"FROM TOXINS TO THERAPEUTICS: A SYMPOSIUM IN HONOR OF PALMER TAYLOR - SCIENTIST, SCHOLAR, MENTOR, AND DEAN"
8:30 AM – 8:45 AM
WELCOME (James
McKerrow, Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences
and Associate Vice Chancellor for Health Sciences, UC San Diego; Pradeep
Khosla, Chancellor, UC San Diego)
SESSION 1
RECEPTORS
(Bill Catterall, Professor and Chair, Department of Pharmacology,
University of Washington; Andy McCammon, Distinguished Professor of
Chemistry and Biochemistry, UC San Diego; Chairs) (8:45 AM – 11:45 AM)
8:45 AM – 9:15 AM
"Voltage-Gated Sodium and Calcium
Channels at Atomic Resolution"
Bill Catterall, Professor and Chair, Department of Pharmacology, University of Washington
9:15 AM – 9:45 AM
"Molecular Recognition Linked to
Biological Function in Nicotinic Receptors"
Steven Sine, Professor, Department of Physiology, Mayo Clinic
9:45 AM – 10:15 AM
"Structural Biology of Nicotinic Acetylcholine Receptors"
Ryan Hibbs, Assistant Professor, Department of Biophysics and Neuroscience, University of Texas (Southwestern)
10:15 AM – 10:45 AM
REFRESHMENT BREAK
10:45 AM – 11:15 AM
"Allosteric Transition of the Pentameric Ligand-Gated Ion Channel"
Pierre-Jean Corringer, Research Director and Head, Channel-Receptor Unit, Pasteur Institute
11:15 AM – 11:45 AM
"Lipid-Gated Ion Channels and Their Roles in General Anesthesia and Mechanosensation"
Scott Hansen, Assistant Professor, Department of Molecular Therapeutics and Neuroscience, The Scripps Research Institute
11:45 AM – 12:15 PM
"The Biogenesis and Trafficking of
Acetylcholinesterase: From Basic Cell Biology to Therapeutic Applications"
Richard Rotundo, Professor of Cell Biology and Anatomy, University of Miami
12:15 PM – 1:15 PM
BOX LUNCH
1:15 PM – 1:30 PM
WELCOME (Richard Atkinson, University of California President Emeritus)
SESSION 2
TOXINS AND
NATURAL PRODUCTS (William Gerwick, Distinguished Professor, Scripps
Institution of Oceanography and Skaggs School of Pharmacy and
Pharmaceutical Sciences, UC San Diego; Barry Sharpless, W.M. Keck
Professor of Chemistry, The Scripps Research Institute; Chairs) (1:30 PM
– 4:30 PM)
1:30 PM – 2:00 PM
"Structural and Functional Studies
on the Reversible and Irreversible Inhibition of Acetylcholinesterase"
Gabriel Amitai, Bernstein-Mason Professorial Chair of Neurochemistry, Weizmann Institute of Science
2:00 PM – 2:30 PM
"The Rapid and Evolving World of
Natural Products Science and Its Impact on Human Health"
Brad
Moore, Professor, Scripps Institution of Oceanography and Skaggs School
of Pharmacy and Pharmaceutical Sciences, UC San Diego
2:30 PM – 3:00 PM
"Common Determinants in Natural
Toxins and Non-Toxin Molecules to Recognize ACh-Binding Macromolecules"
Pascale
Marchot, Senior Researcher & Team Leader, AFMB Lab, Centre National
de la Recherche Scientifique / Aix-Marseille Université, Marseille
3:00 PM – 3:30 PM
REFRESHMENT BREAK
3:30 PM – 4:00 PM
"Acetylcholinesterase: 25 Years
Since the 3D Structure Was Solved – What Have We Learned?"
Joel Sussman, Professor, Department of Structural Biology, Weizmann Institute of Science
4:00 PM – 4:30 PM
"Discovery and Development
of Therapeutic Leads from Toxic Marine Cyanobacterial Natural Products"
William
Gerwick, Distinguished Professor, Scripps Institution of Oceanography
and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego
6:00 PM – 7:00 PM
COCKTAIL RECEPTION (ESTANCIA HOTEL)
7:00 PM
BANQUET AND PROGRAM "Conus Venom Peptides and Ion Channel Pharmacology"
(Keynote
Speaker – Baldomero Olivera, Distinguished Professor of Biology, Howard
Hughes Medical Investigator, University of Utah)
8:30 AM – 8:45 AM
WELCOME (Charlene Zettel, UC Regent)
SESSION 3
PHARMACOLOGY
(Paul Insel, Professor, Department of Pharmacology, UC San Diego; Andy
McCammon, Distinguished Professor of Chemistry and Biochemistry, UC San
Diego; Chairs) (8:45 AM – 11:45 AM)
8:45 AM – 9:15 AM
"Neurotransmitter Transporters and the Cellular Actions of Amphetamines: A Walk on the Presynaptic Side"
Susan Amara, Scientific Director, National Institute of Mental Health
9:15 AM – 9:45 AM
"Human Genomics and the Future of Medicine"
Craig
Venter, Founder, Chairman, and Chief Executive Officer, J. Craig Venter
Institute and HLI - Co-Founder, Executive Chairman, CEO
9:45 AM – 10:15 AM
"Novel Targets for GPCR- and RhoA-medicated Pathophysiological Responses"
Joan Heller-Brown, Professor and Chair, Department of Pharmacology, UC San Diego
10:15 AM – 10:45 AM
REFRESHMENT BREAK
10:45 AM – 11:15 AM
"GPCR Expression in Health and Disease: Using Lessons from Palmer Taylor"
Paul Insel, Professor, Department of Pharmacology, UC San Diego
11:15 AM – 11:45 AM
"GPCR Allostery and Drug Discovery"
Arthur Christopoulos, Professor, Department of Pharmacology, Monash
11:45 AM – 12:15 PM
"Synaptic Connectivity: Molecular
Aspects and Implications in Neurodevelopmental Disorders"
Davide
Comoletti, Assistant Professor of Neurosciences and Cell Biology and
Pediatrics, Child Health Institute of New Jersey, Rutgers University
12:15 PM – 1:15 PM
BOX LUNCH
1:15 PM – 1:30 PM
WELCOME (David Brenner, Vice Chancellor for Health Sciences and Dean, School of Medicine, UC San Diego)
SESSION 4
CHEMISTRY
(Pieter Dorrestein, Professor, Skaggs School of Pharmacy and
Pharmaceutical Sciences, UC San Diego; Tracy Handel, Professor, Skaggs
School of Pharmacy and Pharmaceutical Sciences, UC San Diego) (1:30 PM –
4:30 PM)
1:30 PM – 2:00 PM
"The Art of Falling Apart: Controlling Polymer Degradation for Health Sciences and Medicine"
Adah Almutairi, Associate Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego
2:00 PM – 2:30 PM
"Molecules for Long-Term Memory Storage"
Roger Tsien, Distinguished Professor, Department of Chemistry and Biochemistry, UC San Diego
2:30 PM – 3:00 PM
"Digitizing the Chemistry of Microbes and People through Molecular 3D Cartography"
Pieter Dorrestein, Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego
3:00 PM – 3:30 PM
REFRESHMENT BREAK
3:30 PM – 4:00 PM
"Click Chemistry: New Directions"
Barry Sharpless, W.M. Keck Professor, Department of Chemistry, The Scripps Research Institute
4:00 PM – 4:30 PM
"Molecular Dynamics and Drug Discovery"
Andy McCammon, Distinguished Professor, Department of Chemistry and Biochemistry, UC San Diego
4:30 PM – 4:45 PM
CONCLUDING
REMARKS (Palmer Taylor, Distinguished Professor of Pharmacology and
Pharmacy, Founding Dean, Skaggs School of Pharmacy and Pharmaceutical
Sciences, UC San Diego)