| Title : The effect of cycloheximide on butyrylcholinesterase activity in vivo - Lucic_2002_Arh.Hig.Rada.Toksikol_53_185 |
| Author(s) : Lucic A , Bradamante V , Radic B , Peraica M , Domijan AM , Fuchs R |
| Ref : Arh Hig Rada Toksikol , 53 :185 , 2002 |
| Abstract : The paper describes the catalytic activity of butyrylcholinesterase (BCHE) measured in plasma, liver, white adipose tissue, heart, and brain of rats intraperitoneally administered a single non-lethal dose of cycloheximide (2.0 mg/kg body weight; CHM). The BCHE assay was performed on rats of both sexes either administered CHM or saline (controls), and killed 2, 3, 4, 5, 10 days later. A significant decrease of BCHE catalytic activity was observed in all tested tissues except plasma. In animals of both sexes, the lowest BCHE catalytic activity was found in the liver (2-6%), while it was higher in white adipose tissue, heart, and brain. However, the respective values remained significantly different from controls (33-67%, 49-62%, and 14-71% in males, and 24-82%, 72-86%, and 33-67% in females). Since there was no effect of CHM on BCHE catalytic activity in plasma, the data suggest that CHM inhibits the synthesis of BCHE rather than its active site. |
| ESTHER : Lucic_2002_Arh.Hig.Rada.Toksikol_53_185 |
| PubMedSearch : Lucic_2002_Arh.Hig.Rada.Toksikol_53_185 |
| PubMedID: 12557470 |
Lucic A, Bradamante V, Radic B, Peraica M, Domijan AM, Fuchs R (2002)
The effect of cycloheximide on butyrylcholinesterase activity in vivo
Arh Hig Rada Toksikol
53 :185
Lucic A, Bradamante V, Radic B, Peraica M, Domijan AM, Fuchs R (2002)
Arh Hig Rada Toksikol
53 :185