ESTHER Database

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. Registration is now open Rational design and evaluation of Rivastigmine-based pleiotropic prodrugs for the treatment of Alzheimers disease are published by Travers-Lesage et al. An efficient step-by-step approach to select pleiotropic drug candidatesagainst Alzheimers disease: The discovery of neocopride is published by Rochais et al. Structural basis of substrate recognition and membrane association by the bacterial lysyl-phosphatidylglycerol hydrolase AcvB will be published soon by Hoshi et al. and structure is available (9XHM) Structural insights into the evolution of alpha/beta-hydrolase fold luciferases are published by Majerova et al. and structures of an ancestral bifunctional dehalogenase-luciferase enzyme Anc238Loc will be available soon (9RBN, 9RBP) TEX30 safeguards sperm morphogenesis and quality consistency required for male fertility as published by Kikuchi et al.

Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases as published in a preprint Kelly et al. and structures of alpha/beta-hydrolase macrolide esterase EstT from Bacillus cereus and EstX from Escherichia coli in complex with linearized tylvalosin or Tylosin are available (11TW, 11TU, 11TV11TT, 11TS)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties is published by Karampa et al. and structures of FoFaeC_G122S and FoFaeC_G122S in complex with benzoc acid are available (9I50, 9HUN) FphI, Staphylococcus aureus fluorophosphonate-binding serine hydrolases I, in complex with inhibitors are available (9NIX, 9NIZ) and will be bublished soon by Randall et al. Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - Trp185Tyr/His280Ala with 2-fluoro-3-phenylpropanoic acid is available (9U9L) and will be bublished soon by Huang et al. Crystal structure of de novo designed thermostable esterase RPA1511-5221 based on Rhodopseudomonas palustris RPA1511 for polylactic acid depolymerization is available (21DL) and will be published soon by Liu et al.

Lactylation converts ABHD6 into a mitochondrial regulator that drives Lenvatinib resistance in hepatocellular carcinoma as published by Sun et al. Lactylation of ABHD6 trigger the mitochondrial translocation of ABHD6, where it functioned as a scaffold. Ligand-binding at the catalytic site allosterically controlled a molecular switch between canonical enzymatic and non-canonical scaffolding functions of ABHD6 Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A is published by Wen-Xia et al. .Authors also show that HupA protected pancreatic islet beta-cells in a palmitic acid-induced injury model Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - Lys181Met/Trp185Tyr/His280Ala with 2-fluoro-3-phenylpropanoic acid is available (9U5W) and will be published soon by Huang et al. Unique structural and ligand binding properties of the Staphylococcus aureus serine hydrolase FphE are published in a preprint by Jo et al. and structures are available (8SBQ, 8G49, 9G48, 9COM, 9EBF, 9D87, 9EDJ)

Serine hydrolase targets of a Sarin surrogate anticholinesterase and oxime mediated reactivation in rat brain are published by Price et al. Bortezomib (proteasome inhibitor) induces apoptosis via upregulation of Abhd4 in peripheral nerve cells Konishi et al. Abhd4 is a potential contributor to bortezomib-induced peripheral neuropathy Examining PETase activity across a phylogenetic genus: Investigating thermostability and the effect of a single surface-charge-altering substitution on PET film degradation will be published soon by Wain et al. and crystal structure of a cutinase from Saccharopolyspora Dendranthemae is available (29CU) Structures of Zearalenone degrading enzyme with a-zearalenol and thermostable mutants are available (9M5F, 9M5G, 9M6F) and will be published soon by Ouyang et al. Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning are published by Karasova et al. N-myristoylation is essential for SUMM2 activation, SUMM2 promotes the association of the lipase-like proteins ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and PHYTOALEXIN DEFICIENT 4 (PAD4) with the helper NLR-ACTIVATED DISEASE RESISTANCE 1-LIKE 1 (ADR1-L1). Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR is published by Ge et al.