longtext: 1Q83-pdb

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HEADER    HYDROLASE                               20-AUG-03   1Q83
TITLE     CRYSTAL STRUCTURE OF THE MOUSE ACETYLCHOLINESTERASE-TZ2PA6
TITLE    2 SYN COMPLEX
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACETYLCHOLINESTERASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: ACHE;
COMPND   5 EC: 3.1.1.7;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;
SOURCE   3 ORGANISM_COMMON: MOUSE;
SOURCE   4 GENE: ACHE;
SOURCE   5 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE   6 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE   7 EXPRESSION_SYSTEM_CELL_LINE: HEK 293;
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: LAMBDA CLONING VECTOR;
SOURCE   9 OTHER_DETAILS: LAMBDA-ZAP, LAMBDA-FIX CDNA
KEYWDS    HYDROLASE, SERINE ESTERASE, ACETYLCHOLINESTERASE,
KEYWDS   2 BIFUNCTIONAL INHIBITOR
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.BOURNE,Z.RADIC,H.C.KOLB,K.B.SHARPLESS,P.TAYLOR,P.MARCHOT
REVDAT   1   10-FEB-04 1Q83    0
JRNL        AUTH   Y.BOURNE,Z.RADIC,H.C.KOLB,K.B.SHARPLESS,P.TAYLOR,
JRNL        AUTH 2 P.MARCHOT
JRNL        TITL   FREEZE-FRAME INHIBITORS CAPTURE
JRNL        TITL 2 ACETYLCHOLINESTERASE IN A UNIQUE GATING
JRNL        TITL 3 CONFORMATION
JRNL        REF    PROC.NAT.ACAD.SCI.USA         V. 101  1449 2004
JRNL        REFN   ASTM PNASA6  US ISSN 0027-8424
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.65 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.1.24
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.65
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 58332
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.183
REMARK   3   R VALUE            (WORKING SET) : 0.182
REMARK   3   FREE R VALUE                     : 0.221
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1202
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH           : 2.65
REMARK   3   BIN RESOLUTION RANGE LOW            : 2.72
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 4204
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2740
REMARK   3   BIN FREE R VALUE SET COUNT          : 89
REMARK   3   BIN FREE R VALUE                    : 0.3530
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   ALL ATOMS                : 8768
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 61.00
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 34.49
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 3.34000
REMARK   3    B22 (A**2) : 2.97000
REMARK   3    B33 (A**2) : -6.31000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.299
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.229
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.168
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 8.258
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.955
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.935
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  8775 ; 0.015 ; 0.021
REMARK   3   BOND LENGTHS OTHERS               (A):  7858 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 11997 ; 1.530 ; 1.972
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 18148 ; 1.070 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1063 ; 6.461 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1279 ; 0.085 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  9830 ; 0.006 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  1899 ; 0.002 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  1833 ; 0.202 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  8990 ; 0.233 ; 0.200
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  5094 ; 0.087 ; 0.200
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   253 ; 0.182 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    15 ; 0.187 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):    53 ; 0.345 ; 0.200
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):     9 ; 0.232 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5328 ; 0.633 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  8584 ; 1.241 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3447 ; 1.881 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3413 ; 3.331 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 1
REMARK   3
REMARK   3  NCS GROUP NUMBER               : 1
REMARK   3     CHAIN NAMES                    : A,B
REMARK   3     NUMBER OF COMPONENTS NCS GROUP : 7
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A     16       A      56      3
REMARK   3           1     B     16       B      56      3
REMARK   3           2     A     60       A      74      3
REMARK   3           2     B     60       B      74      3
REMARK   3           3     A     80       A     256      3
REMARK   3           3     B     80       B     256      3
REMARK   3           4     A    265       A     336      3
REMARK   3           4     B    265       B     336      3
REMARK   3           5     A    343       A     382      3
REMARK   3           5     B    343       B     382      3
REMARK   3           6     A    392       A     490      3
REMARK   3           6     B    392       B     490      3
REMARK   3           7     A    508       A     539      3
REMARK   3           7     B    508       B     539      3
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   1    A    (A):   2779 ;  0.04 ;  0.05
REMARK   3   LOOSE POSITIONAL   1    A    (A):   4409 ;  0.39 ;  5.00
REMARK   3   TIGHT THERMAL      1    A (A**2):   2779 ;  1.31 ;  5.00
REMARK   3   LOOSE THERMAL      1    A (A**2):   4409 ;  1.95 ; 20.00
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 2
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     1        A   541
REMARK   3    ORIGIN FOR THE GROUP (A):  27.6795  12.4018  16.8917
REMARK   3    T TENSOR
REMARK   3      T11:   0.0541 T22:   0.0126
REMARK   3      T33:   0.0957 T12:   0.0132
REMARK   3      T13:   0.0117 T23:   0.0324
REMARK   3    L TENSOR
REMARK   3      L11:   0.8033 L22:   0.7245
REMARK   3      L33:   1.6962 L12:   0.0364
REMARK   3      L13:  -0.0204 L23:  -0.2488
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0490 S12:  -0.0450 S13:  -0.0540
REMARK   3      S21:  -0.0267 S22:   0.0101 S23:   0.0419
REMARK   3      S31:   0.1664 S32:  -0.1231 S33:   0.0388
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B     4        B   540
REMARK   3    ORIGIN FOR THE GROUP (A):   7.8248   4.4608 -40.2036
REMARK   3    T TENSOR
REMARK   3      T11:   0.0645 T22:   0.0737
REMARK   3      T33:   0.1188 T12:  -0.0304
REMARK   3      T13:  -0.0192 T23:  -0.0693
REMARK   3    L TENSOR
REMARK   3      L11:   0.6977 L22:   1.0247
REMARK   3      L33:   2.1183 L12:  -0.1624
REMARK   3      L13:   0.1377 L23:   0.3909
REMARK   3    S TENSOR
REMARK   3      S11:   0.1096 S12:   0.0951 S13:  -0.0617
REMARK   3      S21:   0.1079 S22:  -0.0984 S23:   0.1037
REMARK   3      S31:   0.1463 S32:   0.0019 S33:  -0.0111
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS
REMARK   4
REMARK   4 1Q83 COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-AUG-2003.
REMARK 100 THE RCSB ID CODE IS RCSB020034.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 01-JUL-2002
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 6.75
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID14-1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.933
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 59650
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.650
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 3.600
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.06500
REMARK 200   FOR THE DATA SET  : 8.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: FOURIER SYNTHESIS
REMARK 200 SOFTWARE USED: CNS
REMARK 200 STARTING MODEL: 1J06
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): NULL
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 25-32% PEG 600, 20 MM HEPES, PH
REMARK 280  6.75, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   1/2-X,-Y,1/2+Z
REMARK 290       3555   -X,1/2+Y,1/2-Z
REMARK 290       4555   1/2+X,1/2-Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       39.87150
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      113.28850
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       55.97700
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      113.28850
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       39.87150
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       55.97700
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -30
REMARK 465     ARG A   -29
REMARK 465     PRO A   -28
REMARK 465     PRO A   -27
REMARK 465     TRP A   -26
REMARK 465     TYR A   -25
REMARK 465     PRO A   -24
REMARK 465     LEU A   -23
REMARK 465     HIS A   -22
REMARK 465     THR A   -21
REMARK 465     PRO A   -20
REMARK 465     SER A   -19
REMARK 465     LEU A   -18
REMARK 465     ALA A   -17
REMARK 465     PHE A   -16
REMARK 465     PRO A   -15
REMARK 465     LEU A   -14
REMARK 465     LEU A   -13
REMARK 465     PHE A   -12
REMARK 465     LEU A   -11
REMARK 465     LEU A   -10
REMARK 465     LEU A    -9
REMARK 465     SER A    -8
REMARK 465     LEU A    -7
REMARK 465     LEU A    -6
REMARK 465     GLY A    -5
REMARK 465     GLY A    -4
REMARK 465     GLY A    -3
REMARK 465     ALA A    -2
REMARK 465     ARG A    -1
REMARK 465     ALA A     0
REMARK 465     PRO A   259
REMARK 465     GLY A   260
REMARK 465     GLY A   261
REMARK 465     ALA A   262
REMARK 465     GLY A   263
REMARK 465     ALA A   542
REMARK 465     THR A   543
REMARK 465     ASP A   544
REMARK 465     THR A   545
REMARK 465     LEU A   546
REMARK 465     ASP A   547
REMARK 465     GLU A   548
REMARK 465     ALA A   549
REMARK 465     MET B   -30
REMARK 465     ARG B   -29
REMARK 465     PRO B   -28
REMARK 465     PRO B   -27
REMARK 465     TRP B   -26
REMARK 465     TYR B   -25
REMARK 465     PRO B   -24
REMARK 465     LEU B   -23
REMARK 465     HIS B   -22
REMARK 465     THR B   -21
REMARK 465     PRO B   -20
REMARK 465     SER B   -19
REMARK 465     LEU B   -18
REMARK 465     ALA B   -17
REMARK 465     PHE B   -16
REMARK 465     PRO B   -15
REMARK 465     LEU B   -14
REMARK 465     LEU B   -13
REMARK 465     PHE B   -12
REMARK 465     LEU B   -11
REMARK 465     LEU B   -10
REMARK 465     LEU B    -9
REMARK 465     SER B    -8
REMARK 465     LEU B    -7
REMARK 465     LEU B    -6
REMARK 465     GLY B    -5
REMARK 465     GLY B    -4
REMARK 465     GLY B    -3
REMARK 465     ALA B    -2
REMARK 465     ARG B    -1
REMARK 465     ALA B     0
REMARK 465     GLU B     1
REMARK 465     GLY B     2
REMARK 465     ARG B     3
REMARK 465     PRO B   259
REMARK 465     GLY B   260
REMARK 465     GLY B   261
REMARK 465     ALA B   262
REMARK 465     GLY B   263
REMARK 465     GLY B   264
REMARK 465     SER B   541
REMARK 465     ALA B   542
REMARK 465     THR B   543
REMARK 465     ASP B   544
REMARK 465     THR B   545
REMARK 465     LEU B   546
REMARK 465     ASP B   547
REMARK 465     GLU B   548
REMARK 465     ALA B   549
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     SER A 495    OG
REMARK 470     LYS A 496    CG    CD    CE    NZ
REMARK 470     ARG B 493    CG    CD    NE    CZ    NH1   NH2
REMARK 470     SER B 495    OG
REMARK 470     LYS B 496    CG    CD    CE    NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI
REMARK 500   O    HOH     641     O    HOH     666              1.95
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    MET A 195   SD    MET A 195   CE     0.185
REMARK 500    MET A 211   CG    MET A 211   SD    -0.101
REMARK 500    PRO A 258   CB    PRO A 258   CG     0.199
REMARK 500    PRO A 258   CG    PRO A 258   CD     0.132
REMARK 500    MET A 443   SD    MET A 443   CE    -0.110
REMARK 500    MET B 195   SD    MET B 195   CE     0.156
REMARK 500    MET B 211   CG    MET B 211   SD    -0.102
REMARK 500    PRO B 258   CB    PRO B 258   CG     0.132
REMARK 500    MET B 443   SD    MET B 443   CE    -0.140
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    LEU A 161   CA  -  CB  -  CG  ANGL. DEV. =-12.5 DEGREES
REMARK 500    TYR A 341   CB  -  CA  -  C   ANGL. DEV. =  9.5 DEGREES
REMARK 500    GLY A 342   N   -  CA  -  C   ANGL. DEV. =  9.9 DEGREES
REMARK 500    GLY A 422   N   -  CA  -  C   ANGL. DEV. =  9.4 DEGREES
REMARK 500    VAL B 145   N   -  CA  -  C   ANGL. DEV. = -9.9 DEGREES
REMARK 500    GLY B 342   N   -  CA  -  C   ANGL. DEV. = 13.0 DEGREES
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER B 497     -131.45     27.51
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 LYS B  496    SER B  497                  149.96
REMARK 525
REMARK 525 SOLVENT
REMARK 525 THE FOLLOWING SOLVENT MOLECULES LIE FARTHER THAN EXPECTED
REMARK 525 FROM THE PROTEIN OR NUCLEIC ACID MOLECULE AND MAY BE
REMARK 525 ASSOCIATED WITH A SYMMETRY RELATED MOLECULE (M=MODEL
REMARK 525 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH   765        DISTANCE =  5.45 ANGSTROMS
REMARK 525    HOH   792        DISTANCE = 13.57 ANGSTROMS
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 1J06   RELATED DB: PDB
REMARK 900 RELATED ID: 1J07   RELATED DB: PDB
REMARK 900 RELATED ID: 1N5M   RELATED DB: PDB
REMARK 900 RELATED ID: 1N5R   RELATED DB: PDB
DBREF  1Q83 A  -30   549  SWS    P21836   ACES_MOUSE       1    580
DBREF  1Q83 B  -30   549  SWS    P21836   ACES_MOUSE       1    580
SEQRES   1 A  580  MET ARG PRO PRO TRP TYR PRO LEU HIS THR PRO SER LEU
SEQRES   2 A  580  ALA PHE PRO LEU LEU PHE LEU LEU LEU SER LEU LEU GLY
SEQRES   3 A  580  GLY GLY ALA ARG ALA GLU GLY ARG GLU ASP PRO GLN LEU
SEQRES   4 A  580  LEU VAL ARG VAL ARG GLY GLY GLN LEU ARG GLY ILE ARG
SEQRES   5 A  580  LEU LYS ALA PRO GLY GLY PRO VAL SER ALA PHE LEU GLY
SEQRES   6 A  580  ILE PRO PHE ALA GLU PRO PRO VAL GLY SER ARG ARG PHE
SEQRES   7 A  580  MET PRO PRO GLU PRO LYS ARG PRO TRP SER GLY VAL LEU
SEQRES   8 A  580  ASP ALA THR THR PHE GLN ASN VAL CYS TYR GLN TYR VAL
SEQRES   9 A  580  ASP THR LEU TYR PRO GLY PHE GLU GLY THR GLU MET TRP
SEQRES  10 A  580  ASN PRO ASN ARG GLU LEU SER GLU ASP CYS LEU TYR LEU
SEQRES  11 A  580  ASN VAL TRP THR PRO TYR PRO ARG PRO ALA SER PRO THR
SEQRES  12 A  580  PRO VAL LEU ILE TRP ILE TYR GLY GLY GLY PHE TYR SER
SEQRES  13 A  580  GLY ALA ALA SER LEU ASP VAL TYR ASP GLY ARG PHE LEU
SEQRES  14 A  580  ALA GLN VAL GLU GLY ALA VAL LEU VAL SER MET ASN TYR
SEQRES  15 A  580  ARG VAL GLY THR PHE GLY PHE LEU ALA LEU PRO GLY SER
SEQRES  16 A  580  ARG GLU ALA PRO GLY ASN VAL GLY LEU LEU ASP GLN ARG
SEQRES  17 A  580  LEU ALA LEU GLN TRP VAL GLN GLU ASN ILE ALA ALA PHE
SEQRES  18 A  580  GLY GLY ASP PRO MET SER VAL THR LEU PHE GLY GLU SER
SEQRES  19 A  580  ALA GLY ALA ALA SER VAL GLY MET HIS ILE LEU SER LEU
SEQRES  20 A  580  PRO SER ARG SER LEU PHE HIS ARG ALA VAL LEU GLN SER
SEQRES  21 A  580  GLY THR PRO ASN GLY PRO TRP ALA THR VAL SER ALA GLY
SEQRES  22 A  580  GLU ALA ARG ARG ARG ALA THR LEU LEU ALA ARG LEU VAL
SEQRES  23 A  580  GLY CYS PRO PRO GLY GLY ALA GLY GLY ASN ASP THR GLU
SEQRES  24 A  580  LEU ILE ALA CYS LEU ARG THR ARG PRO ALA GLN ASP LEU
SEQRES  25 A  580  VAL ASP HIS GLU TRP HIS VAL LEU PRO GLN GLU SER ILE
SEQRES  26 A  580  PHE ARG PHE SER PHE VAL PRO VAL VAL ASP GLY ASP PHE
SEQRES  27 A  580  LEU SER ASP THR PRO GLU ALA LEU ILE ASN THR GLY ASP
SEQRES  28 A  580  PHE GLN ASP LEU GLN VAL LEU VAL GLY VAL VAL LYS ASP
SEQRES  29 A  580  GLU GLY SER TYR PHE LEU VAL TYR GLY VAL PRO GLY PHE
SEQRES  30 A  580  SER LYS ASP ASN GLU SER LEU ILE SER ARG ALA GLN PHE
SEQRES  31 A  580  LEU ALA GLY VAL ARG ILE GLY VAL PRO GLN ALA SER ASP
SEQRES  32 A  580  LEU ALA ALA GLU ALA VAL VAL LEU HIS TYR THR ASP TRP
SEQRES  33 A  580  LEU HIS PRO GLU ASP PRO THR HIS LEU ARG ASP ALA MET
SEQRES  34 A  580  SER ALA VAL VAL GLY ASP HIS ASN VAL VAL CYS PRO VAL
SEQRES  35 A  580  ALA GLN LEU ALA GLY ARG LEU ALA ALA GLN GLY ALA ARG
SEQRES  36 A  580  VAL TYR ALA TYR ILE PHE GLU HIS ARG ALA SER THR LEU
SEQRES  37 A  580  THR TRP PRO LEU TRP MET GLY VAL PRO HIS GLY TYR GLU
SEQRES  38 A  580  ILE GLU PHE ILE PHE GLY LEU PRO LEU ASP PRO SER LEU
SEQRES  39 A  580  ASN TYR THR THR GLU GLU ARG ILE PHE ALA GLN ARG LEU
SEQRES  40 A  580  MET LYS TYR TRP THR ASN PHE ALA ARG THR GLY ASP PRO
SEQRES  41 A  580  ASN ASP PRO ARG ASP SER LYS SER PRO GLN TRP PRO PRO
SEQRES  42 A  580  TYR THR THR ALA ALA GLN GLN TYR VAL SER LEU ASN LEU
SEQRES  43 A  580  LYS PRO LEU GLU VAL ARG ARG GLY LEU ARG ALA GLN THR
SEQRES  44 A  580  CYS ALA PHE TRP ASN ARG PHE LEU PRO LYS LEU LEU SER
SEQRES  45 A  580  ALA THR ASP THR LEU ASP GLU ALA
SEQRES   1 B  580  MET ARG PRO PRO TRP TYR PRO LEU HIS THR PRO SER LEU
SEQRES   2 B  580  ALA PHE PRO LEU LEU PHE LEU LEU LEU SER LEU LEU GLY
SEQRES   3 B  580  GLY GLY ALA ARG ALA GLU GLY ARG GLU ASP PRO GLN LEU
SEQRES   4 B  580  LEU VAL ARG VAL ARG GLY GLY GLN LEU ARG GLY ILE ARG
SEQRES   5 B  580  LEU LYS ALA PRO GLY GLY PRO VAL SER ALA PHE LEU GLY
SEQRES   6 B  580  ILE PRO PHE ALA GLU PRO PRO VAL GLY SER ARG ARG PHE
SEQRES   7 B  580  MET PRO PRO GLU PRO LYS ARG PRO TRP SER GLY VAL LEU
SEQRES   8 B  580  ASP ALA THR THR PHE GLN ASN VAL CYS TYR GLN TYR VAL
SEQRES   9 B  580  ASP THR LEU TYR PRO GLY PHE GLU GLY THR GLU MET TRP
SEQRES  10 B  580  ASN PRO ASN ARG GLU LEU SER GLU ASP CYS LEU TYR LEU
SEQRES  11 B  580  ASN VAL TRP THR PRO TYR PRO ARG PRO ALA SER PRO THR
SEQRES  12 B  580  PRO VAL LEU ILE TRP ILE TYR GLY GLY GLY PHE TYR SER
SEQRES  13 B  580  GLY ALA ALA SER LEU ASP VAL TYR ASP GLY ARG PHE LEU
SEQRES  14 B  580  ALA GLN VAL GLU GLY ALA VAL LEU VAL SER MET ASN TYR
SEQRES  15 B  580  ARG VAL GLY THR PHE GLY PHE LEU ALA LEU PRO GLY SER
SEQRES  16 B  580  ARG GLU ALA PRO GLY ASN VAL GLY LEU LEU ASP GLN ARG
SEQRES  17 B  580  LEU ALA LEU GLN TRP VAL GLN GLU ASN ILE ALA ALA PHE
SEQRES  18 B  580  GLY GLY ASP PRO MET SER VAL THR LEU PHE GLY GLU SER
SEQRES  19 B  580  ALA GLY ALA ALA SER VAL GLY MET HIS ILE LEU SER LEU
SEQRES  20 B  580  PRO SER ARG SER LEU PHE HIS ARG ALA VAL LEU GLN SER
SEQRES  21 B  580  GLY THR PRO ASN GLY PRO TRP ALA THR VAL SER ALA GLY
SEQRES  22 B  580  GLU ALA ARG ARG ARG ALA THR LEU LEU ALA ARG LEU VAL
SEQRES  23 B  580  GLY CYS PRO PRO GLY GLY ALA GLY GLY ASN ASP THR GLU
SEQRES  24 B  580  LEU ILE ALA CYS LEU ARG THR ARG PRO ALA GLN ASP LEU
SEQRES  25 B  580  VAL ASP HIS GLU TRP HIS VAL LEU PRO GLN GLU SER ILE
SEQRES  26 B  580  PHE ARG PHE SER PHE VAL PRO VAL VAL ASP GLY ASP PHE
SEQRES  27 B  580  LEU SER ASP THR PRO GLU ALA LEU ILE ASN THR GLY ASP
SEQRES  28 B  580  PHE GLN ASP LEU GLN VAL LEU VAL GLY VAL VAL LYS ASP
SEQRES  29 B  580  GLU GLY SER TYR PHE LEU VAL TYR GLY VAL PRO GLY PHE
SEQRES  30 B  580  SER LYS ASP ASN GLU SER LEU ILE SER ARG ALA GLN PHE
SEQRES  31 B  580  LEU ALA GLY VAL ARG ILE GLY VAL PRO GLN ALA SER ASP
SEQRES  32 B  580  LEU ALA ALA GLU ALA VAL VAL LEU HIS TYR THR ASP TRP
SEQRES  33 B  580  LEU HIS PRO GLU ASP PRO THR HIS LEU ARG ASP ALA MET
SEQRES  34 B  580  SER ALA VAL VAL GLY ASP HIS ASN VAL VAL CYS PRO VAL
SEQRES  35 B  580  ALA GLN LEU ALA GLY ARG LEU ALA ALA GLN GLY ALA ARG
SEQRES  36 B  580  VAL TYR ALA TYR ILE PHE GLU HIS ARG ALA SER THR LEU
SEQRES  37 B  580  THR TRP PRO LEU TRP MET GLY VAL PRO HIS GLY TYR GLU
SEQRES  38 B  580  ILE GLU PHE ILE PHE GLY LEU PRO LEU ASP PRO SER LEU
SEQRES  39 B  580  ASN TYR THR THR GLU GLU ARG ILE PHE ALA GLN ARG LEU
SEQRES  40 B  580  MET LYS TYR TRP THR ASN PHE ALA ARG THR GLY ASP PRO
SEQRES  41 B  580  ASN ASP PRO ARG ASP SER LYS SER PRO GLN TRP PRO PRO
SEQRES  42 B  580  TYR THR THR ALA ALA GLN GLN TYR VAL SER LEU ASN LEU
SEQRES  43 B  580  LYS PRO LEU GLU VAL ARG ARG GLY LEU ARG ALA GLN THR
SEQRES  44 B  580  CYS ALA PHE TRP ASN ARG PHE LEU PRO LYS LEU LEU SER
SEQRES  45 B  580  ALA THR ASP THR LEU ASP GLU ALA
MODRES 1Q83 ASN A  350  ASN  GLYCOSYLATION SITE
MODRES 1Q83 ASN A  464  ASN  GLYCOSYLATION SITE
MODRES 1Q83 ASN B  350  ASN  GLYCOSYLATION SITE
HET    NAG  C1501      14
HET    FUL  C1502      10
HET    NAG  B1601      14
HET    NAG  A1701      14
HET    P6G   1901      19
HET    TZ5   1951      50
HET    TZ5   1952      50
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     FUL BETA-L-FUCOSE
HETNAM     P6G HEXAETHYLENE GLYCOL
HETNAM     TZ5 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-
HETNAM   2 TZ5  9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-
HETNAM   3 TZ5  PHENANTHRIDINIUM
HETSYN     NAG NAG
HETSYN     FUL 6-DEOXY-BETA-L-GALACTOSE
HETSYN     P6G POLYETHYLENE GLYCOL PEG400
FORMUL   3  NAG    3(C8 H15 N1 O6)
FORMUL   3  FUL    C6 H12 O5
FORMUL   6  P6G    C12 H26 O7
FORMUL   7  TZ5    2(C42 H45 N8 1+)
FORMUL   9  HOH   *273(H2 O1)
HELIX    1   1 ASP A    5  GLN A    7  5                                   3
HELIX    2   2 VAL A   42  ARG A   46  5                                   5
HELIX    3   3 PHE A   80  MET A   85  1                                   6
HELIX    4   4 LEU A  130  ASP A  134  5                                   5
HELIX    5   5 GLY A  135  GLY A  143  1                                   9
HELIX    6   6 VAL A  153  LEU A  159  1                                   7
HELIX    7   7 ASN A  170  ILE A  187  1                                  18
HELIX    8   8 ALA A  188  PHE A  190  5                                   3
HELIX    9   9 SER A  203  LEU A  214  1                                  12
HELIX   10  10 SER A  215  SER A  220  1                                   6
HELIX   11  11 ALA A  241  VAL A  255  1                                  15
HELIX   12  12 ASN A  265  THR A  275  1                                  11
HELIX   13  13 PRO A  277  GLU A  285  1                                   9
HELIX   14  14 TRP A  286  LEU A  289  5                                   4
HELIX   15  15 THR A  311  GLY A  319  1                                   9
HELIX   16  16 TYR A  337  VAL A  343  1                                   7
HELIX   17  17 SER A  355  VAL A  367  1                                  13
HELIX   18  18 SER A  371  THR A  383  1                                  13
HELIX   19  19 ASP A  390  VAL A  407  1                                  18
HELIX   20  20 VAL A  407  GLN A  421  1                                  15
HELIX   21  21 PRO A  440  GLY A  444  5                                   5
HELIX   22  22 GLU A  450  PHE A  455  1                                   6
HELIX   23  23 GLY A  456  ASN A  464  5                                   9
HELIX   24  24 THR A  466  GLY A  487  1                                  22
HELIX   25  25 ARG A  525  PHE A  535  1                                  11
HELIX   26  26 LEU A  536  LEU A  539  5                                   4
HELIX   27  27 ASP B    5  GLN B    7  5                                   3
HELIX   28  28 VAL B   42  ARG B   46  5                                   5
HELIX   29  29 PHE B   80  MET B   85  1                                   6
HELIX   30  30 LEU B  130  ASP B  134  5                                   5
HELIX   31  31 GLY B  135  GLY B  143  1                                   9
HELIX   32  32 VAL B  153  LEU B  159  1                                   7
HELIX   33  33 ASN B  170  ILE B  187  1                                  18
HELIX   34  34 ALA B  188  PHE B  190  5                                   3
HELIX   35  35 SER B  203  LEU B  214  1                                  12
HELIX   36  36 SER B  215  SER B  220  1                                   6
HELIX   37  37 ALA B  241  VAL B  255  1                                  15
HELIX   38  38 ASN B  265  ARG B  274  1                                  10
HELIX   39  39 PRO B  277  GLU B  285  1                                   9
HELIX   40  40 TRP B  286  LEU B  289  5                                   4
HELIX   41  41 THR B  311  GLY B  319  1                                   9
HELIX   42  42 GLY B  335  TYR B  337  5                                   3
HELIX   43  43 PHE B  338  VAL B  343  1                                   6
HELIX   44  44 SER B  355  VAL B  367  1                                  13
HELIX   45  45 SER B  371  THR B  383  1                                  13
HELIX   46  46 ASP B  390  VAL B  407  1                                  18
HELIX   47  47 VAL B  407  GLN B  421  1                                  15
HELIX   48  48 PRO B  440  GLY B  444  5                                   5
HELIX   49  49 GLU B  450  PHE B  455  1                                   6
HELIX   50  50 GLY B  456  ASN B  464  5                                   9
HELIX   51  51 THR B  466  GLY B  487  1                                  22
HELIX   52  52 ARG B  525  ARG B  534  1                                  10
HELIX   53  53 PHE B  535  LEU B  539  5                                   5
SHEET    1   A 3 LEU A   9  VAL A  12  0
SHEET    2   A 3 GLY A  15  ARG A  18 -1  O  LEU A  17   N  VAL A  10
SHEET    3   A 3 VAL A  59  ASP A  61  1  O  LEU A  60   N  GLN A  16
SHEET    1   B11 ILE A  20  ALA A  24  0
SHEET    2   B11 GLY A  27  PRO A  36 -1  O  VAL A  29   N  LEU A  22
SHEET    3   B11 TYR A  98  PRO A 104 -1  O  VAL A 101   N  PHE A  32
SHEET    4   B11 VAL A 145  MET A 149 -1  O  SER A 148   N  ASN A 100
SHEET    5   B11 THR A 112  ILE A 118  1  N  LEU A 115   O  VAL A 147
SHEET    6   B11 GLY A 192  GLU A 202  1  O  ASP A 193   N  THR A 112
SHEET    7   B11 ARG A 224  GLN A 228  1  O  ARG A 224   N  LEU A 199
SHEET    8   B11 GLN A 325  VAL A 331  1  O  LEU A 327   N  LEU A 227
SHEET    9   B11 ARG A 424  PHE A 430  1  O  PHE A 430   N  VAL A 330
SHEET   10   B11 GLN A 509  LEU A 513  1  O  LEU A 513   N  ILE A 429
SHEET   11   B11 GLU A 519  ARG A 522 -1  O  ARG A 521   N  TYR A 510
SHEET    1   C 2 VAL A  68  CYS A  69  0
SHEET    2   C 2 LEU A  92  SER A  93  1  O  SER A  93   N  VAL A  68
SHEET    1   D 2 VAL A 239  SER A 240  0
SHEET    2   D 2 VAL A 302  VAL A 303  1  O  VAL A 303   N  VAL A 239
SHEET    1   E 3 LEU B   9  VAL B  12  0
SHEET    2   E 3 GLY B  15  ARG B  18 -1  O  GLY B  15   N  VAL B  12
SHEET    3   E 3 VAL B  59  ASP B  61  1  O  LEU B  60   N  GLN B  16
SHEET    1   F11 ILE B  20  ALA B  24  0
SHEET    2   F11 GLY B  27  PRO B  36 -1  O  VAL B  29   N  LEU B  22
SHEET    3   F11 TYR B  98  PRO B 104 -1  O  VAL B 101   N  PHE B  32
SHEET    4   F11 VAL B 145  MET B 149 -1  O  SER B 148   N  ASN B 100
SHEET    5   F11 THR B 112  ILE B 118  1  N  LEU B 115   O  VAL B 147
SHEET    6   F11 GLY B 192  GLU B 202  1  O  ASP B 193   N  THR B 112
SHEET    7   F11 ARG B 224  GLN B 228  1  O  ARG B 224   N  LEU B 199
SHEET    8   F11 GLN B 325  VAL B 331  1  O  LEU B 327   N  LEU B 227
SHEET    9   F11 ARG B 424  PHE B 430  1  O  TYR B 426   N  VAL B 328
SHEET   10   F11 GLN B 509  LEU B 513  1  O  LEU B 513   N  ILE B 429
SHEET   11   F11 GLU B 519  ARG B 522 -1  O  ARG B 521   N  TYR B 510
SHEET    1   G 2 VAL B  68  CYS B  69  0
SHEET    2   G 2 LEU B  92  SER B  93  1  O  SER B  93   N  VAL B  68
SHEET    1   H 2 VAL B 239  SER B 240  0
SHEET    2   H 2 VAL B 302  VAL B 303  1  O  VAL B 303   N  VAL B 239
SSBOND   1 CYS A   69    CYS A   96
SSBOND   2 CYS A  257    CYS A  272
SSBOND   3 CYS A  409    CYS A  529
SSBOND   4 CYS B   69    CYS B   96
SSBOND   5 CYS B  257    CYS B  272
SSBOND   6 CYS B  409    CYS B  529
LINK         ND2 ASN A 350                 C1  NAG C1501
LINK         ND2 ASN A 464                 C1  NAG A1701
LINK         ND2 ASN B 350                 C1  NAG B1601
LINK         O6  NAG C1501                 C1  FUL C1502
CISPEP   1 TYR A  105    PRO A  106          0        -4.45
CISPEP   2 CYS A  257    PRO A  258          0        15.25
CISPEP   3 TYR B  105    PRO B  106          0         2.95
CISPEP   4 CYS B  257    PRO B  258          0         3.23
CISPEP   5 SER B  497    PRO B  498          0       -13.07
CRYST1   79.743  111.954  226.577  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012540  0.000000  0.000000        0.00000
SCALE2      0.000000  0.008932  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004414        0.00000
TER    4183      SER A 541
TER    8326      LEU B 540
MASTER      485    0    7   53   36    0    0    6 8768    2  186   90
END