longtext: 1VKH-pdb

content
HEADER    STRUCTURAL GENOMICS, UNKNOWN FUNCTION   20-MAY-04   1VKH
TITLE     CRYSTAL STRUCTURE OF PUTATIVE SERINE HYDROLASE (YDR428C)
TITLE    2 FROM SACCHAROMYCES CEREVISIAE AT 1.85 A RESOLUTION
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PUTATIVE SERINE HYDROLASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;
SOURCE   3 ORGANISM_COMMON: YEAST;
SOURCE   4 GENE: YDR428C;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_COMMON: BACTERIA;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID
KEYWDS    YDR428C, PUTATIVE SERINE HYDROLASE, STRUCTURAL GENOMICS,
KEYWDS   2 JCSG
EXPDTA    X-RAY DIFFRACTION
AUTHOR    JOINT CENTER FOR STRUCTURAL GENOMICS
REVDAT   1   08-JUN-04 1VKH    0
JRNL        AUTH   JOINT CENTER FOR STRUCTURAL GENOMICS
JRNL        TITL   CRYSTAL STRUCTURE OF PUTATIVE SERINE HYDROLASE
JRNL        TITL 2 (YDR428C) FROM SACCHAROMYCES CEREVISIAE AT 1.85 A
JRNL        TITL 3 RESOLUTION
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 1.85 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.1.9999
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.85
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 37.44
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.0
REMARK   3   NUMBER OF REFLECTIONS             : 39479
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.145
REMARK   3   R VALUE            (WORKING SET) : 0.143
REMARK   3   FREE R VALUE                     : 0.189
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 2060
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH           : 1.85
REMARK   3   BIN RESOLUTION RANGE LOW            : 1.90
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2453
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1740
REMARK   3   BIN FREE R VALUE SET COUNT          : 127
REMARK   3   BIN FREE R VALUE                    : 0.2640
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   ALL ATOMS                : 4659
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 27.53
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 26.64
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.07000
REMARK   3    B22 (A**2) : 0.07000
REMARK   3    B33 (A**2) : -0.01000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -0.02000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.127
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.123
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.082
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 5.233
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.968
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.947
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4282 ; 0.020 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  3868 ; 0.003 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  5801 ; 1.698 ; 1.955
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  9055 ; 0.909 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   505 ; 5.771 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   203 ;40.422 ;25.271
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   782 ;13.328 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    16 ;16.530 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   669 ; 0.110 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  4625 ; 0.008 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):   811 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):   955 ; 0.215 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  4037 ; 0.181 ; 0.200
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  2356 ; 0.088 ; 0.200
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   424 ; 0.170 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    26 ; 0.245 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):    71 ; 0.266 ; 0.200
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):    31 ; 0.237 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  2801 ; 1.496 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  1030 ; 0.373 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  4214 ; 1.659 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1876 ; 3.072 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  1587 ; 4.247 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 0
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 2
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     7        A   261
REMARK   3    ORIGIN FOR THE GROUP (A):  -8.6850  31.7140  73.8620
REMARK   3    T TENSOR
REMARK   3      T11:  -0.1074 T22:  -0.2667
REMARK   3      T33:  -0.2105 T12:  -0.0010
REMARK   3      T13:   0.0052 T23:  -0.0023
REMARK   3    L TENSOR
REMARK   3      L11:   0.6720 L22:   0.5367
REMARK   3      L33:   1.1790 L12:   0.1523
REMARK   3      L13:  -0.0172 L23:  -0.0587
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0142 S12:  -0.0893 S13:  -0.0363
REMARK   3      S21:   0.0354 S22:  -0.0006 S23:  -0.0654
REMARK   3      S31:   0.0542 S32:  -0.0167 S33:   0.0147
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    10        B   261
REMARK   3    ORIGIN FOR THE GROUP (A):   5.0750  37.6100  41.8350
REMARK   3    T TENSOR
REMARK   3      T11:  -0.1262 T22:  -0.2414
REMARK   3      T33:  -0.2004 T12:  -0.0111
REMARK   3      T13:   0.0130 T23:   0.0089
REMARK   3    L TENSOR
REMARK   3      L11:   0.9365 L22:   0.8011
REMARK   3      L33:   1.7341 L12:   0.0487
REMARK   3      L13:   0.0372 L23:   0.1341
REMARK   3    S TENSOR
REMARK   3      S11:   0.0503 S12:   0.1310 S13:  -0.0146
REMARK   3      S21:  -0.0491 S22:   0.0193 S23:  -0.0483
REMARK   3      S31:  -0.0038 S32:  -0.0144 S33:  -0.0696
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: 1. HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS 2. NON-ROTOMERS: LEU 156 AND LEU 160
REMARK   3  (MOLECULE A AND B).
REMARK   4
REMARK   4 1VKH COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-MAY-2004.
REMARK 100 THE RCSB ID CODE IS RCSB001951.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 13-NOV-2003
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 8BM
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9464, 0.979326, 0.979179
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 42225
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.850
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 3.890
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.06900
REMARK 200   FOR THE DATA SET  : 17.8800
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.85
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.92
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.57
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : 0.34300
REMARK 200   FOR SHELL         : 3.570
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: MAD
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MAD
REMARK 200 SOFTWARE USED: SOLVE, RESOLVE
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 35.81
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.93
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 16.00% PEG MME 2000, 0.10M HEPES,
REMARK 280  0.00M HEPES_NA, 5% GLYCEROL , VAPOR DIFFUSION,SITTING DROP,
REMARK 280  NANODROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,1/2+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       42.97950
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -11
REMARK 465     GLY A   -10
REMARK 465     SER A    -9
REMARK 465     ASP A    -8
REMARK 465     LYS A    -7
REMARK 465     ILE A    -6
REMARK 465     HIS A    -5
REMARK 465     HIS A    -4
REMARK 465     HIS A    -3
REMARK 465     HIS A    -2
REMARK 465     SER A     2
REMARK 465     ASN A     3
REMARK 465     MET B   -11
REMARK 465     GLY B   -10
REMARK 465     SER B    -9
REMARK 465     ASP B    -8
REMARK 465     LYS B    -7
REMARK 465     ILE B    -6
REMARK 465     HIS B    -5
REMARK 465     HIS B    -4
REMARK 465     HIS B    -3
REMARK 465     HIS B    -2
REMARK 465     HIS B    -1
REMARK 465     HIS B     0
REMARK 465     MSE B     1
REMARK 465     SER B     2
REMARK 465     ASN B     3
REMARK 465     THR B     4
REMARK 465     VAL B     5
REMARK 465     ARG B     6
REMARK 465     ALA B     7
REMARK 465     ILE B     8
REMARK 465     SER B     9
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A   6    CB    CG    CD    NE    CZ    NH1   NH2
REMARK 470     GLN A  26    CG    CD    OE1   NE2
REMARK 470     ARG A  29    NE    CZ    NH1   NH2
REMARK 470     ARG B  29    NE    CZ    NH1   NH2
REMARK 470     GLU B  78    CG    CD    OE1   OE2
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 CLONING ARTIFACT. THE CONSTRUCT WAS PCR AMPLIFIED WITH
REMARK 999 TAQ POLYMERASE.  SEQUENCING OF THE CLONED CONSTRUCT
REMARK 999 INDICATED THAT VAL IN POSITION 161 WAS MUTATED TO ILE.
DBREF  1VKH A    1   261  GB     6320636  NP_010716        1    261
DBREF  1VKH B    1   261  GB     6320636  NP_010716        1    261
SEQADV 1VKH MET A  -11  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH GLY A  -10  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH SER A   -9  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH ASP A   -8  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH LYS A   -7  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH ILE A   -6  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS A   -5  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS A   -4  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS A   -3  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS A   -2  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS A   -1  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS A    0  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH MSE A    1  GB   6320636   MET     1 MODIFIED RESIDUE
SEQADV 1VKH MSE A   60  GB   6320636   MET    60 MODIFIED RESIDUE
SEQADV 1VKH MSE A  106  GB   6320636   MET   106 MODIFIED RESIDUE
SEQADV 1VKH MSE A  130  GB   6320636   MET   130 MODIFIED RESIDUE
SEQADV 1VKH MSE A  137  GB   6320636   MET   137 MODIFIED RESIDUE
SEQADV 1VKH ILE A  161  GB   6320636   VAL   161 SEE REMARK 999
SEQADV 1VKH MSE A  180  GB   6320636   MET   180 MODIFIED RESIDUE
SEQADV 1VKH MSE A  189  GB   6320636   MET   189 MODIFIED RESIDUE
SEQADV 1VKH MSE A  203  GB   6320636   MET   203 MODIFIED RESIDUE
SEQADV 1VKH MET B  -11  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH GLY B  -10  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH SER B   -9  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH ASP B   -8  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH LYS B   -7  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH ILE B   -6  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS B   -5  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS B   -4  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS B   -3  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS B   -2  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS B   -1  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH HIS B    0  GB   6320636             LEADER SEQUENCE
SEQADV 1VKH MSE B    1  GB   6320636   MET     1 MODIFIED RESIDUE
SEQADV 1VKH MSE B   60  GB   6320636   MET    60 MODIFIED RESIDUE
SEQADV 1VKH MSE B  106  GB   6320636   MET   106 MODIFIED RESIDUE
SEQADV 1VKH MSE B  130  GB   6320636   MET   130 MODIFIED RESIDUE
SEQADV 1VKH MSE B  137  GB   6320636   MET   137 MODIFIED RESIDUE
SEQADV 1VKH ILE B  161  GB   6320636   VAL   161 SEE REMARK 999
SEQADV 1VKH MSE B  180  GB   6320636   MET   180 MODIFIED RESIDUE
SEQADV 1VKH MSE B  189  GB   6320636   MET   189 MODIFIED RESIDUE
SEQADV 1VKH MSE B  203  GB   6320636   MET   203 MODIFIED RESIDUE
SEQRES   1 A  273  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MSE
SEQRES   2 A  273  SER ASN THR VAL ARG ALA ILE SER PRO ASP ILE THR LEU
SEQRES   3 A  273  PHE ASN LYS THR LEU THR PHE GLN GLU ILE SER GLN ASN
SEQRES   4 A  273  THR ARG GLU ALA VAL ILE TYR ILE HIS GLY GLY ALA TRP
SEQRES   5 A  273  ASN ASP PRO GLU ASN THR PRO ASN ASP PHE ASN GLN LEU
SEQRES   6 A  273  ALA ASN THR ILE LYS SER MSE ASP THR GLU SER THR VAL
SEQRES   7 A  273  CYS GLN TYR SER ILE GLU TYR ARG LEU SER PRO GLU ILE
SEQRES   8 A  273  THR ASN PRO ARG ASN LEU TYR ASP ALA VAL SER ASN ILE
SEQRES   9 A  273  THR ARG LEU VAL LYS GLU LYS GLY LEU THR ASN ILE ASN
SEQRES  10 A  273  MSE VAL GLY HIS SER VAL GLY ALA THR PHE ILE TRP GLN
SEQRES  11 A  273  ILE LEU ALA ALA LEU LYS ASP PRO GLN GLU LYS MSE SER
SEQRES  12 A  273  GLU ALA GLN LEU GLN MSE LEU GLY LEU LEU GLN ILE VAL
SEQRES  13 A  273  LYS ARG VAL PHE LEU LEU ASP GLY ILE TYR SER LEU LYS
SEQRES  14 A  273  GLU LEU LEU ILE GLU TYR PRO GLU TYR ASP CYS PHE THR
SEQRES  15 A  273  ARG LEU ALA PHE PRO ASP GLY ILE GLN MSE TYR GLU GLU
SEQRES  16 A  273  GLU PRO SER ARG VAL MSE PRO TYR VAL LYS LYS ALA LEU
SEQRES  17 A  273  SER ARG PHE SER ILE ASP MSE HIS LEU VAL HIS SER TYR
SEQRES  18 A  273  SER ASP GLU LEU LEU THR LEU ARG GLN THR ASN CYS LEU
SEQRES  19 A  273  ILE SER CYS LEU GLN ASP TYR GLN LEU SER PHE LYS LEU
SEQRES  20 A  273  TYR LEU ASP ASP LEU GLY LEU HIS ASN ASP VAL TYR LYS
SEQRES  21 A  273  ASN GLY LYS VAL ALA LYS TYR ILE PHE ASP ASN ILE CYS
SEQRES   1 B  273  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MSE
SEQRES   2 B  273  SER ASN THR VAL ARG ALA ILE SER PRO ASP ILE THR LEU
SEQRES   3 B  273  PHE ASN LYS THR LEU THR PHE GLN GLU ILE SER GLN ASN
SEQRES   4 B  273  THR ARG GLU ALA VAL ILE TYR ILE HIS GLY GLY ALA TRP
SEQRES   5 B  273  ASN ASP PRO GLU ASN THR PRO ASN ASP PHE ASN GLN LEU
SEQRES   6 B  273  ALA ASN THR ILE LYS SER MSE ASP THR GLU SER THR VAL
SEQRES   7 B  273  CYS GLN TYR SER ILE GLU TYR ARG LEU SER PRO GLU ILE
SEQRES   8 B  273  THR ASN PRO ARG ASN LEU TYR ASP ALA VAL SER ASN ILE
SEQRES   9 B  273  THR ARG LEU VAL LYS GLU LYS GLY LEU THR ASN ILE ASN
SEQRES  10 B  273  MSE VAL GLY HIS SER VAL GLY ALA THR PHE ILE TRP GLN
SEQRES  11 B  273  ILE LEU ALA ALA LEU LYS ASP PRO GLN GLU LYS MSE SER
SEQRES  12 B  273  GLU ALA GLN LEU GLN MSE LEU GLY LEU LEU GLN ILE VAL
SEQRES  13 B  273  LYS ARG VAL PHE LEU LEU ASP GLY ILE TYR SER LEU LYS
SEQRES  14 B  273  GLU LEU LEU ILE GLU TYR PRO GLU TYR ASP CYS PHE THR
SEQRES  15 B  273  ARG LEU ALA PHE PRO ASP GLY ILE GLN MSE TYR GLU GLU
SEQRES  16 B  273  GLU PRO SER ARG VAL MSE PRO TYR VAL LYS LYS ALA LEU
SEQRES  17 B  273  SER ARG PHE SER ILE ASP MSE HIS LEU VAL HIS SER TYR
SEQRES  18 B  273  SER ASP GLU LEU LEU THR LEU ARG GLN THR ASN CYS LEU
SEQRES  19 B  273  ILE SER CYS LEU GLN ASP TYR GLN LEU SER PHE LYS LEU
SEQRES  20 B  273  TYR LEU ASP ASP LEU GLY LEU HIS ASN ASP VAL TYR LYS
SEQRES  21 B  273  ASN GLY LYS VAL ALA LYS TYR ILE PHE ASP ASN ILE CYS
MODRES 1VKH MSE A    1  MET  SELENOMETHIONINE
MODRES 1VKH MSE A   60  MET  SELENOMETHIONINE
MODRES 1VKH MSE A  106  MET  SELENOMETHIONINE
MODRES 1VKH MSE A  130  MET  SELENOMETHIONINE
MODRES 1VKH MSE A  137  MET  SELENOMETHIONINE
MODRES 1VKH MSE A  180  MET  SELENOMETHIONINE
MODRES 1VKH MSE A  189  MET  SELENOMETHIONINE
MODRES 1VKH MSE A  203  MET  SELENOMETHIONINE
MODRES 1VKH MSE B   60  MET  SELENOMETHIONINE
MODRES 1VKH MSE B  106  MET  SELENOMETHIONINE
MODRES 1VKH MSE B  130  MET  SELENOMETHIONINE
MODRES 1VKH MSE B  137  MET  SELENOMETHIONINE
MODRES 1VKH MSE B  180  MET  SELENOMETHIONINE
MODRES 1VKH MSE B  189  MET  SELENOMETHIONINE
MODRES 1VKH MSE B  203  MET  SELENOMETHIONINE
HET    MSE  A   1       8
HET    MSE  A  60       8
HET    MSE  A 106      12
HET    MSE  A 130       8
HET    MSE  A 137       8
HET    MSE  A 180       8
HET    MSE  A 189       8
HET    MSE  A 203       8
HET    MSE  B  60       8
HET    MSE  B 106      12
HET    MSE  B 130       8
HET    MSE  B 137       8
HET    MSE  B 180       8
HET    MSE  B 189       8
HET    MSE  B 203      12
HET     CL    455       2
HET    GOL    456       6
HET    GOL    457       6
HETNAM     MSE SELENOMETHIONINE
HETNAM      CL CHLORIDE ION
HETNAM     GOL GLYCEROL
FORMUL   1  MSE    15(C5 H11 N1 O2 SE1)
FORMUL   3   CL    CL1 1-
FORMUL   4  GOL    2(C3 H8 O3)
FORMUL   6  HOH   *454(H2 O1)
HELIX    1   1 LEU A   14  THR A   18  5                                   5
HELIX    2   2 THR A   46  ASP A   49  5                                   4
HELIX    3   3 PHE A   50  ASP A   61  1                                  12
HELIX    4   4 PRO A   82  GLY A  100  1                                  19
HELIX    5   5 SER A  110  ALA A  121  1                                  12
HELIX    6   6 ALA A  122  ASP A  125  5                                   4
HELIX    7   7 SER A  131  GLN A  142  1                                  12
HELIX    8   8 SER A  155  TYR A  163  1                                   9
HELIX    9   9 TYR A  166  PHE A  174  1                                   9
HELIX   10  10 GLY A  177  TYR A  181  5                                   5
HELIX   11  11 GLU A  184  SER A  200  1                                  17
HELIX   12  12 LEU A  216  TYR A  229  1                                  14
HELIX   13  13 LEU A  242  LYS A  248  5                                   7
HELIX   14  14 ASN A  249  ASN A  259  1                                  11
HELIX   15  15 LEU B   14  THR B   18  5                                   5
HELIX   16  16 THR B   46  ASP B   49  5                                   4
HELIX   17  17 PHE B   50  ASP B   61  1                                  12
HELIX   18  18 PRO B   82  GLY B  100  1                                  19
HELIX   19  19 SER B  110  ALA B  121  1                                  12
HELIX   20  20 ALA B  122  ASP B  125  5                                   4
HELIX   21  21 SER B  131  GLN B  142  1                                  12
HELIX   22  22 SER B  155  TYR B  163  1                                   9
HELIX   23  23 TYR B  166  PHE B  174  1                                   9
HELIX   24  24 GLY B  177  TYR B  181  5                                   5
HELIX   25  25 GLU B  184  SER B  200  1                                  17
HELIX   26  26 LEU B  216  TYR B  229  1                                  14
HELIX   27  27 LEU B  242  LYS B  248  5                                   7
HELIX   28  28 ASN B  249  ASN B  259  1                                  11
SHEET    1   A14 LEU A  19  GLN A  22  0
SHEET    2   A14 VAL A  66  ILE A  71 -1  O  GLN A  68   N  GLN A  22
SHEET    3   A14 GLU A  30  ILE A  35  1  N  TYR A  34   O  TYR A  69
SHEET    4   A14 ILE A 104  HIS A 109  1  O  VAL A 107   N  ILE A  33
SHEET    5   A14 VAL A 144  LEU A 150  1  O  LYS A 145   N  ILE A 104
SHEET    6   A14 ASP A 202  SER A 208  1  O  HIS A 204   N  LEU A 149
SHEET    7   A14 PHE A 233  ASP A 238  1  O  LYS A 234   N  LEU A 205
SHEET    8   A14 PHE B 233  ASP B 238 -1  O  PHE B 233   N  LEU A 237
SHEET    9   A14 ASP B 202  SER B 208  1  N  LEU B 205   O  LYS B 234
SHEET   10   A14 VAL B 144  LEU B 150  1  N  LEU B 149   O  HIS B 204
SHEET   11   A14 ILE B 104  HIS B 109  1  N  GLY B 108   O  LEU B 150
SHEET   12   A14 GLU B  30  ILE B  35  1  N  ILE B  33   O  ASN B 105
SHEET   13   A14 VAL B  66  ILE B  71  1  O  TYR B  69   N  TYR B  34
SHEET   14   A14 LEU B  19  GLN B  22 -1  N  LEU B  19   O  SER B  70
CISPEP   1 SER A    9    PRO A   10          0       -11.49
CISPEP   2 SER A   76    PRO A   77          0         7.00
CISPEP   3 ASN A   81    PRO A   82          0         1.42
CISPEP   4 SER B   76    PRO B   77          0        13.13
CISPEP   5 ASN B   81    PRO B   82          0         5.17
CRYST1   41.967   85.959   70.479  90.00  97.71  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.023828  0.000000  0.003226        0.00000
SCALE2      0.000000  0.011633  0.000000        0.00000
SCALE3      0.000000  0.000000  0.014318        0.00000
TER    2121      CYS A 261
TER    4189      CYS B 261
MASTER      308    0   18   28   14    0    0    6 4659    2  144   42
END