N-(3-Carboxy-4-nitrophenyl)phthalamidic-acid
Chromogenic substrate to analyze . o-phthalyl amidase. Phthalimido is a stable protecting group in beta-lactam chemistry but no conventional chemical methods effectively removes this group. xanag-pham catalyzes the removal of the phthalyl group from phthalyl amides generating phthalate and an amine. The enzyme has a broad substrate specificity and hydrolyzes phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines
General
Chemical_Nomenclature : 5-[(2-carboxybenzoyl)amino]-2-nitrobenzoic acid
Canonical SMILES : C1=CC=C(C(=C1)C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O)C(=O)O
InChI : InChI=1S\/C15H10N2O7\/c18-13(9-3-1-2-4-10(9)14(19)20)16-8-5-6-12(17(23)24)11(7-8)15(21)22\/h1-7H,(H,16,18)(H,19,20)(H,21,22)
InChIKey : ZQXCSGXRVQMUMI-UHFFFAOYSA-N
Other name(s) : N-(3-Carboxy-4-nitrophenyl)phthalamidic acid
MW : 330.25
Formula : C15H10N2O7
CAS_number :
PubChem : 102001082
UniChem : ZQXCSGXRVQMUMI-UHFFFAOYSA-N
phthalamidic-acid.gif)
Target
Structures : No structure
Families : 6_AlphaBeta_hydrolase
References (2)
| Title : Discovery, purification, and properties of o-phthalyl amidase from Xanthobacter agilis - Briggs_1996_J.Mol.Catal.B.Enzym_2_53 |
| Author(s) : Briggs BS , Kreuzman AJ , Whitesitt C , Yeh WK , Zmijewski M |
| Ref : J Mol Catal B Enzym , 2 :53 , 1996 |
| Abstract : |
| PubMedSearch : Briggs_1996_J.Mol.Catal.B.Enzym_2_53 |
| PubMedID: |
| Gene_locus related to this paper: xanag-pham |
| Title : o-Phthalyl amidase in the synthesis of loracarbef: Process development using this novel biocatalyst - Black_1996_Biotechnol.Lett_18_875 |
| Author(s) : Black TD , Briggs BS , Evans R , Muth WL , Vangala S , Zmijewski M |
| Ref : Biotechnol Lett , 18 :875 , 1996 |
| Abstract : |
| PubMedSearch : Black_1996_Biotechnol.Lett_18_875 |
| PubMedID: |
| Gene_locus related to this paper: xanag-pham |