ESTHER Database

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. For those who are unable to attend in person, organizers are pleased to announce that virtual registration is now available. Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase is published by De Sousa et al. and structures of Torpedo californica and human AChE in complex with quinoline-3-hydroxy-pyridinaldoxime (JDS364) are available (9F6R, 9SCM, 9SCN) The peptidoglycan-binding domain regulates antimycobacterial activity of LysB by affecting its transportation and/or catalytic activity as published by Zhang et al. Crystal structure of monoalkyl phthalate hydrolase native and in complex with MBP from Rhodococcus sp. EG-5 is available (9WTK; 26QV) and will be published soon by Aggarwal et al. Crystal structure of a leaf-branch compost cutinase variant (LCC_ICCG) is available (9RD2) and will be published soon by Kosinas et al. Structural and functional characterization of thermostable EstS1 esterase for BHET degradation is published by Zhang et al. and structures will be available soon (9WNY, 9WNZ) Chemical neighborhood exploration for substrate discovery in biocatalysis is published by Solovev et al. Neuroligin1 in CCK-interneurons gates social memory formation via a disinhibitory microcircuit in the hippocampal CA2 in male mice as published by Wu et al.

Insights into a versatile PET-degrading enzyme TmFae-PETase : from molecular mechanism to practical applications will be published soon by Hou et al. and structures are available (9V6M, 9V77) Effect of surface electrostatic potential on pH-activity profile in PET depolymerases is published by Seo et al. and structures of Micromonospora ureilytica, Allorhizocola rhizosphaerae and Saccharothrix sp. CB00851 Polyesterases-lipases-cutinases are available (9XV5, 9XV6,9XV7,9XV8) Alpha/beta-hydrolase domain containing 5 supports glucose-stimulated lipolysis and insulin secretion in pancreatic beta-cells as published by Kim et al. Evolutionary clade-guided consensus redesign of IsPETase: A computational framework for enhancing thermodynamic stability and MM/PBSA-derived binding energetics. is published by Nezhad et al. GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain as published by Liu et al. Molecular imaging of butyrylcholinesterase associated with amyloid-beta plaques distinguishes 5XFAD from wild-type mice: A proof-of-concept is published by Reid et al. The ABHD10-KCMF1 complex mitigates cochlear aging by regulating mitochondrial lipid metabolism as published by Peng et al. Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis asd published by Sakers et al. . The thioesterase APT1 is a bidirectional-adjustment redox sensor Ji et al.

Computational engineering of the polyester hydrolase PHL7 for efficient poly(ethylene terephthalate) degradation in biocatalytic recycling processes is published by Blazquez-Sanchez et al. and structures are available (9QNM, 9QT8, 9QV8, 9QVA, 9QYA, 9QYB, 9QYC) Structural insights into the evolution of alpha/beta-hydrolase fold luciferases are published by Majerova et al. and structures of an ancestral bifunctional dehalogenase-luciferase enzyme Anc238Loc are available (9RBN, 9RBP) Structural basis for dimerization, catalytic regulation, and substrate selectivity of the chloroplast S9D CGEP protease in Arabidopsis thaliana is published by Ehrlich et al. and structures are available (9QNM, 10EO, 10EP, 10EQ, 10ER, 10ES, 10ET, 10EU) (first structures of a mamber of this family Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes are published by Rullo et al. and structure is available (9RGC) Crystal structure of monoalkyl phthalate hydrolase in complex with MBP from Rhodococcus sp. EG-5 is available (9WTK) and will be published soon by Aggarwal et al. Barley HvBODYGUARD1 controls cuticular specialisations regulated by SHINE transcription factors and is crucial for leaf cuticular integrity and wax-bloom deposition as published by McAllister et al.

Orobanche cumana KAI2d2 mediates perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas as published by Shahul Hameed et al. an structures are available (9WGK, 9WGM, 9WGN, 9WGO, 9WGQ) ABHD17C-mediated S-Depalmitoylation of BCL6B enhances CD24 transcription to resist macrophage phagocytosis in pancreatic cancer is published by Zhang et al. A phase 1, safety, tolerability, and pharmacokinetics study of bisnorcymserine, a highly selective inhibitor of butyrylcholinesterase is published by Tzieras et al. Reverse prediction of carbohydrate esterase polysaccharide targets is published by Barrett et al. (Among CE families only CE1, CE5, CE7, CE10, CE13, CE15, CE19 are alpha/beta hydrolases) PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function Tong et al. NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer as published by Li et al.

Integrative structural and kinetic analysis of the molecular basis for reduced carbamate inhibition in Atypical butyrylcholinesterase is published by Matosevic et al. and structure of carbamoylated recombinant human butyrylcholinesterase by the biscarbamte 5-(1-hydroxy-2-(piperidin-1-yl)ethyl)-1,3-phenylene bis(piperidine-1-carboxylate) is available (9I4W) Zhu et al. published convergent amino acid substitution that has independently evolved in cardiac glycosides-adapted insects in Gliotactin gene involved in the septate junction. Thus modulating epithelial permeability, potentially facilitating the sequestration of toxic cardiac glycosides Rational design of the Polyethylene Terephthalate-degrading enzyme PES-H1 with low salt tolerance will be published soon by Xie et al. and the structures of the Q174E, D197K, and E147K/Q174E/D197K mutants of PES-H1 are available (9UTX, 9UTY, 9UTZ) de Moura Bones et al. published about Butyrylcholinesterase as a potential biomarker of metabolic imbalances in Afro-descendant populations Ustilago maydis phosphatidic acid and phosphatidylserine-targeting secreted lipase Lip3 is involved in pathogenesis as published by Roy et al.