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P-nitrophenol

product of hydrolysis of pNP-esters || Leaving group of paraoxon when inhibiting enzymes. Product of hydrolysis of Esters of 4-Nitrophenol. Amounts of 4-nitrophenol produced by a particular enzyme in the presence of its corresponding substrate can be measured with a spectrophotometer at or around 405 nm and used as a proxy measurement for the amount of the enzyme activity in the sample. Leaving group of NEMP, Methylparaoxon, VXS

General

Type : pNP, Chromogen

Chemical_Nomenclature : 4-nitrophenol

Canonical SMILES : C1=CC(=CC=C1[N+](=O)[O-])O

InChI : InChI=1S\/C6H5NO3\/c8-6-3-1-5(2-4-6)7(9)10\/h1-4,8H

InChIKey : BTJIUGUIPKRLHP-UHFFFAOYSA-N

Other name(s) : pNP  ||  NPO  ||  4-Nitrophenol  ||  P-nitrophenol  ||  Phenol, 4-nitro-  ||  Niphen  ||  Paranitrophenol

MW : 139.11

Formula : C6H5NO3

CAS_number : 100-02-7

PubChem : 980

UniChem : BTJIUGUIPKRLHP-UHFFFAOYSA-N

Target

Families : Polyesterase-lipase-cutinase, Hormone-sensitive_lipase_like

Protein : idesa-peth, 9bact-H6BDX1, 9delt-EstD11

References (2)

Title : Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family - Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214
Author(s) : Miguel-Ruano V , Rivera I , Rajkovic J , Knapik K , Torrado A , Otero JM , Beneventi E , Becerra M , Sanchez-Costa M , Hidalgo A , Berenguer J , Gonzalez-Siso MI , Cruces J , Rua ML , Hermoso JA
Ref : Comput Struct Biotechnol J , 19 :1214 , 2021
Abstract :
PubMedSearch : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214
PubMedID: 33680362
Gene_locus related to this paper: 9delt-EstD11

Title : Structural insights of a hormone sensitive lipase homologue Est22 - Huang_2016_Sci.Rep_6_28550
Author(s) : Huang J , Huo YY , Ji R , Kuang S , Ji C , Xu XW , Li J
Ref : Sci Rep , 6 :28550 , 2016
Abstract :
PubMedSearch : Huang_2016_Sci.Rep_6_28550
PubMedID: 27328716
Gene_locus related to this paper: 9bact-H6BDX1