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human-ACHE

Homo sapiens (Human) acetylcholinesterase

Comment

Acetylcholinesterase (ACHE\; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. (H322N)

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

A127S_human-ACHE A141T_human-ACHE A278P_human-ACHE A318N_human-ACHE A357E_human-ACHE A361E_human-ACHE A434S_human-ACHE A467K_human-ACHE A507E_human-ACHE C580A\/DL582-583KDEL_human-ACHE C580A_human-ACHE C580K_human-ACHE C580S_human-ACHE D131N_human-ACHE D134H\/F338A_human-ACHE D134H\/R136Q_human-ACHE D134H\/Y337A_human-ACHE D134H_human-ACHE D175N_human-ACHE D333N_human-ACHE D349N\/E358Q\/E389Q\/D390N_human-ACHE D349N\/E358Q_human-ACHE D349N_human-ACHE D390N_human-ACHE D404N_human-ACHE D582A\/L583V_human-ACHE D74E_human-ACHE D74G_human-ACHE D74K_human-ACHE D74N\/W286A\/Y341A_human-ACHE D74N\/W286A_human-ACHE D74N\/Y341A_human-ACHE D74N_human-ACHE D95N_human-ACHE DL582-583KDEL_human-ACHE E202A_human-ACHE E202D_human-ACHE E202Q\/F295L\/Y337A_human-ACHE E202Q\/F297I\/Y337A_human-ACHE E202Q\/F338A_human-ACHE E202Q\/Y337A_human-ACHE E202Q_human-ACHE E285A\/W286A_human-ACHE E285A_human-ACHE E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE E292A\/D349N\/E358Q_human-ACHE E292A\/E389Q\/D390N_human-ACHE E292A_human-ACHE E313G_human-ACHE E334A_human-ACHE E334D_human-ACHE E334N_human-ACHE E334Q_human-ACHE E358Q_human-ACHE E389Q\/D390N_human-ACHE E389Q_human-ACHE E396D_human-ACHE E450A_human-ACHE E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE E84Q\/D349N\/E358Q_human-ACHE E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE E84Q\/E292A\/D349N\/E358Q_human-ACHE E84Q\/E292A_human-ACHE E84Q_human-ACHE E91N_human-ACHE F295A\/F297A_human-ACHE F295A\/F338A\/V407F_human-ACHE F295A\/F338A_human-ACHE F295A_human-ACHE F295I\/F338A_human-ACHE F295L\/F297V\/Y337A_human-ACHE F295L\/F297V_human-ACHE F295L\/F338A_human-ACHE F295L\/Y337A\/F338A_human-ACHE F295L\/Y337A_human-ACHE F295L_human-ACHE F295M\/F338A_human-ACHE F295N\/F338A_human-ACHE F295S\/F338A_human-ACHE F295T\/F338A_human-ACHE F295V\/F338A_human-ACHE F297A_human-ACHE F297I\/Y337A_human-ACHE F297I_human-ACHE F297V_human-ACHE F338A_human-ACHE G120A_human-ACHE G121A_human-ACHE G122A_human-ACHE G234A_human-ACHE G240S_human-ACHE G242E_human-ACHE G26R_human-ACHE G416Q_human-ACHE G506D_human-ACHE H253K_human-ACHE H287C_human-ACHE H322K_human-ACHE H322N_human-ACHE H432A_human-ACHE H447A_human-ACHE K23T_human-ACHE L115M_human-ACHE L380R\/F535K_human-ACHE L394N_human-ACHE L414F_human-ACHE L418Y_human-ACHE L441E_human-ACHE L48R_human-ACHE M241R_human-ACHE M42V_human-ACHE M85A_human-ACHE N265Q\/N350Q\/N464Q_human-ACHE N265Q\/N350Q_human-ACHE N265Q\/N464Q_human-ACHE N265Q_human-ACHE N350Q\/N464Q_human-ACHE N350Q_human-ACHE N464Q_human-ACHE N87A_human-ACHE P561R_human-ACHE P78A_human-ACHE P88A_human-ACHE Q140R_human-ACHE Q325D_human-ACHE Q421N_human-ACHE Q474R_human-ACHE Q509K_human-ACHE R393K_human-ACHE R3Q_human-ACHE S110N_human-ACHE S203A_human-ACHE S203C_human-ACHE S203T_human-ACHE S229A_human-ACHE S309P_human-ACHE S438P_human-ACHE S67N_human-ACHE T109K_human-ACHE T112A_human-ACHE T144V_human-ACHE T238Y_human-ACHE T249L_human-ACHE T275N_human-ACHE V12T_human-ACHE V132A_human-ACHE V132K_human-ACHE V187I_human-ACHE V226I_human-ACHE V280E_human-ACHE V331N_human-ACHE V378I_human-ACHE V408I_human-ACHE V60W_human-ACHE W286A\/Y341A_human-ACHE W286A_human-ACHE W86A_human-ACHE W86E_human-ACHE W86F_human-ACHE WT_human-ACHE Y124A\/E285A\/W286A_human-ACHE Y124A_human-ACHE Y124F_human-ACHE Y124H_human-ACHE Y124Q_human-ACHE Y133A_human-ACHE Y133F_human-ACHE Y337A\/F338A_human-ACHE Y337A_human-ACHE Y337F_human-ACHE Y337G_human-ACHE Y337W_human-ACHE Y341A_human-ACHE Y449A_human-ACHE Y72A\/E285A\/W286A_human-ACHE Y72A\/E285A_human-ACHE Y72A\/W286A_human-ACHE Y72A\/Y124A_human-ACHE Y72A_human-ACHE Y72D\/Y124H_human-ACHE Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A\/V407F_human-ACHE Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Y72N\/Y124Q\/W286A\/F295L\/F297W\/Y337A_human-ACHE Y72N\/Y124Q\/W286A_human-ACHE Y72N\/Y124Q_human-ACHE Y72N_human-ACHE Y77A_human-ACHE g.-17113T>A_human-ACHE g.-17116delTGTT_human-ACHE

1B41 - Human acetylcholinesterase + fasciculin 1F8U - Human acetylcholinesterase E202Q + fasciculin 2X8B - Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II 3LII - Recombinant human acetylcholinesterase 4BDT - Human acetylcholinesterase in complex with huprine W and fasciculin 2 4EY4 - Crystal structure of recombinant human Acetylcholinesterase in the Apo state 4EY5 - Crystal structure of recombinant human acetylcholinesterase in complex with (-)-huperzine A 4EY6 - Crystal structure of recombinant human Acetylcholinesterase in complex with (-)-galantamine 4EY7 - Crystal Structure of recombinant human acetylcholinesterase in complex with Donepezil 4EY8 - Crystal Structure of Recombinant Human Acetylcholinesterase in complex with fasciculin-2 4M0E - Structure of human acetylcholinesterase in complex with dihydrotanshinone I 4M0F - Structure of human acetylcholinesterase in complex with territrem B 4PQE - Human acetylcholinesterase 5FPP - Structure of a pre-reaction ternay complex between sarin- acetylcholinesterase and HI-6 5FPQ - Structure of Homo sapiens acetylcholinesterase phosphonylated by sarin 5HF5 - Crystal structure of human acetylcholinesterase in complex with paraoxon 5HF6 - Crystal structure of human acetylcholinesterase in complex with paraoxon (aged) 5HF8 - Crystal structure of human acetylcholinesterase in complex with paraoxon (alternative acyl loop conformation) 5HF9 - Crystal structure of human acetylcholinesterase in complex with paraoxon and HI-6 5HFA - Crystal structure of human acetylcholinesterase in complex with paraoxon and 2-PAM 5HQ3 - Human acetylcholinesterase designed variant expressed in bacteria 6CQT - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by (-) Stereoisomer of VX 6CQU - Crystal Structure of Recombinant Human Acetylcholinesterase with Reactivator HI-6 6CQV - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with VX(+) and HI-6 6CQW - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with VX(-) and HI-6 6CQX - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by VX(+) 6CQY - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with EMPA and HI-6 6CQZ - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with VX 6F25 - Crystal structure of human acetylcholinesterase in complex with C35 6NEA - Human Acetylcholinesterase in complex with reactivator, HLo7 6NTG - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234 in Complex with Reactivator, HI-6 6NTH - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by (S) Stereoisomer of A-232 6NTK - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-232 6NTL - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234 6NTM - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-232 in Complex with the Reactivator, HI-6 6NTN - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-230 in Complex with the Reactivator, HI-6 6NTO - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-230 6O4W - Binary complex of native hAChE with Donepezil 6O4X - Binary complex of native hAChE with 9-aminoacridine 6O50 - Binary complex of native hAChE with BW284c51 6O52 - Room temperature structure of binary complex of native hAChE with BW284c51 6O5R - Room temperature structure of binary complex of native hAChE with oxime reactivator RS-170B 6O5S - Room temperature structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B 6O5V - Binary complex of native hAChE with oxime reactivator RS-170B 6O66 - Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B 6O69 - Crystal Structure of Double Mutant L380R\/F535K of Human Acetylcholinesterase 6U34 - Binary complex of native hAChE with oxime reactivator RS194B 6U37 - Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS194B 6U3P - Binary complex of native hAChE with oxime reactivator LG-703 6WUV - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GA (Tabun) 6WUY - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GA (Tabun) and HI-6 6WUZ - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GB (Sarin) 6WV1 - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GB (Sarin) and HI-6 6WVC - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GD (Soman) 6WVO - Crystal Structure of Recombinant Human Acetylcholinesterase In Complex with GD (Soman) and HI-6 6WVP - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GF 6WVQ - Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GP (GV) 6ZWE - Crystal structure of human acetylcholinesterase in complex with ((6-((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamido)hexyl)triphenylphosphonium bromide) 7D9O - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 2 H0L-7D9O 7D9P - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 12 H0R-7D9P 7D9Q - Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 7 H1R-7D9Q 7E3D - Crystal structure of human acetylcholinesterase 7E3H - Crystal structure of human acetylcholinesterase in complex with donepezil 7P1N - Crystal structure of human acetylcholinesterase in complexe with (2R,3R,4S,5S,6R)-2-{4-[1-(4-{5-hydroxy-6-[(E)-(hydroxyimino)methyl]pyridin-2-yl}butyl)-1H-1,2,3-triazol-4-yl]butoxy}-6-(hydroxymethyl)oxane-3,4,5-triol oxime 7P1P - Crystal structure of human acetylcholinesterase in complexe with (E)-3-hydroxy-6-(3-(4-(4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)-1H-1,2,3-triazol-1-yl)propyl)picolinaldehyde oxime 7P28 - WITHDRAWN Crystal structure of human acetylcholinesterase inibited by chlorpyryfos oxon 7P29 - WITHDRAWN Crystal structure of human acetylcholinesterase inibited by chlorpyrifos-methyl oxon 7P7V - WITHDRAWN Crystal structure of human acetylcholinesterase inibited by fention oxon 7P7Z - WITHDRAWN Crystal structure of human acetylcholinesterase inibited by omethoate 7RB5 - Crystal structure of human acetylcholinesterase in complex with substrate analog 4K-TMA at room temperature 7RB6 - Crystal structure of human acetylcholinesterase in complex with substrate analog 4K-TMA at low temperature 100K 7RB7 - Crystal structure of human acetylcholinesterase in complex with substrate analog 4K-TMA and MMB4 oxime 7XN1 - Crystal structure of human acetylcholinesterase in complex with tacrine (replace 7E3I) 8AEN - Human acetylcholinesterase in complex with zinc and N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium 8AEV - Human acetylcholinesterase in complex with N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium 8DT2 - X-ray structure of human acetylcholinesterase inhibited by paraoxon (POX-hAChE) 8DT4 - X-ray structure of human acetylcholinesterase ternary complex with paraoxon and oxime MMB4 (POX-hAChE-MMB4) 8DT5 - X-ray structure of human acetylcholinesterase ternary complex with paraoxon and oxime RS170B (POX-hAChE-RS170B) 8DT7 - X-ray structure of human acetylcholinesterase ternary complex with oxime MMB4 (hAChE-MMB4) 9F6R - Crystal structure of human acetylcholinesterase in complex with the uncharged hybrid reactivator quinoline-3-hydroxy-pyridinaldoxime

3,3-dimethylbutylthioacetate_D131N_human-ACHE 3,3-dimethylbutylthioacetate_D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_D349N_human-ACHE 3,3-dimethylbutylthioacetate_D390N_human-ACHE 3,3-dimethylbutylthioacetate_E202Q_human-ACHE 3,3-dimethylbutylthioacetate_E285A_human-ACHE 3,3-dimethylbutylthioacetate_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E292A\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E292A\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E292A_human-ACHE 3,3-dimethylbutylthioacetate_E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E389Q_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E292A\/D349N\/E358Q_human-ACHE 3,3-dimethylbutylthioacetate_E84Q\/E292A_human-ACHE 3,3-dimethylbutylthioacetate_E84Q_human-ACHE 3,3-dimethylbutylthioacetate_F338A_human-ACHE 3,3-dimethylbutylthioacetate_V132A_human-ACHE 3,3-dimethylbutylthioacetate_V132K_human-ACHE 3,3-dimethylbutylthioacetate_W286A_human-ACHE 3,3-dimethylbutylthioacetate_W86A_human-ACHE 3,3-dimethylbutylthioacetate_W86E_human-ACHE 3,3-dimethylbutylthioacetate_W86F_human-ACHE 3,3-dimethylbutylthioacetate_WT_human-ACHE 3,3-dimethylbutylthioacetate_Y133A_human-ACHE 3,3-dimethylbutylthioacetate_Y133F_human-ACHE 3,3-dimethylbutylthioacetate_Y337A_human-ACHE 3,3-dimethylbutylthioacetate_Y337F_human-ACHE Acetylthiocholine_C580A_human-ACHE Acetylthiocholine_D131N_human-ACHE Acetylthiocholine_D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_D349N\/E358Q_human-ACHE Acetylthiocholine_D349N_human-ACHE Acetylthiocholine_D390N_human-ACHE Acetylthiocholine_D74E_human-ACHE Acetylthiocholine_D74G_human-ACHE Acetylthiocholine_D74K_human-ACHE Acetylthiocholine_D74N_human-ACHE Acetylthiocholine_E202A_human-ACHE Acetylthiocholine_E202D_human-ACHE Acetylthiocholine_E202Q_human-ACHE Acetylthiocholine_E285A\/W286A_human-ACHE Acetylthiocholine_E285A_human-ACHE Acetylthiocholine_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E292A\/D349N\/E358Q_human-ACHE Acetylthiocholine_E292A\/E389Q\/D390N_human-ACHE Acetylthiocholine_E292A_human-ACHE Acetylthiocholine_E358Q_human-ACHE Acetylthiocholine_E389Q\/D390N_human-ACHE Acetylthiocholine_E389Q_human-ACHE Acetylthiocholine_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/D349N\/E358Q_human-ACHE Acetylthiocholine_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE Acetylthiocholine_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Acetylthiocholine_E84Q\/E292A\/D349N\/E358Q_human-ACHE Acetylthiocholine_E84Q\/E292A_human-ACHE Acetylthiocholine_E84Q_human-ACHE Acetylthiocholine_F295A_human-ACHE Acetylthiocholine_F295L\/F297V\/Y337A_human-ACHE Acetylthiocholine_F295L\/F297V_human-ACHE Acetylthiocholine_F295L_human-ACHE Acetylthiocholine_F297A_human-ACHE Acetylthiocholine_F297V_human-ACHE Acetylthiocholine_F338A_human-ACHE Acetylthiocholine_V132A_human-ACHE Acetylthiocholine_V132K_human-ACHE Acetylthiocholine_W286A_human-ACHE Acetylthiocholine_W86A_human-ACHE Acetylthiocholine_W86E_human-ACHE Acetylthiocholine_W86F_human-ACHE Acetylthiocholine_WT_human-ACHE Acetylthiocholine_Y124A\/E285A\/W286A_human-ACHE Acetylthiocholine_Y124A_human-ACHE Acetylthiocholine_Y124Q_human-ACHE Acetylthiocholine_Y133A_human-ACHE Acetylthiocholine_Y133F_human-ACHE Acetylthiocholine_Y337A_human-ACHE Acetylthiocholine_Y337F_human-ACHE Acetylthiocholine_Y341A_human-ACHE Acetylthiocholine_Y72A\/E285A\/W286A_human-ACHE Acetylthiocholine_Y72A\/E285A_human-ACHE Acetylthiocholine_Y72A\/W286A_human-ACHE Acetylthiocholine_Y72A\/Y124A_human-ACHE Acetylthiocholine_Y72A_human-ACHE Acetylthiocholine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Acetylthiocholine_Y72N\/Y124Q\/W286A_human-ACHE Acetylthiocholine_Y72N\/Y124Q_human-ACHE Acetylthiocholine_Y72N_human-ACHE BW284C51_D74E_human-ACHE BW284C51_D74G_human-ACHE BW284C51_D74K_human-ACHE BW284C51_D74N_human-ACHE BW284C51_E202A_human-ACHE BW284C51_E202D_human-ACHE BW284C51_E202Q_human-ACHE BW284C51_E285A\/W286A_human-ACHE BW284C51_E285A_human-ACHE BW284C51_F295A_human-ACHE BW284C51_F295L\/F297V\/Y337A_human-ACHE BW284C51_F295L\/F297V_human-ACHE BW284C51_F297A_human-ACHE BW284C51_F338A_human-ACHE BW284C51_W286A_human-ACHE BW284C51_W86A_human-ACHE BW284C51_WT_human-ACHE BW284C51_Y124A\/E285A\/W286A_human-ACHE BW284C51_Y124A_human-ACHE BW284C51_Y337A_human-ACHE BW284C51_Y337F_human-ACHE BW284C51_Y341A_human-ACHE BW284C51_Y72A\/E285A\/W286A_human-ACHE BW284C51_Y72A\/E285A_human-ACHE BW284C51_Y72A\/W286A_human-ACHE BW284C51_Y72A\/Y124A_human-ACHE BW284C51_Y72A_human-ACHE BW284C51_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE BW284C51_Y72N\/Y124Q\/W286A_human-ACHE BW284C51_Y72N\/Y124Q_human-ACHE Bambuterol_WT_human-ACHE Butyrylthiocholine_F295L\/F297V\/Y337A_human-ACHE Butyrylthiocholine_F295L\/F297V_human-ACHE Butyrylthiocholine_F295L_human-ACHE Butyrylthiocholine_F297V_human-ACHE Butyrylthiocholine_W286A_human-ACHE Butyrylthiocholine_WT_human-ACHE Butyrylthiocholine_Y124Q_human-ACHE Butyrylthiocholine_Y337A_human-ACHE Butyrylthiocholine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Butyrylthiocholine_Y72N\/Y124Q\/W286A_human-ACHE Butyrylthiocholine_Y72N\/Y124Q_human-ACHE Butyrylthiocholine_Y72N_human-ACHE Cocaine_WT_human-ACHE Decamethonium_D74E_human-ACHE Decamethonium_D74G_human-ACHE Decamethonium_D74K_human-ACHE Decamethonium_D74N_human-ACHE Decamethonium_E202A_human-ACHE Decamethonium_E202D_human-ACHE Decamethonium_E202Q_human-ACHE Decamethonium_E285A\/W286A_human-ACHE Decamethonium_E285A_human-ACHE Decamethonium_F295A_human-ACHE Decamethonium_F295L\/F297V_human-ACHE Decamethonium_F297A_human-ACHE Decamethonium_F338A_human-ACHE Decamethonium_W286A_human-ACHE Decamethonium_W86A_human-ACHE Decamethonium_W86E_human-ACHE Decamethonium_W86F_human-ACHE Decamethonium_WT_human-ACHE Decamethonium_Y124A\/E285A\/W286A_human-ACHE Decamethonium_Y124A_human-ACHE Decamethonium_Y133A_human-ACHE Decamethonium_Y133F_human-ACHE Decamethonium_Y337A_human-ACHE Decamethonium_Y337F_human-ACHE Decamethonium_Y341A_human-ACHE Decamethonium_Y72A\/E285A\/W286A_human-ACHE Decamethonium_Y72A\/E285A_human-ACHE Decamethonium_Y72A\/W286A_human-ACHE Decamethonium_Y72A\/Y124A_human-ACHE Decamethonium_Y72A_human-ACHE Decamethonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Decamethonium_Y72N\/Y124Q\/W286A_human-ACHE Decamethonium_Y72N\/Y124Q_human-ACHE Dibucaine_WT_human-ACHE Edrophonium_D131N_human-ACHE Edrophonium_D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_D349N\/E358Q_human-ACHE Edrophonium_D349N_human-ACHE Edrophonium_D390N_human-ACHE Edrophonium_D74E_human-ACHE Edrophonium_D74G_human-ACHE Edrophonium_D74K_human-ACHE Edrophonium_D74N_human-ACHE Edrophonium_E202A_human-ACHE Edrophonium_E202D_human-ACHE Edrophonium_E202Q_human-ACHE Edrophonium_E285A\/W286A_human-ACHE Edrophonium_E285A_human-ACHE Edrophonium_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E292A\/D349N\/E358Q_human-ACHE Edrophonium_E292A\/E389Q\/D390N_human-ACHE Edrophonium_E292A_human-ACHE Edrophonium_E358Q_human-ACHE Edrophonium_E389Q\/D390N_human-ACHE Edrophonium_E389Q_human-ACHE Edrophonium_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/D349N\/E358Q_human-ACHE Edrophonium_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE Edrophonium_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE Edrophonium_E84Q\/E292A\/D349N\/E358Q_human-ACHE Edrophonium_E84Q\/E292A_human-ACHE Edrophonium_E84Q_human-ACHE Edrophonium_F295A_human-ACHE Edrophonium_F295L\/F297V\/Y337A_human-ACHE Edrophonium_F295L\/F297V_human-ACHE Edrophonium_F297A_human-ACHE Edrophonium_F338A_human-ACHE Edrophonium_V132A_human-ACHE Edrophonium_V132K_human-ACHE Edrophonium_W286A_human-ACHE Edrophonium_W86A_human-ACHE Edrophonium_W86E_human-ACHE Edrophonium_W86F_human-ACHE Edrophonium_WT_human-ACHE Edrophonium_Y124A\/E285A\/W286A_human-ACHE Edrophonium_Y124A_human-ACHE Edrophonium_Y133A_human-ACHE Edrophonium_Y133F_human-ACHE Edrophonium_Y337A_human-ACHE Edrophonium_Y337F_human-ACHE Edrophonium_Y341A_human-ACHE Edrophonium_Y72A\/E285A\/W286A_human-ACHE Edrophonium_Y72A\/E285A_human-ACHE Edrophonium_Y72A\/W286A_human-ACHE Edrophonium_Y72A\/Y124A_human-ACHE Edrophonium_Y72A_human-ACHE Edrophonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Edrophonium_Y72N\/Y124Q\/W286A_human-ACHE Edrophonium_Y72N\/Y124Q_human-ACHE Hexamethonium_D74N_human-ACHE Hexamethonium_E285A\/W286A_human-ACHE Hexamethonium_E285A_human-ACHE Hexamethonium_F295A_human-ACHE Hexamethonium_F297A_human-ACHE Hexamethonium_F338A_human-ACHE Hexamethonium_W286A_human-ACHE Hexamethonium_W86A_human-ACHE Hexamethonium_WT_human-ACHE Hexamethonium_Y124A\/E285A\/W286A_human-ACHE Hexamethonium_Y124A_human-ACHE Hexamethonium_Y337A_human-ACHE Hexamethonium_Y337F_human-ACHE Hexamethonium_Y341A_human-ACHE Hexamethonium_Y72A\/E285A\/W286A_human-ACHE Hexamethonium_Y72A\/E285A_human-ACHE Hexamethonium_Y72A\/W286A_human-ACHE Hexamethonium_Y72A\/Y124A_human-ACHE Hexamethonium_Y72A_human-ACHE HuperzineA_D74N_human-ACHE HuperzineA_E202A_human-ACHE HuperzineA_E202Q_human-ACHE HuperzineA_E450A_human-ACHE HuperzineA_F295A_human-ACHE HuperzineA_F295L\/F297V\/Y337A_human-ACHE HuperzineA_F295L\/F297V_human-ACHE HuperzineA_F297A_human-ACHE HuperzineA_F338A_human-ACHE HuperzineA_W286A_human-ACHE HuperzineA_W86A_human-ACHE HuperzineA_W86F_human-ACHE HuperzineA_WT_human-ACHE HuperzineA_Y124A_human-ACHE HuperzineA_Y133A_human-ACHE HuperzineA_Y133F_human-ACHE HuperzineA_Y337A_human-ACHE HuperzineA_Y337F_human-ACHE HuperzineA_Y341A_human-ACHE HuperzineA_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE HuperzineA_Y72N\/Y124Q\/W286A_human-ACHE HuperzineA_Y72N\/Y124Q_human-ACHE Paranitrophenylacetate_F338A_human-ACHE Paranitrophenylacetate_W286A_human-ACHE Paranitrophenylacetate_W86A_human-ACHE Paranitrophenylacetate_WT_human-ACHE Paranitrophenylacetate_Y337A_human-ACHE Propidium_D74E_human-ACHE Propidium_D74G_human-ACHE Propidium_D74K_human-ACHE Propidium_D74N_human-ACHE Propidium_E202A_human-ACHE Propidium_E202D_human-ACHE Propidium_E202Q_human-ACHE Propidium_E285A\/W286A_human-ACHE Propidium_E285A_human-ACHE Propidium_F295A_human-ACHE Propidium_F297A_human-ACHE Propidium_F338A_human-ACHE Propidium_W286A_human-ACHE Propidium_W86A_human-ACHE Propidium_W86E_human-ACHE Propidium_W86F_human-ACHE Propidium_WT_human-ACHE Propidium_Y124A\/E285A\/W286A_human-ACHE Propidium_Y124A_human-ACHE Propidium_Y133A_human-ACHE Propidium_Y133F_human-ACHE Propidium_Y337A_human-ACHE Propidium_Y337F_human-ACHE Propidium_Y341A_human-ACHE Propidium_Y72A\/E285A\/W286A_human-ACHE Propidium_Y72A\/E285A_human-ACHE Propidium_Y72A\/W286A_human-ACHE Propidium_Y72A\/Y124A_human-ACHE Propidium_Y72A_human-ACHE S-N-Propylthioacetate_F338A_human-ACHE S-N-Propylthioacetate_W286A_human-ACHE S-N-Propylthioacetate_W86A_human-ACHE S-N-Propylthioacetate_WT_human-ACHE S-N-Propylthioacetate_Y337A_human-ACHE Succinylcholine~Suxamethonium_WT_human-ACHE Tacrine_D74N_human-ACHE Tacrine_E202A_human-ACHE Tacrine_E202Q_human-ACHE Tacrine_E450A_human-ACHE Tacrine_F295A_human-ACHE Tacrine_F295L\/F297V\/Y337A_human-ACHE Tacrine_F295L\/F297V_human-ACHE Tacrine_F297A_human-ACHE Tacrine_F338A_human-ACHE Tacrine_W286A_human-ACHE Tacrine_W86A_human-ACHE Tacrine_W86F_human-ACHE Tacrine_WT_human-ACHE Tacrine_Y124A_human-ACHE Tacrine_Y133A_human-ACHE Tacrine_Y133F_human-ACHE Tacrine_Y337A_human-ACHE Tacrine_Y337F_human-ACHE Tacrine_Y341A_human-ACHE Tacrine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE Tacrine_Y72N\/Y124Q\/W286A_human-ACHE Tacrine_Y72N\/Y124Q_human-ACHE

No disease

(-)-phenethylcymserine (S)Aporphine-N-benzylpyridinium 1d-phosphoryl-dihydroacridine 2-tolylazo-1,3-aminoenketone-tacrine-7a 3,5-dihydroxybenzamido-huprine-hybrid-11 3-(Dimethylamino)-N-propanamide-Tryptanthrin 3-butyl-6-benzyloxyphthalide-Mannich-base-7d 4-aminopyridine-1,3,4-oxadiazole-9 5-pyrid-3-yl-1,3,4-oxadiazole-5e 6ZWE-Cpd3 6o-5-HT3 7-Methyloxyde-PhO-cpd-I52 7-PhO-THA 7P1P-4IX 8-Hydroxydihydrochelerythrine 8AEV-LWU A-230-Nerve-agent A-232-Nerve-agent A-234-Nerve-agent A-242-Nerve-agent A-262-Nerve-agent ACHE-GSK-3-27g AChE-HDAC-IN-1 AChE-IN-27 AChE-IN-39 ADS031 AI0-7QBQ ANMP AP2238 Aricept~Donepezil~E2020 Aryl-carboxamide-benzoxazole-cpd36 Aurone-Donepezil-Cpd5g Aurone-Donepezil-Cpd6b AzoTHA BW284C51 Benzothiazole-phenyl-thioacetamide-Cpd30 Benzyl-piperidine-4-ethyl-phthalimide-6c Benzylpiperidin-methylene-methoxy-dihydro-inden-one Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b Benzylpiperidin-oxoindolin-acetamide-Cpd23 Biphenyl-oxo-triazine-S-12 Biphenyl-oxo-triazine-piperazine-cpd6g BisQ Bivalent-4-Aminopyridine-12i Butoxy-methyl-oxadiazol-aniline-4a C35-CVZ CHDA CHEMBL3585776 CHEMBL4177075 CHEMBL4177075-INDY CHEMBL4207101 CHEMBL4240861 CHEMBL4278686 CHEMBL4292235 CHEMBL459756 CHEMBL4793341 CHEMBL5206601 Caffeic-acid-phenethyl-ester ChEs-MAOs-IN-1 Chelerythrine Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b Colchicine-donepezil-SBN-284-3x Coumarin-Pyridine-3f Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b Coumarin-phosphazide-Cpd8b Cpd-17-Cycloheptyl-Indole-undecyl-carbamate Cymyl-carbamate-physovenol DFP DL0410 DTE-bis8-Tacrine Di-tert-butyl-phenol-octylamino-acridine-17d Diallyl-disulfide Diallyl-sulphide Diallyl-trisulfide Diclofenac-derivative-39 Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 Dihydrotanshinone-I Dimethoxy-phenyl-pyrazino-indol-cpd5i Donecopride EA-2192 EMPA Edrophonium FG1912 FUB833 Fasciculin2 Ferulic-Acid-Piperazine-Cpd13a Flucopride Fluoropezil GD29 GT15 Galanthamine Gamma-carboline-nonyl-bivalent Genistein-O-alkylbenzylamine-25d H0L-7D9O H0R-7D9P H1R-7D9Q HDAC6-IN-5 Homocysteine-thiolactone HuperzineA HuprineW Hydrazide-Hydrazone-Cpd12 Hypaphorine IMP-pNP IMP-pNP-F Indole-piperidine-amide-cpd23a Isoeugenol-acetate Itopride JM-20 JW8 K-1234 Lipocrine Lycocasuarine-C Lycocasuarinine-D M30D MR33317 MT-031 MTDZ Mahanimbine Methoctramine N,N-diethyl-4,5-dimethoxy-2-methylbenzenesulfonamide N-10-Phenothiazine-isopropyl-carbamate N-alkyl-quinuclidine-cpd14 N-demethylhuperzinine N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t NEMP NTMGMP Nitrophenyl-thiophen-morpholinyl-phenyl-pyrazoline-2l Novichok-5~A-230 Novichok-5~A-232 Novichok-C01-A035 Novichok-C01-A039 Oprea1_491201 P11149 PE154 Palmatine Paraoxon Phenolic-deriv-Donecopride-20 Phenolic-deriv-Donecopride-4 Phenothiazine-Tacrine-1dC Phenyl-phenylpyridin-oxadiazol-cpd5a Piperidine-4-carboxamide-alkyl-tacrine-cpd16 Propargyl-Tacrine-15 PyrTac-5f Pyridostigmine Quinolinetrione-tacrine-Cpd3 RS67333 Rivastigmine-Donepezil-COR783 SB-1436 SB-1448 Salicylamide-8-Tacrine Sanguinarine Sanguinine Sarin T-1123 TAC-PhBTA-Cpd16 TAK-802 TEMP TI45b TPPU-6-Chlorotacrine-12c Tacrine Tacrine-Benzofuran Tacrine-CA-Activator-Cpd30 Tacrine-Sibiriline-Cpd7 Tacrine-dehydrozingerone Tacrine-pentylmethylene-tolylsulfonamide Tacrine-selegiline-7d Tacrine-selegiline-8g Tanshinone-IIA TerritremB Tetrabenzyl-D-glucosamine-oxadiazole-6i Tetracyclic-triterpene-1 Tetracyclic-triterpene-36e Tetrahydrofurobenzofuran-cymserine Tilorone Toluidine-Blue Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k VN-19 VX VX-Biotin VXS Xanthostigmine ZINC11709541 ZINC11996936 ZINC59501712 hAChE-IN-6 lipoicacid-donepezil-cpd5 m-Amino-donepezil tacrine-isatin-Cpd7k

Database

Sequence

Peptide

MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ VSDLAAEAVV LHYTDWLHPE DPARLREALS DVVGDHNVVC PVAQLAGRLA AQGARVYAYV FEHRASTLSW PLWMGVPHGY EIEFIFGIPL DPSRNYTAEE KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ YVSLDLRPLE VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN QFDHYSKQDR CSDL

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Gene_locus related to this paper: human-ACHE

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Title : Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6 - McGuire_2021_Chem.Res.Toxicol_34_804
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Abstract :
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PubMedID: 33356266
Gene_locus related to this paper: human-ACHE

Title : Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase - Gorecki_2020_J.Biol.Chem_295_4079
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Gene_locus related to this paper: human-ACHE

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Gene_locus related to this paper: human-ACHE

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Abstract :
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PubMedID: 30993792
Gene_locus related to this paper: human-ACHE

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Abstract :
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PubMedID: 31176713
Gene_locus related to this paper: human-ACHE

Title : Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase - Gerlits_2019_J.Biol.Chem_294_10607
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Gene_locus related to this paper: human-ACHE

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Gene_locus related to this paper: human-ACHE

Title : Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase - Kovarik_2019_Toxicol.Appl.Pharmacol_372_40
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Abstract :
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PubMedID: 30978400
Gene_locus related to this paper: human-ACHE

Title : Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6 - Bester_2018_Chem.Res.Toxicol_31_1405
Author(s) : Bester SM , Guelta MA , Cheung J , Winemiller MD , Bae SY , Myslinski J , Pegan SD , Height JJ
Ref : Chemical Research in Toxicology , 31 :1405 , 2018
Abstract :
PubMedSearch : Bester_2018_Chem.Res.Toxicol_31_1405
PubMedID: 30462502
Gene_locus related to this paper: human-ACHE

Title : Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 - Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
Author(s) : Allgardsson A , Berg L , Akfur C , Hornberg A , Worek F , Linusson A , Ekstrom F
Ref : Proc Natl Acad Sci U S A , 113 :5514 , 2016
Abstract :
PubMedSearch : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
PubMedID: 27140636
Gene_locus related to this paper: human-ACHE

Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability - Goldenzweig_2016_Mol.Cell_63_337
Author(s) : Goldenzweig A , Goldsmith M , Hill SE , Gertman O , Laurino P , Ashani Y , Dym O , Unger T , Albeck S , Prilusky J , Lieberman RL , Aharoni A , Silman I , Sussman JL , Tawfik DS , Fleishman SJ
Ref : Mol Cell , 63 :337 , 2016
Abstract :
PubMedSearch : Goldenzweig_2016_Mol.Cell_63_337
PubMedID: 27425410
Gene_locus related to this paper: human-ACHE

Title : HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants - Macek Hrvat_2016_Chem.Biol.Interact_259_148
Author(s) : Macek Hrvat N , Zunec S , Taylor P , Radic Z , Kovarik Z
Ref : Chemico-Biological Interactions , 259 :148 , 2016
Abstract :
PubMedSearch : Macek Hrvat_2016_Chem.Biol.Interact_259_148
PubMedID: 27083141
Gene_locus related to this paper: human-ACHE

Title : Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface - Franklin_2016_Proteins_84_1246
Author(s) : Franklin MC , Rudolph MJ , Ginter C , Cassidy MS , Cheung J
Ref : Proteins , 84 :1246 , 2016
Abstract :
PubMedSearch : Franklin_2016_Proteins_84_1246
PubMedID: 27191504
Gene_locus related to this paper: human-ACHE

Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393
Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY
Ref : Biochemical Journal , 453 :393 , 2013
Abstract :
PubMedSearch : Nachon_2013_Biochem.J_453_393
PubMedID: 23679855
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility - Cheung_2013_ACS.Med.Chem.Lett_4_1091
Author(s) : Cheung J , Gary EN , Shiomi K , Rosenberry TL
Ref : ACS Med Chem Lett , 4 :1091 , 2013
Abstract :
PubMedSearch : Cheung_2013_ACS.Med.Chem.Lett_4_1091
PubMedID: 24900610
Gene_locus related to this paper: human-ACHE

Title : Structures of human acetylcholinesterase in complex with pharmacologically important ligands - Cheung_2012_J.Med.Chem_55_10282
Author(s) : Cheung J , Rudolph MJ , Burshteyn F , Cassidy MS , Gary EN , Love J , Franklin MC , Height JJ
Ref : Journal of Medicinal Chemistry , 55 :10282 , 2012
Abstract :
PubMedSearch : Cheung_2012_J.Med.Chem_55_10282
PubMedID: 23035744
Gene_locus related to this paper: human-ACHE

Title : Acetylcholinesterase: from 3D structure to function - Dvir_2010_Chem.Biol.Interact_187_10
Author(s) : Dvir H , Silman I , Harel M , Rosenberry TL , Sussman JL
Ref : Chemico-Biological Interactions , 187 :10 , 2010
Abstract :
PubMedSearch : Dvir_2010_Chem.Biol.Interact_187_10
PubMedID: 20138030
Gene_locus related to this paper: human-ACHE

Title : Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation - Carletti_2010_J.Med.Chem_53_4002
Author(s) : Carletti E , Colletier JP , Dupeux F , Trovaslet M , Masson P , Nachon F
Ref : Journal of Medicinal Chemistry , 53 :4002 , 2010
Abstract :
PubMedSearch : Carletti_2010_J.Med.Chem_53_4002
PubMedID: 20408548
Gene_locus related to this paper: human-ACHE

Title : The DNA sequence of human chromosome 7 - Hillier_2003_Nature_424_157
Author(s) : Hillier LW , Fulton RS , Fulton LA , Graves TA , Pepin KH , Wagner-McPherson C , Layman D , Maas J , Jaeger S , Walker R , Wylie K , Sekhon M , Becker MC , O'Laughlin MD , Schaller ME , Fewell GA , Delehaunty KD , Miner TL , Nash WE , Cordes M , Du H , Sun H , Edwards J , Bradshaw-Cordum H , Ali J , Andrews S , Isak A , Vanbrunt A , Nguyen C , Du F , Lamar B , Courtney L , Kalicki J , Ozersky P , Bielicki L , Scott K , Holmes A , Harkins R , Harris A , Strong CM , Hou S , Tomlinson C , Dauphin-Kohlberg S , Kozlowicz-Reilly A , Leonard S , Rohlfing T , Rock SM , Tin-Wollam AM , Abbott A , Minx P , Maupin R , Strowmatt C , Latreille P , Miller N , Johnson D , Murray J , Woessner JP , Wendl MC , Yang SP , Schultz BR , Wallis JW , Spieth J , Bieri TA , Nelson JO , Berkowicz N , Wohldmann PE , Cook LL , Hickenbotham MT , Eldred J , Williams D , Bedell JA , Mardis ER , Clifton SW , Chissoe SL , Marra MA , Raymond C , Haugen E , Gillett W , Zhou Y , James R , Phelps K , Iadanoto S , Bubb K , Simms E , Levy R , Clendenning J , Kaul R , Kent WJ , Furey TS , Baertsch RA , Brent MR , Keibler E , Flicek P , Bork P , Suyama M , Bailey JA , Portnoy ME , Torrents D , Chinwalla AT , Gish WR , Eddy SR , McPherson JD , Olson MV , Eichler EE , Green ED , Waterston RH , Wilson RK
Ref : Nature , 424 :157 , 2003
Abstract :
PubMedSearch : Hillier_2003_Nature_424_157
PubMedID: 12853948
Gene_locus related to this paper: human-ABHD11 , human-ACHE , human-CPVL , human-DPP6 , human-MEST

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
Abstract :
PubMedSearch : Venter_2001_Science_291_1304
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : Comparative analysis of the gene-dense ACHE\/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 - Wilson_2001_Nucleic.Acids.Res_29_1352
Author(s) : Wilson MD , Riemer C , Martindale DW , Schnupf P , Boright AP , Cheung TL , Hardy DM , Schwartz S , Scherer SW , Tsui LC , Miller W , Koop BF
Ref : Nucleic Acids Research , 29 :1352 , 2001
Abstract :
PubMedSearch : Wilson_2001_Nucleic.Acids.Res_29_1352
PubMedID: 11239002
Gene_locus related to this paper: human-ACHE , mouse-ACHE

Title : Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II - Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
Author(s) : Kryger G , Harel M , Giles K , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL
Ref : Acta Crystallographica D Biol Crystallogr , 56 :1385 , 2000
Abstract :
PubMedSearch : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
PubMedID: 11053835
Gene_locus related to this paper: human-ACHE

Title : A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases - Shapira_2000_Hum.Mol.Genet_9_1273
Author(s) : Shapira M , Tur-Kaspa I , Bosgraaf L , Livni N , Grant AD , Grisaru D , Korner M , Ebstein RP , Soreq H
Ref : Hum Mol Genet , 9 :1273 , 2000
Abstract :
PubMedSearch : Shapira_2000_Hum.Mol.Genet_9_1273
PubMedID: 10814709
Gene_locus related to this paper: human-ACHE

Title : Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase - Ashani_1994_Mol.Pharmacol_45_555
Author(s) : Ashani Y , Grunwald J , Kronman C , Velan B , Shafferman A
Ref : Molecular Pharmacology , 45 :555 , 1994
Abstract :
PubMedSearch : Ashani_1994_Mol.Pharmacol_45_555
PubMedID: 8145739
Gene_locus related to this paper: human-ACHE

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
Abstract :
PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure - Soreq_1990_Proc.Natl.Acad.Sci.U.S.A_87_9688
Author(s) : Soreq H , Ben-Aziz R , Prody CA , Seidman S , Gnatt A , Neville LF , Lieman-Hurwitz J , Lev-Lehman E , Ginzberg D , Lipidot-Lifson Y
Ref : Proceedings of the National Academy of Sciences of the United States of America , 87 :9688 , 1990
Abstract :
PubMedSearch : Soreq_1990_Proc.Natl.Acad.Sci.U.S.A_87_9688
PubMedID: 2263619
Gene_locus related to this paper: human-ACHE

Title : Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase - Chhajlani_1989_FEBS.Lett_247_279
Author(s) : Chhajlani V , Derr D , Earles B , Schmell ED , August T
Ref : FEBS Letters , 247 :279 , 1989
Abstract :
PubMedSearch : Chhajlani_1989_FEBS.Lett_247_279
PubMedID: 2714437
Gene_locus related to this paper: human-ACHE