ESTHER Database

A super-resolution approach for astrocyte-specific molecular imaging reveals the nanoscale distribution of Monoacylglycerol Lipase, the metabolic node between endocannabinoid and prostaglandin signaling, as published by Zoldi et al. Discovery and engineering of cold-active lipases facilitating the biodegradation of poly(epsilon-caprolactone) and polyurethane from the functional mixed genomic library is published by Jeong et al. Dynamic conformations of fluorophores on self-labeling protein tags is published by Zhang et al. and structures of the Haloalkane dehalogenase HaloTag7 labeled with BD566-HTL substrate are available (21DT) Crystal structure of Phthalate Hydrolase EstJ6 native and in complex are available (9VMR, 9VMU, 9VMW) and will be published soon by Wang et al. Structural and functional characterization of dsPETase05 for the degradation of Polyethylene terephthalate is published by Zhang et al. and structure (9W68) is available Crystal structure of de novo designed esterase RPA1511-2297 is available (27CT) and will be published soon by Liu et al. Acyl-protein thioesterases APT1 and APT2 regulate the de-palmitoylation of the tight junction protein CLDN12, thereby negatively regulating Hepatitis C virus (HCV) entry Zhang et al.

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) took place in Montreal, Canada, June 19-26 2026 ISCM2026 and was very successful. The progrem booklet is available at ISCM2026 program Crystal structure of monoalkyl phthalate hydrolase from Rhodococcus sp. EG-5 n complex with Paranitrophenyl butyrate (PNPB) is available (27XP) and will be published soon by Aggarwal et al. Structure-guided optimization of 4-chloro-pyrazolopyridine analogs for covalent PREP inhibition is published by Thakur et al. and another stucture is available (9Q6I) Engineering and application of a thermostable MHETase for PET depolymerization are published by Murphy et al. and structures will be available soon (9PIC, 9PID, 9PJB, 9PIR)

Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity as published by Singh et al. Strength training induces ABHD5-ATGL axis to counteract mesenteric fat accumulation in obese Swiss mice as published by de Melo et al.

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026. For those who are unable to attend in person, organizers are pleased to announce that virtual registration is now available. Canonical EDS1/PAD4 small-molecule binding sites are required for LRR-RP-mediated pattern-triggered immunity as published by Fliegmann et al. Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats is published by Lara et al. Synthesis and evaluation of novel cinnamic acid hybrids with antiacetylcholinesterase, antioxidant, and anti-inflammatory properties by Sdougkou et al. Genetic interaction of DISC1 and Neuroligin in regulation of glutamatergic synaptogenesis in drosophila by Honda et al. Molecular dynamics simulations elucidate the misfolding mechanisms of secretion-defective pancreatic lipase variants as published by Hoffka et al. SlABH15 Promotes jasmonate-mediated lead detoxification in tomato: A promising target for enhancing Phytoremediation and lead stress tolerance is published by Li et al. A dual phospholipase system instructs membrane hydrolysis during the final stages of plant autophagy as published by Castets et al.. Arabidopsis phospholipases, LCAT4 and LCAT3, traffic to the vacuolar lumen and converge on autophagic bodies through fundamentally different routes

Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase is published by De Sousa et al. and structures of Torpedo californica and human AChE in complex with quinoline-3-hydroxy-pyridinaldoxime (JDS364) are available (9F6R, 9SCM, 9SCN) The peptidoglycan-binding domain regulates antimycobacterial activity of LysB by affecting its transportation and/or catalytic activity as published by Zhang et al. Crystal structure of monoalkyl phthalate hydrolase native and in complex with MBP from Rhodococcus sp. EG-5 is available (9WTK; 26QV) and will be published soon by Aggarwal et al. Crystal structure of a leaf-branch compost cutinase variant (LCC_ICCG) is available (9RD2) and will be published soon by Kosinas et al. Structural and functional characterization of thermostable EstS1 esterase for BHET degradation is published by Verma et al. and structures will be available soon (9WNY, 9WNZ) Chemical neighborhood exploration for substrate discovery in biocatalysis is published by Solovev et al. Neuroligin1 in CCK-interneurons gates social memory formation via a disinhibitory microcircuit in the hippocampal CA2 in male mice as published by Wu et al.