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Mequitazine

General

Type : Phenothiazine,Sulfur Compound,Not A\/B H target,Azabicyclo

Chemical_Nomenclature : 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine

Canonical SMILES : C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53

InChI : InChI=1S\/C20H22N2S\/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21\/h1-8,15-16H,9-14H2

InChIKey : HOKDBMAJZXIPGC-UHFFFAOYSA-N

Other name(s) : Metaplexan,Primalan,Virginan

MW : 322.5

Formula : C20H22N2S

CAS_number : 29216-28-2

PubChem : 4066

UniChem : HOKDBMAJZXIPGC-UHFFFAOYSA-N

Target

References (4)

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
ESTHER : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : An In Vitro Study on the Metabolism and Possible Drug Interactions of Rokitamycin, a Macrolide Antibiotic, Using Human Liver Microsomes - Zhao_1999_Drug.Metab.Dispos_27_776
Author(s) : Zhao XJ , Koyama E , Ishizaki T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 27 :776 , 1999
Abstract : Zhao_1999_Drug.Metab.Dispos_27_776
ESTHER : Zhao_1999_Drug.Metab.Dispos_27_776
PubMedSearch : Zhao_1999_Drug.Metab.Dispos_27_776
PubMedID: 10383920

Title : An in-vitro study on the metabolism of rokitamycin and possible interactions of the drug with rat liver microsomes - Zhao_1999_J.Pharm.Pharmacol_51_1167
Author(s) : Zhao XJ , Ishizaki T
Ref : J Pharm Pharmacol , 51 :1167 , 1999
Abstract : Zhao_1999_J.Pharm.Pharmacol_51_1167
ESTHER : Zhao_1999_J.Pharm.Pharmacol_51_1167
PubMedSearch : Zhao_1999_J.Pharm.Pharmacol_51_1167
PubMedID: 10579688

Title : Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics - Stanton_1993_Biochem.Pharmacol_45_2352
Author(s) : Stanton T , Bolden-Watson C , Cusack B , Richelson E
Ref : Biochemical Pharmacology , 45 :2352 , 1993
Abstract : Stanton_1993_Biochem.Pharmacol_45_2352
ESTHER : Stanton_1993_Biochem.Pharmacol_45_2352
PubMedSearch : Stanton_1993_Biochem.Pharmacol_45_2352
PubMedID: 8100134 
Array
(
    [id] => 5514
    [inhibitor] => Mequitazine
    [type] => Array
        (
            [0] => Phenothiazine
            [1] => Sulfur Compound
            [2] => Not A\/B H target
            [3] => Azabicyclo
        )

    [other_name] => Array
        (
            [0] => Metaplexan
            [1] => Primalan
            [2] => Virginan
        )

    [chemical_nomenclature] => 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine
    [formula] => C20H22N2S
    [cas_number] => 29216-28-2
    [mw] => 322.5
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 || Stanton_1993_Biochem.Pharmacol_45_2352 || Zhao_1999_Drug.Metab.Dispos_27_776 || Zhao_1999_J.Pharm.Pharmacol_51_1167
    [comment] => 
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 4066
    [family] => 
    [inchikey] => HOKDBMAJZXIPGC-UHFFFAOYSA-N
    [canonicalsmiles] => C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
    [inchi] => InChI=1S\/C20H22N2S\/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21\/h1-8,15-16H,9-14H2
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)