V581L_drome-glita

General

Gene Locus : drome-glita

Mode of mutation : Natural mutant

Disease :

Summary :

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification :

Torpedo_number : 423

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
Convergent amino acid substitution that has independently evolved in cardiac glycosides-adapted insects in Gliotactin (Gli) gene involved in the septate junction. Modulating epithelial permeability, potentially facilitating the sequestration of toxic CGs

References (1)

Title : Genomic basis of adaptation to cardiac glycosides in three insect orders - Zhu_2026_Front.Genet_17_1808090
Author(s) : Zhu K , Zhu C , Zhen Y
Ref : Front Genet , 17 :1808090 , 2026
Abstract :
PubMedSearch : Zhu_2026_Front.Genet_17_1808090
PubMedID: 42095022
Gene_locus related to this paper: drome-glita