R197L_human-LPL

General

Gene Locus : human-LPL, human-LPL, human-LPL

Mode of mutation : Natural mutant

Disease : Hyperlipoproteinemia TypeI

Summary :

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification :

Torpedo_number : No torpedo number

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.R197L Arg197Leu c.590G>L in homozygous patient but also as simple heterozygotes with mutation in GPIHBP1 C14F or in APO5 S19W

References (6)

Title : Lipoprotein lipase deficiency: heterozygotes match homozygotes in severity - Szczesniak_2025_Arch.Med.Sci_21_750
Author(s) : Szczesniak D , Bednarska-Makaruk M , Drgas O , Kowalczyk K , Kacprzak MM , Aleksandrowicz P , Kotula L , Mroczek M
Ref : Arch Med Sci , 21 :750 , 2025
Abstract :
PubMedSearch : Szczesniak_2025_Arch.Med.Sci_21_750
PubMedID: 40741268
Gene_locus related to this paper: human-LPL

Title : Lipoprotein lipase deficiency: heterozygotes match homozygotes in severity - Szczesniak_2025_Arch.Med.Sci_21_750
Author(s) : Szczesniak D , Bednarska-Makaruk M , Drgas O , Kowalczyk K , Kacprzak MM , Aleksandrowicz P , Kotula L , Mroczek M
Ref : Arch Med Sci , 21 :750 , 2025
Abstract :
PubMedSearch : Szczesniak_2025_Arch.Med.Sci_21_750
PubMedID: 40741268
Gene_locus related to this paper: human-LPL

Title : Lipoprotein lipase deficiency: heterozygotes match homozygotes in severity - Szczesniak_2025_Arch.Med.Sci_21_750
Author(s) : Szczesniak D , Bednarska-Makaruk M , Drgas O , Kowalczyk K , Kacprzak MM , Aleksandrowicz P , Kotula L , Mroczek M
Ref : Arch Med Sci , 21 :750 , 2025
Abstract :
PubMedSearch : Szczesniak_2025_Arch.Med.Sci_21_750
PubMedID: 40741268
Gene_locus related to this paper: human-LPL

Title : Spectrum of mutations of the LPL gene identified in Italy in patients with severe hypertriglyceridemia - Rabacchi_2015_Atherosclerosis_241_79
Author(s) : Rabacchi C , Pisciotta L , Cefalu AB , Noto D , Fresa R , Tarugi P , Averna M , Bertolini S , Calandra S
Ref : Atherosclerosis , 241 :79 , 2015
Abstract :
PubMedSearch : Rabacchi_2015_Atherosclerosis_241_79
PubMedID: 25966443
Gene_locus related to this paper: human-LPL

Title : Spectrum of mutations of the LPL gene identified in Italy in patients with severe hypertriglyceridemia - Rabacchi_2015_Atherosclerosis_241_79
Author(s) : Rabacchi C , Pisciotta L , Cefalu AB , Noto D , Fresa R , Tarugi P , Averna M , Bertolini S , Calandra S
Ref : Atherosclerosis , 241 :79 , 2015
Abstract :
PubMedSearch : Rabacchi_2015_Atherosclerosis_241_79
PubMedID: 25966443
Gene_locus related to this paper: human-LPL

Title : Spectrum of mutations of the LPL gene identified in Italy in patients with severe hypertriglyceridemia - Rabacchi_2015_Atherosclerosis_241_79
Author(s) : Rabacchi C , Pisciotta L , Cefalu AB , Noto D , Fresa R , Tarugi P , Averna M , Bertolini S , Calandra S
Ref : Atherosclerosis , 241 :79 , 2015
Abstract :
PubMedSearch : Rabacchi_2015_Atherosclerosis_241_79
PubMedID: 25966443
Gene_locus related to this paper: human-LPL