longtext: 1UZA-pdb

content
HEADER    HYDROLASE                               05-MAR-04   1UZA
TITLE     CRYSTALLOGRAPHIC STRUCTURE OF A FERULOYL ESTERASE FROM
TITLE    2 ASPERGILLUS NIGER
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FERULOYL ESTERASE A;
COMPND   3 SYNONYM: FERULIC ACID ESTERASE A, FAE-III,
COMPND   4  CINNAMOYL ESTERASE;
COMPND   5 CHAIN: A, B;
COMPND   6 EC: 3.1.1.73;
COMPND   7 ENGINEERED: YES;
COMPND   8 OTHER_DETAILS: N-ACETYLGLUCOSAMINE AT ASN 79
SOURCE    MOL_ID: 1;
SOURCE   2 EXPRESSION_SYSTEM: ASPERGILLUS ORYZAE;
SOURCE   3 ORGANISM_SCIENTIFIC: ASPERGILLUS NIGER
KEYWDS    HYDROLASE, SERINE ESTERASE, XYLAN DEGRADATION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    K.E.MCAULEY,A.SVENDSEN,S.A.PATKAR,K.S.WILSON
REVDAT   1   19-OCT-04 1UZA    0
JRNL        AUTH   K.E.MCAULEY,A.SVENDSEN,S.A.PATKAR,K.S.WILSON
JRNL        TITL   STRUCTURE OF A FERULOYL ESTERASE FROM ASPERGILLUS
JRNL        TITL 2 NIGER
JRNL        REF    ACTA CRYSTALLOGR.,SECT.D      V.  60   878 2004
JRNL        REFN   ASTM ABCRE6  DK ISSN 0907-4449
REMARK   2
REMARK   2 RESOLUTION. 1.5  ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.1
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3   REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.500
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 74.536
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.8
REMARK   3   NUMBER OF REFLECTIONS             : 64009
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.158
REMARK   3   R VALUE            (WORKING SET) : 0.1562
REMARK   3   FREE R VALUE                     : 0.1876
REMARK   3   FREE R VALUE TEST SET SIZE   (%) :  5.11
REMARK   3   FREE R VALUE TEST SET COUNT      : 3252
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.500
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.5392
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 4388
REMARK   3   BIN R VALUE           (WORKING SET) : 0.168
REMARK   3   BIN FREE R VALUE SET COUNT          : 223
REMARK   3   BIN FREE R VALUE                    : 0.231
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4039
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 38
REMARK   3   SOLVENT ATOMS            : 398
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 14.8
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 13.530
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.131
REMARK   3    B22 (A**2) : 0.988
REMARK   3    B33 (A**2) : -1.128
REMARK   3    B12 (A**2) : 0.122
REMARK   3    B13 (A**2) : 0.318
REMARK   3    B23 (A**2) : 0.137
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.078
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.079
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.051
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.314
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.970
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.958
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES    COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED           (A):  4175 ; 0.019 ; 0.021
REMARK   3   BOND LENGTHS OTHERS            (A):  3462 ; 0.005 ; 0.020
REMARK   3   BOND ANGLES REFINED      (DEGREES):  5711 ; 1.766 ; 1.925
REMARK   3   BOND ANGLES OTHERS       (DEGREES):  8100 ; 0.965 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1 (DEGREES):   516 ; 6.035 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2 (DEGREES):   211 ;38.612 ;25.640
REMARK   3   TORSION ANGLES, PERIOD 3 (DEGREES):   621 ;12.886 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4 (DEGREES):    13 ;11.628 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS    (A**3):   633 ; 0.126 ; 0.200
REMARK   3   GENERAL PLANES REFINED         (A):  4749 ; 0.009 ; 0.020
REMARK   3   GENERAL PLANES OTHERS          (A):   816 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED    (A):   923 ; 0.229 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS     (A):  3527 ; 0.202 ; 0.200
REMARK   3   NON-BONDED TORSION REFINED     (A):  2186 ; 0.189 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS      (A):  2221 ; 0.090 ; 0.200
REMARK   3   H-BOND (X...Y) REFINED         (A):   301 ; 0.144 ; 0.200
REMARK   3   SYMMETRY VDW REFINED           (A):    29 ; 0.188 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS            (A):    84 ; 0.198 ; 0.200
REMARK   3   SYMMETRY H-BOND REFINED        (A):    28 ; 0.194 ; 0.200
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT  RMS   WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED   (A**2):  3235 ; 1.388 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED  (A**2):  4174 ; 1.732 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED   (A**2):  1872 ; 2.915 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED  (A**2):  1537 ; 3.829 ; 4.500
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF NCS GROUPS : 1
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   1
REMARK   3     CHAIN NAMES                    : A B
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    6
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A      1       A      28      4
REMARK   3           1     B      1       B      28      4
REMARK   3           2     A     35       A      56      4
REMARK   3           2     B     35       B      56      4
REMARK   3           3     A     60       A     116      4
REMARK   3           3     B     60       B     116      4
REMARK   3           4     A    127       A     222      4
REMARK   3           4     B    127       B     222      4
REMARK   3           5     A    224       A     227      4
REMARK   3           5     B    224       B     227      4
REMARK   3           6     A    233       A     256      4
REMARK   3           6     B    233       B     256      4
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   MEDIUM POSITIONAL  1    A    (A):   3169 ;  0.32 ;  0.50
REMARK   3   MEDIUM THERMAL     1    B (A**2):   3169 ;  0.92 ;  2.00
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL PLUS MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   :1.200
REMARK   3   ION PROBE RADIUS   : 0.800
REMARK   3   SHRINKAGE RADIUS   : 0.800
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3   RIDING POSITIONS.
REMARK   4
REMARK   4 1UZA COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY EBI  ON 11-MAR-2004.
REMARK 100 THE EBI ID CODE IS EBI-20007.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : NULL
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 4.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF BEAMLINE ID14-EH2
REMARK 200  BEAMLINE                       : ID14-EH2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.933
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : NULL
REMARK 200  DETECTOR MANUFACTURER          : NULL
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 64076
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.50
REMARK 200  RESOLUTION RANGE LOW       (A) : 25.00
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.4
REMARK 200  DATA REDUNDANCY                : 2.1
REMARK 200  R MERGE                    (I) : 0.06
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.50
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.51
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.53
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.3
REMARK 200  DATA REDUNDANCY IN SHELL       : 1.8
REMARK 200  R MERGE FOR SHELL          (I) : 0.17
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.50
REMARK 200
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: AMORE
REMARK 200 STARTING MODEL: PDB ENTRY 4TGL
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 32
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.8
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.0 M AMMONIUM SULPHATE, 0.1M
REMARK 280  NA ACETATE PH 4.5
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 295
REMARK 295 NON-CRYSTALLOGRAPHIC SYMMETRY
REMARK 295 THE TRANSFORMATIONS PRESENTED ON THE MTRIX RECORDS BELOW
REMARK 295 DESCRIBE NON-CRYSTALLOGRAPHIC RELATIONSHIPS AMONG ATOMS
REMARK 295 IN THIS ENTRY.  APPLYING THE APPROPRIATE MTRIX
REMARK 295 TRANSFORMATION TO THE RESIDUES LISTED FIRST WILL YIELD
REMARK 295 APPROXIMATE COORDINATES FOR THE RESIDUES LISTED SECOND.
REMARK 295 CHAIN IDENTIFIERS GIVEN AS "?" REFER TO CHAINS FOR WHICH
REMARK 295 ATOMS ARE NOT FOUND IN THIS ENTRY.
REMARK 295
REMARK 295               APPLIED TO          TRANSFORMED TO
REMARK 295   TRANSFORM CHAIN  RESIDUES       CHAIN  RESIDUES     RMSD
REMARK 295    M  1       B    2 .. 260         A    2 .. 260     0.390
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF   2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 300
REMARK 300 QUATERNARY STRUCTURE FOR THIS ENTRY: MONOMERIC
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE:  1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE:  2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 400
REMARK 400 COMPOUND
REMARK 400  INVOLVED IN DEGRADATION OF PLANT CELL WALLS. HYDROLYZES
REMARK 400  THE FERULOYL-ARABINOSE ESTER BOND IN ARABINOXYLANS, AND THE
REMARK 400  FERULOYL-GALACTOSE ESTER BOND IN PECTIN. BINDS TO CELLULOSE.
REMARK 400  FERULOYL-POLYSACCHARIDE + H(2)O = FERULATE + POLYSACCHARIDE.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ALA A     1
REMARK 465     ALA B     1
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     VAL A 261    CA   C    O    CB   CG1  CG2
REMARK 470     VAL B 261    CA   C    O    CB   CG1  CG2
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES ARE GIVEN CHAIN IDENTIFIERS TO
REMARK 525 INDICATE THE PROTEIN CHAIN TO WHICH THEY ARE MOST CLOSELY
REMARK 525 ASSOCIATED WITH:
REMARK 525   PROTEIN CHAIN  SOLVENT CHAIN
REMARK 525     A              Z
REMARK 525     B              Y
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 SITE_DESCRIPTION: SO4 BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 SITE_DESCRIPTION: SO4 BINDING SITE FOR CHAIN B
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 1USW   RELATED DB: PDB
REMARK 900  CRYSTAL STRUCTURE OF FERULIC ACID ESTERASE
REMARK 900  FROM ASPERGILLUS NIGER
REMARK 900 RELATED ID: 1UWC   RELATED DB: PDB
REMARK 900  FERULOYL ESTERASE FROM ASPERGILLUS NIGER
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 THE CONFLICT DESCRIBED IN THE SEQADV RECORDS BELOW
REMARK 999 HAVE BEEN DESCRIBED IN UNIPROT ENTRY O42807 BY
REMARK 999 JUGE ET AL 2001. PUBMED ID: 12702357
DBREF  1UZA A    1   261  UNP    O42807   FAEA_ASPNG      22    281
DBREF  1UZA B    1   261  UNP    O42807   FAEA_ASPNG      22    281
SEQADV 1UZA GLU A  203  UNP  O42807    ASP   224 CONFLICT SEE REMARK 999
SEQADV 1UZA GLN A  204  UNP  O42807    GLU   225 CONFLICT SEE REMARK 999
SEQADV 1UZA GLU B  203  UNP  O42807    ASP   224 CONFLICT SEE REMARK 999
SEQADV 1UZA GLN B  204  UNP  O42807    GLU   225 CONFLICT SEE REMARK 999
SEQRES   1 A  261  ALA SER THR GLN GLY ILE SER GLU ASP LEU TYR ASN ARG
SEQRES   2 A  261  LEU VAL GLU MET ALA THR ILE SER GLN ALA ALA TYR ALA
SEQRES   3 A  261  ASP LEU CYS ASN ILE PRO SER THR ILE ILE LYS GLY GLU
SEQRES   4 A  261  LYS ILE TYR ASN ALA GLN THR ASP ILE ASN GLY TRP ILE
SEQRES   5 A  261  LEU ARG ASP ASP THR SER LYS GLU ILE ILE THR VAL PHE
SEQRES   6 A  261  ARG GLY THR GLY SER ASP THR ASN LEU GLN LEU ASP THR
SEQRES   7 A  261  ASN TYR THR LEU THR PRO PHE ASP THR LEU PRO GLN CYS
SEQRES   8 A  261  ASN ASP CYS GLU VAL HIS GLY GLY TYR TYR ILE GLY TRP
SEQRES   9 A  261  ILE SER VAL GLN ASP GLN VAL GLU SER LEU VAL LYS GLN
SEQRES  10 A  261  GLN ALA SER GLN TYR PRO ASP TYR ALA LEU THR VAL THR
SEQRES  11 A  261  GLY HIS SER LEU GLY ALA SER MET ALA ALA LEU THR ALA
SEQRES  12 A  261  ALA GLN LEU SER ALA THR TYR ASP ASN VAL ARG LEU TYR
SEQRES  13 A  261  THR PHE GLY GLU PRO ARG SER GLY ASN GLN ALA PHE ALA
SEQRES  14 A  261  SER TYR MET ASN ASP ALA PHE GLN VAL SER SER PRO GLU
SEQRES  15 A  261  THR THR GLN TYR PHE ARG VAL THR HIS SER ASN ASP GLY
SEQRES  16 A  261  ILE PRO ASN LEU PRO PRO ALA GLU GLN GLY TYR ALA HIS
SEQRES  17 A  261  GLY GLY VAL GLU TYR TRP SER VAL ASP PRO TYR SER ALA
SEQRES  18 A  261  GLN ASN THR PHE VAL CYS THR GLY ASP GLU VAL GLN CYS
SEQRES  19 A  261  CYS GLU ALA GLN GLY GLY GLN GLY VAL ASN ASP ALA HIS
SEQRES  20 A  261  THR THR TYR PHE GLY MET THR SER GLY ALA CYS THR TRP
SEQRES  21 A  261  VAL
SEQRES   1 B  261  ALA SER THR GLN GLY ILE SER GLU ASP LEU TYR ASN ARG
SEQRES   2 B  261  LEU VAL GLU MET ALA THR ILE SER GLN ALA ALA TYR ALA
SEQRES   3 B  261  ASP LEU CYS ASN ILE PRO SER THR ILE ILE LYS GLY GLU
SEQRES   4 B  261  LYS ILE TYR ASN ALA GLN THR ASP ILE ASN GLY TRP ILE
SEQRES   5 B  261  LEU ARG ASP ASP THR SER LYS GLU ILE ILE THR VAL PHE
SEQRES   6 B  261  ARG GLY THR GLY SER ASP THR ASN LEU GLN LEU ASP THR
SEQRES   7 B  261  ASN TYR THR LEU THR PRO PHE ASP THR LEU PRO GLN CYS
SEQRES   8 B  261  ASN ASP CYS GLU VAL HIS GLY GLY TYR TYR ILE GLY TRP
SEQRES   9 B  261  ILE SER VAL GLN ASP GLN VAL GLU SER LEU VAL LYS GLN
SEQRES  10 B  261  GLN ALA SER GLN TYR PRO ASP TYR ALA LEU THR VAL THR
SEQRES  11 B  261  GLY HIS SER LEU GLY ALA SER MET ALA ALA LEU THR ALA
SEQRES  12 B  261  ALA GLN LEU SER ALA THR TYR ASP ASN VAL ARG LEU TYR
SEQRES  13 B  261  THR PHE GLY GLU PRO ARG SER GLY ASN GLN ALA PHE ALA
SEQRES  14 B  261  SER TYR MET ASN ASP ALA PHE GLN VAL SER SER PRO GLU
SEQRES  15 B  261  THR THR GLN TYR PHE ARG VAL THR HIS SER ASN ASP GLY
SEQRES  16 B  261  ILE PRO ASN LEU PRO PRO ALA GLU GLN GLY TYR ALA HIS
SEQRES  17 B  261  GLY GLY VAL GLU TYR TRP SER VAL ASP PRO TYR SER ALA
SEQRES  18 B  261  GLN ASN THR PHE VAL CYS THR GLY ASP GLU VAL GLN CYS
SEQRES  19 B  261  CYS GLU ALA GLN GLY GLY GLN GLY VAL ASN ASP ALA HIS
SEQRES  20 B  261  THR THR TYR PHE GLY MET THR SER GLY ALA CYS THR TRP
SEQRES  21 B  261  VAL
HET    NAG  A1261      14
HET    NAG  B1261      14
HET    SO4  A1262       5
HET    SO4  B1262       5
HETNAM     SO4 SULFATE ION
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETSYN     NAG NAG
FORMUL   3  SO4    2(O4 S1 2-)
FORMUL   4  NAG    2(C8 H15 N1 O6)
FORMUL   5  HOH   *398(H2 O1)
HELIX    1   1 SER A    7  ALA A   24  1                                  18
HELIX    2   2 TYR A   25  ASP A   27  5                                   3
HELIX    3   3 SER A   70  THR A   78  1                                   9
HELIX    4   4 GLY A   98  TYR A  122  1                                  25
HELIX    5   5 SER A  133  ALA A  148  1                                  16
HELIX    6   6 ASN A  165  PHE A  176  1                                  12
HELIX    7   7 GLY A  195  LEU A  199  5                                   5
HELIX    8   8 PRO A  201  GLY A  205  5                                   5
HELIX    9   9 SER A  220  GLN A  222  5                                   3
HELIX   10  10 GLN A  233  GLN A  238  1                                   6
HELIX   11  11 ASN A  244  THR A  248  1                                   5
HELIX   12  12 SER B    7  ALA B   24  1                                  18
HELIX   13  13 TYR B   25  ASP B   27  5                                   3
HELIX   14  14 SER B   70  THR B   78  1                                   9
HELIX   15  15 GLY B   98  TYR B  122  1                                  25
HELIX   16  16 SER B  133  ALA B  148  1                                  16
HELIX   17  17 ASN B  165  PHE B  176  1                                  12
HELIX   18  18 ILE B  196  LEU B  199  5                                   4
HELIX   19  19 PRO B  201  GLY B  205  5                                   5
HELIX   20  20 GLN B  233  GLY B  239  5                                   7
HELIX   21  21 ASN B  244  THR B  248  1                                   5
SHEET    1  AA 9 THR A   3  GLN A   4  0
SHEET    2  AA 9 THR A 224  CYS A 227 -1  O  VAL A 226   N  THR A   3
SHEET    3  AA 9 VAL A 211  SER A 215 -1  O  GLU A 212   N  CYS A 227
SHEET    4  AA 9 TYR A 186  HIS A 191  1  O  TYR A 186   N  VAL A 211
SHEET    5  AA 9 VAL A 153  PHE A 158  1  O  LEU A 155   N  PHE A 187
SHEET    6  AA 9 ALA A 126  HIS A 132  1  O  LEU A 127   N  ARG A 154
SHEET    7  AA 9 GLU A  60  PHE A  65  1  O  ILE A  61   N  THR A 128
SHEET    8  AA 9 ILE A  48  ASP A  55 -1  O  TRP A  51   N  VAL A  64
SHEET    9  AA 9 ILE A  35  ASN A  43 -1  O  ILE A  36   N  ARG A  54
SHEET    1  AB 2 LEU A  82  PRO A  84  0
SHEET    2  AB 2 GLU A  95  HIS A  97 -1  O  VAL A  96   N  THR A  83
SHEET    1  AC 2 THR A 249  TYR A 250  0
SHEET    2  AC 2 MET A 253  THR A 254 -1  O  MET A 253   N  TYR A 250
SHEET    1  BA 9 THR B   3  GLN B   4  0
SHEET    2  BA 9 THR B 224  CYS B 227 -1  O  VAL B 226   N  THR B   3
SHEET    3  BA 9 VAL B 211  SER B 215 -1  O  GLU B 212   N  CYS B 227
SHEET    4  BA 9 TYR B 186  HIS B 191  1  O  TYR B 186   N  VAL B 211
SHEET    5  BA 9 VAL B 153  PHE B 158  1  O  LEU B 155   N  PHE B 187
SHEET    6  BA 9 ALA B 126  HIS B 132  1  O  LEU B 127   N  ARG B 154
SHEET    7  BA 9 GLU B  60  PHE B  65  1  O  ILE B  61   N  THR B 128
SHEET    8  BA 9 ILE B  48  ASP B  55 -1  O  TRP B  51   N  VAL B  64
SHEET    9  BA 9 ILE B  35  ASN B  43 -1  O  ILE B  36   N  ARG B  54
SHEET    1  BB 2 LEU B  82  PRO B  84  0
SHEET    2  BB 2 GLU B  95  HIS B  97 -1  O  VAL B  96   N  THR B  83
SHEET    1  BC 2 THR B 249  TYR B 250  0
SHEET    2  BC 2 MET B 253  THR B 254 -1  O  MET B 253   N  TYR B 250
SSBOND   1 CYS A   29    CYS A  258                          1555   1555
SSBOND   2 CYS A   91    CYS A   94                          1555   1555
SSBOND   3 CYS A  227    CYS A  234                          1555   1555
SSBOND   4 CYS B   29    CYS B  258                          1555   1555
SSBOND   5 CYS B   91    CYS B   94                          1555   1555
SSBOND   6 CYS B  227    CYS B  234                          1555   1555
LINK         ND2 ASN A  79                 C1  NAG A1261     1555   1555
LINK         ND2 ASN B  79                 C1  NAG B1261     1555   1555
CISPEP   1 LEU A  199    PRO A  200          0       -11.74
CISPEP   2 ASP A  217    PRO A  218          0        -8.84
CISPEP   3 LEU B  199    PRO B  200          0        -9.69
CISPEP   4 ASP B  217    PRO B  218          0        -4.26
SITE     1 AC1 12 ASN A  79  THR A  83  GLY A  98  ILE A 102
SITE     2 AC1 12 ASN B  43  ILE B 105  SER B 106  GLN B 108
SITE     3 AC1 12 ASP B 109  GLN B 110  HOH Z  91  HOH Z 212
SITE     1 AC2 13 ASN A  43  ILE A 105  SER A 106  GLN A 108
SITE     2 AC2 13 ASP A 109  GLN A 110  ASN B  79  THR B  83
SITE     3 AC2 13 GLY B  98  TYR B 101  ILE B 102  HOH Y  65
SITE     4 AC2 13 HOH Y 181
SITE     1 AC3  9 ARG A 162  ALA A 207  HIS A 208  HOH Z 171
SITE     2 AC3  9 HOH Z 173  HOH Z 213  HOH Z 214  HOH Z 215
SITE     3 AC3  9 HOH Z 216
SITE     1 AC4  4 SER B  70  ASP B  71  LYS B 116  HOH Y 182
CRYST1   38.298   39.681   77.071  75.24  78.82  71.30 P 1           2
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.026111 -0.008839 -0.003401        0.00000
SCALE2      0.000000  0.026606 -0.005639        0.00000
SCALE3      0.000000  0.000000  0.013520        0.00000
MTRIX1   1  0.375560  0.901630  0.214530       20.76293    1
MTRIX2   1  0.900910 -0.409480  0.143820       15.65211    1
MTRIX3   1  0.217520  0.139260 -0.966070       37.79221    1
TER    2016      VAL A 261
TER    4041      VAL B 261
MASTER      298    0    4   21   26    0   11    9 4475    2   52   42
END