ESTHER Database

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. Registration is now open Potent and selective indole-based inhibitors targeting disease-transmitting mosquitoes are published by Rajeshwari et al. and structures (9SNJ, 9SND) are available Structural and functional characterization of dsPETase05 for the degradation of Polyethylene terephthalate is published by Zhang et al. and structure (9W68 is availble Unique structural and ligand binding properties of the Staphylococcus aureus serine hydrolase FphE are published in a preprint by Jo et al. and structures are available (8SBQ, 8G49, 9G48, 9COM, 9EBF, 9D87, 9EDJ) Enhancing the specificity of a thermostable PET hydrolase toward aromatic polyesters via Piscinibacter sakaiensis PETase-inspired mutations is published by Chek et al. and structures are available (9M8H, 9M8I) Structure-guided optimization of 4-chloro-pyrazolopyridine analogs for covalent PREP inhibition is published by Thakur et al. and stuctures are available (9Q5G, , 9Q5Y, 9Q5Z, 9Q62, 9Q64, 9Q65, 9Q66, 9Q6J, 9Q6K, 9Q6L, 9Q6X, 9XYK, 9XYL, 9XZZ) Computational discovery, biochemical characterization, crystal structure, and catalytic mechanism of a highly efficient Poly (Ethylene Terephthalate) hydrolase ICCG-H218S/F222I is published by Wang et al. and struvcture is available (9LJ7) Crystal structures of the Fluoroacetate dehalogenase RPA1163 mutants in complex with inhibitors are available (9UE2, 9U5X, 9U9U, 21BK) and will be published soon by Huang et al. An improved nerve agent bioscavenger based on the fast self-reactivation mechanism of porcine butyrylcholinesterase is decribed by Brazzolotto et al. A review of covalent fluorescent probes for 2-arachidonoylglycerol metabolic pathways is published by Puijmbroeck et al.

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. Registration is now open Interaction of a glucuronyl esterase with complex fragments of the plant cell wall will be published soon by Zaghini et al. and structures of glucuronyl esterase OtCE15A from Opitutus terrae native and in complex with a heptasaccharide are available (9HUC, 9HVR Structural basis for human DPP4 receptor recognition by MERS-like coronaviruses 2014-422 and GX2012 is published by Lin et al. and structures (9V2L, 9V2P) are availble Genetic architecture of the tomato fruit lipidome is published by Kuhalskaya et al. Chronic suppression of monoacylglycerol lipase restores adult neurogenesis in the septal but not the temporal DG in Ts65Dn mouse model of Down syndrome as published by Fozoonmayeh et al.

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. Registration is now open Interaction of a glucuronyl esterase with complex fragments of the plant cell wall will be published soon by Zaghini et al. and structures of glucuronyl esterase OtCE15A from Opitutus terrae native and in complex with a heptasaccharide are available (9HUC, 9HVR Structural basis for human DPP4 receptor recognition by MERS-like coronaviruses 2014-422 and GX2012 is published by Lin et al. and structures (9V2L, 9V2P) are availble Genetic architecture of the tomato fruit lipidome is published by Kuhalskaya et al. Chronic suppression of monoacylglycerol lipase restores adult neurogenesis in the septal but not the temporal DG in Ts65Dn mouse model of Down syndrome as published by Fozoonmayeh et al.

The ESTHER curators wish to all users and colleagues a happy new year! The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. Registration is now open Crystal structures of the Fluoroacetate dehalogenase RPA1163 mutants in complex with inhibitors are available (9UE2, 9U5X, 9U9U, 21BK) and will be published soon by Huang et al. Structure of a novel PE hydrolase and its structural basis is available (9L75) and will be published soon by Sun et al. Hormone-sensitive lipase drives pro-resolving macrophage polarization and enhances efferocytosis as published by Watanabe et al.

The ESTHER curators wish to all users and colleagues a happy new year! The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. Registration is now open Crystal structures of the Fluoroacetate dehalogenase RPA1163 mutants in complex with inhibitors are available (9UE2, 9U9U, 21BK) and will be published soon by Huang et al. Structure of a novel PE hydrolase and its structural basis is available (9L75) and will be published soon by Sun et al. Hormone-sensitive lipase drives pro-resolving macrophage polarization and enhances efferocytosis as published by Watanabe et al.