ESTHER Database

Structural insights into sequential phthalic acid ester degradation: Co-crystal structures of a dialkyl/monoalkyl phthalate hydrolase with intermediate and product are published by Chen et al. and crystal structure of Phthalate Hydrolase EstJ6 native and in complex are available (9VMR, 9VMU, 9VMW) Crystal structures of PA14 Cif bound to nanobodies VHH219 and VHH108 is available (9Y3I, 9Y3J) and will be published soon by Simard and Madden New families have been extracted (Duf_7379, Conditioned-medium-factor-Cterm)

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health as published by Li et al. Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum is published by Delgado-Rey et al. and structure (10XN) is available Structures of MERS-CoV RBD in complex with receptor DPP4 (22EA, 22EB, 22DX, 22DY) are available and will be published soon by Wang, Y.J. and Sun, L. Pectin acetylesterases PAE8 and PAE9 double mutant reduces auxin and alters resistance against selected bacteria and fungi in Arabidopsis thaliana as published by Ahmad et al. Dual inhibitors of p38alpha mitogen-activated protein kinase and butyrylcholinesterase for the modulation of neuroinflammation and cognitive dysfunction are published by Knez et al. and structures of human BChE with inhibitors 8 and 21 are available (9GCQ, 9GCR)

New structures of FphA, Staphylococcus aureus fluorophosphonate-binding serine hydrolases A, apo form, crystal form 2 and 3 are available (9Q21, 9Q27) and will be publishesd soon by You and Fellner Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum is published by Delgado-Rey et al. and structure (10XN) will be available soon. Potato purple top Phytoplasma infection induces autophagy-associated lipid dynamics that support pathogen proliferation and depends on a specific lipase as published by Inaba et al.. Genome-wide identification of CXE gene family in soybean and functional characterization of GmCXE31 in lipid biosynthesis and salt tolerance are published by Guo et al. FphI, Staphylococcus aureus fluorophosphonate-binding serine hydrolases I, in complex with inhibitors are available (9NIX, 9NIZ) and arepublished by Randall et al. Beyond model substrates: Reevaluating enzymes claimed to hydrolyze zearalenone is publishd by Emodi et al. Adaptive variation in butyrylcholinesterase-influenced lipid metabolism during horse domestication as published by Zhang et al. Organophosphate pesticide poisoning: benefits and limitations of oxime therapy as published by Crepinsek et al. Association of ABHD12 variants with the spectrum of PHARC syndrome phenotypes is published by Romero-Vazquez et al.

Crystal structure of a bifunctional enzyme PaLipO from Pseudoalteromonas aliena SW19 is available (9WO1) and is published by Zhang et al. alpha/beta-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP gamma-2-containing AMPA receptors as published by Cong et al.

Alternative splicing: ABHD4-1 localizes to lipid droplets, whereas ABHD4-2 selectively targets mitochondria and is enriched in oxidative tissues. ABHD4-2 localize to the cytosolic face of the OMM (outer mitochondrial membrane). ABHD4-2 selectively hydrolyzes Cardiolipin (CL) in vitro, producing monolysocardiolipin (MLCL) and dilysocardiolipin (DLCL) as published by Narayanasamy et al. Analysis of the Atypical Temperature Dependence and Conformational Changes During Turnover of a Lactobacillus Chlorogenic Acid Esterase is published by Carl et al. structure of a loop mutant of a chlorogenic acid esterase from Lactobacillus helveticus is available (10BV) Neuroligin-3-CSPG4 interaction maintains oligodendrocyte precursor cell progenitor state and promotes glioma proliferation through mechanotransduction as published by Kim et al.