan troglodytes0001.15749e-311.01366e-226.88217e-301.79568e-272.12582e-311.38909e-35
Danio rerio0001.1542e-271.01731e-201.02766e-176.15569e-382.63423e-356.12555e-40
Drosophila melanogaster6.76603e-275.00762e-275.95508e-2101.26875e-238.57523e-444.94422e-256.68896e-339.54177e-36
Caenorhabditis elegans1.09477e-249.40072e-259.81018e-198.57798e-2401.95536e-444.7924e-211.65847e-261.48196e-21
Schistosoma mansoni3.86603e-153.89442e-151.57551e-142.12193e-092.31418e-1201.87097e-091.1048e-081.63847e-22
Nematostella vectensis8.12454e-245.73376e-242.79063e-181.32566e-181.65235e-156.77843e-2605.48577e-211.36497e-23
Trichoplax adhaerens2.67305e-262.3726e-265.11581e-221.96554e-213.18737e-161.08296e-119.80952e-2402.64003e-27
Monosiga brevicollis4.03031e-272.84239e-271.40358e-222.86014e-233.99593e-175.38462e-078.52765e-181.14556e-260


Table S4: Comparative domain composition for BAA24846

BAA24846 sp|O43300|LRRT2_HUMAN Leucine-rich repeat transmembrane neuronal protein 2 OS=Homo sapiens GN=LRRTM2 PE=2 SV=3
LRR_4 (1)
.......FromHomo sapiens
BAA24846
LRR_4 (1)
Pan troglodytes
XP_001172386
LRR_4 (1)
Danio rerio
XP_003201382
Drosophila melanogaster
NP_647931
Caenorhabditis elegans
NP_491035
LRR_4 (1), LRR_1 (1)
Schistosoma mansoni
CCD80354
I-set (2), An_peroxidase (1)
Nematostella vectensis
XP_001627507
Trichoplax adhaerens
XP_002110298
LRR_1 (1)
Monosiga brevicollis
XP_001749401
Pkinase (1), LRR_5 (1)
Homo sapiens
LRR_4 (0)

LRR_4 (0)

LRR_4 (0)
n.a.
LRR_4 (0)LRR_1 (1)

LRR_4 (-1)VWC (1), I-set (4), An_peroxidase (1)
n.a.
LRR_4 (-1)LRR_1 (2), LRRNT (1)

LRR_4 (0)LRR_1 (1)
Pan troglodytes
LRR_4 (0)

LRR_4 (0)

LRR_4 (0)

LRR_4 (0)LRR_1 (1), LRRNT (1)

LRR_4 (0)LRR_1 (1), LRRNT (1)

LRR_4 (-1)VWC (1), I-set (4), An_peroxidase (1)

LRR_4 (-1)I-set (1), LRR_1 (1), LRR_5 (1)
n.a.
LRR_4 (-1)
Danio rerion.a.n.a.n.a.
LRR_4 (-1)LRR_1 (3), LRR_5 (1)
n.a.
LRR_4 (-1)LRR_1 (1), LRRNT (1)
n.a.
LRR_4 (-1)LRR_1 (1), LRRNT (1)

LRR_4 (-1)LRR_1 (3), LRR_5 (1)
Drosophila melanogastern.a.n.a.n.a.n.a.
LRR_4 (-1)LRRCT (1)

LRR_4 (-1)VWC (1), I-set (3), An_peroxidase (1)
n.a.
LRR_4 (0)LRR_1 (2)

LRR_4 (-1)TIR (1), LRR_5 (1)
Caenorhabditis elegans
LRR_4 (0)LRR_1 (1)

LRR_4 (0)LRR_1 (1)

LRR_4 (-1)Laminin_G_2 (1), EGF (3), LRR_1 (2), LRRNT (4)

LRR_4 (0)LRR_1 (1)

LRR_4 (0)LRR_1 (1)

LRR_4 (-1)I-set (2), LRRNT (1), An_peroxidase (1)

LRR_4 (-1)I-set (2), LRR_1 (1)

LRR_4 (-1)I-set (2), LRR_1 (1)

LRR_4 (-1)
Schistosoma mansoni
LRR_4 (-1)I-set (2), An_peroxidase (1)

LRR_4 (-1)I-set (2), An_peroxidase (1)
n.a.n.a.
LRR_4 (-1)Laminin_G_2 (1), EGF (5), LRR_1 (1), LRRCT (3), LRRNT (1)

LRR_4 (-1)I-set (2), An_peroxidase (1)

LRR_4 (-1)Laminin_G_2 (1), EGF (5), LRR_1 (1), LRRCT (3), LRRNT (1)

LRR_4 (0)

LRR_4 (3)LRR_1 (1)
Nematostella vectensisn.a.n.a.n.a.n.a.
LRR_4 (-1)I-set (2)

LRR_4 (-1)An_peroxidase (1)
n.a.
LRR_4 (-1)I-set (2)

LRR_4 (-1)
Trichoplax adhaerens
LRR_4 (-1)LRR_1 (1)

LRR_4 (-1)LRR_1 (1)

LRR_4 (-1)LRR_1 (1)

LRR_4 (-1)LRR_5 (1)

LRR_4 (-1)LRR_5 (1)

LRR_4 (-1)An_peroxidase (1)
n.a.
LRR_4 (-1)LRR_1 (1)

LRR_4 (-1)LRR_5 (1)
Monosiga brevicollis
LRR_4 (-1)Pkinase (1), LRR_5 (1)

LRR_4 (-1)Pkinase (1), LRR_5 (1)

LRR_4 (-1)Pkinase (1), LRR_5 (1)
n.a.n.a.
LRR_4 (-1)
n.a.
LRR_4 (-1)Pkinase (1), RrnaAD (1)

LRR_4 (-1)Pkinase (1), LRR_5 (1)



Tree S1: Tree for BAA24846

BAA24846 LRR_4BAA24846 HS Pt Dr XP_001172386 LRR_4XP 001172386 PT Hs Dr XP_003201382 n.a.XP 003201382 DR Hs Pt CCD80354 I-set, An_peroxidaseCCD80354 SM Hs Pt NP_510437 Laminin_G_2, LRRNT, EGF, LRR_1NP 510437 CE Dr AAH93131 LRRNT, LRR_1AAH93131 DR Sm XP_002110298 LRR_1XP 002110298 TA Hs Pt XP_001627507 n.a.XP 001627507 NV Hs Pt Dr XP_692401 n.a.XP 692401 DR Nv ADP69283 n.a.ADP69283 DM Nv XP_508374 I-set, LRR_1, LRR_5XP 508374 PT Nv 3ZYJ_A n.a.3ZYJ A HS Nv NP_499897 I-set, LRR_1NP 499897 CE Nv Ta XP_519754 VWC, I-set, An_peroxidaseXP 519754 PT Sm NP_036425 VWC, I-set, An_peroxidaseNP 036425 HS Sm AAK92960 VWC, I-set, An_peroxidaseAAK92960 DM Sm XP_001631487 An_peroxidaseXP 001631487 NV Sm XP_002114354 An_peroxidaseXP 002114354 TA Sm NP_505188 LRRNT, I-set, An_peroxidaseNP 505188 CE Sm XP_002573338 n.a.XP 002573338 SM Dr CCD78880 Laminin_G_2, LRRNT, EGF, LRR_1, LRRCTCCD78880 SM Ce Nv XP_002112269 n.a.XP 002112269 TA Nv XP_001638921 n.a.XP 001638921 NV Dm ADP07746 LRRCTADP07746 DM Ce CCD78175 LRR_4CCD78175 SM Ta XP_002573271 n.a.XP 002573271 SM Dm XP_002572767 LRR_1, LRR_4XP 002572767 SM Mb ABA86508 TIR, LRR_5ABA86508 DM Mb XP_002116060 LRR_1XP 002116060 TA Dr AAH25681 LRRNT, LRR_1AAH25681 HS Ta XP_003198203 LRRNT, LRR_1XP 003198203 DR Ta XP_001640242 I-setXP 001640242 NV Ce Ta XP_002117677 LRR_5XP 002117677 TA Dm XP_002109698 LRR_5XP 002109698 TA Ce Mb XP_003313024 n.a.XP 003313024 PT Ta AAH42334 LRR_4, LRR_1AAH42334 HS Ce Mb XP_005269337 n.a.XP 005269337 HS Dm XP_001162714 LRRNT, LRR_4, LRR_1XP 001162714 PT Dm Ce XP_001631475 XP 001631475 NV Mb NP_001074151 n.a.NP 001074151 DR Ce XP_001147414 XP 001147414 PT Mb XP_002664664 LRR_1, LRR_5XP 002664664 DR Dm Mb NP_492348 NP 492348 CE Mb XP_001746607 XP 001746607 MB Sm XP_001749401 Pkinase, LRR_5XP 001749401 MB Hs Pt Dr XP_001745897 Pkinase, RrnaADXP 001745897 MB Ta NP_647931 n.a.NP 647931 DM Hs Pt Dr NP_491035 LRR_4, LRR_1NP 491035 CE Hs Pt Dm ADP95695 LRR_4, LRR_1ADP95695 DM Ta XP_001745932 n.a.XP 001745932 MB Ce Nv XP_001744945 n.a.XP 001744945 MB Dm
((((((NP_499897_CE_Nv_Ta:1.04515,((3ZYJ_A_HS_Nv:0.0,XP_508374_PT_Nv:0.0):0.72716,((XP_692401_DR_Nv:0.76987,XP_001627507_NV_Hs_Pt_Dr:0.74546):0.17653,ADP69283_DM_Nv:1.03521):0.10845):0.08431):0.24592,(XP_002110298_TA_Hs_Pt:0.94048,((XP_003201382_DR_Hs_Pt:0.25086,(XP_001172386_PT_Hs_Dr:0.0,BAA24846_HS_Pt_Dr:0.0):0.18111):0.85640,(AAH93131_DR_Sm:0.28223,(NP_510437_CE_Dr:0.68853,CCD80354_SM_Hs_Pt:1.13414):0.17557):0.47992):0.29834):0.13879):0.04026,(((CCD78880_SM_Ce_Nv:0.00014,XP_002573338_SM_Dr:0.00633):0.79624,(NP_505188_CE_Sm:0.82032,((XP_001631487_NV_Sm:0.14853,((NP_036425_HS_Sm:0.16862,XP_519754_PT_Sm:0.44907):0.25456,AAK92960_DM_Sm:0.74770):0.04490):0.10371,XP_002114354_TA_Sm:0.47859):0.25893):0.76003):0.40778,(XP_001638921_NV_Dm:1.20306,XP_002112269_TA_Nv:0.73559):0.15044):0.10274):0.09822,ADP07746_DM_Ce:1.19612):0.17319,((XP_002572767_SM_Mb:0.53846,(XP_002573271_SM_Dm:0.00014,CCD78175_SM_Ta:0.00014):0.35893):0.63573,(XP_002116060_TA_Dr:0.58700,ABA86508_DM_Mb:0.74018):0.30763):0.15529):0.10646,((XP_001745932_MB_Ce_Nv:0.52585,ADP95695_DM_Ta:0.89400):0.09100,XP_001744945_MB_Dm:1.02304):0.12167,((NP_491035_CE_Hs_Pt_Dm:0.80429,NP_647931_DM_Hs_Pt_Dr:0.85938):0.24241,((((XP_001147414_PT_Mb:0.43338,NP_001074151_DR_Ce:0.53961):0.30082,(NP_492348_CE_Mb:0.91075,XP_002664664_DR_Dm_Mb:0.56168):0.17988):0.10595,((XP_001631475_NV_Mb:1.17168,(XP_001162714_PT_Dm_Ce:0.00506,(XP_005269337_HS_Dm:0.00014,AAH42334_HS_Ce_Mb:0.00264):0.00016):0.65818):0.28659,((XP_002117677_TA_Dm:0.72781,(XP_001640242_NV_Ce_Ta:0.74671,(XP_003198203_DR_Ta:0.33414,AAH25681_HS_Ta:0.28719):0.59137):0.14493):0.09784,(XP_003313024_PT_Ta:1.06204,XP_002109698_TA_Ce_Mb:0.76398):0.11037):0.07533):0.06845):0.10639,((XP_001749401_MB_Hs_Pt_Dr:0.48031,XP_001746607_MB_Sm:0.85392):0.23887,XP_001745897_MB_Ta:0.61722):0.18998):0.02662):0.03718);