ESTHER Database

The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.

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News

May-15-2024

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 ESTHER successfully switched to its new operating system on April 2 - long life to the new ESTHER server! There are still many pages from the old server that need to be implemented: we are working, and apologize for the delay. The BLAST page is however now operational! Characterization and engineering of novel fungal PET degrading enzyme from Aspergillus fumigatiaffinis will be published soon by Lee et al. and structure is available (8JCT) Leafhopper salivary carboxylesterase CarE10 suppresses JA-Ile synthesis to facilitate initial arbovirus transmission in rice phloem by direct association of CarE10 with JAR1 impairs JAR1 (Jasmonate resistant 1) enzyme activity for JA conversion to JA-Ile as published by Chi et al.

May-01-2024

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 arath-At5g14390 ABAPT3 (Alpha/Beta Hydrolase Domain-containing Protein 17-like Acyl Protein Thioesterase 3 is the de-S-acylation enzyme of homologs of critical viral proteins in monopartite and bipartite geminiviruses. ABAPT3 overexpression disrupted the S-acylation, subcellular localization, and function of the virus proteins, as shown by Zhao et al. Structural and enzymatic characterization of an esterase with a monomeric cooperative, hysteresis or allokairy from a metagenomic library amazonian dark soil is published by Vinces et al. and structures are available (8V16, 6EB3) Structural and functional insights into the enzymatic activities of lipases from Burkholderia stagnalis and Burkholderia plantarii are published by Kataoka et al. and struture of lipase from Burkholderia stagnalis (BsL) is available (8XY5). This lipase exhibits higher interesterification activity than that from Burkholderia plantarii (BpL) The transport of water molecules across three different alpha/beta-hydrolases: haloalkane dehalogenase, epoxide hydrolase, and lipase analysed by molecular dynamics simulations is published by Sequeiros-Borja et al. Exploring the pH dependence of an improved PETase is published by Charlier et al. and structure (8OTA) will be available soon The crystal structures of Thermomyces (Humicola) lanuginosa lipase in complex with enzymatic reactants are published by McPherson et al. and are available (6XOK, 6XRV, 6XS3, 6O8V, 6O9F, 6OSZ) New crystal structures of SulE mutants are available (8J7I, 8J7L) and will be published soon by Liu et al. Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy are published by Waiker et al. Identification of DAGLA as an autoantibody target in cerebellar ataxia is published by Miske et al.

April-24-2024

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 Structure of Mus musculus acetylcholinesterase in complex with AL237 is available (8ORC) and enzyme dynamics that determine potency and selectivity of inhibitors targeting disease-transmitting mosquitoes will be published soon by Kumari et al. Inhibitors of the thioesterase activity of Mycobacterium tuberculosis Pks13 discovered using DNA-encoded chemical library screening are published by Krieger et al. and structures are available (8TQG, 8TQV, 8TR4, 8TRY) Crystal structure of a IsPETase variant V22 and V20 from Ideonella sakaiensis are available (8H83, 8J5N) and will be published soon by Wei et al. Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) are published by Horn et al. Reid and Darvesh show interaction of exogenous Acetylcholinesterase and Butyrylcholinesterase with amyloid-beta plaques in human brain tissue

April-17-2024

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 Thermodynamics of the hyperthermostable carboxylesterase from Anoxybacillus geothermalis D9 9baci-EstD9 is further characterized by Johan et al. Quinone methide precursors developped as nonoxime reactivators of organophosphorus-inhibited cholinesterases and resurrectors of organophosphorus-aged acetylcholinesterase are described by Clay et al. and Lovins et al. Structure-based characterization and improvement of an enzymatic activity of Acremonium alcalophilum (Sodiomyces alcalophilus) feruloyl esterase is published by Phienluphon et al. and structures of AaFaeD-CD are available (8JH8, 8JH9) Crystal structure of HaloTag complexed with BTTA is available (8J1O) and will be published soon by Kim et aL. Structure of FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, fluorophosphonate JB101 bound is available (8SBQ) and will be published soon by Fellner et al.

April-10-2024

Crystal structure of FphA, Staphylococcus aureus fluorophosphonate-binding serine hydrolases A, apo form is available (8S9J) as well as structure of SAL2, Staphylococcus aureus lipase 2 (geh, lip2) (8S9R) and will be published soon by Fellner et al. New structures of Hansschlegelia zhihuaiae SulE, a sulfonylurea herbicide de-esterification esterase ara available (8IVH, 8IW8) and will be published soon by Liu et al. Onset of Alzheimer disease in apolipoprotein E4 carriers is earlier in butyrylcholinesterase K variant carriers as published by Lane et al. Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles is published by Stojan et al. and structures of Torpedo californica AChE-MSF and AChE-MSF-BTA complexes are available (5EHX, 5EI5) A comprehensive review on the risk associated with organophosphorus nerve agents, current medical countermeasures and perspectives is published by Voros et al.

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