ESTHER Database

Crystal structures of human butyrylcholinesterase in complex with indol derivatives are available (9RZO, 9RZP) and will be published soon by Brazzolotto et al. Influence of N-Functionalization of amiridine on the biological activity of its conjugates as multitarget agents for potential treatment of Alzheimer's disease is published by Makhaeva et al. Structural and mechanistic basis for membrane recognition and activation of the vacuolar lipase Atg15 are published by Kawamata et al. A cold-adapted polyurethane-degrading lipase from the gut bacterium of plastic-eating superworms is published by Liu et al. Modular access to diverse soluble epoxide hydrolase degraders as potential agents for alleviating LPS-induced acute inflammation is published by Yin et al. Identification of a new, potent, and stable tetrahydroquinoline-based 5-LOX/sEH dual inhibitor with polymodal anti-inflammatory activity in acute pancreatitis D'Avino et al.

Crystal structures of engineered PETase, EV2 and EV3, derived from Thermobifida fusca cutinase (TfCut2) are available(9PM1, 9PM2) and will be published soon by Mathews et al.

Engineering and application of a thermostable MHETase for PET depolymerization are published by Murphy et al. and structures are available (9PIC, 9PID, 9PJB, 9PIR) Structural and functional characterization of thermostable EstS1 esterase for BHET degradation is published by Verma et al. and structures are available (9WNY, 9WNZ) Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases as published by Kelly et al. and structures of alpha/beta-hydrolase macrolide esterase EstT from Bacillus cereus and EstX from Escherichia coli in complex with linearized tylvalosin or tylosin are available (11TW, 11TU, 11TV, 11TT, 11TS) Combining beta(2)-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease is published by Wang et al.

A super-resolution approach for astrocyte-specific molecular imaging reveals the nanoscale distribution of Monoacylglycerol Lipase, the metabolic node between endocannabinoid and prostaglandin signaling, as published by Zoldi et al. Discovery and engineering of cold-active lipases facilitating the biodegradation of poly(epsilon-caprolactone) and polyurethane from the functional mixed genomic library is published by Jeong et al. Dynamic conformations of fluorophores on self-labeling protein tags is published by Zhang et al. and structures of the Haloalkane dehalogenase HaloTag7 labeled with BD566-HTL substrate are available (21DT) Crystal structure of Phthalate Hydrolase EstJ6 native and in complex are available (9VMR, 9VMU, 9VMW) and will be published soon by Wang et al. Structural and functional characterization of dsPETase05 for the degradation of Polyethylene terephthalate is published by Zhang et al. and structure (9W68) is available Crystal structure of de novo designed esterase RPA1511-2297 is available (27CT) and will be published soon by Liu et al. Acyl-protein thioesterases APT1 and APT2 regulate the de-palmitoylation of the tight junction protein CLDN12, thereby negatively regulating Hepatitis C virus (HCV) entry Zhang et al.

The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) took place in Montreal, Canada, June 19-26 2026 ISCM2026 and was very successful. The progrem booklet is available at ISCM2026 program Crystal structure of monoalkyl phthalate hydrolase from Rhodococcus sp. EG-5 n complex with Paranitrophenyl butyrate (PNPB) is available (27XP) and will be published soon by Aggarwal et al. Structure-guided optimization of 4-chloro-pyrazolopyridine analogs for covalent PREP inhibition is published by Thakur et al. and another stucture is available (9Q6I) Engineering and application of a thermostable MHETase for PET depolymerization are published by Murphy et al. and structures will be available soon (9PIC, 9PID, 9PJB, 9PIR)