I392T_lepde-ACHE

General

Gene Locus : lepde-ACHE

Mode of mutation : Natural mutant

Disease :

Summary : OP-resistance Natural mutation Resistance to N-methyl carbofuran susceptible to azinphosmethyl Zhu_1996_Pestic.Biochem.Physiol_55_100

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 337

Kinetic Parameter : No kinetic parameter

News : JULY-05-2006

Comment :
The genbank entry correspond to the mutated enzyme. The BERTS strain of colorado potato beetle is highly resistant to N-methyl carbofuran but relatively susceptible to azinphosmethyl. The derived BERTS-R and BERTS-S substrains differ only by I392T present only in BERTS-S strain. This mutation reverses the resistance properties of S291G || p.Ile392Thr

References (4)

Title : Functional analysis of mutations in expressed acetylcholinesterasenext term that result in azinphosmethyl and carbofuran resistance in Colorado potato beetle - Kim_2007_Pestic.Biochem.Physiol_88_181
Author(s) : Kim HJ , Yoon KS , Clark JM
Ref : Pesticide Biochemistry and Physiology , 88 :181 , 2007
Abstract :
PubMedSearch : Kim_2007_Pestic.Biochem.Physiol_88_181
PubMedID:
Gene_locus related to this paper: lepde-ACHE

Title : Target site insensitivity and mutational analysis of acetylcholinesterase from a carbofuran-resistant population of Colorado potato beetle, Leptinotarsa decemlineata (Say) - Kim_2006_Pestic.Biochem.Physiol_84_165
Author(s) : Kim HJ , Dunnb JB , Yoon KS , Clark JM
Ref : Pesticide Biochemistry and Physiology , 84 :165 , 2006
Abstract :
PubMedSearch : Kim_2006_Pestic.Biochem.Physiol_84_165
PubMedID:
Gene_locus related to this paper: lepde-ACHE

Title : Validation of a Point Mutation of Acetylcholinesterase in Colorado Potato Beetle by Polymerase Chain Reaction Coupled to Enzyme Inhibition Assay - Zhu_1997_Pestic.Biochem.Physiol_57_28
Author(s) : Zhu KY , Clark JM
Ref : Pesticide Biochemistry and Physiology , 57 :28 , 1997
Abstract :
PubMedSearch : Zhu_1997_Pestic.Biochem.Physiol_57_28
PubMedID:
Gene_locus related to this paper: lepde-ACHE

Title : A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitness in Colorado Potato Beetle - Zhu_1996_Pestic.Biochem.Physiol_55_100
Author(s) : Zhu KY , Lee SH , Clark JM
Ref : Pestic Biochem Physiol , 55 :100 , 1996
Abstract :
PubMedSearch : Zhu_1996_Pestic.Biochem.Physiol_55_100
PubMedID: 8980034
Gene_locus related to this paper: lepde-ACHE