ESTHER Database

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape as published by Vongsouthi et al. and structures of Ancestral PETase are available (8ETX, 8ETY) Zhang et al. publish that root microbiota regulates tiller number in rice, and structure rice DWARF14 in complex with Cyclo(L-Leu-L-Pro) is available (9JQG) They revealed that cyclo(Leu-Pro), produced by the tiller-inhibiting bacterium Exiguobacterium R2567, activates the rice strigolactone (SL) signaling pathway by binding to the SL receptor OsD14 Cryogenic APO structure of soluble Epoxide Hydrolase is available (9EXM) and will be published by Dunge et al. Structures of polyhydroxyalkanoate synthase PhaC from Aeromonas caviae, producing biodegradable plastics are available (9KNJ, 9KNK, 9KNL) and published by Chek et al. They show that the alpha/beta catalytic domain forms a tunnel that connects the catalytic center embedded inside the protein to the protein surface, and that this tunnel is a putative egress tunnel for the product PHA chain. An aggregation-induced conformation locking strategy facilitates the activation of lipase biocatalyst is published by Huang et al.. rs1051931 nonsynonymous polymorphism of platelet-activating factor acetylhydrolase gene PLA2G7 is associated with dysesthesia and pain severity after surgery as published by Hayashi et al. ABHD18 degrades cardiolipin by stepwise hydrolysis of fatty acids as published by Ren et al.

Weaker neuroligin 2 - neurexin 1 interaction tethers membranes and signal synaptogenesis through clustering as published by Boyd et al. Electron microscopy structures of full-length NL2 alone, and in complex with NRX1beta in several conformations are available (8G7Y, 8G7Z, 8G80, 8G81, 8G7D) Unveiling the crystal structure of thermostable dienelactone hydrolase exhibiting activity on terephthalate esters is published by Almeida et al. and structures are available (9BLD, 9BLE) Structure of the Burkholderia gladioli thioesterase domain (GbnD6 TE domain) from the gladiolin PKS is available (9F7B) and will be published soon by Alkhalaf et al. Volume 211 of Handbook of Clinical Neurology: Cholinergic involvement in neurodegenerative diseases, edited by A. Claudio Cuello is published and chapters are available : Chapters Treatment of acute organophosphate poisoning by using a cocaine hydrolase engineered from human butyrylcholinesterase is published by LeSaint et al. Ionic and non-ionic counterparts based on Bis(Uracilyl)Alkane moiety with highest selectivity towards Acetylcholinesterase for protection against organophosphate poisoning and treating Alzheimer's disease is published by Zueva et al. Disruption of the Karrikin receptor DWARF 14 LIKE (D14L) gene leads to distinct effects on root and shoot growth, and reprogramming of central metabolism in rice is published by Salem et al.

Structure of YqiA, Klebsiella pneumoniae serine hydrolase, unbound is available (9BI7) and will be published soon by Randall, G.T. and Fellner, M. PME-1 S156A and M335D knock-in mice deficient in methylesterase and PP2A inhibitory activity, respectively showed phenotypes distinct from the perinatal lethality of PME-1 null mice. The loss of methylesterase activity due to the S156A mutation resulted in systemic apoptosis characterized by brain atrophy: the layers of the cerebellum collapsed with fewer Purkinje cells and more microglia. M335D mutant pups did not appear deformed and had intact brains but died about two days after birth with a demonstrated loss of olfaction and apoptosis in the olfactory epithelium (Ikeda et al. ) A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade as published by Olivier et al. A review on non-oxime reactivators of organophosphate-inhibited cholinesterases is published by Knittelova et al. A preprint by Furlong et al. is investigating biomarkers of exposure to jet aircraft oil fumes using mass spectrometry Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly is published by Mostert et al. Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut is published by Bao et al.

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression, as published by Brugia et al. The Potato StNAC2-StSABP2 Module Enhanced Resistance to Phytophthora infestans Through Activating the Salicylic Acid Pathway as published by Yan et al. Structural analysis shows the mode of inhibition for Staphylococcus aureus lipase by antipsychotic penfluridol is published by Kitadokoro et al. and structures of Staphylococcus aureus lipase Penfluridol complex on the ground and in space are available (9L3C, 9L3S) Structure of YjfP, Klebsiella pneumoniae serine hydrolase is available (9BD4) and will be published soon by Randall and Fellner. It is the first structure in this family. Crystal structure of human soluble epoxide hydrolase C-terminal domain in complex with a benzohomoadamantane-based urea inhibitor UB-BJ-05 is available (9BD4) and will be published soon by Qiu et al. DPP8/9 processing of human AK2 unmasks an IAP binding motif as published by Lapacz et al.

Structure of Arabidopsis Dwarf14 (AtD14) co-crystallized in the presence of Zaxinone is available (8Z53) and will be published soon by Arold, S.T., Hameed U.F.S. Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets are published by Peng et al. and first cryo-EM structure of human hormone-sensitive lipase is available (8ZVQ)