| Title : cis-Prenyltransferase 3 and alpha\/beta-hydrolase are new determinants of dolichol accumulation in Arabidopsis - Gawarecka_2021_Plant.Cell.Environ__ |
| Author(s) : Gawarecka K , Siwinska J , Poznanski J , Onysk A , Surowiecki P , Sztompka K , Surmacz L , Ahn JH , Korte A , Swiezewska E , Ihnatowicz A |
| Ref : Plant Cell Environ , : , 2021 |
| Abstract : Dolichols (Dols), ubiquitous components of living organisms, are indispensable for cell survival. In plants, as well as other eukaryotes, Dols are crucial for posttranslational protein glycosylation, aberration of which leads to fatal metabolic disorders in humans and male sterility in plants. Until now, the mechanisms underlying Dol accumulation remain elusive. In this report, we have analyzed the natural variation of the accumulation of Dols and six other isoprenoids among more than 120 Arabidopsis thaliana accessions. Subsequently, by combining QTL and GWAS approaches, we have identified several candidate genes involved in the accumulation of Dols, polyprenols, plastoquinone, and phytosterols. The role of two genes implicated in the accumulation of major Dols in Arabidopsis - the AT2G17570 gene encoding a long searched for cis-prenyltransferase (CPT3) and the AT1G52460 gene encoding an alpha/beta-hydrolase (ABH) - is experimentally confirmed. These data will help to generate Dol-enriched plants which might serve as a remedy for Dol-deficiency in humans. This article is protected by copyright. All rights reserved. |
| ESTHER : Gawarecka_2021_Plant.Cell.Environ__ |
| PubMedSearch : Gawarecka_2021_Plant.Cell.Environ__ |
| PubMedID: 34778961 |
| Gene_locus related to this paper: arath-F6D8.32 |
| Gene_locus related to this paper: arath-F6D8.32 |
Gawarecka K, Siwinska J, Poznanski J, Onysk A, Surowiecki P, Sztompka K, Surmacz L, Ahn JH, Korte A, Swiezewska E, Ihnatowicz A (2021)
cis-Prenyltransferase 3 and alpha\/beta-hydrolase are new determinants of dolichol accumulation in Arabidopsis
Plant Cell Environ
:
Gawarecka K, Siwinska J, Poznanski J, Onysk A, Surowiecki P, Sztompka K, Surmacz L, Ahn JH, Korte A, Swiezewska E, Ihnatowicz A (2021)
Plant Cell Environ
: