longtext: 1ETH-pdb

content
HEADER    COMPLEX (HYDROLASE/COFACTOR)            13-SEP-95   1ETH
TITLE     TRIACYLGLYCEROL LIPASE/COLIPASE COMPLEX
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: TRIACYLGLYCEROL ACYL-HYDROLASE;
COMPND   3 CHAIN: A, C;
COMPND   4 SYNONYM: TRIACYLGLYCEROL LIPASE;
COMPND   5 EC: 3.1.1.3;
COMPND   6 MOL_ID: 2;
COMPND   7 MOLECULE: COLIPASE;
COMPND   8 CHAIN: B, D
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SUS SCROFA;
SOURCE   3 ORGANISM_COMMON: PIG;
SOURCE   4 ORGAN: PANCREAS;
SOURCE   5 MOL_ID: 2;
SOURCE   6 ORGANISM_SCIENTIFIC: SUS SCROFA;
SOURCE   7 ORGANISM_COMMON: PIG
KEYWDS    COMPLEX (HYDROLASE/COFACTOR), LIPID DEGRADATION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.HERMOSO,D.PIGNOL,B.KERFELEC,I.CRENON,C.CHAPUS,
AUTHOR   2 J.C.FONTECILLA-CAMPS
REVDAT   1   07-DEC-96 1ETH    0
JRNL        AUTH   J.HERMOSO,D.PIGNOL,B.KERFELEC,I.CRENON,C.CHAPUS,
JRNL        AUTH 2 J.C.FONTECILLA-CAMPS
JRNL        TITL   LIPASE ACTIVATION BY NON-IONIC DETERGENTS. THE
JRNL        TITL 2 CRYSTAL STRUCTURE OF THE PORCINE
JRNL        TITL 3 LIPASE-COLIPASE-TETRAETHYLENE GLYCOL MONOOCTYL
JRNL        TITL 4 ETHER COMPLEX
JRNL        REF    J.BIOL.CHEM.                  V. 271 18007 1996
JRNL        REFN   ASTM JBCHA3  US ISSN 0021-9258                 0071
REMARK   1
REMARK   1 REFERENCE 1
REMARK   1  AUTH   H.VAN TILBEURGH,M.P.EGLOFF,C.MARTINEZ,N.RUGANI,
REMARK   1  AUTH 2 R.VERGER,C.CAMBILLAU
REMARK   1  TITL   INTERFACIAL ACTIVATION OF THE LIPASE-PROCOLIPASE
REMARK   1  TITL 2 COMPLEX BY MIXED MICELLES REVEALED BY X-RAY
REMARK   1  TITL 3 CRYSTALLOGRAPHY
REMARK   1  REF    NATURE                        V. 362   814 1993
REMARK   1  REFN   ASTM NATUAS  UK ISSN 0028-0836                 0006
REMARK   1 REFERENCE 2
REMARK   1  AUTH   H.VAN TILBEURGH,L.SARDA,R.VERGER,C.CAMBILLAU
REMARK   1  TITL   STRUCTURE OF THE PANCREATIC LIPASE-PROCOLIPASE
REMARK   1  TITL 2 COMPLEX
REMARK   1  REF    NATURE                        V. 359   159 1992
REMARK   1  REFN   ASTM NATUAS  UK ISSN 0028-0836                 0006
REMARK   2
REMARK   2 RESOLUTION. 2.8  ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : X-PLOR 3.1
REMARK   3   AUTHORS     : BRUNGER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.8
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 6.
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 2.
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 76.
REMARK   3   NUMBER OF REFLECTIONS             : 33758
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : NULL
REMARK   3   FREE R VALUE TEST SET SELECTION  : NULL
REMARK   3   R VALUE            (WORKING SET) : 0.21
REMARK   3   FREE R VALUE                     : 0.29
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 7.
REMARK   3   FREE R VALUE TEST SET COUNT      : NULL
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL
REMARK   3   BIN R VALUE           (WORKING SET) : NULL
REMARK   3   BIN FREE R VALUE                    : NULL
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 8340
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 272
REMARK   3   SOLVENT ATOMS            : 357
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 19.73
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL
REMARK   3   ESD FROM SIGMAA              (A) : NULL
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.011
REMARK   3   BOND ANGLES            (DEGREES) : 1.44
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 27.26
REMARK   3   IMPROPER ANGLES        (DEGREES) : 2.57
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : NULL
REMARK   3  PARAMETER FILE  2  : NULL
REMARK   3  TOPOLOGY FILE  1   : NULL
REMARK   3  TOPOLOGY FILE  2   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS:
REMARK   3  DESCRIPTION OF MODIFICATION: THE AUTHORS HAVE A PROBLEM
REMARK   3  WITH X-PLOR WHEN PRO 4 IS THE FIRST RESIDUE IN THE
REMARK   3  COLIPASE CHAIN.  THEY HAVE OVERCOME THE DIFFICULTY BY
REMARK   3  GIVING THE ADJACENT RESIDUE ASP 3 AN OCCUPANCY OF ZERO.
REMARK   3  THE COORDINATE FILE FOR RUNNING X-PLOR PROGRAM IS
REMARK   3  LIPCOL_XPLOR.PDB.
REMARK   4
REMARK   4 1ETH COMPLIES WITH FORMAT V. 2.1, 25-OCT-1996
REMARK   6
REMARK   6 CRYST1
REMARK   6   UNUSUAL UNIT-CELL DATA: PSEUDOSYMMETRY P 23
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 08-12-1994
REMARK 200  TEMPERATURE           (KELVIN) : NULL
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : NULL
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : LURE
REMARK 200  BEAMLINE                       : W32
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.90
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : NULL
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : NULL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 42501
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.80
REMARK 200  RESOLUTION RANGE LOW       (A) : 12.4
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 86.
REMARK 200  DATA REDUNDANCY                : 4.
REMARK 200  R MERGE                    (I) : 0.13
REMARK 200  R SYM                      (I) : NULL
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL
REMARK 200
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 61.
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: NULL
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: F 2 3
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -X,Y,-Z
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   Z,X,Y
REMARK 290       6555   Z,-X,-Y
REMARK 290       7555   -Z,-X,Y
REMARK 290       8555   -Z,X,-Y
REMARK 290       9555   Y,Z,X
REMARK 290      10555   -Y,Z,-X
REMARK 290      11555   Y,-Z,-X
REMARK 290      12555   -Y,-Z,X
REMARK 290      13555   X,1/2+Y,1/2+Z
REMARK 290      14555   -X,1/2-Y,1/2+Z
REMARK 290      15555   -X,1/2+Y,1/2-Z
REMARK 290      16555   X,1/2-Y,1/2-Z
REMARK 290      17555   Z,1/2+X,1/2+Y
REMARK 290      18555   Z,1/2-X,1/2-Y
REMARK 290      19555   -Z,1/2-X,1/2+Y
REMARK 290      20555   -Z,1/2+X,1/2-Y
REMARK 290      21555   Y,1/2+Z,1/2+X
REMARK 290      22555   -Y,1/2+Z,1/2-X
REMARK 290      23555   Y,1/2-Z,1/2-X
REMARK 290      24555   -Y,1/2-Z,1/2+X
REMARK 290      25555   1/2+X,Y,1/2+Z
REMARK 290      26555   1/2-X,-Y,1/2+Z
REMARK 290      27555   1/2-X,Y,1/2-Z
REMARK 290      28555   1/2+X,-Y,1/2-Z
REMARK 290      29555   1/2+Z,X,1/2+Y
REMARK 290      30555   1/2+Z,-X,1/2-Y
REMARK 290      31555   1/2-Z,-X,1/2+Y
REMARK 290      32555   1/2-Z,X,1/2-Y
REMARK 290      33555   1/2+Y,Z,1/2+X
REMARK 290      34555   1/2-Y,Z,1/2-X
REMARK 290      35555   1/2+Y,-Z,1/2-X
REMARK 290      36555   1/2-Y,-Z,1/2+X
REMARK 290      37555   1/2+X,1/2+Y,Z
REMARK 290      38555   1/2-X,1/2-Y,Z
REMARK 290      39555   1/2-X,1/2+Y,-Z
REMARK 290      40555   1/2+X,1/2-Y,-Z
REMARK 290      41555   1/2+Z,1/2+X,Y
REMARK 290      42555   1/2+Z,1/2-X,-Y
REMARK 290      43555   1/2-Z,1/2-X,Y
REMARK 290      44555   1/2-Z,1/2+X,-Y
REMARK 290      45555   1/2+Y,1/2+Z,X
REMARK 290      46555   1/2-Y,1/2+Z,-X
REMARK 290      47555   1/2+Y,1/2-Z,-X
REMARK 290      48555   1/2-Y,1/2-Z,X
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1   6  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2   6 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2   7 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2   8  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1   9  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   9  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3   9  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  10  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  10  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3  10 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  11  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2  11  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  11 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  12  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  12  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  12  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  13  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2  13  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY3  13  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY1  14 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2  14  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY3  14  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY1  15 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2  15  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY3  15  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY1  16  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2  16  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY3  16  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY1  17  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2  17  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  17  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY1  18  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2  18 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  18  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY1  19  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2  19 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  19  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY1  20  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2  20  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  20  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY1  21  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2  21  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY3  21  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  22  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  22  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY3  22 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  23  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2  23  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY3  23 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  24  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  24  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY3  24  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  25  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  25  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3  25  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY1  26 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  26  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3  26  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY1  27 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  27  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3  27  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY1  28  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  28  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3  28  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY1  29  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY2  29  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3  29  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY1  30  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY2  30 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3  30  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY1  31  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY2  31 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3  31  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY1  32  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY2  32  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3  32  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY1  33  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY2  33  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3  33  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  34  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY2  34  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3  34 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  35  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY2  35  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  35 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  36  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY2  36  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  36  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY1  37  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  37  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY3  37  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1  38 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  38  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY3  38  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1  39 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  39  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY3  39  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1  40  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY2  40  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY3  40  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1  41  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY2  41  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  41  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1  42  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY2  42 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  42  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1  43  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY2  43 -1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  43  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1  44  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY2  44  1.000000  0.000000  0.000000      144.55045
REMARK 290   SMTRY3  44  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1  45  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY2  45  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY3  45  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  46  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY2  46  0.000000  0.000000  1.000000      144.55045
REMARK 290   SMTRY3  46 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  47  0.000000  1.000000  0.000000      144.55045
REMARK 290   SMTRY2  47  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY3  47 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  48  0.000000 -1.000000  0.000000      144.55045
REMARK 290   SMTRY2  48  0.000000  0.000000 -1.000000      144.55045
REMARK 290   SMTRY3  48  1.000000  0.000000  0.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 ALA A  208    PRO A  209          0       245.70
REMARK 500 ALA A  333    SER A  334          0       232.31
REMARK 500 SER A  334    ASN A  335          0       125.45
REMARK 500 ASN A  405    VAL A  406          0       147.07
REMARK 500 ALA C  208    PRO C  209          0       246.00
REMARK 500 ALA C  333    SER C  334          0       232.99
REMARK 500 SER C  334    ASN C  335          0       127.23
REMARK 500 ASN C  405    VAL C  406          0       146.42
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  SOME OF THESE MAY BE ATOMS
REMARK 500 LOCATED ON SPECIAL POSITIONS IN THE CELL.
REMARK 500
REMARK 500 DISTANCE CUTOFF: 2.2 ANGSTROMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500  2H    HOH D   310     HE   ARG A   413    18555     1.74
REMARK 500   HE   ARG A   413    2H    HOH D   310    48555     1.74
REMARK 500  2H    HOH D   310    2HH1  ARG A   438    18555     1.77
REMARK 500  2HH1  ARG A   438    2H    HOH D   310    48555     1.77
REMARK 500  1H    HOH D   310    1HH2  ARG A   413    18555     1.86
REMARK 500  1HH2  ARG A   413    1H    HOH D   310    48555     1.86
REMARK 500  1H    HOH D   216     CG2  VAL D    76    19655     1.95
REMARK 500   CG2  VAL D    76    1H    HOH D   216    46546     1.95
REMARK 500  2H    HOH D    28    3H    SER A     1    21545     2.00
REMARK 500  3H    SER A     1    2H    HOH D    28    29455     2.00
REMARK 500   H    CYS C     4     O    GLN A   434    18555     2.01
REMARK 500   O    GLN A   434     H    CYS C     4    48555     2.01
REMARK 500   H    THR C   116     OD2  ASP D    72    19655     2.02
REMARK 500   OD2  ASP D    72     H    THR C   116    46546     2.02
REMARK 500  2HH1  ARG A   438    1H    HOH D   310    48555     2.05
REMARK 500  1H    HOH D   310    2HH1  ARG A   438    18555     2.05
REMARK 500   OD2  ASP B    72     H    THR A   116    23555     2.06
REMARK 500   H    THR A   116     OD2  ASP B    72    32555     2.06
REMARK 500   O    ASN B    81    1H    HOH D   251    23555     2.08
REMARK 500   O    HOH D    28    3H    SER A     1    21545     2.08
REMARK 500  1H    HOH D   251     O    ASN B    81    32555     2.08
REMARK 500  3H    SER A     1     O    HOH D    28    29455     2.08
REMARK 500   H    CYS A     4     O    GLN C   434    29455     2.14
REMARK 500   O    GLN C   434     H    CYS A     4    21545     2.14
REMARK 500  2H    HOH D   251     CE1  TYR B    59    32555     2.16
REMARK 500   CE1  TYR B    59    2H    HOH D   251    23555     2.16
REMARK 850
REMARK 850 CORRECTION BEFORE RELEASE
REMARK 850 ORIGINAL DEPOSITION REVISED PRIOR TO RELEASE
REMARK 850 DATE REVISED: 20-DEC-1995  TRACKING NUMBER: T7138
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 1ETH  B    SWS     P02703       1 -     3 NOT IN ATOMS LIST
REMARK 999 1ETH  B    SWS     P02703      91 -    95 NOT IN ATOMS LIST
REMARK 999 1ETH  D    SWS     P02703       1 -     3 NOT IN ATOMS LIST
REMARK 999 1ETH  D    SWS     P02703      91 -    95 NOT IN ATOMS LIST
REMARK 999
REMARK 999 PART OF THE DISCREPANCIES IN SEQUENCE IS EXPLAINED AS
REMARK 999 FOLLOWS:
REMARK 999 CHAIN A AND C; MODIFICATIONS ABOUT RESIDUE 30 ARE
REMARK 999 EXPLAINED BY PROTEIN SEQUENCING AND ELECTRON DENSITY MAP.
REMARK 999 MAP.  ASN 405 AND ASN 406 WERE NOT FOUND IN THE ELECTRON
REMARK 999 DENSITY MAP.
REMARK 999 CHAINS B AND D:  MUTATION AT LEU 37 (SWISSPROT) TO SER 37
REMARK 999 IS MADE AFTER EGLOFF ET AL. (PDB ENTRY 1LPB) ON THE BASIS
REMARK 999 OF MASS SPECTROSCOPY.
DBREF  1ETH A    1   448  SWS    P00591   LIPP_PIG         1    449
DBREF  1ETH B    4    90  SWS    P02703   COL2_PIG         4     90
DBREF  1ETH C    1   448  SWS    P00591   LIPP_PIG         1    449
DBREF  1ETH D    4    90  SWS    P02703   COL2_PIG         4     90
SEQADV 1ETH TRP A   30  SWS  P00591              MISSING FROM SWS
SEQADV 1ETH SER A   31  SWS  P00591    PRO    30 CONFLICT
SEQADV 1ETH PRO A   32  SWS  P00591    ASP    31 CONFLICT
SEQADV 1ETH     A       SWS  P00591    ASN   405 GAP IN PDB ENTRY
SEQADV 1ETH     A       SWS  P00591    ASN   406 GAP IN PDB ENTRY
SEQADV 1ETH TRP C   30  SWS  P00591              MISSING FROM SWS
SEQADV 1ETH SER C   31  SWS  P00591    PRO    30 CONFLICT
SEQADV 1ETH PRO C   32  SWS  P00591    ASP    31 CONFLICT
SEQADV 1ETH     C       SWS  P00591    ASN   405 GAP IN PDB ENTRY
SEQADV 1ETH     C       SWS  P00591    ASN   406 GAP IN PDB ENTRY
SEQRES   1 A  448  SER GLU VAL CYS PHE PRO ARG LEU GLY CYS PHE SER ASP
SEQRES   2 A  448  ASP ALA PRO TRP ALA GLY ILE VAL GLN ARG PRO LEU LYS
SEQRES   3 A  448  ILE LEU PRO TRP SER PRO LYS ASP VAL ASP THR ARG PHE
SEQRES   4 A  448  LEU LEU TYR THR ASN GLN ASN GLN ASN ASN TYR GLN GLU
SEQRES   5 A  448  LEU VAL ALA ASP PRO SER THR ILE THR ASN SER ASN PHE
SEQRES   6 A  448  ARG MET ASP ARG LYS THR ARG PHE ILE ILE HIS GLY PHE
SEQRES   7 A  448  ILE ASP LYS GLY GLU GLU ASP TRP LEU SER ASN ILE CYS
SEQRES   8 A  448  LYS ASN LEU PHE LYS VAL GLU SER VAL ASN CYS ILE CYS
SEQRES   9 A  448  VAL ASP TRP LYS GLY GLY SER ARG THR GLY TYR THR GLN
SEQRES  10 A  448  ALA SER GLN ASN ILE ARG ILE VAL GLY ALA GLU VAL ALA
SEQRES  11 A  448  TYR PHE VAL GLU VAL LEU LYS SER SER LEU GLY TYR SER
SEQRES  12 A  448  PRO SER ASN VAL HIS VAL ILE GLY HIS SER LEU GLY SER
SEQRES  13 A  448  HIS ALA ALA GLY GLU ALA GLY ARG ARG THR ASN GLY THR
SEQRES  14 A  448  ILE GLU ARG ILE THR GLY LEU ASP PRO ALA GLU PRO CYS
SEQRES  15 A  448  PHE GLN GLY THR PRO GLU LEU VAL ARG LEU ASP PRO SER
SEQRES  16 A  448  ASP ALA LYS PHE VAL ASP VAL ILE HIS THR ASP ALA ALA
SEQRES  17 A  448  PRO ILE ILE PRO ASN LEU GLY PHE GLY MET SER GLN THR
SEQRES  18 A  448  VAL GLY HIS LEU ASP PHE PHE PRO ASN GLY GLY LYS GLN
SEQRES  19 A  448  MET PRO GLY CYS GLN LYS ASN ILE LEU SER GLN ILE VAL
SEQRES  20 A  448  ASP ILE ASP GLY ILE TRP GLU GLY THR ARG ASP PHE VAL
SEQRES  21 A  448  ALA CYS ASN HIS LEU ARG SER TYR LYS TYR TYR ALA ASP
SEQRES  22 A  448  SER ILE LEU ASN PRO ASP GLY PHE ALA GLY PHE PRO CYS
SEQRES  23 A  448  ASP SER TYR ASN VAL PHE THR ALA ASN LYS CYS PHE PRO
SEQRES  24 A  448  CYS PRO SER GLU GLY CYS PRO GLN MET GLY HIS TYR ALA
SEQRES  25 A  448  ASP ARG PHE PRO GLY LYS THR ASN GLY VAL SER GLN VAL
SEQRES  26 A  448  PHE TYR LEU ASN THR GLY ASP ALA SER ASN PHE ALA ARG
SEQRES  27 A  448  TRP ARG TYR LYS VAL SER VAL THR LEU SER GLY LYS LYS
SEQRES  28 A  448  VAL THR GLY HIS ILE LEU VAL SER LEU PHE GLY ASN GLU
SEQRES  29 A  448  GLY ASN SER ARG GLN TYR GLU ILE TYR LYS GLY THR LEU
SEQRES  30 A  448  GLN PRO ASP ASN THR HIS SER ASP GLU PHE ASP SER ASP
SEQRES  31 A  448  VAL GLU VAL GLY ASP LEU GLN LYS VAL LYS PHE ILE TRP
SEQRES  32 A  448  TYR ASN VAL ILE ASN PRO THR LEU PRO ARG VAL GLY ALA
SEQRES  33 A  448  SER LYS ILE THR VAL GLU ARG ASN ASP GLY LYS VAL TYR
SEQRES  34 A  448  ASP PHE CYS SER GLN GLU THR VAL ARG GLU GLU VAL LEU
SEQRES  35 A  448  LEU THR LEU ASN PRO CYS
SEQRES   1 B   95  VAL PRO ASP PRO ARG GLY ILE ILE ILE ASN LEU ASP GLU
SEQRES   2 B   95  GLY GLU LEU CYS LEU ASN SER ALA GLN CYS LYS SER ASN
SEQRES   3 B   95  CYS CYS GLN HIS ASP THR ILE LEU SER LEU SER ARG CYS
SEQRES   4 B   95  ALA LEU LYS ALA ARG GLU ASN SER GLU CYS SER ALA PHE
SEQRES   5 B   95  THR LEU TYR GLY VAL TYR TYR LYS CYS PRO CYS GLU ARG
SEQRES   6 B   95  GLY LEU THR CYS GLU GLY ASP LYS SER LEU VAL GLY SER
SEQRES   7 B   95  ILE THR ASN THR ASN PHE GLY ILE CYS HIS ASN VAL GLY
SEQRES   8 B   95  ARG SER ASP SER
SEQRES   1 C  448  SER GLU VAL CYS PHE PRO ARG LEU GLY CYS PHE SER ASP
SEQRES   2 C  448  ASP ALA PRO TRP ALA GLY ILE VAL GLN ARG PRO LEU LYS
SEQRES   3 C  448  ILE LEU PRO TRP SER PRO LYS ASP VAL ASP THR ARG PHE
SEQRES   4 C  448  LEU LEU TYR THR ASN GLN ASN GLN ASN ASN TYR GLN GLU
SEQRES   5 C  448  LEU VAL ALA ASP PRO SER THR ILE THR ASN SER ASN PHE
SEQRES   6 C  448  ARG MET ASP ARG LYS THR ARG PHE ILE ILE HIS GLY PHE
SEQRES   7 C  448  ILE ASP LYS GLY GLU GLU ASP TRP LEU SER ASN ILE CYS
SEQRES   8 C  448  LYS ASN LEU PHE LYS VAL GLU SER VAL ASN CYS ILE CYS
SEQRES   9 C  448  VAL ASP TRP LYS GLY GLY SER ARG THR GLY TYR THR GLN
SEQRES  10 C  448  ALA SER GLN ASN ILE ARG ILE VAL GLY ALA GLU VAL ALA
SEQRES  11 C  448  TYR PHE VAL GLU VAL LEU LYS SER SER LEU GLY TYR SER
SEQRES  12 C  448  PRO SER ASN VAL HIS VAL ILE GLY HIS SER LEU GLY SER
SEQRES  13 C  448  HIS ALA ALA GLY GLU ALA GLY ARG ARG THR ASN GLY THR
SEQRES  14 C  448  ILE GLU ARG ILE THR GLY LEU ASP PRO ALA GLU PRO CYS
SEQRES  15 C  448  PHE GLN GLY THR PRO GLU LEU VAL ARG LEU ASP PRO SER
SEQRES  16 C  448  ASP ALA LYS PHE VAL ASP VAL ILE HIS THR ASP ALA ALA
SEQRES  17 C  448  PRO ILE ILE PRO ASN LEU GLY PHE GLY MET SER GLN THR
SEQRES  18 C  448  VAL GLY HIS LEU ASP PHE PHE PRO ASN GLY GLY LYS GLN
SEQRES  19 C  448  MET PRO GLY CYS GLN LYS ASN ILE LEU SER GLN ILE VAL
SEQRES  20 C  448  ASP ILE ASP GLY ILE TRP GLU GLY THR ARG ASP PHE VAL
SEQRES  21 C  448  ALA CYS ASN HIS LEU ARG SER TYR LYS TYR TYR ALA ASP
SEQRES  22 C  448  SER ILE LEU ASN PRO ASP GLY PHE ALA GLY PHE PRO CYS
SEQRES  23 C  448  ASP SER TYR ASN VAL PHE THR ALA ASN LYS CYS PHE PRO
SEQRES  24 C  448  CYS PRO SER GLU GLY CYS PRO GLN MET GLY HIS TYR ALA
SEQRES  25 C  448  ASP ARG PHE PRO GLY LYS THR ASN GLY VAL SER GLN VAL
SEQRES  26 C  448  PHE TYR LEU ASN THR GLY ASP ALA SER ASN PHE ALA ARG
SEQRES  27 C  448  TRP ARG TYR LYS VAL SER VAL THR LEU SER GLY LYS LYS
SEQRES  28 C  448  VAL THR GLY HIS ILE LEU VAL SER LEU PHE GLY ASN GLU
SEQRES  29 C  448  GLY ASN SER ARG GLN TYR GLU ILE TYR LYS GLY THR LEU
SEQRES  30 C  448  GLN PRO ASP ASN THR HIS SER ASP GLU PHE ASP SER ASP
SEQRES  31 C  448  VAL GLU VAL GLY ASP LEU GLN LYS VAL LYS PHE ILE TRP
SEQRES  32 C  448  TYR ASN VAL ILE ASN PRO THR LEU PRO ARG VAL GLY ALA
SEQRES  33 C  448  SER LYS ILE THR VAL GLU ARG ASN ASP GLY LYS VAL TYR
SEQRES  34 C  448  ASP PHE CYS SER GLN GLU THR VAL ARG GLU GLU VAL LEU
SEQRES  35 C  448  LEU THR LEU ASN PRO CYS
SEQRES   1 D   95  VAL PRO ASP PRO ARG GLY ILE ILE ILE ASN LEU ASP GLU
SEQRES   2 D   95  GLY GLU LEU CYS LEU ASN SER ALA GLN CYS LYS SER ASN
SEQRES   3 D   95  CYS CYS GLN HIS ASP THR ILE LEU SER LEU SER ARG CYS
SEQRES   4 D   95  ALA LEU LYS ALA ARG GLU ASN SER GLU CYS SER ALA PHE
SEQRES   5 D   95  THR LEU TYR GLY VAL TYR TYR LYS CYS PRO CYS GLU ARG
SEQRES   6 D   95  GLY LEU THR CYS GLU GLY ASP LYS SER LEU VAL GLY SER
SEQRES   7 D   95  ILE THR ASN THR ASN PHE GLY ILE CYS HIS ASN VAL GLY
SEQRES   8 D   95  ARG SER ASP SER
HET     CA  A 449       1
HET    NAG  A 450      27
HET    NAG  A 451      27
HET    BMA  A 452      20
HET    BMA  A 453      22
HET    BMA  A 454      22
HET    C8E  A 455      55
HET    C8E  A 456      55
HET    BME  A 456       4
HET     CA  C 449       1
HET    NAG  C 450      27
HET    NAG  C 451      27
HET    BMA  C 452      20
HET    BMA  C 453      22
HET    BMA  C 454      22
HET    C8E  C 455      55
HET    C8E  C 456      55
HET    BME  C 456       4
HETNAM      CA CALCIUM ION
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     BMA BETA-D-MANNOSE
HETNAM     C8E (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
HETNAM     BME BETA-MERCAPTOETHANOL
FORMUL   5   CA    2(CA1 2+)
FORMUL   6  NAG    4(C8 H15 N1 O6)
FORMUL   7  BMA    6(C6 H12 O6)
FORMUL   8  C8E    4(C16 H34 O5)
FORMUL   9  BME    2(C2 H6 O1 S1)
FORMUL  10  HOH   *357(H2 O1)
HELIX    1   1 PRO A   32  VAL A   35  1                                   4
HELIX    2   2 ASN A   44  ASN A   46  5                                   3
HELIX    3   3 SER A   58  ASN A   62  1                                   5
HELIX    4   4 ASP A   85  VAL A   97  1                                  13
HELIX    5   5 LYS A  108  ARG A  112  1                                   5
HELIX    6   6 TYR A  115  SER A  138  1                                  24
HELIX    7   7 PRO A  144  ASN A  146  5                                   3
HELIX    8   8 SER A  153  ARG A  164  5                                  12
HELIX    9   9 PRO A  194  ASP A  196  5                                   3
HELIX   10  10 PRO A  229  GLY A  231  5                                   3
HELIX   11  11 ILE A  242  ILE A  246  1                                   5
HELIX   12  12 ILE A  252  ILE A  275  1                                  24
HELIX   13  13 ASN A  290  THR A  293  1                                   4
HELIX   14  14 GLY A  309  ARG A  314  5                                   6
HELIX   15  15 LEU B   75  ILE B   79  1                                   5
HELIX   16  16 PRO C    6  LEU C    8  5                                   3
HELIX   17  17 ASN C   44  ASN C   46  5                                   3
HELIX   18  18 PRO C   57  THR C   61  1                                   5
HELIX   19  19 ASP C   85  VAL C   97  5                                  13
HELIX   20  20 GLY C  110  ARG C  112  5                                   3
HELIX   21  21 TYR C  115  LEU C  140  1                                  26
HELIX   22  22 PRO C  144  ASN C  146  5                                   3
HELIX   23  23 SER C  153  THR C  166  5                                  14
HELIX   24  24 PRO C  194  ASP C  196  5                                   3
HELIX   25  25 ILE C  210  ASN C  213  1                                   4
HELIX   26  26 PRO C  229  GLY C  232  5                                   4
HELIX   27  27 ILE C  242  ILE C  246  1                                   5
HELIX   28  28 ILE C  252  ALA C  261  1                                  10
HELIX   29  29 ASN C  263  LEU C  276  1                                  14
HELIX   30  30 TYR C  289  ALA C  294  1                                   6
HELIX   31  31 ALA C  312  ARG C  314  5                                   3
HELIX   32  32 LEU D   75  ILE D   79  1                                   5
SHEET    1   A 2 GLU A   2  PHE A   5  0
SHEET    2   A 2 GLY A   9  SER A  12 -1  N  PHE A  11   O  VAL A   3
SHEET    1   B 6 ARG A  38  THR A  43  0
SHEET    2   B 6 ASN A 101  ASP A 106 -1  N  ASP A 106   O  ARG A  38
SHEET    3   B 6 THR A  71  ILE A  75  1  N  ARG A  72   O  ASN A 101
SHEET    4   B 6 VAL A 147  SER A 153  1  N  HIS A 148   O  THR A  71
SHEET    5   B 6 ILE A 173  PRO A 178  1  N  THR A 174   O  VAL A 149
SHEET    6   B 6 VAL A 200  ILE A 203  1  N  ASP A 201   O  ILE A 173
SHEET    1   C 2 LEU A 225  PRO A 229  0
SHEET    2   C 2 GLN A 324  LEU A 328  1  N  GLN A 324   O  ASP A 226
SHEET    1   D 4 THR A 382  SER A 389  0
SHEET    2   D 4 TRP A 339  LEU A 347 -1  N  VAL A 345   O  HIS A 383
SHEET    3   D 4 ALA A 416  ARG A 423 -1  N  GLU A 422   O  LYS A 342
SHEET    4   D 4 VAL A 428  CYS A 432 -1  N  PHE A 431   O  ILE A 419
SHEET    1   E 4 LEU A 443  LEU A 445  0
SHEET    2   E 4 VAL A 399  TYR A 404 -1  N  PHE A 401   O  LEU A 443
SHEET    3   E 4 VAL A 352  LEU A 360 -1  N  SER A 359   O  LYS A 400
SHEET    4   E 4 TYR A 370  LEU A 377 -1  N  LEU A 377   O  VAL A 352
SHEET    1   F 2 LEU B  67  GLY B  71  0
SHEET    2   F 2 GLY B  85  ASN B  89 -1  N  HIS B  88   O  THR B  68
SHEET    1   G 2 GLU C   2  PHE C   5  0
SHEET    2   G 2 GLY C   9  SER C  12 -1  N  PHE C  11   O  VAL C   3
SHEET    1   H 7 GLN C  51  LEU C  53  0
SHEET    2   H 7 THR C  37  LEU C  41 -1  N  LEU C  41   O  GLN C  51
SHEET    3   H 7 ASN C 101  TRP C 107 -1  N  ASP C 106   O  ARG C  38
SHEET    4   H 7 THR C  71  ILE C  75  1  N  ARG C  72   O  ASN C 101
SHEET    5   H 7 VAL C 147  HIS C 152  1  N  HIS C 148   O  THR C  71
SHEET    6   H 7 ARG C 172  LEU C 176  1  N  ARG C 172   O  VAL C 149
SHEET    7   H 7 VAL C 200  ILE C 203  1  N  ASP C 201   O  ILE C 173
SHEET    1   I 2 LEU C 225  PHE C 227  0
SHEET    2   I 2 GLN C 324  PHE C 326  1  N  GLN C 324   O  ASP C 226
SHEET    1   J 4 THR C 382  SER C 389  0
SHEET    2   J 4 TRP C 339  GLY C 349 -1  N  VAL C 345   O  HIS C 383
SHEET    3   J 4 VAL C 414  ARG C 423 -1  N  GLU C 422   O  LYS C 342
SHEET    4   J 4 VAL C 428  CYS C 432 -1  N  PHE C 431   O  ILE C 419
SHEET    1   K 2 GLU D  48  SER D  50  0
SHEET    2   K 2 PHE D  84  ILE D  86 -1  N  GLY D  85   O  CYS D  49
SHEET    1   L 2 LEU D  67  CYS D  69  0
SHEET    2   L 2 CYS D  87  ASN D  89 -1  N  HIS D  88   O  THR D  68
SHEET    1   M 2 HIS C 355  VAL C 358  0
SHEET    2   M 2 TYR C 370  LYS C 374 -1  N  TYR C 373   O  ILE C 356
SHEET    1   N 2 SER C 359  GLY C 362  0
SHEET    2   N 2 LEU C 396  LYS C 400 -1  N  LYS C 400   O  SER C 359
SSBOND   1 CYS A    4    CYS A   10
SSBOND   2 CYS A   91    CYS A  102
SSBOND   3 CYS A  238    CYS A  262
SSBOND   4 CYS A  286    CYS A  297
SSBOND   5 CYS A  300    CYS A  305
SSBOND   6 CYS A  432    CYS A  448
SSBOND   7 CYS B   17    CYS B   28
SSBOND   8 CYS B   23    CYS B   39
SSBOND   9 CYS B   27    CYS B   61
SSBOND  10 CYS B   49    CYS B   69
SSBOND  11 CYS B   63    CYS B   87
SSBOND  12 CYS C    4    CYS C   10
SSBOND  13 CYS C   91    CYS C  102
SSBOND  14 CYS C  238    CYS C  262
SSBOND  15 CYS C  286    CYS C  297
SSBOND  16 CYS C  300    CYS C  305
SSBOND  17 CYS C  432    CYS C  448
SSBOND  18 CYS D   17    CYS D   28
SSBOND  19 CYS D   23    CYS D   39
SSBOND  20 CYS D   27    CYS D   61
SSBOND  21 CYS D   49    CYS D   69
SSBOND  22 CYS D   63    CYS D   87
LINK        CA    CA A 449                 O   GLU A 188
LINK        CA    CA A 449                 O   ARG A 191
LINK        CA    CA A 449                 OD2 ASP A 196
LINK         C1  NAG A 450                 CG  ASN C 167
LINK         C1  NAG A 450                 ND2 ASN C 167
LINK         O4  NAG A 450                 C1  NAG A 451
LINK         O5  NAG A 450                 OD1 ASN C 167
LINK         O5  NAG A 450                 ND2 ASN C 167
LINK         O4  NAG A 451                 C1  BMA A 452
LINK         O3  BMA A 452                 C1  BMA A 454
LINK         O6  BMA A 452                 C1  BMA A 453
LINK        CA    CA C 449                 O   GLU C 188
LINK        CA    CA C 449                 O   ARG C 191
LINK         C1  NAG C 450                 ND2 ASN A 167
LINK         O4  NAG C 450                 C1  NAG C 451
LINK         O4  NAG C 451                 C1  BMA C 452
LINK         O3  BMA C 452                 C1  BMA C 454
LINK         O6  BMA C 452                 C1  BMA C 453
CISPEP   1 ALA A   15    PRO A   16          0         5.56
CISPEP   2 ILE A  211    PRO A  212          0       -12.40
CISPEP   3 PHE A  298    PRO A  299          0       -15.97
CISPEP   4 ALA C   15    PRO C   16          0         4.55
CISPEP   5 ILE C  211    PRO C  212          0       -12.68
CISPEP   6 PHE C  298    PRO C  299          0       -14.32
CRYST1  289.100  289.100  289.100  90.00  90.00  90.00 F 2 3        96
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.003459  0.000000  0.000000        0.00000
SCALE2      0.000000  0.003459  0.000000        0.00000
SCALE3      0.000000  0.000000  0.003459        0.00000