longtext: 1N8S-pdb

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HEADER    HYDROLASE                               21-NOV-02   1N8S
TITLE     STRUCTURE OF THE PANCREATIC LIPASE-COLIPASE COMPLEX
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: TRIACYLGLYCEROL LIPASE, PANCREATIC;
COMPND   3 CHAIN: A;
COMPND   4 SYNONYM: PANCREATIC LIPASE, PL;
COMPND   5 EC: 3.1.1.3;
COMPND   6 MOL_ID: 2;
COMPND   7 MOLECULE: COLIPASE II;
COMPND   8 CHAIN: C
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 OTHER_DETAILS: PANCREATIC JUICE;
SOURCE   5 MOL_ID: 2;
SOURCE   6 ORGANISM_SCIENTIFIC: SUS SCROFA;
SOURCE   7 ORGANISM_COMMON: PIG;
SOURCE   8 OTHER_DETAILS: EXTRACTED FROM PANCREAS
KEYWDS    HYDROLASE, PANCREAS, SIGNAL
EXPDTA    X-RAY DIFFRACTION
AUTHOR    H.VAN TILBEURGH,L.SARDA,R.VERGER,C.CAMBILLAU
REVDAT   1   18-DEC-02 1N8S    0
JRNL        AUTH   H.VAN TILBEURGH,L.SARDA,R.VERGER,C.CAMBILLAU
JRNL        TITL   STRUCTURE OF THE PANCREATIC LIPASE-PROCOLIPASE
JRNL        TITL 2 COMPLEX
JRNL        REF    NATURE                        V. 359   159 1992
JRNL        REFN   ASTM NATUAS  UK ISSN 0028-0836
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 3.04 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : X-PLOR
REMARK   3   AUTHORS     : BRUNGER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.04
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 8.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 1.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL
REMARK   3   NUMBER OF REFLECTIONS             : 17720
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : NULL
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.230
REMARK   3   FREE R VALUE                     : 0.290
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL
REMARK   3   FREE R VALUE TEST SET COUNT      : 1114
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL
REMARK   3   BIN R VALUE           (WORKING SET) : NULL
REMARK   3   BIN FREE R VALUE                    : NULL
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4131
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 0
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL
REMARK   3   ESD FROM SIGMAA              (A) : NULL
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.003
REMARK   3   BOND ANGLES            (DEGREES) : NULL
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : NULL
REMARK   3  TOPOLOGY FILE  1   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 1N8S COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-DEC-2002.
REMARK 100 THE RCSB ID CODE IS RCSB017661.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 11-DEC-1991; 11-DEC-1991
REMARK 200  TEMPERATURE           (KELVIN) : 277; 277
REMARK 200  PH                             : 6.00
REMARK 200  NUMBER OF CRYSTALS USED        : 2
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y; Y
REMARK 200  RADIATION SOURCE               : LURE ; LURE
REMARK 200  BEAMLINE                       : DW32; DW32
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M; M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.98; 0.98
REMARK 200  MONOCHROMATOR                  : MIRRORS; MIRRORS
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE; IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH; MARRESEARCH
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MARXDS
REMARK 200  DATA SCALING SOFTWARE          : MARSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 17720
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.040
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 92.0
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : 0.08500
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.04
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.15
REMARK 200  COMPLETENESS FOR SHELL     (%) : 62.0
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MIR
REMARK 200 SOFTWARE USED: MLPHARE
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): NULL
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: NACL-0.2-0.5M, PEG 8000 2%, MES
REMARK 280  0.1M, BETAOG BEYOND CMC, PH 6.0, VAPOR DIFFUSION, HANGING
REMARK 280  DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 32 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,2/3+Z
REMARK 290       3555   -X+Y,-X,1/3+Z
REMARK 290       4555   Y,X,-Z
REMARK 290       5555   X-Y,-Y,1/3-Z
REMARK 290       6555   -X,-X+Y,2/3-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      167.33333
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       83.66667
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       83.66667
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      167.33333
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     VAL C   501
REMARK 465     PRO C   502
REMARK 465     ASP C   503
REMARK 465     PRO C   504
REMARK 465     ARG C   505
REMARK 465     GLY C   591
REMARK 465     ARG C   592
REMARK 465     SER C   593
REMARK 465     ASP C   594
REMARK 465     SER C   595
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A 337   CA  -  CB  -  CG  ANGL. DEV. =-25.2 DEGREES
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ARG A   7      -52.74     82.20
REMARK 500    SER A 333     -105.51     53.06
REMARK 500    THR C 532      142.85     73.80
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 1LPA   RELATED DB: PDB
REMARK 900 RELATED ID: 1LPB   RELATED DB: PDB
DBREF  1N8S A    1   449  SWS    P16233   LIPP_HUMAN      17    465
DBREF  1N8S C  501   595  PIR    XLPG2    XLPG2            1     95
SEQRES   1 A  449  LYS GLU VAL CYS TYR GLU ARG LEU GLY CYS PHE SER ASP
SEQRES   2 A  449  ASP SER PRO TRP SER GLY ILE THR GLU ARG PRO LEU HIS
SEQRES   3 A  449  ILE LEU PRO TRP SER PRO LYS ASP VAL ASN THR ARG PHE
SEQRES   4 A  449  LEU LEU TYR THR ASN GLU ASN PRO ASN ASN PHE GLN GLU
SEQRES   5 A  449  VAL ALA ALA ASP SER SER SER ILE SER GLY SER ASN PHE
SEQRES   6 A  449  LYS THR ASN ARG LYS THR ARG PHE ILE ILE HIS GLY PHE
SEQRES   7 A  449  ILE ASP LYS GLY GLU GLU ASN TRP LEU ALA ASN VAL CYS
SEQRES   8 A  449  LYS ASN LEU PHE LYS VAL GLU SER VAL ASN CYS ILE CYS
SEQRES   9 A  449  VAL ASP TRP LYS GLY GLY SER ARG THR GLY TYR THR GLN
SEQRES  10 A  449  ALA SER GLN ASN ILE ARG ILE VAL GLY ALA GLU VAL ALA
SEQRES  11 A  449  TYR PHE VAL GLU PHE LEU GLN SER ALA PHE GLY TYR SER
SEQRES  12 A  449  PRO SER ASN VAL HIS VAL ILE GLY HIS SER LEU GLY ALA
SEQRES  13 A  449  HIS ALA ALA GLY GLU ALA GLY ARG ARG THR ASN GLY THR
SEQRES  14 A  449  ILE GLY ARG ILE THR GLY LEU ASP PRO ALA GLU PRO CYS
SEQRES  15 A  449  PHE GLN GLY THR PRO GLU LEU VAL ARG LEU ASP PRO SER
SEQRES  16 A  449  ASP ALA LYS PHE VAL ASP VAL ILE HIS THR ASP GLY ALA
SEQRES  17 A  449  PRO ILE VAL PRO ASN LEU GLY PHE GLY MET SER GLN VAL
SEQRES  18 A  449  VAL GLY HIS LEU ASP PHE PHE PRO ASN GLY GLY VAL GLU
SEQRES  19 A  449  MET PRO GLY CYS LYS LYS ASN ILE LEU SER GLN ILE VAL
SEQRES  20 A  449  ASP ILE ASP GLY ILE TRP GLU GLY THR ARG ASP PHE ALA
SEQRES  21 A  449  ALA CYS ASN HIS LEU ARG SER TYR LYS TYR TYR THR ASP
SEQRES  22 A  449  SER ILE VAL ASN PRO ASP GLY PHE ALA GLY PHE PRO CYS
SEQRES  23 A  449  ALA SER TYR ASN VAL PHE THR ALA ASN LYS CYS PHE PRO
SEQRES  24 A  449  CYS PRO SER GLY GLY CYS PRO GLN MET GLY HIS TYR ALA
SEQRES  25 A  449  ASP ARG TYR PRO GLY LYS THR ASN ASP VAL GLY GLN LYS
SEQRES  26 A  449  PHE TYR LEU ASP THR GLY ASP ALA SER ASN PHE ALA ARG
SEQRES  27 A  449  TRP ARG TYR LYS VAL SER VAL THR LEU SER GLY LYS LYS
SEQRES  28 A  449  VAL THR GLY HIS ILE LEU VAL SER LEU PHE GLY ASN LYS
SEQRES  29 A  449  GLY ASN SER LYS GLN TYR GLU ILE PHE LYS GLY THR LEU
SEQRES  30 A  449  LYS PRO ASP SER THR HIS SER ASN GLU PHE ASP SER ASP
SEQRES  31 A  449  VAL ASP VAL GLY ASP LEU GLN MET VAL LYS PHE ILE TRP
SEQRES  32 A  449  TYR ASN ASN VAL ILE ASN PRO THR LEU PRO ARG VAL GLY
SEQRES  33 A  449  ALA SER LYS ILE ILE VAL GLU THR ASN VAL GLY LYS GLN
SEQRES  34 A  449  PHE ASN PHE CYS SER PRO GLU THR VAL ARG GLU GLU VAL
SEQRES  35 A  449  LEU LEU THR LEU THR PRO CYS
SEQRES   1 C   95  VAL PRO ASP PRO ARG GLY ILE ILE ILE ASN LEU ASP GLU
SEQRES   2 C   95  GLY GLU LEU CYS LEU ASN SER ALA GLN CYS LYS SER ASN
SEQRES   3 C   95  CYS CYS GLN HIS ASP THR ILE LEU SER LEU LEU ARG CYS
SEQRES   4 C   95  ALA LEU LYS ALA ARG GLU ASN SER GLU CYS SER ALA PHE
SEQRES   5 C   95  THR LEU TYR GLY VAL TYR TYR LYS CYS PRO CYS GLU ARG
SEQRES   6 C   95  GLY LEU THR CYS GLU GLY ASP LYS SER LEU VAL GLY SER
SEQRES   7 C   95  ILE THR ASN THR ASN PHE GLY ILE CYS HIS ASN VAL GLY
SEQRES   8 C   95  ARG SER ASP SER
HELIX    1   1 SER A   30B ASN A   35  1                                   6
HELIX    2   2 ASP A   55  SER A   60  1                                   6
HELIX    3   3 GLY A   81  GLU A   83  5                                   3
HELIX    4   4 ASN A   84  GLU A   97  1                                  14
HELIX    5   5 TRP A  106  ARG A  111  1                                   6
HELIX    6   6 GLY A  113  GLY A  140  1                                  28
HELIX    7   7 SER A  142  SER A  144  5                                   3
HELIX    8   8 SER A  152  THR A  165  1                                  14
HELIX    9   9 ASP A  192  ALA A  196  5                                   5
HELIX   10  10 ASP A  247  GLU A  253  1                                   7
HELIX   11  11 ALA A  260  VAL A  275  1                                  16
HELIX   12  12 SER A  287  ALA A  293  1                                   7
HELIX   13  13 TYR A  310  TYR A  314  5                                   5
HELIX   14  14 ASN C  519  CYS C  523  5                                   5
SHEET    1   A 2 CYS A   4  TYR A   5  0
SHEET    2   A 2 GLY A   9  CYS A  10 -1  O  GLY A   9   N  TYR A   5
SHEET    1   B 9 ASN A  45  VAL A  52  0
SHEET    2   B 9 ARG A  37  THR A  42 -1  O  PHE A  38   N  VAL A  52
SHEET    3   B 9 VAL A  99  ASP A 105 -1  N  CYS A 101   O  TYR A  41
SHEET    4   B 9 LYS A  69  ILE A  74  1  O  LYS A  69   N  ASN A 100
SHEET    5   B 9 VAL A 146  HIS A 151  1  O  HIS A 147   N  PHE A  72
SHEET    6   B 9 ARG A 171  LEU A 175  1  O  ARG A 171   N  VAL A 148
SHEET    7   B 9 PHE A 198  ILE A 202  1  O  PHE A 198   N  ILE A 172
SHEET    8   B 9 LEU A 224  PRO A 228  1  O  LEU A 224   N  VAL A 201
SHEET    9   B 9 GLN A 323  LEU A 327  1  O  GLN A 323   N  ASP A 225
SHEET    1   C12 THR A 381  SER A 388  0
SHEET    2   C12 TRP A 338  GLY A 348 -1  N  TRP A 338   O  SER A 388
SHEET    3   C12 ARG A 414  GLU A 423 -1  N  GLY A 416   O  SER A 347
SHEET    4   C12 VAL A 438  ARG A 439 -1  N  VAL A 438   O  VAL A 415
SHEET    5   C12 ARG A 414  GLU A 423 -1  O  VAL A 415   N  VAL A 438
SHEET    6   C12 GLN A 429  CYS A 433 -1  N  PHE A 430   O  VAL A 422
SHEET    7   C12 LEU A 444  PRO A 448 -1  O  THR A 447   N  CYS A 433
SHEET    8   C12 LEU A 395  TYR A 403 -1  O  VAL A 398   N  LEU A 446
SHEET    9   C12 VAL A 351  GLY A 361 -1  N  HIS A 354   O  TYR A 403
SHEET   10   C12 GLY A 364  ASN A 365 -1  O  GLY A 364   N  GLY A 361
SHEET   11   C12 VAL A 351  GLY A 361 -1  N  GLY A 361   O  GLY A 364
SHEET   12   C12 TYR A 369  LEU A 376 -1  N  TYR A 369   O  VAL A 357
SHEET    1   D 2 CYS C 528  GLN C 529  0
SHEET    2   D 2 ARG C 538  CYS C 539 -1  N  ARG C 538   O  GLN C 529
SHEET    1   E 3 GLU C 548  SER C 550  0
SHEET    2   E 3 PHE C 584  ASN C 589 -1  O  GLY C 585   N  CYS C 549
SHEET    3   E 3 LEU C 567  GLY C 571 -1  N  THR C 568   O  HIS C 588
SSBOND   1 CYS A    4    CYS A   10
SSBOND   2 CYS A   90    CYS A  101
SSBOND   3 CYS A  237    CYS A  261
SSBOND   4 CYS A  285    CYS A  296
SSBOND   5 CYS A  299    CYS A  304
SSBOND   6 CYS A  433    CYS A  449
SSBOND   7 CYS C  517    CYS C  528
SSBOND   8 CYS C  523    CYS C  539
SSBOND   9 CYS C  527    CYS C  561
SSBOND  10 CYS C  549    CYS C  569
SSBOND  11 CYS C  563    CYS C  587
CISPEP   1 SER A   15    PRO A   16          0        16.55
CISPEP   2 VAL A  210    PRO A  211          0        16.18
CISPEP   3 PHE A  297    PRO A  298          0       -20.39
CRYST1   80.300   80.300  251.000  90.00  90.00 120.00 P 32 2 1      6
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012453  0.007190  0.000000        0.00000
SCALE2      0.000000  0.014380  0.000000        0.00000
SCALE3      0.000000  0.000000  0.003984        0.00000
TER    3492      CYS A 449
TER    4133      VAL C 590
MASTER      259    0    0   14   28    0    0    6 4131    2   22   43
END