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IAEDANS

A mutant of the thermophilic esterase 2 from A. acidocaldarious where the serine 35, a residue located at the entrance of the alcohol binding site, has been replaced by a cysteine residue. The addition of 1,5-IAEDANS as a fluorescent probe to the thiol group of the mutant-protein. Inhibition by organophosphate results in fluorescence quenching of the probe-enzyme complex

General

Type : Fluorescent probe

Chemical_Nomenclature : 5-[2-[(2-iodoacetyl)amino]ethylamino]naphthalene-1-sulfonic acid

Canonical SMILES : C1=CC2=C(C=CC=C2S(=O)(=O)O)C(=C1)NCCNC(=O)CI

InChI : InChI=1S\/C14H15IN2O4S\/c15-9-14(18)17-8-7-16-12-5-1-4-11-10(12)3-2-6-13(11)22(19,20)21\/h1-6,16H,7-9H2,(H,17,18)(H,19,20,21)

InChIKey : ZMERMCRYYFRELX-UHFFFAOYSA-N

Other name(s) : 1,5-I-Aedans || IAEDANS || 5-[2-(Iodoacetamido)ethylamino]naphthalene-1-sulfonic acid || UNII-6V7G304M5M

MW : 434.25

Formula : C14H15IN2O4S

CAS_number : 36930-63-9

PubChem : 91621

UniChem : ZMERMCRYYFRELX-UHFFFAOYSA-N

Target

Families : No family

Protein : aliac-est2

References (1)

Title : Direct detection of organophosphate compounds in water by a fluorescence-based biosensing device - Carullo_2018_Sens.Actuators.B.Chem_255_3257
Author(s) : Carullo P , Chino M , Cetrangolo GP , Terreri S , Lombardi A , Manco G , Cimmino A , Febbraio F
Ref : Sensors and Actuators B: Chemical , 255 :3257 , 2018
Abstract : Carullo_2018_Sens.Actuators.B.Chem_255_3257
ESTHER : Carullo_2018_Sens.Actuators.B.Chem_255_3257
PubMedSearch : Carullo_2018_Sens.Actuators.B.Chem_255_3257
PubMedID:
Gene_locus related to this paper: aliac-est2