Gene Locus : lepde-ACHE
Mode of mutation : Natural mutant
Disease :
Summary : OP-resistance Natural mutation Resistance to N-methyl carbofuran susceptible to azinphosmethyl Zhu_1996_Pestic.Biochem.Physiol_55_100
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 337
Kinetic Parameter : No kinetic parameter
News : JULY-05-2006
Comment :
The genbank entry correspond to the mutated enzyme. The BERTS strain of colorado potato beetle is highly resistant to N-methyl carbofuran but relatively susceptible to azinphosmethyl. The derived BERTS-R and BERTS-S substrains differ only by I392T present only in BERTS-S strain. This mutation reverses the resistance properties of S291G || p.Ile392Thr
| Title : Functional analysis of mutations in expressed acetylcholinesterasenext term that result in azinphosmethyl and carbofuran resistance in Colorado potato beetle - Kim_2007_Pestic.Biochem.Physiol_88_181 |
| Author(s) : Kim HJ , Yoon KS , Clark JM |
| Ref : Pesticide Biochemistry and Physiology , 88 :181 , 2007 |
| Abstract : |
| PubMedSearch : Kim_2007_Pestic.Biochem.Physiol_88_181 |
| PubMedID: |
| Gene_locus related to this paper: lepde-ACHE |
| Title : Target site insensitivity and mutational analysis of acetylcholinesterase from a carbofuran-resistant population of Colorado potato beetle, Leptinotarsa decemlineata (Say) - Kim_2006_Pestic.Biochem.Physiol_84_165 |
| Author(s) : Kim HJ , Dunnb JB , Yoon KS , Clark JM |
| Ref : Pesticide Biochemistry and Physiology , 84 :165 , 2006 |
| Abstract : |
| PubMedSearch : Kim_2006_Pestic.Biochem.Physiol_84_165 |
| PubMedID: |
| Gene_locus related to this paper: lepde-ACHE |
| Title : Validation of a Point Mutation of Acetylcholinesterase in Colorado Potato Beetle by Polymerase Chain Reaction Coupled to Enzyme Inhibition Assay - Zhu_1997_Pestic.Biochem.Physiol_57_28 |
| Author(s) : Zhu KY , Clark JM |
| Ref : Pesticide Biochemistry and Physiology , 57 :28 , 1997 |
| Abstract : |
| PubMedSearch : Zhu_1997_Pestic.Biochem.Physiol_57_28 |
| PubMedID: |
| Gene_locus related to this paper: lepde-ACHE |
| Title : A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitness in Colorado Potato Beetle - Zhu_1996_Pestic.Biochem.Physiol_55_100 |
| Author(s) : Zhu KY , Lee SH , Clark JM |
| Ref : Pestic Biochem Physiol , 55 :100 , 1996 |
| Abstract : |
| PubMedSearch : Zhu_1996_Pestic.Biochem.Physiol_55_100 |
| PubMedID: 8980034 |
| Gene_locus related to this paper: lepde-ACHE |