ESTHER Database

The web site for the 15th conference on cholinesterases and the 9th on paraoxonases is now open. The book of abstract is available chepon2024 Crystal structure of RBBP9 with spacegroup p212121 is available (9FCR) and will be published soon by Gorrec, F. and Bellini, D. Repurposing Duloxetine as a potent butyrylcholinesterase inhibitor: potential cholinergic enhancing benefits for elderly individuals with depression and cognitive impairment is published by Darreh-Shori et al. Novel Mechanisms of Strigolactone-Induced DWARF14 Degradation in Arabidopsis thaliana is described by Martin-Fontecha et al. Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) is published in a pre-print by Sundararaman et al.

Exploring the pH dependence of an improved PETase is published by Charlier et al. and structure (8OTA) is available Missense variants in CMS22 patients reveal that PREPL has both enzymatic and non-enzymatic functions as published by Monnens et al.. Cryo-EM structure of the R243C mutant of human Prolyl Endopeptidase-Like (PREPL) protein involved in Congenital myasthenic syndrome-22 (CMS22) is available: Electron Microscopy Data Bank (EMDB) with the accession number EMD-19117 and PDB entry (8RFB) Effective parallel evaluation of molecular design, expression and bioactivity of novel recombinant butyrylcholinesterase medical countermeasures is published by Allard et al. ABHD8 antagonizes inflammation by facilitating chaperone-mediated autophagy-mediated degradation of NLRP3 Yang et al.. A novel pathogenic homozygous frameshift variant in ABHD12 in a patient with PHARC disease is described by Daneshi et al.

Structural, biochemical, and phylogenetic analysis of bacterial and fungal carbohydrate esterase family 15 Glucuronoyl esterases in the Rumen is published by Gruninger et al. and structures are available (8TSE 8TRU 8TRX).

Structural, biochemical, and phylogenetic analysis of bacterial and fungal carbohydrate esterase family 15 Glucuronoyl esterases in the Rumen is published by Gruninger et al. and structures will be available soon (8TSE, 8TRU 8TRX). A comprehensive review on Haloalkane dehalogenase (LinB): a beta-hexachlorocyclohexane (HCH) degrading enzyme is published by Verma et al. The evolution of cutinase Est1 based on the clustering strategy and its application for commercial PET bottles degradation is published by Lu et al. Investigating lipase/stain interactions: Determining interfacial protein conformation with surface spectroscopy is published by Saeed et al.

The web site for the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 A new method to screen for optimal microcrystallization conditions suitable for use in serial crystallography and a number of RT ligand-bound structures of epoxide-hydroalase are published by Dunge et al. and structures are available (8QVM, 8QVI, 8QVL, 8QVG, 8QWG, 8QWI, 8QVK, 8QVF, 8QVH) Structure of a toxin/immunity complex for a T6SS lipase effector from E. cloacae is available (9CYSand will be published soon by Jensen et al. Genotype-phenotype spectrum and correlation of PHARC Syndrome due to pathogenic ABHD12 variants are published by Long et al.