ESTHER database
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Enzyme
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Genes Locus
Inhibitor
Interact Gene Locus
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Type inhibitor
Type reactivator
Type substrate
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Overall table
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Kinetics notes
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Program:
BlastN
BlastP
BlastX
tBlastN
tBlastX
DeltaBlast
PSI-Blast
RPS-Blast
RPS-tBlastN
Database:
_Totale.nuc
_Totale.pep
5_AlphaBeta_hydrolase.pep
6_AlphaBeta_hydrolase.nuc
6_AlphaBeta_hydrolase.pep
A85-Est-Putative.pep
A85-EsteraseD-FGH.nuc
A85-EsteraseD-FGH.pep
A85-Feruloyl-Esterase.pep
A85-IroE-IroD-Fes-Yiel.pep
A85-Mycolyl-transferase.nuc
A85-Mycolyl-transferase.pep
ABHD10.pep
ABHD11-Acetyl_transferase.nuc
ABHD11-Acetyl_transferase.pep
ABHD12-PHARC.pep
ABHD13-BEM46.pep
ABHD16.pep
ABHD17-depalmitoylase.pep
ABHD18.pep
ABHD6-Lip.nuc
ABHD6-Lip.pep
ABHD8.nuc
ABHD8.pep
ACHE.nuc
ACHE.pep
ACPH_Peptidase_S9.nuc
ACPH_Peptidase_S9.pep
AHL-acylase.pep
ATG15-related-lipase.nuc
ATG15-related-lipase.pep
Abhydr_predicted.pep
Abhydrolase_10.pep
Abhydrolase_5.pep
Abhydrolase_6.nuc
Abhydrolase_6.pep
Abhydrolase_7.pep
Abhydrolase_9.pep
Acetyl-esterase_deacetylase.nuc
Acetyl-esterase_deacetylase.pep
Acetyl_esterase.nuc
Acetyl_esterase.pep
Acetylxylan_esterase.nuc
Acetylxylan_esterase.pep
Acidic_Lipase.nuc
Acidic_Lipase.pep
Aclacinomycin-methylesterase_RdmC.nuc
Aclacinomycin-methylesterase_RdmC.pep
AcoC_BiotinLipoyl-ABH.nuc
AcoC_BiotinLipoyl-ABH.pep
Acyl-CoA_Thioesterase.pep
AlphaBeta_hydrolase.nuc
AlphaBeta_hydrolase.pep
Antigen85c.nuc
Antigen85c.pep
Arb2.pep
Arb2_FAM172A.pep
Arb2_domain.pep
Arylacetamide_deacetylase.nuc
Arylacetamide_deacetylase.pep
Asp2.pep
Atu1826-like.pep
Auxin-response-4.pep
Avian-virus_vlip.pep
BCHE.nuc
BCHE.pep
BD-FAE.nuc
BD-FAE.pep
Bacillus_lip.pep
Bact_LipEH166_FamXII.pep
Bacterial_Est97.pep
Bacterial_EstLip_FamX.pep
Bacterial_EstLip_FamXIV.pep
Bacterial_esterase.pep
Bacterial_lip_FamI.1.nuc
Bacterial_lip_FamI.1.pep
Bacterial_lip_FamI.2.nuc
Bacterial_lip_FamI.2.pep
Bacterial_lip_FamI.3.nuc
Bacterial_lip_FamI.3.pep
Bacterial_lip_FamI.5.nuc
Bacterial_lip_FamI.5.pep
Bacterial_lip_FamI.6.nuc
Bacterial_lip_FamI.6.pep
Bacterial_lip_FamI.8.pep
Bacterial_lipase.nuc
Bacterial_lipase.pep
BioG_Pimeloyl-ACP-methyl-esterase.pep
BioH.nuc
BioH.pep
BlEst2-lipase-like.pep
Block_C.nuc
Block_C.pep
Block_H.nuc
Block_H.pep
Block_L.nuc
Block_L.pep
Block_X.nuc
Block_X.pep
Bodyguard.nuc
Bodyguard.pep
BotH.pep
CFTR-inhibitory-factor_Cif.nuc
CFTR-inhibitory-factor_Cif.pep
CGI-58_ABHD5_ABHD4.nuc
CGI-58_ABHD5_ABHD4.pep
CIB-CCG1-interacting-factor-B.nuc
CIB-CCG1-interacting-factor-B.pep
CMBL.pep
Canar_LipB.nuc
Canar_LipB.pep
CarbLipBact_1.nuc
CarbLipBact_1.pep
CarbLipBact_2.pep
Carb_B_Annelida.pep
Carb_B_Arthropoda.nuc
Carb_B_Arthropoda.pep
Carb_B_Bacteria.nuc
Carb_B_Bacteria.pep
Carb_B_Brachiopoda.pep
Carb_B_Chordata.nuc
Carb_B_Chordata.pep
Carb_B_Mollusca.pep
Carb_B_Nematoda.nuc
Carb_B_Nematoda.pep
Carb_B_Platyhelminthe.pep
Carb_B_Root.pep
Carbon-carbon_bond_hydrolase.nuc
Carbon-carbon_bond_hydrolase.pep
Carboxylesterase.nuc
Carboxylesterase.pep
Carboxymethylbutenolide_lactonase.nuc
Carboxymethylbutenolide_lactonase.pep
Carboxypeptidase_S10.nuc
Carboxypeptidase_S10.pep
Chlorophyllase.pep
Chlorophyllase_Plant.pep
Cholesterol_esterase.nuc
Cholesterol_esterase.pep
Cholinesterase-like.nuc
Cholinesterase-like.pep
Cholinesterase.nuc
Cholinesterase.pep
Cocaine_esterase.nuc
Cocaine_esterase.pep
Crenarchaeota-hydrolase.pep
Cutinase.nuc
Cutinase.pep
Cutinase_like.nuc
Cutinase_like.pep
DLH-S.pep
DPP4N_Peptidase_S9.nuc
DPP4N_Peptidase_S9.pep
Dieckmann_Cyclase.pep
Dienelactone_hydrolase.nuc
Dienelactone_hydrolase.pep
Duf_1023.pep
Duf_1057.pep
Duf_1100-R.pep
Duf_1100-S.pep
Duf_1350.pep
Duf_1400.pep
Duf_2920.pep
Duf_3089.pep
Duf_3141.pep
Duf_3530.pep
Duf_676.pep
Duf_726.pep
Duf_818.pep
Duf_829.pep
Duf_900.pep
Duf_915.pep
Epoxide-hydrolase_like.nuc
Epoxide-hydrolase_like.pep
Epoxide_hydrolase.nuc
Epoxide_hydrolase.pep
Est-OsmC.pep
Est9X.nuc
Est9X.pep
Esterase_phb.pep
Esterase_phb_PHAZ.pep
Extracel-MCL-phaZ.pep
FAE-Bacterial-promiscuous.pep
FSH1.pep
FaeC.pep
Fungal-Bact_LIP.pep
Fungal-D14-Strigolactone-R.pep
Fungal_carboxylesterase_lipase.nuc
Fungal_carboxylesterase_lipase.pep
Fusarinine_C_esterase_sidJ.pep
GTSAGmotif.nuc
GTSAGmotif.pep
Gliotactin.nuc
Gliotactin.pep
Glucuronoyl_esterase.pep
Glutactin.nuc
Glutactin.pep
Glutamyl_Peptidase_S9.pep
HAA-synthase-thioesterase-RhlA-PhaG.nuc
HAA-synthase-thioesterase-RhlA-PhaG.pep
HNLyase_Bact.nuc
HNLyase_Bact.pep
HOD-cofactorfree-dioxygenase.nuc
HOD-cofactorfree-dioxygenase.pep
Haloacetate_dehalogenase.nuc
Haloacetate_dehalogenase.pep
Haloalkane_dehalogenase-HLD1.nuc
Haloalkane_dehalogenase-HLD1.pep
Haloalkane_dehalogenase-HLD2.nuc
Haloalkane_dehalogenase-HLD2.pep
Haloperoxidase.nuc
Haloperoxidase.pep
Hepatic_Lipase.nuc
Hepatic_Lipase.pep
Homoserine_transacetylase.pep
Homoserine_transacetylase_like_est.pep
Hormone-sensitive_lipase_like.nuc
Hormone-sensitive_lipase_like.pep
Hydrolase-1_PEP.pep
Hydrolase-2_PEP.pep
Hydrolase_4.nuc
Hydrolase_4.pep
Hydrolase_RBBP9_YdeN.pep
Hydroxynitrile_lyase.nuc
Hydroxynitrile_lyase.pep
Insect_Phospholipase.nuc
Insect_Phospholipase.pep
Insect_lipase.nuc
Insect_lipase.pep
Juvenile_hormone_esterase.nuc
Juvenile_hormone_esterase.pep
Kynurenine-formamidase.nuc
Kynurenine-formamidase.pep
LIDHydrolase.pep
LYsophospholipase_carboxylesterase.nuc
LYsophospholipase_carboxylesterase.pep
Lactobacillus_peptidase.nuc
Lactobacillus_peptidase.pep
LipSM54-like_FamXVI.pep
Lipase_2.nuc
Lipase_2.pep
Lipase_3.nuc
Lipase_3.pep
Lipase_bact_N_lipase.nuc
Lipase_bact_N_lipase.pep
Lipoprotein_Lipase.nuc
Lipoprotein_Lipase.pep
Lysin_B_C_ter.pep
MEST-like.nuc
MEST-like.pep
Maspardin-ACP33-SPG21_like.nuc
Maspardin-ACP33-SPG21_like.pep
Mbeg1-like.pep
MenH_SHCHC.nuc
MenH_SHCHC.pep
Mg-chelatase_BchO.nuc
Mg-chelatase_BchO.pep
Monoglyceridelipase_lysophospholip.nuc
Monoglyceridelipase_lysophospholip.pep
MpaH.pep
NFM-deformylase.pep
NLS3-Tex30.nuc
NLS3-Tex30.pep
Ndr_family.pep
Neuroligin.nuc
Neuroligin.pep
Neurotactin.nuc
Neurotactin.pep
Non-catalytic_C.nuc
Non-catalytic_C.pep
OHBut_olig_hydro_put.pep
OtherNon-catalytic_C.nuc
OtherNon-catalytic_C.pep
PAF-Acetylhydrolase.nuc
PAF-Acetylhydrolase.pep
PAF_acetylhydro-like.nuc
PAF_acetylhydro-like.pep
PC-sterol_acyltransferase.nuc
PC-sterol_acyltransferase.pep
PE-PPE.pep
PGAP1.pep
PHAZ7_phb_depolymerase.pep
PHA_depolymerase_arom.nuc
PHA_depolymerase_arom.pep
PHA_synth_I.pep
PHA_synth_II.pep
PHA_synth_III_C.pep
PHB_depolymerase_PhaZ.pep
PMH_Peptidase_S9.pep
PPase_methylesterase_euk.pep
Palmitoyl-protein_thioesterase.nuc
Palmitoyl-protein_thioesterase.pep
Pancreatic_lipase.nuc
Pancreatic_lipase.pep
Pectin_methylesterase.pep
Pectinacetylesterase-Notum.pep
Peptidase_S15.nuc
Peptidase_S15.pep
Peptidase_S37.pep
Peptidase_S9.nuc
Peptidase_S9.pep
PhaC_cen_dom.pep
Pheophytinase.pep
PhoPQ_related.pep
Phospholipase.nuc
Phospholipase.pep
PlaB.pep
Plant_carboxylesterase.nuc
Plant_carboxylesterase.pep
Plant_lipase_EDS1-like.nuc
Plant_lipase_EDS1-like.pep
Plant_phospholipase.nuc
Plant_phospholipase.pep
Plasmodium_subtelomeric_PST-A.pep
PolyAspartate-hydrolase.pep
Polyesterase-MGS0156-like.pep
Polyesterase-lipase-cutinase.nuc
Polyesterase-lipase-cutinase.pep
Proline_iminopeptidase.nuc
Proline_iminopeptidase.pep
Prolyl_oligopeptidase_S9.nuc
Prolyl_oligopeptidase_S9.pep
Prolylcarboxypeptidase.nuc
Prolylcarboxypeptidase.pep
RsbQ-like.nuc
RsbQ-like.pep
RutD.nuc
RutD.pep
S9N_PPCE_Peptidase_S9.nuc
S9N_PPCE_Peptidase_S9.pep
S9N_PREPL_Peptidase_S9.nuc
S9N_PREPL_Peptidase_S9.pep
SERAC1.pep
SERHL.pep
Steryl_acetyl_hydrolase.nuc
Steryl_acetyl_hydrolase.pep
Structure.pep
T6SS-TLE1.pep
T6SS-TLE3.pep
T7SS-TslA.pep
TGL-GrainShapeFactor.nuc
TGL-GrainShapeFactor.pep
TTHA1544-like.pep
Tannase.pep
Tannase_Bact.pep
Thioesterase-YsfF-HD.pep
Thioesterase.pep
Thioesterase_acyl-transferase.pep
Thiohydrolase.pep
Thyroglobulin.nuc
Thyroglobulin.pep
Tiancimycin-TnmK-Tripeptidase-HIP.pep
Triacylglycerol-lipase-OBL1-like.pep
UCP031088.pep
UCP031982.pep
UCP033634.pep
UCP037442.pep
UPF0255.pep
Valacyclovir-hydrolase.nuc
Valacyclovir-hydrolase.pep
VirJ.pep
Xaa-Pro-like_dom.pep
XcbB_CpsF_sero.pep
YcjY-like.pep
Yolk-Protein_dipter.nuc
Yolk-Protein_dipter.pep
Zearalenone-hydrolase-fam2.nuc
Zearalenone-hydrolase-fam2.pep
Zearalenone-hydrolase-fam2_Frgt.pep
Zearalenone-hydrolase.pep
Zearalenone-hydrolase_Frgt.pep
abh_upf0017.nuc
abh_upf0017.pep
abh_upf00227.pep
lpg2422.pep
yjfP_esterase-like.pep
Non-redundant Protein/Nucleotide Sequences (NR/NT)
UniProtKB/Swiss-Prot (SwissProt)
Reference Proteins Sequences (RefSeq_Protein)
Reference RNA Sequences (RefSeq_RNA)
Expressed Sequence Tags (EST)
Protein Data Bank (PDB)
Patented Protein Sequences (PAT)
Test Nucleotide Sequence
Test Protein Sequence
Test SMART v6.0 Domain Database (SMART)
Phytochemical and Drug Target Database (PDTDB)
Enter sequence below in
FASTA
format (
DEMO
)
Or load it from disk
Output:
Graphical Overview
Plain Text
Algorithm Parameters:
Default
Advanced
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
11
20
24
28
32
48
64
128
256
Match/Mismatch Scores:
Match: 1, Mismatch: -2
Match: 1, Mismatch: -3
Match: 1, Mismatch: -4
Match: 2, Mismatch: -3
Match: 4, Mismatch: -5
Match: 1, Mismatch: -1
Gap Costs:
Linear
Existence: 5, Extension: 2
Existence: 2, Extension: 2
Existence: 1, Extension: 2
Existence: 0, Extension: 2
Existence: 3, Extension: 1
Existence: 2, Extension: 1
Existence: 1, Extension: 1
Filter Low Complexity Regions
Mask for Lookup Table Only
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
6
11
20
24
28
32
48
64
128
256
Matrix:
PAM30
PAM70
PAM250
BLOSUM80
BLOSUM62
BLOSUM45
BLOSUM50
BLOSUM90
Gap Costs:
Existence: 11, Extension: 2
Existence: 10, Extension: 2
Existence: 9, Extension: 2
Existence: 8, Extension: 2
Existence: 7, Extension: 2
Existence: 6, Extension: 2
Existence: 13, Extension: 1
Existence: 12, Extension: 1
Existence: 11, Extension: 1
Existence: 10, Extension: 1
Existence: 9, Extension: 1
Filter Low Complexity Regions
Mask for Lookup Table Only
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
6
11
20
24
28
32
48
64
128
256
Matrix:
PAM30
PAM70
PAM250
BLOSUM80
BLOSUM62
BLOSUM45
BLOSUM50
BLOSUM90
Gap Costs:
Existence: 11, Extension: 2
Existence: 10, Extension: 2
Existence: 9, Extension: 2
Existence: 8, Extension: 2
Existence: 7, Extension: 2
Existence: 6, Extension: 2
Existence: 13, Extension: 1
Existence: 12, Extension: 1
Existence: 11, Extension: 1
Existence: 10, Extension: 1
Existence: 9, Extension: 1
Filter Low Complexity Regions
Mask for Lookup Table Only
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
6
11
20
24
28
32
48
64
128
256
Matrix:
PAM30
PAM70
PAM250
BLOSUM80
BLOSUM62
BLOSUM45
BLOSUM50
BLOSUM90
Gap Costs:
Existence: 11, Extension: 2
Existence: 10, Extension: 2
Existence: 9, Extension: 2
Existence: 8, Extension: 2
Existence: 7, Extension: 2
Existence: 6, Extension: 2
Existence: 13, Extension: 1
Existence: 12, Extension: 1
Existence: 11, Extension: 1
Existence: 10, Extension: 1
Existence: 9, Extension: 1
Filter Low Complexity Regions
Mask for Lookup Table Only
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
2
3
Matrix:
PAM30
PAM70
PAM250
BLOSUM80
BLOSUM62
BLOSUM45
BLOSUM50
BLOSUM90
Strand:
Both
Plus
Minus
Mask for Lookup Table Only
Mask Lower Case Letters
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
2
3
Matrix:
PAM30
PAM70
PAM250
BLOSUM80
BLOSUM62
BLOSUM45
BLOSUM50
BLOSUM90
Gap Costs:
Existence: 11, Extension: 2
Existence: 10, Extension: 2
Existence: 9, Extension: 2
Existence: 8, Extension: 2
Existence: 7, Extension: 2
Existence: 6, Extension: 2
Existence: 13, Extension: 1
Existence: 12, Extension: 1
Existence: 11, Extension: 1
Existence: 10, Extension: 1
Existence: 9, Extension: 1
DELTA-BLAST Threshold:
Pseudocount:
Maximum Target Sequences:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Word Size:
2
3
Matrix:
PAM30
PAM70
PAM250
BLOSUM80
BLOSUM62
BLOSUM45
BLOSUM50
BLOSUM90
Gap Costs:
Existence: 11, Extension: 2
Existence: 10, Extension: 2
Existence: 9, Extension: 2
Existence: 8, Extension: 2
Existence: 7, Extension: 2
Existence: 6, Extension: 2
Existence: 13, Extension: 1
Existence: 12, Extension: 1
Existence: 11, Extension: 1
Existence: 10, Extension: 1
Existence: 9, Extension: 1
PSI-BLAST Threshold:
Pseudocount:
Maximum Target Sequences:
0
10
50
100
250
500
Maximum Descriptions:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Filter Low Complexity Regions
Mask for Lookup Table Only
Mask Lower Case Letters
Maximum Target Sequences:
0
10
50
100
250
500
Maximum Descriptions:
0
10
50
100
250
500
Expect Threshold:
0.0001
0.01
1.0
10.0
100.0
1000.0
Strand:
Both
Plus
Minus
Filter Low Complexity Regions
Mask for Lookup Table Only
Mask Lower Case Letters