longtext: 1JKM-pdb

content
HEADER    SERINE HYDROLASE                        04-FEB-98   1JKM
TITLE     BREFELDIN A ESTERASE, A BACTERIAL HOMOLOGUE OF HUMAN
TITLE    2 HORMONE SENSITIVE LIPASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: BREFELDIN A ESTERASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;
SOURCE   3 EXPRESSION_SYSTEM: ESCHERICHIA COLI
KEYWDS    SERINE HYDROLASE, DEGRADATION OF BREFELDIN A, ALPHA/BETA
KEYWDS   2 HYDROLASE FAMILY
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.WEI,A.J.CARRERAS,P.SHEFFIELD,T.OSTERLUND,U.DEREWENDA,
AUTHOR   2 U.O.MATERN,Z.S.DEREWENDA
REVDAT   1   16-FEB-99 1JKM    0
JRNL        AUTH   Y.WEI,A.J.CARRERAS,P.SHEFFIELD,T.OSTERLUND,
JRNL        AUTH 2 U.DEREWENDA,U.O.MATERN,Z.S.DEREWENDA
JRNL        TITL   CRYSTAL STRUCTURE OF BREFELDIN A ESTERASE, A
JRNL        TITL 2 BACTERIAL HORMOLOGUE OF THE HUMAN HORMONE SENSITIVE
JRNL        TITL 3 LIPASE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN                                                  0353
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 1.85 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 8.0
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 1.85
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.0
REMARK   3   COMPLETENESS FOR RANGE        (%) : 85.8
REMARK   3   NUMBER OF REFLECTIONS             : 62664
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : FREE R
REMARK   3   FREE R VALUE TEST SET SELECTION  : NULL
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.170
REMARK   3   R VALUE            (WORKING SET) : 0.169
REMARK   3   FREE R VALUE                     : 0.206
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5
REMARK   3   FREE R VALUE TEST SET COUNT      : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 5012
REMARK   3   NUCLEIC ACID ATOMS       : NULL
REMARK   3   HETEROGEN ATOMS          : NULL
REMARK   3   SOLVENT ATOMS            : 524
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 18.1 (MAIN CHAIN),
REMARK   3   23.4 (SIDE CHAIN)
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): NULL
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): NULL
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): NULL
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   DISTANCE RESTRAINTS.                    RMS    SIGMA
REMARK   3    BOND LENGTH                     (A) : 0.013 ; 0.020
REMARK   3    ANGLE DISTANCE                  (A) : 0.028 ; 0.040
REMARK   3    INTRAPLANAR 1-4 DISTANCE        (A) : 0.033 ; 0.050
REMARK   3    H-BOND OR METAL COORDINATION    (A) : NULL  ; NULL
REMARK   3
REMARK   3   PLANE RESTRAINT                  (A) : NULL  ; NULL
REMARK   3   CHIRAL-CENTER RESTRAINT       (A**3) : NULL  ; NULL
REMARK   3
REMARK   3   NON-BONDED CONTACT RESTRAINTS.
REMARK   3    SINGLE TORSION                  (A) : NULL  ; NULL
REMARK   3    MULTIPLE TORSION                (A) : NULL  ; NULL
REMARK   3    H-BOND (X...Y)                  (A) : NULL  ; NULL
REMARK   3    H-BOND (X-H...Y)                (A) : NULL  ; NULL
REMARK   3
REMARK   3   CONFORMATIONAL TORSION ANGLE RESTRAINTS.
REMARK   3    SPECIFIED                 (DEGREES) : NULL  ; NULL
REMARK   3    PLANAR                    (DEGREES) : 9.2   ; 7.0
REMARK   3    STAGGERED                 (DEGREES) : 21.0  ; 15.0
REMARK   3    TRANSVERSE                (DEGREES) : NULL  ; NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 2.301 ; 2.000
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 3.390 ; 3.000
REMARK   3   SIDE-CHAIN BOND              (A**2) : 2.846 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 4.216 ; 3.000
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 1JKM COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : NULL
REMARK 200  TEMPERATURE           (KELVIN) : 295
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 20
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : DESY-EMBL,HAMBURG
REMARK 200  BEAMLINE                       : WB7, X31
REMARK 200  X-RAY GENERATOR MODEL          : SIEMENS
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.54
REMARK 200  MONOCHROMATOR                  : GRAPHITE
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : MULTIWIRE AND IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : SIEMENS AND MAR
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XENGEN AND DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK, CCP4 SUITE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 62664
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.85
REMARK 200  RESOLUTION RANGE LOW       (A) : 20
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NONE
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 86
REMARK 200  DATA REDUNDANCY                : 1.8
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.108
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 9.4
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: NULL
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MIR
REMARK 200 SOFTWARE USED: SHELX90, CCP4
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 54
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.7
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: AMMONIUM SULFATE AS MAJOR
REMARK 280 PRECIPITANT AT PH=6.5
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   1/2+X,1/2+Y,Z
REMARK 290       4555   1/2-X,1/2+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       70.35317
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       41.29842
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       70.35317
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       41.29842
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   CA   ALA B    48     CD   ARG A   217     2656     0.12
REMARK 500   C    VAL B   337     NH1  ARG A   295     2656     0.17
REMARK 500   CE1  PHE B   259     CA   GLY A   296     2656     0.34
REMARK 500   O    HOH     408     CB   HIS B   346     2656     0.36
REMARK 500   NH1  ARG B    15     O    PHE A   288     2656     0.37
REMARK 500   CB   ASP B    43     CD1  LEU A   321     2656     0.37
REMARK 500   O    HOH     516     N    GLU B   261     2656     0.41
REMARK 500   CA   ARG B   218     CA   ALA B   215     2655     0.41
REMARK 500   CA   PRO B    83     CB   ASP B    81     2656     0.42
REMARK 500   C    ALA B    38     N    PHE A   300     2656     0.43
REMARK 500   CG   PRO B    83     N    ASP B    81     2656     0.46
REMARK 500   CD1  LEU B    42     C    LEU A   297     2656     0.48
REMARK 500   C    VAL B    34     CG2  VAL A   328     2656     0.51
REMARK 500   CG   MET B    33     O    ALA A   322     2656     0.52
REMARK 500   O    HOH     507     OD2  ASP B    26     2656     0.52
REMARK 500   CD2  LEU B    37     CG2  VAL A   326     2656     0.53
REMARK 500   CG1  VAL B   337     CA   ALA A   324     2656     0.58
REMARK 500   CD   PRO B   309     OD1  ASP A   292     2656     0.58
REMARK 500   O    HOH     495     CG   PRO B    27     2656     0.58
REMARK 500   N    ALA B   351     OE2  GLU B    35     2656     0.59
REMARK 500   CA   ALA B    36     CA   ASP A   327     2656     0.59
REMARK 500   CB   PHE B   259     CA   ARG A   295     2656     0.60
REMARK 500   O    SER B    20     O    TYR A   287     2656     0.60
REMARK 500   C    GLY B    41     CE1  PHE A   300     2656     0.60
REMARK 500   CG   TYR B   258     CA   GLU A   291     2656     0.60
REMARK 500   CG2  VAL B   337     O    ALA A   324     2656     0.62
REMARK 500   CA   GLY B   257     CB   GLU A   293     2656     0.64
REMARK 500   O    HOH     358     CD1  PHE B   344     2656     0.66
REMARK 500   C    GLU B    35     N    VAL A   328     2656     0.69
REMARK 500   O    VAL B    45     CD1  LEU A   213     2656     0.70
REMARK 500   N    GLY B    22     NH1  ARG A   320     2656     0.71
REMARK 500   N    LEU B   221     NE   ARG B   218     2655     0.72
REMARK 500   O    PRO B    23     N    ARG A   320     2656     0.74
REMARK 500   C    ALA B    36     N    ASP A   327     2656     0.75
REMARK 500   O    TRP B   347     O    TRP B   347     2656     0.77
REMARK 500   CG   PHE B   259     C    ARG A   295     2656     0.77
REMARK 500   O    HOH     130     CD1  PHE A   317     2656     0.77
REMARK 500   O    HOH     189     CA   ASN B   255     2656     0.78
REMARK 500   CD1  PHE B   259     N    GLY A   296     2656     0.80
REMARK 500   CG   PHE B   259     N    GLY A   296     2656     0.82
REMARK 500   N    THR B    25     O    ALA A   316     2656     0.82
REMARK 500   O    HOH     426     CA   PRO B    27     2656     0.83
REMARK 500   O    HOH      95     CA   PRO B    31     2656     0.86
REMARK 500   O    HOH     139     CB   ARG A   319     2656     0.86
REMARK 500   C    ARG B    24     C    ALA A   316     2656     0.86
REMARK 500   CB   PHE B    40     CA   PRO A   298     2656     0.87
REMARK 500   O    HOH      35     C    PHE B    29     2656     0.87
REMARK 500   CA   LEU B    37     CG1  VAL A   326     2656     0.88
REMARK 500   O    HOH     269     N    SER B    21     2656     0.88
REMARK 500   N    GLY B    22     CZ   ARG A   320     2656     0.88
REMARK 500   O    ALA B    38     CA   PHE A   300     2656     0.88
REMARK 500   N    THR B    25     C    ALA A   316     2656     0.89
REMARK 500   O    GLY B    41     CZ   PHE A   300     2656     0.89
REMARK 500   O    HOH     189     CB   ASN B   255     2656     0.89
REMARK 500   CA   GLY B    22     NH1  ARG A   320     2656     0.89
REMARK 500   O    HOH     176     CD   PRO B    31     2656     0.89
REMARK 500   OD1  ASP B    43     CD2  PHE A   300     2656     0.91
REMARK 500   CB   TYR B   258     C    GLU A   291     2656     0.91
REMARK 500   CG   LEU B    42     CB   LEU A   297     2656     0.92
REMARK 500   CB   THR B    39     CB   PRO A   299     2656     0.92
REMARK 500   O    HOH      35     O    PHE B    29     2656     0.92
REMARK 500   O    HOH     439     CB   SER B    77     2656     0.93
REMARK 500   O    HOH     351     CD2  LEU B   214     2655     0.94
REMARK 500   CE2  PHE B    29     O    ARG A   320     2656     0.95
REMARK 500   N    PHE B   259     C    LEU A   294     2656     0.96
REMARK 500   O    HOH     296     CG   LEU B   221     2655     0.97
REMARK 500   CG2  VAL B    45     CB   ALA A   289     2656     0.97
REMARK 500   C    ARG B   220     CD   ARG B   218     2655     0.97
REMARK 500   CD2  TYR B   258     CB   GLU A   291     2656     0.98
REMARK 500   O    HOH     370     CA   ALA B   350     2656     0.99
REMARK 500   CE   MET B    33     CA   GLY A   325     2656     1.00
REMARK 500   O    ASP B    26     NH1  ARG A   323     2656     1.00
REMARK 500   N    ARG B   218     C    ALA B   215     2655     1.02
REMARK 500   O    HOH     118     CZ   PHE B   344     2656     1.02
REMARK 500   CB   SER B    30     CB   SER B    30     2656     1.02
REMARK 500   CA   ARG B    24     C    PHE A   317     2656     1.03
REMARK 500   N    THR B    39     N    PHE A   300     2656     1.04
REMARK 500   O    HOH     358     CE1  PHE B   344     2656     1.04
REMARK 500   N    LEU B   221     CD   ARG B   218     2655     1.04
REMARK 500   N    SER B    20     CD1  PHE A   288     2656     1.04
REMARK 500   N    PRO B   309     OD1  ASP A   292     2656     1.04
REMARK 500   CD   PRO B    50     CG   ARG A   218     2656     1.05
REMARK 500   CB   VAL B    45     CB   ALA A   289     2656     1.05
REMARK 500   CB   PHE B    29     O    ARG A   319     2656     1.05
REMARK 500   O    HOH     482     OE1  GLU A   293     2656     1.06
REMARK 500   CA   ALA B    44     CZ   PHE A   317     2656     1.06
REMARK 500   N    LEU B    42     CE1  PHE A   300     2656     1.07
REMARK 500   O    PRO B    83     OD2  ASP B    81     2656     1.07
REMARK 500   CB   SER B    30     CA   SER B    30     2656     1.07
REMARK 500   O    HOH     224     CE   LYS A   216     2656     1.07
REMARK 500   O    HOH     262     N    ASP B    26     2656     1.07
REMARK 500   CA   GLU B    35     O    VAL A   328     2656     1.08
REMARK 500   O    HOH     237     CA   LEU B   348     2656     1.08
REMARK 500   CA   PHE B   259     N    ARG A   295     2656     1.08
REMARK 500   N    ARG B   217     N    ARG B   217     2655     1.09
REMARK 500   CB   PHE B    40     CB   PRO A   298     2656     1.10
REMARK 500   CD   PRO B    83     C    ASP B    81     2656     1.10
REMARK 500   O    HOH     224     CD   LYS A   216     2656     1.10
REMARK 500   CD   PRO B    50     CD   ARG A   218     2656     1.10
REMARK 500   O    GLU B    35     C    ASP A   327     2656     1.11
REMARK 500   CZ   ARG B   217     NZ   LYS B   216     2655     1.11
REMARK 500   C    ALA B   350     OE2  GLU B    35     2656     1.12
REMARK 500   C    ARG B    24     O    ALA A   316     2656     1.12
REMARK 500   O    HOH     516     CA   GLU B   261     2656     1.12
REMARK 500   CD1  LEU B    42     CA   LEU A   297     2656     1.12
REMARK 500   CG   LEU B    37     CB   VAL A   326     2656     1.13
REMARK 500   O    HOH     237     N    LEU B   348     2656     1.13
REMARK 500   CB   MET B    33     O    ALA A   322     2656     1.14
REMARK 500   N    ARG B    24     O    PHE A   317     2656     1.14
REMARK 500   CB   LEU B    37     CB   VAL A   326     2656     1.15
REMARK 500   N    LEU B    37     C    VAL A   326     2656     1.15
REMARK 500   CD   PRO B    83     O    ASP B    81     2656     1.15
REMARK 500   CB   ASP B    26     NH2  ARG A   323     2656     1.15
REMARK 500   CB   LEU B    42     CB   LEU A   297     2656     1.16
REMARK 500   NH1  ARG B   217     NZ   LYS B   216     2655     1.16
REMARK 500   C    ALA B    36     CA   ASP A   327     2656     1.17
REMARK 500   CG   PRO B    83     CA   ASP B    81     2656     1.17
REMARK 500   C    ALA B    38     CA   PHE A   300     2656     1.17
REMARK 500   N    ALA B    48     NE   ARG A   217     2656     1.18
REMARK 500   CB   GLU B    35     O    VAL A   328     2656     1.18
REMARK 500   O    VAL B    34     CG2  VAL A   328     2656     1.18
REMARK 500   O    SER B    20     C    TYR A   287     2656     1.19
REMARK 500   CA   PHE B   259     C    LEU A   294     2656     1.20
REMARK 500   CG   TYR B   258     N    GLU A   291     2656     1.21
REMARK 500   N    ARG B    24     C    PHE A   317     2656     1.21
REMARK 500   CD1  PHE B    40     CD   PRO A   299     2656     1.21
REMARK 500   N    PHE B   259     N    ARG A   295     2656     1.22
REMARK 500   CG   ASP B    26     NH2  ARG A   323     2656     1.22
REMARK 500   CG2  THR B    39     CG   PRO A   299     2656     1.22
REMARK 500   CA   SER B    30     CA   SER B    30     2656     1.23
REMARK 500   CZ   PHE B   259     CA   GLY A   296     2656     1.23
REMARK 500   CD2  TYR B   258     CA   GLU A   291     2656     1.24
REMARK 500   O    HOH     420     CZ   PHE B    40     2656     1.24
REMARK 500   N    PHE B    40     N    PRO A   299     2656     1.24
REMARK 500   O    ALA B    38     N    PHE A   300     2656     1.24
REMARK 500   CD   PRO B   309     CG   ASP A   292     2656     1.24
REMARK 500   CZ   ARG B   217     CE   LYS B   216     2655     1.24
REMARK 500   CB   TYR B   258     O    GLU A   291     2656     1.24
REMARK 500   O    HOH     223     NH2  ARG B    15     2656     1.25
REMARK 500   CE1  PHE B   259     C    GLY A   296     2656     1.25
REMARK 500   CD   ARG B   217     CG   LYS B   216     2655     1.26
REMARK 500   O    HOH     291     CA   ALA B    32     2656     1.26
REMARK 500   CG   LEU B    42     CA   LEU A   297     2656     1.27
REMARK 500   O    HOH     331     O    ARG B    28     2656     1.27
REMARK 500   NE   ARG B   217     CE   LYS B   216     2655     1.27
REMARK 500   CB   PRO B    83     CA   ASP B    81     2656     1.28
REMARK 500   O    HOH      38     NE   ARG A   295     2656     1.28
REMARK 500   N    PHE B   259     CA   LEU A   294     2656     1.28
REMARK 500   CB   ARG B    24     N    ALA A   318     2656     1.28
REMARK 500   C    ALA B    66     O    GLY A   219     2656     1.29
REMARK 500   CB   TYR B   258     CA   GLU A   291     2656     1.29
REMARK 500   O    HOH     111     CE2  PHE B    40     2656     1.29
REMARK 500   O    HOH     320     O    HOH     231     2656     1.29
REMARK 500   O    HOH     161     O    ALA B    32     2656     1.30
REMARK 500   CB   PRO B    23     N    LEU A   321     2656     1.31
REMARK 500   O    HOH     262     C    THR B    25     2656     1.31
REMARK 500   N    PRO B   309     CG   ASP A   292     2656     1.31
REMARK 500   O    HOH     130     CG   PHE A   317     2656     1.32
REMARK 500   CA   ARG B   218     C    ALA B   215     2655     1.32
REMARK 500   CD1  PHE B   259     CA   GLY A   296     2656     1.32
REMARK 500   CG   PRO B    83     C    LEU B    80     2656     1.32
REMARK 500   N    PRO B    49     CB   ARG A   217     2656     1.32
REMARK 500   C    ASP B   256     OG   SER A   290     2656     1.32
REMARK 500   N    HIS B   338     NH1  ARG A   295     2656     1.32
REMARK 500   CA   THR B    39     CB   PRO A   299     2656     1.32
REMARK 500   CA   ALA B    38     CB   PHE A   300     2656     1.33
REMARK 500   CD1  TYR B   258     C    SER A   290     2656     1.33
REMARK 500   O    HOH     291     C    ALA B    32     2656     1.33
REMARK 500   CA   THR B    39     CA   PRO A   299     2656     1.34
REMARK 500   NH1  ARG B    15     C    PHE A   288     2656     1.34
REMARK 500   CD1  LEU B    42     O    LEU A   297     2656     1.36
REMARK 500   CD2  LEU B    42     CB   LEU A   297     2656     1.36
REMARK 500   O    VAL B    34     CB   VAL A   328     2656     1.36
REMARK 500   O    HOH     296     CB   LEU B   221     2655     1.36
REMARK 500   CA   GLU B    35     C    VAL A   328     2656     1.36
REMARK 500   O    ARG B    24     O    ILE A   315     2656     1.36
REMARK 500   CG2  THR B    39     CB   PRO A   299     2656     1.37
REMARK 500   O    GLU B    35     N    VAL A   328     2656     1.38
REMARK 500   CB   ARG B   217     CB   LYS B   216     2655     1.38
REMARK 500   O    VAL B   337     NH1  ARG A   295     2656     1.38
REMARK 500   CB   PHE B   259     C    ARG A   295     2656     1.38
REMARK 500   CA   ASP B    43     CD2  LEU A   321     2656     1.38
REMARK 500   CD1  TYR B   258     N    GLU A   291     2656     1.38
REMARK 500   CB   PHE B   259     N    ARG A   295     2656     1.38
REMARK 500   CA   ARG B    24     N    ALA A   318     2656     1.38
REMARK 500   CB   PRO B    83     N    ASP B    81     2656     1.39
REMARK 500   CB   ARG B    24     C    PHE A   317     2656     1.39
REMARK 500   O    HOH     223     CZ   ARG B    15     2656     1.39
REMARK 500   O    GLY B   257     N    LEU A   294     2656     1.40
REMARK 500   N    LEU B    37     N    ASP A   327     2656     1.40
REMARK 500   CA   ASP B    43     CG   LEU A   321     2656     1.40
REMARK 500   CA   VAL B   337     NH1  ARG A   295     2656     1.40
REMARK 500   C    THR B    39     C    PRO A   299     2656     1.40
REMARK 500   C    THR B    39     CA   PRO A   299     2656     1.40
REMARK 500   O    HOH     120     CD1  TRP B   347     2656     1.40
REMARK 500   O    ASN B   255     N    ASP A   292     2656     1.41
REMARK 500   CG   PRO B    50     CD   ARG A   218     2656     1.42
REMARK 500   NE   ARG B    24     CG2  VAL A   302     2656     1.42
REMARK 500   C    ARG B   217     N    LYS B   216     2655     1.42
REMARK 500   CG2  VAL B    34     O    ALA A   318     2656     1.42
REMARK 500   C    GLU B    19     CD1  PHE A   288     2656     1.42
REMARK 500   CA   VAL B   337     CZ   ARG A   295     2656     1.42
REMARK 500   CZ   ARG B    15     O    PHE A   288     2656     1.43
REMARK 500   C    ARG B   218     CA   ALA B   215     2655     1.43
REMARK 500   C    THR B    39     O    PRO A   299     2656     1.43
REMARK 500   CB   PHE B    40     C    PRO A   298     2656     1.43
REMARK 500   O    ALA B    46     OE2  GLU A   293     2656     1.43
REMARK 500   CA   ALA B    46     CD2  LEU A   213     2656     1.43
REMARK 500   CA   VAL B    34     CG2  VAL A   328     2656     1.43
REMARK 500   CE   MET B    33     C    GLY A   325     2656     1.44
REMARK 500   C    VAL B   337     CZ   ARG A   295     2656     1.44
REMARK 500   O    HOH     471     CG1  ILE B    78     2656     1.44
REMARK 500   CD1  LEU B    37     O    LEU A   321     2656     1.45
REMARK 500   CA   ASP B    43     CD1  LEU A   321     2656     1.45
REMARK 500   C    GLU B    35     C    ASP A   327     2656     1.45
REMARK 500   CA   ALA B    48     NE   ARG A   217     2656     1.45
REMARK 500   O    GLY B    41     CE1  PHE A   300     2656     1.45
REMARK 500   O    HOH     358     CG   PHE B   344     2656     1.45
REMARK 500   C    GLY B    41     CZ   PHE A   300     2656     1.46
REMARK 500   CD   PRO B    83     CA   ASP B    81     2656     1.46
REMARK 500   N    ASP B   256     OG   SER A   290     2656     1.46
REMARK 500   O    ASP B   256     OG   SER A   290     2656     1.46
REMARK 500   O    HOH     291     N    MET B    33     2656     1.46
REMARK 500   CB   ARG B   217     CA   LYS B   216     2655     1.47
REMARK 500   CD2  LEU B    42     CG   LEU A   297     2656     1.47
REMARK 500   O    HOH     370     C    ALA B   350     2656     1.47
REMARK 500   N    PRO B    83     CB   ASP B    81     2656     1.47
REMARK 500   O    ALA B    66     O    GLY A   219     2656     1.48
REMARK 500   CD   PRO B    23     CD1  LEU A   294     2656     1.48
REMARK 500   O    ILE B   260     O    ASP A   292     2656     1.48
REMARK 500   OE2  GLU B    19     OE1  GLU A   280     2656     1.49
REMARK 500   CB   VAL B   337     O    ALA A   324     2656     1.49
REMARK 500   OG   SER B    20     CD2  TYR A   287     2656     1.49
REMARK 500   O    HOH     224     CG   LYS A   216     2656     1.49
REMARK 500   C    ARG B    28     CD   ARG A   323     2656     1.49
REMARK 500   O    VAL B    45     CG   LEU A   213     2656     1.50
REMARK 500   CD2  LEU B    42     CA   LEU A   297     2656     1.50
REMARK 500   CG   ARG B   218     O    ALA B   215     2655     1.50
REMARK 500   CB   SER B    30     C    SER B    30     2656     1.51
REMARK 500   CG   PHE B    40     CA   PRO A   298     2656     1.51
REMARK 500   C    SER B    20     O    TYR A   287     2656     1.52
REMARK 500   CG1  VAL B   337     C    ALA A   324     2656     1.52
REMARK 500   CA   PHE B    29     CG   ARG A   323     2656     1.52
REMARK 500   CA   PRO B    83     CG   ASP B    81     2656     1.52
REMARK 500   CA   ASP B   256     OG   SER A   290     2656     1.52
REMARK 500   O    ARG B    24     C    ALA A   316     2656     1.52
REMARK 500   CG   ARG B    24     N    ALA A   318     2656     1.52
REMARK 500   O    GLU B    35     O    ASP A   327     2656     1.52
REMARK 500   N    PHE B    29     CD   ARG A   323     2656     1.52
REMARK 500   CB   ARG B   218     O    ALA B   215     2655     1.52
REMARK 500   CZ3  TRP B   347     OD2  ASP A   327     2656     1.53
REMARK 500   CB   PRO B   349     CD2  HIS B   346     2656     1.54
REMARK 500   C    ALA B    48     CD   ARG A   217     2656     1.54
REMARK 500   O    HOH     238     CA   ARG B   220     2655     1.54
REMARK 500   N    ALA B    36     N    VAL A   328     2656     1.54
REMARK 500   C    ARG B    24     N    PHE A   317     2656     1.54
REMARK 500   N    ALA B    48     CD   ARG A   217     2656     1.54
REMARK 500   CD2  TYR B   258     CG   GLU A   291     2656     1.54
REMARK 500   CB   THR B    25     CB   ALA A   316     2656     1.55
REMARK 500   CD2  PHE B    29     O    ARG A   320     2656     1.55
REMARK 500   CG1  VAL B   337     CB   ALA A   324     2656     1.55
REMARK 500   CB   LEU B    37     CG1  VAL A   326     2656     1.55
REMARK 500   CB   PRO B    83     CB   ASP B    81     2656     1.55
REMARK 500   O    HOH     227     CH2  TRP B   347     2656     1.55
REMARK 500   N    THR B    39     C    PRO A   299     2656     1.55
REMARK 500   N    PHE B    40     C    PRO A   299     2656     1.55
REMARK 500   N    PHE B    40     CA   PRO A   299     2656     1.56
REMARK 500   N    HIS B   338     CZ   ARG A   295     2656     1.56
REMARK 500   N    ALA B   350     NE1  TRP B   347     2656     1.56
REMARK 500   CB   ALA B    48     NH1  ARG A   217     2656     1.56
REMARK 500   O    HOH     388     CE3  TRP B   347     2656     1.56
REMARK 500   O    HOH     464     CB   LEU B   178     2655     1.56
REMARK 500   CB   ALA B    48     CD   ARG A   217     2656     1.56
REMARK 500   N    PHE B    40     O    PRO A   299     2656     1.56
REMARK 500   CB   ARG B    24     CA   PHE A   317     2656     1.56
REMARK 500   O    GLY B   257     C    GLU A   293     2656     1.56
REMARK 500   O    HOH     426     CB   PRO B    27     2656     1.56
REMARK 500   N    VAL B    34     CB   ALA A   322     2656     1.57
REMARK 500   N    ARG B   218     CA   ALA B   215     2655     1.57
REMARK 500   O    ALA B    36     N    ASP A   327     2656     1.57
REMARK 500   O    PHE B   259     O    ARG A   295     2656     1.57
REMARK 500   O    HOH     119     CA   LEU A   294     2656     1.57
REMARK 500   CA   ARG B   217     O    LEU B   213     2655     1.57
REMARK 500   O    HOH     439     CA   SER B    77     2656     1.57
REMARK 500   O    HOH     139     CA   ARG A   319     2656     1.57
REMARK 500   C    SER B    21     NH1  ARG A   320     2656     1.58
REMARK 500   CZ   PHE B    29     O    ARG A   320     2656     1.58
REMARK 500   CD   PRO B    50     NE   ARG A   218     2656     1.58
REMARK 500   CA   THR B    39     C    PRO A   299     2656     1.58
REMARK 500   CD   GLU B    19     OE1  GLU A   280     2656     1.58
REMARK 500   O    ARG B    24     C    ILE A   315     2656     1.58
REMARK 500   CA   PRO B   309     OD2  ASP A   292     2656     1.58
REMARK 500   CD2  PHE B   259     N    GLY A   296     2656     1.58
REMARK 500   O    HOH     495     CD   PRO B    27     2656     1.59
REMARK 500   OG   SER B    30     OG   SER B    30     2656     1.59
REMARK 500   CD1  PHE B   259     C    ARG A   295     2656     1.59
REMARK 500   CA   ALA B    48     CG   ARG A   217     2656     1.59
REMARK 500   O    HOH     119     CB   LEU A   294     2656     1.59
REMARK 500   CG   PHE B    40     CB   PRO A   298     2656     1.59
REMARK 500   C    LEU B    37     CG1  VAL A   326     2656     1.59
REMARK 500   N    ALA B   351     CD   GLU B    35     2656     1.60
REMARK 500   CD2  LEU B    37     CB   VAL A   326     2656     1.60
REMARK 500   C    VAL B    34     CB   VAL A   328     2656     1.60
REMARK 500   N    GLY B    22     NH2  ARG A   320     2656     1.60
REMARK 500   O    HOH     525     C    LEU B   348     2656     1.60
REMARK 500   CG   LEU B    37     CG2  VAL A   326     2656     1.61
REMARK 500   O    MET B    33     O    VAL A   326     2656     1.61
REMARK 500   NH1  ARG B   217     CE   LYS B   216     2655     1.61
REMARK 500   CD2  LEU B   307     OE1  GLU A   291     2656     1.61
REMARK 500   CA   LEU B    37     CB   VAL A   326     2656     1.61
REMARK 500   C    ASP B    26     NH1  ARG A   323     2656     1.61
REMARK 500   O    HOH     388     CZ3  TRP B   347     2656     1.61
REMARK 500   N    LEU B    42     CD1  PHE A   300     2656     1.62
REMARK 500   OG   SER B    30     CB   SER B    30     2656     1.62
REMARK 500   O    HOH     334     CB   ALA B    79     2656     1.62
REMARK 500   CG   MET B    33     C    ALA A   322     2656     1.62
REMARK 500   O    HOH     454     CB   ASP B   292     2655     1.62
REMARK 500   O    HOH     238     CG   ARG B   220     2655     1.62
REMARK 500   CE1  PHE B   259     N    GLY A   296     2656     1.62
REMARK 500   CB   ARG B   217     C    LYS B   216     2655     1.62
REMARK 500   O    HOH     507     CG   ASP B    26     2656     1.62
REMARK 500   CA   ALA B    36     N    ASP A   327     2656     1.62
REMARK 500   O    HOH     483     O    ARG B   345     2656     1.63
REMARK 500   CA   ILE B   260     NZ   LYS A   216     2656     1.63
REMARK 500   N    GLY B   219     C    LEU B   214     2655     1.63
REMARK 500   O    ARG B    24     CA   ALA A   316     2656     1.63
REMARK 500   O    HOH     525     CA   LEU B   348     2656     1.63
REMARK 500   CG   PHE B   259     CA   ARG A   295     2656     1.63
REMARK 500   OG   SER B    20     CE2  TYR A   287     2656     1.63
REMARK 500   CG   PRO B    49     O    ARG A   217     2656     1.63
REMARK 500   N    TYR B   258     N    GLU A   293     2656     1.63
REMARK 500   N    PRO B    83     C    ASP B    81     2656     1.63
REMARK 500   CA   VAL B   337     NH2  ARG A   295     2656     1.64
REMARK 500   NH2  ARG B   217     NZ   LYS B   216     2655     1.64
REMARK 500   CG2  VAL B   337     C    ALA A   324     2656     1.64
REMARK 500   CA   ARG B   217     N    ARG B   217     2655     1.64
REMARK 500   O    HOH     516     C    ILE B   260     2656     1.64
REMARK 500   O    HOH     496     CD1  ILE B    78     2656     1.64
REMARK 500   CA   GLY B   257     CA   GLU A   293     2656     1.64
REMARK 500   N    ARG B   218     N    LYS B   216     2655     1.64
REMARK 500   CA   GLU B    35     N    VAL A   328     2656     1.64
REMARK 500   CG1  VAL B    45     CB   ALA A   289     2656     1.64
REMARK 500   N    PHE B    40     C    PRO A   298     2656     1.64
REMARK 500   CB   ALA B    44     CG2  ILE A   209     2656     1.65
REMARK 500   N    PRO B    83     CA   ASP B    81     2656     1.65
REMARK 500   N    HIS B   338     NE   ARG A   295     2656     1.65
REMARK 500   O    HOH     269     CA   SER B    21     2656     1.65
REMARK 500   N    PRO B   309     OD2  ASP A   292     2656     1.65
REMARK 500   O    HOH     426     N    PRO B    27     2656     1.65
REMARK 500   CA   ARG B   220     CD   ARG B   218     2655     1.65
REMARK 500   C    PHE B   259     O    ARG A   295     2656     1.66
REMARK 500   CA   THR B    25     CA   ALA A   316     2656     1.66
REMARK 500   O    HOH     237     C    TRP B   347     2656     1.66
REMARK 500   O    HOH     482     CD   GLU A   293     2656     1.66
REMARK 500   N    PHE B    29     CG   ARG A   323     2656     1.66
REMARK 500   OD1  ASP B    43     CG   PHE A   300     2656     1.67
REMARK 500   CA   LEU B   221     NE   ARG B   218     2655     1.67
REMARK 500   CA   TYR B   258     O    GLU A   291     2656     1.67
REMARK 500   CG2  THR B    25     CB   ALA A   316     2656     1.67
REMARK 500   CA   PHE B   259     O    LEU A   294     2656     1.67
REMARK 500   O    LEU B    42     CD2  LEU A   321     2656     1.68
REMARK 500   O    HOH     407     O    LEU B   348     2656     1.68
REMARK 500   C    PRO B    23     N    ARG A   320     2656     1.68
REMARK 500   CA   PRO B    83     CA   ASP B    81     2656     1.68
REMARK 500   CA   GLU B    35     CA   VAL A   328     2656     1.68
REMARK 500   CD2  TYR B   258     N    GLU A   291     2656     1.69
REMARK 500   N    HIS B   338     CD   ARG A   295     2656     1.69
REMARK 500   O    HOH     176     CG   PRO B    31     2656     1.69
REMARK 500   O    HOH     408     CG   HIS B   346     2656     1.69
REMARK 500   C    PRO B    23     O    PHE A   317     2656     1.69
REMARK 500   N    TYR B   258     O    SER A   290     2656     1.69
REMARK 500   O    HOH     332     CD2  LEU B    82     2656     1.69
REMARK 500   O    PRO B    23     C    ARG A   319     2656     1.70
REMARK 500   N    VAL B    34     CA   ALA A   322     2656     1.70
REMARK 500   N    ALA B    47     CB   LEU A   213     2656     1.70
REMARK 500   OD1  ASP B    26     NH2  ARG A   323     2656     1.70
REMARK 500   C    SER B    21     CZ   ARG A   320     2656     1.70
REMARK 500   O    HOH     238     CB   ARG B   220     2655     1.70
REMARK 500   N    ALA B    46     CD2  LEU A   213     2656     1.71
REMARK 500   CB   PRO B    49     C    ARG A   217     2656     1.71
REMARK 500   CA   SER B    20     CG   PHE A   288     2656     1.71
REMARK 500   CA   THR B    25     C    ALA A   316     2656     1.71
REMARK 500   CA   ALA B    38     CA   PHE A   300     2656     1.72
REMARK 500   C    TYR B   258     N    ARG A   295     2656     1.72
REMARK 500   N    PHE B   259     N    LEU A   294     2656     1.72
REMARK 500   O    HOH     189     N    ASN B   255     2656     1.72
REMARK 500   CB   THR B    39     CA   PRO A   299     2656     1.72
REMARK 500   CD1  TYR B   258     O    SER A   290     2656     1.72
REMARK 500   N    ALA B    44     CZ   PHE A   317     2656     1.72
REMARK 500   CA   ARG B    24     CA   PHE A   317     2656     1.72
REMARK 500   CA   PHE B    40     C    PRO A   298     2656     1.72
REMARK 500   CA   ARG B   218     CB   ALA B   215     2655     1.72
REMARK 500   O    ALA B    44     CD2  LEU A   294     2656     1.72
REMARK 500   CD2  PHE B    29     N    ARG A   323     2656     1.73
REMARK 500   C    ALA B    36     C    ASP A   327     2656     1.73
REMARK 500   N    ALA B    36     CA   ASP A   327     2656     1.73
REMARK 500   CA   THR B    25     CB   ALA A   316     2656     1.73
REMARK 500   CD   ARG B   217     CD   LYS B   216     2655     1.73
REMARK 500   CE3  TRP B   347     OD1  ASP A   327     2656     1.73
REMARK 500   C    GLY B   257     CA   GLU A   293     2656     1.73
REMARK 500   C    ARG B   218     N    ALA B   215     2655     1.73
REMARK 500   CG   PRO B    23     CD1  LEU A   294     2656     1.73
REMARK 500   CB   LEU B   307     OE1  GLU A   291     2656     1.73
REMARK 500   N    GLY B   257     CB   GLU A   293     2656     1.74
REMARK 500   O    ALA B    38     C    PRO A   299     2656     1.74
REMARK 500   O    HOH     120     CG   TRP B   347     2656     1.74
REMARK 500   C    ALA B    38     C    PRO A   299     2656     1.74
REMARK 500   CD2  LEU B    42     CD1  LEU A   297     2656     1.74
REMARK 500   CD   PRO B   349     CA   TRP B   347     2656     1.74
REMARK 500   C    TYR B   258     O    GLU A   291     2656     1.74
REMARK 500   N    SER B    20     CE1  PHE A   288     2656     1.74
REMARK 500   CD1  LEU B    42     N    PRO A   298     2656     1.74
REMARK 500   O    HOH     335     O    HOH     246     2656     1.75
REMARK 500   CD   PRO B    83     N    ASP B    81     2656     1.75
REMARK 500   O    HOH     291     N    ALA B    32     2656     1.75
REMARK 500   O    ARG B    24     N    ALA A   316     2656     1.75
REMARK 500   O    TYR B   258     O    GLU A   291     2656     1.75
REMARK 500   O    ARG B   217     N    ALA B   215     2655     1.75
REMARK 500   CA   PRO B    23     CB   ARG A   320     2656     1.75
REMARK 500   O    PHE B   259     NZ   LYS A   216     2656     1.76
REMARK 500   O    HOH     469     O    HOH      24     2656     1.76
REMARK 500   CH2  TRP B   347     OD2  ASP A   327     2656     1.76
REMARK 500   N    GLU B    35     CG2  VAL A   328     2656     1.76
REMARK 500   C    PRO B    83     OD2  ASP B    81     2656     1.76
REMARK 500   O    HOH     417     CA   MET B    33     2656     1.76
REMARK 500   C    ALA B    36     C    VAL A   326     2656     1.76
REMARK 500   CA   ARG B   218     N    ALA B   215     2655     1.76
REMARK 500   O    GLY B    22     CB   ARG A   320     2656     1.77
REMARK 500   CG2  VAL B    45     CA   ALA A   289     2656     1.77
REMARK 500   O    HOH     458     CG   HIS B   346     2656     1.77
REMARK 500   N    GLY B   219     N    ALA B   215     2655     1.77
REMARK 500   CB   MET B    33     C    ALA A   322     2656     1.77
REMARK 500   O    HOH     118     CE2  PHE B   344     2656     1.77
REMARK 500   O    HOH     408     CA   HIS B   346     2656     1.77
REMARK 500   CA   SER B    20     CD1  PHE A   288     2656     1.77
REMARK 500   CB   PRO B    83     CG   ASP B    81     2656     1.77
REMARK 500   O    HOH      38     CD   ARG A   295     2656     1.77
REMARK 500   CZ   ARG B    24     CB   VAL A   302     2656     1.78
REMARK 500   O    HOH     544     CD   LYS B   216     2655     1.78
REMARK 500   CG   LEU B   307     OE1  GLU A   291     2656     1.78
REMARK 500   O    HOH     189     C    ASN B   255     2656     1.78
REMARK 500   N    ALA B    36     C    ASP A   327     2656     1.78
REMARK 500   CA   GLY B    41     CE1  PHE A   300     2656     1.78
REMARK 500   N    ASP B    43     CD2  LEU A   321     2656     1.78
REMARK 500   O    LYS B   216     CA   LEU B   214     2655     1.78
REMARK 500   CD   ARG B   217     CE   LYS B   216     2655     1.79
REMARK 500   O    PHE B   259     CE   LYS A   216     2656     1.79
REMARK 500   CB   THR B    39     CG   PRO A   299     2656     1.79
REMARK 500   O    HOH     439     N    SER B    77     2656     1.79
REMARK 500   O    HOH     223     NE   ARG B    15     2656     1.79
REMARK 500   CA   GLY B   335     CG   PRO B    31     2656     1.80
REMARK 500   O    ALA B    47     CG   ARG A   217     2656     1.80
REMARK 500   C    THR B    39     CB   PRO A   299     2656     1.80
REMARK 500   O    HOH     167     O    HOH      87     2656     1.80
REMARK 500   CB   ALA B    38     O    PHE A   300     2656     1.80
REMARK 500   CD1  LEU B   307     CB   ARG A   323     2656     1.80
REMARK 500   CE2  TYR B   258     CG   GLU A   291     2656     1.81
REMARK 500   CB   PRO B    50     NE   ARG A   218     2656     1.81
REMARK 500   NH1  ARG B    24     CB   ALA A   318     2656     1.81
REMARK 500   CA   PRO B    23     C    ARG A   320     2656     1.81
REMARK 500   C    GLY B   257     N    LEU A   294     2656     1.81
REMARK 500   C    GLY B   257     C    GLU A   293     2656     1.81
REMARK 500   O    HOH     262     CA   ASP B    26     2656     1.81
REMARK 500   CB   VAL B   337     C    ALA A   324     2656     1.82
REMARK 500   CG   LEU B    42     C    LEU A   297     2656     1.82
REMARK 500   O    HOH     420     CE1  PHE B    40     2656     1.82
REMARK 500   N    ARG B   218     O    ALA B   215     2655     1.82
REMARK 500   O    HOH     495     CB   PRO B    27     2656     1.82
REMARK 500   CB   ALA B    48     NE   ARG A   217     2656     1.82
REMARK 500   O    HOH     296     CD1  LEU B   221     2655     1.82
REMARK 500   O    HOH     407     C    PRO B   349     2656     1.82
REMARK 500   CG1  VAL B    34     O    ALA A   318     2656     1.83
REMARK 500   OE1  GLU B    19     OE1  GLU A   280     2656     1.83
REMARK 500   CB   ARG B   218     C    ALA B   215     2655     1.83
REMARK 500   O    HOH     249     O    HOH     218     2656     1.83
REMARK 500   O    HOH     358     CZ   PHE B   344     2656     1.83
REMARK 500   O    PHE B    40     CG   PRO A   298     2656     1.83
REMARK 500   CA   GLY B    22     CZ   ARG A   320     2656     1.83
REMARK 500   N    SER B    67     O    GLY A   219     2656     1.83
REMARK 500   O    HOH      35     N    SER B    30     2656     1.83
REMARK 500   C    GLY B    41     CD1  PHE A   300     2656     1.83
REMARK 500   O    HOH     176     N    PRO B    31     2656     1.83
REMARK 500   O    HOH     291     CB   ALA B    32     2656     1.84
REMARK 500   N    ARG B   218     O    LEU B   214     2655     1.84
REMARK 500   CB   ARG B   217     N    ARG B   217     2655     1.84
REMARK 500   O    TRP B   347     C    TRP B   347     2656     1.84
REMARK 500   CA   PRO B   309     CG   ASP A   292     2656     1.84
REMARK 500   CA   ALA B    36     CB   ASP A   327     2656     1.84
REMARK 500   O    SER B    30     CB   ALA A   322     2656     1.84
REMARK 500   C    VAL B    45     CD1  LEU A   213     2656     1.84
REMARK 500   C    THR B    39     N    PRO A   299     2656     1.84
REMARK 500   C    TYR B   258     N    LEU A   294     2656     1.84
REMARK 500   CD2  TRP B   347     OD1  ASP A   327     2656     1.84
REMARK 500   CD2  PHE B   259     C    ARG A   295     2656     1.84
REMARK 500   O    HOH     237     CB   LEU B   348     2656     1.84
REMARK 500   CB   ALA B    48     CZ   ARG A   217     2656     1.85
REMARK 500   CG   PRO B    50     NE   ARG A   218     2656     1.85
REMARK 500   CD1  PHE B   259     C    GLY A   296     2656     1.85
REMARK 500   O    TYR B   258     N    ARG A   295     2656     1.86
REMARK 500   OD1  ASP B    43     CE2  PHE A   300     2656     1.86
REMARK 500   CA   PRO B    23     CA   ARG A   320     2656     1.86
REMARK 500   O    HOH     370     O    ALA B   350     2656     1.86
REMARK 500   CD   PRO B    49     CB   ARG A   217     2656     1.86
REMARK 500   CB   HIS B   338     CD   ARG A   295     2656     1.86
REMARK 500   C    GLU B    35     CA   VAL A   328     2656     1.86
REMARK 500   O    ALA B    47     O    LEU A   213     2656     1.86
REMARK 500   N    ARG B    24     CA   PHE A   317     2656     1.86
REMARK 500   N    THR B    25     N    PHE A   317     2656     1.87
REMARK 500   CG   PHE B    29     O    ARG A   319     2656     1.87
REMARK 500   CB   ASP B    43     CG   LEU A   321     2656     1.87
REMARK 500   N    GLY B   257     N    GLU A   293     2656     1.87
REMARK 500   O    ILE B   260     C    ASP A   292     2656     1.87
REMARK 500   CG   PHE B    40     CD   PRO A   299     2656     1.87
REMARK 500   CE1  PHE B    40     CD   PRO A   299     2656     1.87
REMARK 500   N    LEU B   221     CZ   ARG B   218     2655     1.87
REMARK 500   OD2  ASP B    43     CG2  VAL A   302     2656     1.87
REMARK 500   O    SER B    21     O    ALA A   289     2656     1.87
REMARK 500   CA   PHE B   259     CA   ARG A   295     2656     1.87
REMARK 500   C    MET B    33     CA   ALA A   322     2656     1.87
REMARK 500   O    HOH     256     OG   SER B    77     2656     1.88
REMARK 500   CG   ASP B    43     CD1  LEU A   321     2656     1.88
REMARK 500   CB   VAL B    34     O    ALA A   318     2656     1.88
REMARK 500   SD   MET B    33     N    GLY A   325     2656     1.88
REMARK 500   CB   PRO B    49     O    ARG A   217     2656     1.88
REMARK 500   CB   ARG B   218     CA   ALA B   215     2655     1.88
REMARK 500   O    VAL B    34     CA   VAL A   328     2656     1.88
REMARK 500   N    THR B    39     CA   PRO A   299     2656     1.88
REMARK 500   N    ARG B   218     N    ALA B   215     2655     1.89
REMARK 500   CG   PRO B   309     CG   ASP A   292     2656     1.89
REMARK 500   O    HOH     259     N    PHE B    29     2656     1.89
REMARK 500   O    HOH     331     C    ARG B    28     2656     1.89
REMARK 500   CG   PRO B   309     CB   ASP A   292     2656     1.89
REMARK 500   O    ALA B    36     CA   ASP A   327     2656     1.89
REMARK 500   O    PRO B    27     O    PRO B    27     2656     1.89
REMARK 500   CG   TYR B   258     C    GLU A   291     2656     1.89
REMARK 500   O    HOH     351     CG   LEU B   214     2655     1.89
REMARK 500   N    LEU B    37     O    VAL A   326     2656     1.89
REMARK 500   O    HOH     382     O    GLY B   335     2656     1.89
REMARK 500   N    ASP B   256     CB   SER A   290     2656     1.89
REMARK 500   C    PRO B    83     CB   ASP B    81     2656     1.90
REMARK 500   CD2  PHE B    40     CB   PRO A   298     2656     1.90
REMARK 500   C    ARG B   217     C    ALA B   215     2655     1.90
REMARK 500   N    ARG B   220     CD   ARG B   218     2655     1.90
REMARK 500   C    ALA B    48     CB   ARG A   217     2656     1.90
REMARK 500   O    ASP B   256     N    SER A   290     2656     1.90
REMARK 500   O    ILE B   260     CA   GLU A   293     2656     1.90
REMARK 500   O    ALA B    46     CD   GLU A   293     2656     1.90
REMARK 500   CA   TYR B   258     N    LEU A   294     2656     1.90
REMARK 500   N    GLU B    35     O    VAL A   328     2656     1.90
REMARK 500   NE   ARG B    24     CB   VAL A   302     2656     1.90
REMARK 500   CA   ALA B    38     N    PHE A   300     2656     1.90
REMARK 500   CA   PRO B    23     N    LEU A   321     2656     1.91
REMARK 500   O    ASP B    43     CE2  PHE A   317     2656     1.91
REMARK 500   O    HOH      95     C    PRO B    31     2656     1.91
REMARK 500   CB   ALA B   350     CG   GLU B    35     2656     1.92
REMARK 500   CA   ALA B    36     C    ASP A   327     2656     1.92
REMARK 500   O    GLU B    19     CB   PHE A   288     2656     1.92
REMARK 500   CG   ARG B   218     C    ALA B   215     2655     1.92
REMARK 500   C    GLY B   257     CB   GLU A   293     2656     1.92
REMARK 500   CE   MET B    33     N    GLY A   325     2656     1.92
REMARK 500   O    HOH     331     O    HOH      87     2656     1.93
REMARK 500   O    HOH     269     C    SER B    20     2656     1.93
REMARK 500   CB   PRO B   309     CG   ASP A   292     2656     1.93
REMARK 500   CE1  TYR B   258     N    GLU A   291     2656     1.93
REMARK 500   C    ARG B   220     NE   ARG B   218     2655     1.93
REMARK 500   SD   MET B    33     CA   GLY A   325     2656     1.94
REMARK 500   C    ASP B   308     OD1  ASP A   292     2656     1.94
REMARK 500   CG   PRO B   309     OD1  ASP A   292     2656     1.94
REMARK 500   CA   PHE B    40     N    PRO A   299     2656     1.94
REMARK 500   CB   PRO B    83     OD1  ASP B    81     2656     1.94
REMARK 500   CG   PHE B   259     O    ARG A   295     2656     1.94
REMARK 500   O    HOH     311     O    ALA B    63     2656     1.94
REMARK 500   O    HOH     130     CE1  PHE A   317     2656     1.94
REMARK 500   CG   ARG B    24     C    PHE A   317     2656     1.94
REMARK 500   O    ALA B    38     O    PRO A   299     2656     1.94
REMARK 500   O    HOH     237     O    TRP B   347     2656     1.94
REMARK 500   N    GLY B    70     OD1  ASP A   222     2656     1.95
REMARK 500   O    HOH     259     O    PHE B    29     2656     1.95
REMARK 500   CG   LEU B    37     CA   VAL A   326     2656     1.95
REMARK 500   CB   PHE B    40     CG   PRO A   298     2656     1.95
REMARK 500   O    HOH     227     CZ2  TRP B   347     2656     1.95
REMARK 500   O    HOH     290     O    GLU B   254     2656     1.95
REMARK 500   C    GLY B    22     CB   ARG A   320     2656     1.95
REMARK 500   C    PRO B    83     CG   ASP B    81     2656     1.95
REMARK 500   O    ALA B    36     CB   ASP A   327     2656     1.95
REMARK 500   C    LEU B    42     CD2  LEU A   321     2656     1.95
REMARK 500   CD   PRO B   309     CB   ASP A   292     2656     1.95
REMARK 500   CB   SER B    20     CD2  PHE A   288     2656     1.96
REMARK 500   C    ARG B   217     C    LEU B   214     2655     1.96
REMARK 500   O    HOH     407     O    PRO B   349     2656     1.96
REMARK 500   N    PRO B    23     CB   ARG A   320     2656     1.96
REMARK 500   O    LEU B    37     O    PRO A   298     2656     1.96
REMARK 500   N    GLY B   219     O    LEU B   214     2655     1.96
REMARK 500   CB   SER B    20     CE2  PHE A   288     2656     1.97
REMARK 500   O    ASP B    26     CZ   ARG A   323     2656     1.97
REMARK 500   C    ASN B   255     OG   SER A   290     2656     1.97
REMARK 500   O    HOH     454     CG   ASP B   292     2655     1.97
REMARK 500   CB   PHE B    40     N    PRO A   298     2656     1.97
REMARK 500   N    PRO B    83     O    ASP B    81     2656     1.97
REMARK 500   O    HOH      35     CA   PHE B    29     2656     1.97
REMARK 500   O    ASP B   256     CB   SER A   290     2656     1.97
REMARK 500   C    ARG B   217     N    ALA B   215     2655     1.97
REMARK 500   O    HOH     439     OG   SER B    77     2656     1.97
REMARK 500   O    HOH      95     N    PRO B    31     2656     1.97
REMARK 500   O    HOH     167     CG   ARG A   319     2656     1.98
REMARK 500   O    THR B    39     O    PRO A   299     2656     1.98
REMARK 500   CB   PRO B    23     CA   LEU A   321     2656     1.98
REMARK 500   N    TYR B   258     N    LEU A   294     2656     1.98
REMARK 500   O    HOH     463     CB   GLU B   261     2656     1.98
REMARK 500   CG   TYR B   258     CB   GLU A   291     2656     1.98
REMARK 500   CD1  TYR B   258     CA   GLU A   291     2656     1.98
REMARK 500   CD1  PHE B   259     N    LEU A   297     2656     1.98
REMARK 500   CA   ARG B    24     O    PHE A   317     2656     1.98
REMARK 500   CB   PRO B    49     N    ARG A   218     2656     1.98
REMARK 500   O    HOH     485     CD   PRO B   282     2655     1.98
REMARK 500   CA   ALA B   351     OE2  GLU B    35     2656     1.98
REMARK 500   CG   PRO B    83     O    LEU B    80     2656     1.98
REMARK 500   C    LYS B   216     O    LEU B   214     2655     1.99
REMARK 500   O    HOH     382     CA   LEU B   336     2656     1.99
REMARK 500   CE1  TYR B   258     C    SER A   290     2656     1.99
REMARK 500   CG1  VAL B   337     N    ALA A   324     2656     1.99
REMARK 500   CZ   ARG B    24     CG2  VAL A   302     2656     1.99
REMARK 500   NH1  ARG B   217     CD   LYS B   216     2655     1.99
REMARK 500   O    HOH     458     CD2  HIS B   346     2656     1.99
REMARK 500   N    GLU B    35     CB   VAL A   328     2656     1.99
REMARK 500   CA   THR B    25     O    ALA A   316     2656     2.00
REMARK 500   CB   ALA B    47     CD1  ILE A   283     2656     2.00
REMARK 500   O    HOH      95     CB   PRO B    31     2656     2.00
REMARK 500   CA   ARG B   218     O    ALA B   215     2655     2.00
REMARK 500   N    ALA B    44     CE2  PHE A   317     2656     2.00
REMARK 500   O    ARG B   217     O    THR B   212     2655     2.00
REMARK 500   C    ALA B    48     CG   ARG A   217     2656     2.01
REMARK 500   CB   ALA B    38     CB   PHE A   300     2656     2.01
REMARK 500   N    ALA B    48     CZ   ARG A   217     2656     2.01
REMARK 500   N    PRO B    50     NE   ARG A   218     2656     2.01
REMARK 500   C    ASP B    43     CE2  PHE A   317     2656     2.01
REMARK 500   O    ASP B    43     CZ   PHE A   317     2656     2.01
REMARK 500   O    LYS B   216     O    LEU B   214     2655     2.01
REMARK 500   O    HOH     525     O    HOH     225     2656     2.01
REMARK 500   O    HOH     516     CB   GLU B   261     2656     2.01
REMARK 500   CB   ALA B    36     CA   ASP A   327     2656     2.01
REMARK 500   CA   TYR B   258     C    GLU A   291     2656     2.01
REMARK 500   CB   ARG B    24     N    PHE A   317     2656     2.01
REMARK 500   CA   ARG B    24     N    PHE A   317     2656     2.01
REMARK 500   N    ARG B   218     C    LEU B   214     2655     2.02
REMARK 500   O    HOH     525     O    LEU B   348     2656     2.02
REMARK 500   CA   GLY B    41     CD1  PHE A   300     2656     2.02
REMARK 500   CB   ALA B    38     C    PHE A   300     2656     2.02
REMARK 500   C    GLY B   257     N    GLU A   293     2656     2.02
REMARK 500   CA   ALA B   350     OE2  GLU B    35     2656     2.02
REMARK 500   CD1  PHE B    40     N    PRO A   299     2656     2.02
REMARK 500   CA   ASP B    26     NH2  ARG A   323     2656     2.02
REMARK 500   O    PRO B    23     CA   ARG A   320     2656     2.02
REMARK 500   O    HOH     111     CZ   PHE B    40     2656     2.03
REMARK 500   O    HOH     112     O    ASP B   256     2656     2.03
REMARK 500   O    HOH     262     O    THR B    25     2656     2.03
REMARK 500   O    SER B    77     O    LEU A   369     2656     2.03
REMARK 500   O    GLU B    35     CA   VAL A   328     2656     2.03
REMARK 500   O    HOH     544     CG   LYS B   216     2655     2.04
REMARK 500   O    ARG B   218     CD2  LEU B   178     2655     2.04
REMARK 500   CA   GLY B    70     N    ASP A   222     2656     2.04
REMARK 500   CB   PHE B   259     C    LEU A   294     2656     2.04
REMARK 500   CG   TYR B   258     C    SER A   290     2656     2.04
REMARK 500   O    PRO B    83     CG   ASP B    81     2656     2.04
REMARK 500   O    ASN B   255     CA   ASP A   292     2656     2.04
REMARK 500   C    ARG B    24     CA   ALA A   316     2656     2.05
REMARK 500   CB   ARG B    24     CB   PHE A   317     2656     2.05
REMARK 500   N    PHE B    40     O    PRO A   298     2656     2.05
REMARK 500   O    HOH     262     C    ASP B    26     2656     2.05
REMARK 500   CB   PRO B    23     C    ARG A   320     2656     2.05
REMARK 500   N    ALA B   350     CD1  TRP B   347     2656     2.05
REMARK 500   CB   VAL B   337     CA   ALA A   324     2656     2.05
REMARK 500   CE2  PHE B    29     N    ALA A   324     2656     2.05
REMARK 500   O    HOH     358     CD2  PHE B   344     2656     2.06
REMARK 500   O    HOH     139     C    ARG A   319     2656     2.06
REMARK 500   O    HOH     253     CB   MET B    33     2656     2.06
REMARK 500   O    ILE B   260     N    GLU A   293     2656     2.06
REMARK 500   CA   THR B    39     N    PHE A   300     2656     2.07
REMARK 500   O    ALA B    38     C    PHE A   300     2656     2.07
REMARK 500   CG   LEU B    37     N    VAL A   326     2656     2.07
REMARK 500   O    HOH     259     C    ARG B    28     2656     2.07
REMARK 500   O    LEU B    37     CG1  VAL A   326     2656     2.07
REMARK 500   O    HOH     311     CB   ALA B    66     2656     2.07
REMARK 500   CA   ALA B    44     CE1  PHE A   317     2656     2.07
REMARK 500   CD2  PHE B   344     O    GLY A   325     2656     2.08
REMARK 500   CA   SER B    21     NH2  ARG A   320     2656     2.08
REMARK 500   O    HOH     492     CA   GLY B    70     2656     2.08
REMARK 500   N    THR B    25     CA   ALA A   316     2656     2.08
REMARK 500   NH2  ARG B    24     CB   VAL A   302     2656     2.08
REMARK 500   CD1  PHE B   259     O    ARG A   295     2656     2.08
REMARK 500   O    GLY B    22     NE   ARG A   320     2656     2.08
REMARK 500   N    SER B    20     CG   PHE A   288     2656     2.08
REMARK 500   CB   ALA B    46     O    GLU A   293     2656     2.08
REMARK 500   CB   PRO B   349     NE2  HIS B   346     2656     2.08
REMARK 500   CG1  VAL B   337     O    ALA A   324     2656     2.08
REMARK 500   O    SER B    21     NH1  ARG A   320     2656     2.08
REMARK 500   CA   VAL B    45     CB   ALA A   289     2656     2.08
REMARK 500   N    ALA B    48     CG   ARG A   217     2656     2.08
REMARK 500   CB   ALA B    47     N    LEU A   214     2656     2.08
REMARK 500   CA   LEU B    82     O    ASP B    81     2656     2.09
REMARK 500   O    HOH     370     N    ALA B   350     2656     2.09
REMARK 500   CB   PRO B    50     CZ   ARG A   218     2656     2.09
REMARK 500   O    HOH     525     CB   LEU B   348     2656     2.09
REMARK 500   O    LEU B   336     NH2  ARG A   295     2656     2.09
REMARK 500   C    VAL B    45     CD2  LEU A   213     2656     2.09
REMARK 500   N    GLY B   257     CA   GLU A   293     2656     2.09
REMARK 500   O    ASN B   255     CB   ASP A   292     2656     2.10
REMARK 500   O    HOH     458     ND1  HIS B   346     2656     2.10
REMARK 500   CG   ASP B    43     CD2  PHE A   300     2656     2.10
REMARK 500   CE1  PHE B   259     O    GLY A   296     2656     2.10
REMARK 500   OG1  THR B    25     NH2  ARG A   320     2656     2.10
REMARK 500   CE2  PHE B   259     CA   GLY A   296     2656     2.10
REMARK 500   CA   ARG B    24     O    ALA A   316     2656     2.10
REMARK 500   O    HOH      24     OE1  GLU B    35     2656     2.10
REMARK 500   CA   PHE B   259     C    ARG A   295     2656     2.11
REMARK 500   O    HOH     189     CG   ASN B   255     2656     2.11
REMARK 500   CG   ARG B   217     CB   LYS B   216     2655     2.11
REMARK 500   C    SER B    21     NH2  ARG A   320     2656     2.11
REMARK 500   O    ARG B    24     O    ALA A   316     2656     2.11
REMARK 500   CG   PRO B    83     C    ASP B    81     2656     2.11
REMARK 500   CG1  VAL B    45     CA   ALA A   289     2656     2.11
REMARK 500   NH1  ARG B    15     N    ALA A   289     2656     2.11
REMARK 500   CD1  LEU B    42     CB   LEU A   297     2656     2.11
REMARK 500   NH2  ARG B    24     CG2  VAL A   302     2656     2.11
REMARK 500   O    HOH     483     N    PRO B   349     2656     2.11
REMARK 500   CD1  LEU B    42     N    LEU A   297     2656     2.11
REMARK 500   CA   SER B    30     N    SER B    30     2656     2.11
REMARK 500   CB   ALA B   351     OE1  GLU B    35     2656     2.11
REMARK 500   O    HOH     482     OE2  GLU A   293     2656     2.12
REMARK 500   O    SER B    20     N    PHE A   288     2656     2.12
REMARK 500   N    LEU B    37     CA   VAL A   326     2656     2.12
REMARK 500   O    ALA B    36     O    ASP A   327     2656     2.12
REMARK 500   CB   PHE B   259     CB   ARG A   295     2656     2.12
REMARK 500   O    VAL B    45     CD2  LEU A   213     2656     2.12
REMARK 500   CB   PHE B   259     O    LEU A   294     2656     2.12
REMARK 500   O    HOH     492     N    GLY B    70     2656     2.12
REMARK 500   O    HOH     516     C    GLU B   261     2656     2.12
REMARK 500   O    GLU B    19     CD1  PHE A   288     2656     2.13
REMARK 500   O    HOH     119     CD2  LEU A   294     2656     2.13
REMARK 500   C    ALA B    44     CD2  LEU A   294     2656     2.13
REMARK 500   O    ARG B   220     CD   ARG B   218     2655     2.13
REMARK 500   N    THR B    39     O    ASP A   327     2656     2.13
REMARK 500   CA   ALA B    44     CE2  PHE A   317     2656     2.13
REMARK 500   C    ALA B    38     CB   PHE A   300     2656     2.13
REMARK 500   C    ASP B    43     CZ   PHE A   317     2656     2.13
REMARK 500   CE2  TYR B   258     CB   GLU A   291     2656     2.13
REMARK 500   OD1  ASP B    26     CZ   ARG A   323     2656     2.13
REMARK 500   O    ARG B   217     N    LYS B   216     2655     2.13
REMARK 500   C    SER B    20     C    TYR A   287     2656     2.13
REMARK 500   N    GLY B    22     NE   ARG A   320     2656     2.13
REMARK 500   CA   PHE B   259     O    ARG A   295     2656     2.13
REMARK 500   N    LEU B   221     CG   ARG B   218     2655     2.13
REMARK 500   CB   GLU B    35     C    VAL A   328     2656     2.14
REMARK 500   N    ILE B   260     O    ASP A   292     2656     2.14
REMARK 500   CE2  PHE B   259     N    GLY A   296     2656     2.14
REMARK 500   CG   PRO B   349     CG   TRP B   347     2656     2.14
REMARK 500   N    ILE B   260     NZ   LYS A   216     2656     2.14
REMARK 500   CG   GLU B   261     CD   GLU A   293     2656     2.14
REMARK 500   CB   PHE B    29     C    ARG A   319     2656     2.14
REMARK 500   CB   ALA B    36     OD1  ASP A   327     2656     2.14
REMARK 500   C    ALA B    38     C    PHE A   300     2656     2.14
REMARK 500   O    HOH     105     CE2  PHE B   344     2656     2.15
REMARK 500   O    ARG B   217     C    LEU B   214     2655     2.15
REMARK 500   CG   PRO B    49     C    ARG A   217     2656     2.15
REMARK 500   C    ALA B    36     CB   ASP A   327     2656     2.15
REMARK 500   O    HOH     167     CB   ARG A   319     2656     2.15
REMARK 500   CB   ALA B    36     N    ASP A   327     2656     2.15
REMARK 500   O    HOH     130     CB   PHE A   317     2656     2.15
REMARK 500   O    ARG B   217     C    LEU B   213     2655     2.16
REMARK 500   C    ALA B   350     CD   GLU B    35     2656     2.16
REMARK 500   CG   PHE B   344     O    GLY A   325     2656     2.16
REMARK 500   CB   ALA B    47     C    LEU A   213     2656     2.16
REMARK 500   O    HOH     312     O    THR B    25     2656     2.16
REMARK 500   CA   GLY B   257     CG   GLU A   293     2656     2.16
REMARK 500   CE3  TRP B   347     CG   ASP A   327     2656     2.16
REMARK 500   O    LYS B   216     C    LEU B   214     2655     2.16
REMARK 500   O    GLY B    22     CZ   ARG A   320     2656     2.16
REMARK 500   CD   ARG B   217     CB   LYS B   216     2655     2.17
REMARK 500   CB   PHE B    40     N    PRO A   299     2656     2.17
REMARK 500   CD2  PHE B    29     C    ARG A   320     2656     2.17
REMARK 500   CA   PHE B    40     CB   PRO A   298     2656     2.17
REMARK 500   O    ARG B    24     N    PHE A   317     2656     2.17
REMARK 500   CA   ARG B    28     CD   ARG A   323     2656     2.17
REMARK 500   CG   LEU B    42     CG   LEU A   297     2656     2.17
REMARK 500   CE2  PHE B    29     C    ARG A   320     2656     2.17
REMARK 500   C    ALA B    36     O    ASP A   327     2656     2.17
REMARK 500   C    ILE B   260     O    ASP A   292     2656     2.17
REMARK 500   C    PHE B   259     N    ARG A   295     2656     2.17
REMARK 500   O    ALA B   350     OE2  GLU B    35     2656     2.17
REMARK 500   O    HOH     246     CA   GLY B   264     2656     2.18
REMARK 500   C    PRO B    23     CA   ARG A   320     2656     2.18
REMARK 500   N    PHE B   259     O    LEU A   294     2656     2.18
REMARK 500   C    TYR B   258     C    LEU A   294     2656     2.18
REMARK 500   O    ARG B    28     CD   ARG A   323     2656     2.18
REMARK 500   CG   GLU B    35     O    VAL A   328     2656     2.18
REMARK 500   CZ   PHE B   259     N    GLY A   296     2656     2.18
REMARK 500   O    HOH     176     CB   PRO B    31     2656     2.19
REMARK 500   CG   PHE B    40     N    PRO A   299     2656     2.19
REMARK 500   C    GLY B    22     NH1  ARG A   320     2656     2.19
REMARK 500   O    HOH      57     CE1  PHE B   344     2656     2.19
REMARK 500   O    ALA B   215     O    LEU B   214     2655     2.19
REMARK 500   CD1  PHE B    29     CA   ARG A   320     2656     2.19
REMARK 500   O    HOH     259     O    PRO B    27     2656     2.19
REMARK 500   CA   SER B    20     CA   PHE A   288     2656     2.19
REMARK 500   CB   TYR B   258     N    ASP A   292     2656     2.20
REMARK 500   O    HOH     259     C    PHE B    29     2656     2.20
REMARK 500   CE2  TYR B   258     N    GLU A   291     2656     2.20
REMARK 500   OD1  ASP B   222     NH1  ARG B   218     2655     2.20
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 PHE B  300    VAL B  301          0       148.76
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 15 DEGREES (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION
REMARK 500 CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500  0 LEU A 121   CA  -  CB  -  CG  ANGL. DEV. =  22.0 DEGREES
REMARK 500  0 ARG A 220   CD  -  NE  -  CZ  ANGL. DEV. =  15.5 DEGREES
REMARK 500  0 VAL A 304   N   -  CA  -  CB  ANGL. DEV. =  17.5 DEGREES
REMARK 500  0 VAL A 328   C   -  CA  -  CB  ANGL. DEV. =  15.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
DBREF  1JKM A   13   370  PDB    1JKM     1JKM            13    370
DBREF  1JKM B   10   370  PDB    1JKM     1JKM            10    370
SEQRES   1 A  358  PRO GLY ARG LEU GLY ASP GLU SER SER GLY PRO ARG THR
SEQRES   2 A  358  ASP PRO ARG PHE SER PRO ALA MET VAL GLU ALA LEU ALA
SEQRES   3 A  358  THR PHE GLY LEU ASP ALA VAL ALA ALA ALA PRO PRO VAL
SEQRES   4 A  358  SER ALA SER ASP ASP LEU PRO THR VAL LEU ALA ALA VAL
SEQRES   5 A  358  GLY ALA SER HIS ASP GLY PHE GLN ALA VAL TYR ASP SER
SEQRES   6 A  358  ILE ALA LEU ASP LEU PRO THR ASP ARG ASP ASP VAL GLU
SEQRES   7 A  358  THR SER THR GLU THR ILE LEU GLY VAL ASP GLY ASN GLU
SEQRES   8 A  358  ILE THR LEU HIS VAL PHE ARG PRO ALA GLY VAL GLU GLY
SEQRES   9 A  358  VAL LEU PRO GLY LEU VAL TYR THR HIS GLY GLY GLY MET
SEQRES  10 A  358  THR ILE LEU THR THR ASP ASN ARG VAL HIS ARG ARG TRP
SEQRES  11 A  358  CYS THR ASP LEU ALA ALA ALA GLY SER VAL VAL VAL MET
SEQRES  12 A  358  VAL ASP PHE ARG ASN ALA TRP THR ALA GLU GLY HIS HIS
SEQRES  13 A  358  PRO PHE PRO SER GLY VAL GLU ASP CYS LEU ALA ALA VAL
SEQRES  14 A  358  LEU TRP VAL ASP GLU HIS ARG GLU SER LEU GLY LEU SER
SEQRES  15 A  358  GLY VAL VAL VAL GLN GLY GLU SER GLY GLY GLY ASN LEU
SEQRES  16 A  358  ALA ILE ALA THR THR LEU LEU ALA LYS ARG ARG GLY ARG
SEQRES  17 A  358  LEU ASP ALA ILE ASP GLY VAL TYR ALA SER ILE PRO TYR
SEQRES  18 A  358  ILE SER GLY GLY TYR ALA TRP ASP HIS GLU ARG ARG LEU
SEQRES  19 A  358  THR GLU LEU PRO SER LEU VAL GLU ASN ASP GLY TYR PHE
SEQRES  20 A  358  ILE GLU ASN GLY GLY MET ALA LEU LEU VAL ARG ALA TYR
SEQRES  21 A  358  ASP PRO THR GLY GLU HIS ALA GLU ASP PRO ILE ALA TRP
SEQRES  22 A  358  PRO TYR PHE ALA SER GLU ASP GLU LEU ARG GLY LEU PRO
SEQRES  23 A  358  PRO PHE VAL VAL ALA VAL ASN GLU LEU ASP PRO LEU ARG
SEQRES  24 A  358  ASP GLU GLY ILE ALA PHE ALA ARG ARG LEU ALA ARG ALA
SEQRES  25 A  358  GLY VAL ASP VAL ALA ALA ARG VAL ASN ILE GLY LEU VAL
SEQRES  26 A  358  HIS GLY ALA ASP VAL ILE PHE ARG HIS TRP LEU PRO ALA
SEQRES  27 A  358  ALA LEU GLU SER THR VAL ARG ASP VAL ALA GLY PHE ALA
SEQRES  28 A  358  ALA ASP ARG ALA ARG LEU ARG
SEQRES   1 B  361  TYR THR PRO PRO GLY ARG LEU GLY ASP GLU SER SER GLY
SEQRES   2 B  361  PRO ARG THR ASP PRO ARG PHE SER PRO ALA MET VAL GLU
SEQRES   3 B  361  ALA LEU ALA THR PHE GLY LEU ASP ALA VAL ALA ALA ALA
SEQRES   4 B  361  PRO PRO VAL SER ALA SER ASP ASP LEU PRO THR VAL LEU
SEQRES   5 B  361  ALA ALA VAL GLY ALA SER HIS ASP GLY PHE GLN ALA VAL
SEQRES   6 B  361  TYR ASP SER ILE ALA LEU ASP LEU PRO THR ASP ARG ASP
SEQRES   7 B  361  ASP VAL GLU THR SER THR GLU THR ILE LEU GLY VAL ASP
SEQRES   8 B  361  GLY ASN GLU ILE THR LEU HIS VAL PHE ARG PRO ALA GLY
SEQRES   9 B  361  VAL GLU GLY VAL LEU PRO GLY LEU VAL TYR THR HIS GLY
SEQRES  10 B  361  GLY GLY MET THR ILE LEU THR THR ASP ASN ARG VAL HIS
SEQRES  11 B  361  ARG ARG TRP CYS THR ASP LEU ALA ALA ALA GLY SER VAL
SEQRES  12 B  361  VAL VAL MET VAL ASP PHE ARG ASN ALA TRP THR ALA GLU
SEQRES  13 B  361  GLY HIS HIS PRO PHE PRO SER GLY VAL GLU ASP CYS LEU
SEQRES  14 B  361  ALA ALA VAL LEU TRP VAL ASP GLU HIS ARG GLU SER LEU
SEQRES  15 B  361  GLY LEU SER GLY VAL VAL VAL GLN GLY GLU SER GLY GLY
SEQRES  16 B  361  GLY ASN LEU ALA ILE ALA THR THR LEU LEU ALA LYS ARG
SEQRES  17 B  361  ARG GLY ARG LEU ASP ALA ILE ASP GLY VAL TYR ALA SER
SEQRES  18 B  361  ILE PRO TYR ILE SER GLY GLY TYR ALA TRP ASP HIS GLU
SEQRES  19 B  361  ARG ARG LEU THR GLU LEU PRO SER LEU VAL GLU ASN ASP
SEQRES  20 B  361  GLY TYR PHE ILE GLU ASN GLY GLY MET ALA LEU LEU VAL
SEQRES  21 B  361  ARG ALA TYR ASP PRO THR GLY GLU HIS ALA GLU ASP PRO
SEQRES  22 B  361  ILE ALA TRP PRO TYR PHE ALA SER GLU ASP GLU LEU ARG
SEQRES  23 B  361  GLY LEU PRO PRO PHE VAL VAL ALA VAL ASN GLU LEU ASP
SEQRES  24 B  361  PRO LEU ARG ASP GLU GLY ILE ALA PHE ALA ARG ARG LEU
SEQRES  25 B  361  ALA ARG ALA GLY VAL ASP VAL ALA ALA ARG VAL ASN ILE
SEQRES  26 B  361  GLY LEU VAL HIS GLY ALA ASP VAL ILE PHE ARG HIS TRP
SEQRES  27 B  361  LEU PRO ALA ALA LEU GLU SER THR VAL ARG ASP VAL ALA
SEQRES  28 B  361  GLY PHE ALA ALA ASP ARG ALA ARG LEU ARG
FORMUL   3  HOH   *531(H2 O1)
HELIX    1   1 GLY A   14  GLY A   17  1                                   4
HELIX    2   2 PRO A   31  PHE A   40  1                                  10
HELIX    3   3 LEU A   57  SER A   77  1                                  21
HELIX    4   4 ARG A  137  ALA A  148  1                                  12
HELIX    5   5 SER A  172  LEU A  191  1                                  20
HELIX    6   6 SER A  202  ARG A  217  5                                  16
HELIX    7   7 LEU A  221  ALA A  223  5                                   3
HELIX    8   8 HIS A  242  GLU A  248  1                                   7
HELIX    9   9 PRO A  250  GLU A  254  5                                   5
HELIX   10  10 ASN A  262  TYR A  272  1                                  11
HELIX   11  11 PRO A  286  PHE A  288  5                                   3
HELIX   12  12 GLU A  291  LEU A  294  1                                   4
HELIX   13  13 PRO A  309  ARG A  323  5                                  15
HELIX   14  14 ALA A  340  ILE A  343  1                                   4
HELIX   15  15 ARG A  345  TRP A  347  5                                   3
HELIX   16  16 PRO A  349  ARG A  368  1                                  20
HELIX   17  17 GLY B   14  GLY B   17  1                                   4
HELIX   18  18 PRO B   31  PHE B   40  1                                  10
HELIX   19  19 LEU B   57  SER B   77  1                                  21
HELIX   20  20 ARG B  137  ALA B  148  1                                  12
HELIX   21  21 SER B  172  GLU B  186  1                                  15
HELIX   22  22 ARG B  188  LEU B  191  1                                   4
HELIX   23  23 SER B  202  ARG B  217  5                                  16
HELIX   24  24 LEU B  221  ALA B  223  5                                   3
HELIX   25  25 HIS B  242  GLU B  248  1                                   7
HELIX   26  26 PRO B  250  GLU B  254  5                                   5
HELIX   27  27 ASN B  262  TYR B  272  1                                  11
HELIX   28  28 PRO B  286  PHE B  288  5                                   3
HELIX   29  29 GLU B  291  LEU B  294  1                                   4
HELIX   30  30 PRO B  309  ARG B  323  5                                  15
HELIX   31  31 ALA B  340  ILE B  343  1                                   4
HELIX   32  32 ARG B  345  TRP B  347  5                                   3
HELIX   33  33 PRO B  349  ARG B  368  1                                  20
SHEET    1   A 8 VAL A  89  LEU A  97  0
SHEET    2   A 8 GLU A 103  PRO A 111 -1  N  ARG A 110   O  GLU A  90
SHEET    3   A 8 VAL A 152  ASP A 157 -1  N  ASP A 157   O  THR A 105
SHEET    4   A 8 LEU A 118  THR A 124  1  N  LEU A 121   O  VAL A 152
SHEET    5   A 8 LEU A 193  GLU A 201  1  N  SER A 194   O  LEU A 118
SHEET    6   A 8 GLY A 226  SER A 230  1  N  GLY A 226   O  VAL A 198
SHEET    7   A 8 PRO A 299  ASN A 305  1  N  PRO A 299   O  VAL A 227
SHEET    8   A 8 VAL A 328  ASN A 333  1  N  ALA A 329   O  PHE A 300
SHEET    1   B 8 VAL B  89  LEU B  97  0
SHEET    2   B 8 GLU B 103  PRO B 111 -1  N  ARG B 110   O  GLU B  90
SHEET    3   B 8 SER B 151  VAL B 156 -1  N  MET B 155   O  HIS B 107
SHEET    4   B 8 LEU B 118  THR B 124  1  N  PRO B 119   O  VAL B 152
SHEET    5   B 8 LEU B 193  GLU B 201  1  N  SER B 194   O  LEU B 118
SHEET    6   B 8 GLY B 226  SER B 230  1  N  GLY B 226   O  VAL B 198
SHEET    7   B 8 PRO B 299  ASN B 305  1  N  PRO B 299   O  VAL B 227
SHEET    8   B 8 VAL B 328  ASN B 333  1  N  ALA B 329   O  PHE B 300
CISPEP   1 PHE A  170    PRO A  171          0         7.03
CISPEP   2 PHE B  170    PRO B  171          0        13.08
CRYST1  140.700   82.600   81.500  90.00 112.50  90.00 C 1 2 1       4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007107  0.000000  0.002944        0.00000
SCALE2      0.000000  0.012107  0.000000        0.00000
SCALE3      0.000000  0.000000  0.013281        0.00000