longtext: 1WB5-pdb

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HEADER    HYDROLASE                               30-OCT-04   1WB5
TITLE     S954A MUTANT OF THE FERULOYL ESTERASE MODULE FROM
TITLE    2 CLOSTRIDIUM THERMOCELLUM COMPLEXED WITH SYRINGATE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ENDO-1,4-BETA-XYLANASE Y;
COMPND   3 SYNONYM: XYLANASE Y, XYLY, 1,4-BETA-D-XYLAN
COMPND   4  XYLANOHYDROLASE Y, XYLANASE XYN10B;
COMPND   5 CHAIN: A, B;
COMPND   6 FRAGMENT: FERULOYL ESTERASE DOMAIN, RESIDUES 792-1077;
COMPND   7 EC: 3.2.1.8;
COMPND   8 MUTATION: YES;
COMPND   9 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   3 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   4 EXPRESSION_SYSTEM_PLASMID: PET22B;
SOURCE   5 ORGANISM_SCIENTIFIC: CLOSTRIDIUM THERMOCELLUM
KEYWDS    ESTERASE FAMILY 1, FERULIC ACID, GLYCOSIDASE, HYDROLASE,
KEYWDS   2 REPEAT, XYLAN DEGRADATION, XYLANASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    N.TARBOURIECH,J.A.PRATES,C.FONTES,G.J.DAVIES
REVDAT   1   02-FEB-05 1WB5    0
JRNL        AUTH   N.TARBOURIECH,J.A.PRATES,C.FONTES,G.J.DAVIES
JRNL        TITL   MOLECULAR DETERMINANTS OF SUBSTRATE SPECIFICITY IN
JRNL        TITL 2 THE FERULOYL ESTERASE MODULE OF XYLANASE 10B FROM
JRNL        TITL 3 CLOSTRIDIUM THERMOCELLUM
JRNL        REF    ACTA CRYSTALLOGR.,SECT.D      V.  61   194 2005
JRNL        REFN   ASTM ABCRE6  DK ISSN 0907-4449
REMARK   2
REMARK   2 RESOLUTION. 1.4  ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC REFMAC 5.1.24
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3   REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.40
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE
REMARK   3   COMPLETENESS FOR RANGE        (%) : 90.72
REMARK   3   NUMBER OF REFLECTIONS             : 136029
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.11909
REMARK   3   R VALUE            (WORKING SET) : 0.11806
REMARK   3   FREE R VALUE                     : 0.13855
REMARK   3   FREE R VALUE TEST SET SIZE   (%) :  5.0
REMARK   3   FREE R VALUE TEST SET COUNT      : 7161
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.399
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.435
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 9063
REMARK   3   BIN R VALUE           (WORKING SET) : 0.123
REMARK   3   BIN FREE R VALUE SET COUNT          : 477
REMARK   3   BIN FREE R VALUE                    : 0.157
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4720
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 79
REMARK   3   SOLVENT ATOMS            : 659
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 10.945
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.30
REMARK   3    B22 (A**2) : -0.06
REMARK   3    B33 (A**2) : -0.24
REMARK   3    B12 (A**2) : 0.00
REMARK   3    B13 (A**2) : 0.00
REMARK   3    B23 (A**2) : 0.00
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.043
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.041
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.021
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 0.517
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.979
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.974
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES    COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED           (A):  4947 ; 0.024 ; 0.021
REMARK   3   BOND LENGTHS OTHERS            (A):  4085 ; 0.088 ; 0.020
REMARK   3   BOND ANGLES REFINED      (DEGREES):  6728 ; 1.618 ; 1.925
REMARK   3   BOND ANGLES OTHERS       (DEGREES):  9570 ; 2.169 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1 (DEGREES):   582 ; 5.858 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2 (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 3 (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 4 (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   CHIRAL-CENTER RESTRAINTS    (A**3):   657 ; 0.106 ; 0.200
REMARK   3   GENERAL PLANES REFINED         (A):  5628 ; 0.028 ; 0.020
REMARK   3   GENERAL PLANES OTHERS          (A):  1106 ; 0.045 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED    (A):  1024 ; 0.251 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS     (A):  5037 ; 0.257 ; 0.200
REMARK   3   NON-BONDED TORSION REFINED     (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS      (A):  2523 ; 0.094 ; 0.200
REMARK   3   H-BOND (X...Y) REFINED         (A):   439 ; 0.180 ; 0.200
REMARK   3   SYMMETRY VDW REFINED           (A):    14 ; 0.245 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS            (A):    28 ; 0.213 ; 0.200
REMARK   3   SYMMETRY H-BOND REFINED        (A):    36 ; 0.187 ; 0.200
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT  RMS   WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED   (A**2):  2875 ; 1.262 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED  (A**2):  4648 ; 1.825 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED   (A**2):  2070 ; 2.467 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED  (A**2):  2078 ; 3.540 ; 4.500
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   :1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3    RIDING POSITIONS.
REMARK   4
REMARK   4 1WB5 COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY EBI  ON  1-NOV-2004.
REMARK 100 THE EBI ID CODE IS EBI-21468.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 13-OCT-2001
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF BEAMLINE ID13-EH2
REMARK 200  BEAMLINE                       : ID13-EH2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.934
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 158021
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.40
REMARK 200  RESOLUTION RANGE LOW       (A) : 80.00
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 96.4
REMARK 200  DATA REDUNDANCY                : 4.2
REMARK 200  R MERGE                    (I) : 0.05
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 22.40
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.40
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.42
REMARK 200  COMPLETENESS FOR SHELL     (%) : 90.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 4
REMARK 200  R MERGE FOR SHELL          (I) : 0.18
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 6.40
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: PDB ENTRY 1GKL
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 58
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.95
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: NA ACETATE 1M HEPES PH 7.5
REMARK 280  100MM CD ACETATE 50MM GLYCEROL 5%
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   1/2-X,-Y,1/2+Z
REMARK 290       3555   -X,1/2+Y,1/2-Z
REMARK 290       4555   1/2+X,1/2-Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       32.46650
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       56.48450
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       54.31550
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       56.48450
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       32.46650
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       54.31550
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF   2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 300
REMARK 300 QUATERNARY STRUCTURE FOR THIS ENTRY: MONOMERIC
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE:  1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE:  2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 400
REMARK 400 COMPOUND
REMARK 400 ENGINEERED MUTATION IN CHAIN A, SER 954 TO ALA
REMARK 400 ENGINEERED MUTATION IN CHAIN B, SER 954 TO ALA
REMARK 400  CATALYTIC ACTIVITY: ENDOHYDROLYSIS OF 1,4-BETA-D-XYLOSIDIC
REMARK 400  LINKAGES IN XYLANS.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   792
REMARK 465     ALA A   793
REMARK 465     SER A   794
REMARK 465     ASP A   795
REMARK 465     LYS A   796
REMARK 465     PHE A   797
REMARK 465     PRO A   798
REMARK 465     VAL A   799
REMARK 465     ALA A   800
REMARK 465     GLU A   801
REMARK 465     ASN A   802
REMARK 465     PRO A   803
REMARK 465     SER A   804
REMARK 465     SER A   805
REMARK 465     MET B   789
REMARK 465     ALA B   790
REMARK 465     SER B   791
REMARK 465     ASP B   792
REMARK 465     LYS B   793
REMARK 465     PHE B   794
REMARK 465     PRO B   795
REMARK 465     VAL B   796
REMARK 465     ALA B   797
REMARK 465     GLU B   798
REMARK 465     ASN B   799
REMARK 465     PRO B   800
REMARK 465     SER B   801
REMARK 465     SER B   802
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    HIS A 886   N   -  CA  -  CB  ANGL. DEV. =   9.0 DEGREES
REMARK 500    HIS A 886   ND1 -  CE1 -  NE2 ANGL. DEV. = -16.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD AND BY MORE THAN 0.150 ANGSTROMS (M=MODEL
REMARK 500 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 500 NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,1X,2(A4,A1,3X),12X,F5.3)
REMARK 500
REMARK 500 EXPECTED VALUESS: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    HIS A 886  CE1    HIS A 886  NE2      0.177
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OH   TYR A   819     OE2  GLU A   892               1.97
REMARK 500   OE2  GLU A   892     OH   TYR A   819               1.97
REMARK 500   NH2  ARG A  1000     O    HOH Z   228               2.07
REMARK 500   OH   TYR B   819     OE2  GLU B   892               2.04
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A 954     -117.38     67.13
REMARK 500    ALA B 954     -116.48     67.84
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES ARE GIVEN CHAIN IDENTIFIERS TO
REMARK 525 INDICATE THE PROTEIN CHAIN TO WHICH THEY ARE MOST CLOSELY
REMARK 525 ASSOCIATED WITH:
REMARK 525   PROTEIN CHAIN  SOLVENT CHAIN
REMARK 525     A              Z
REMARK 525     B              Y
REMARK 600
REMARK 600 HETEROGEN
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2090  THE COORDINATION ANGLES ARE:
REMARK 600  1 CYS   823A  SG
REMARK 600  2 HIS   886A  ND1        84.5
REMARK 600  3 GLU  1017B  OE1       109.5  97.5
REMARK 600  4 GLU  1017B  OE2       155.5 112.6  52.8
REMARK 600  5 HOH   140Z  O         129.2  96.3 120.6  68.5
REMARK 600                             1     2     3     4
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2091  THE COORDINATION ANGLES ARE:
REMARK 600  1 GLU  1079A  OE1
REMARK 600  2 GLU  1079A  OE2        54.0
REMARK 600  3 GLU   894A  OE2       118.1 170.4
REMARK 600  4 HIS  1076A  ND1        96.6  97.7  88.3
REMARK 600  5 HIS  1083A  ND1        86.7  87.1  87.0 175.2
REMARK 600  6 HIS  1085A  NE2       142.5  88.8  99.3  82.6  96.9
REMARK 600                             1     2     3     4     5
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2092  THE COORDINATION ANGLES ARE:
REMARK 600  1 HIS  1082B  NE2
REMARK 600  2 HIS  1084B  NE2       101.4
REMARK 600  3 HOH   313Y  O          93.2 134.3
REMARK 600  4 GLU  1007A  OE1       155.8  90.9  92.9
REMARK 600  5 GLU  1007A  OE2       101.7 115.3 103.4  54.1
REMARK 600                             1     2     3     4
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2093  THE COORDINATION ANGLES ARE:
REMARK 600  1 HIS   947A  NE2
REMARK 600  2 HOH   191Z  O         119.1
REMARK 600  3 HOH   194Z  O          91.8  89.6
REMARK 600  4 HIS  1080A  NE2        90.7 147.6 102.5
REMARK 600  5 HOH   295Z  O          93.0  71.7 160.6  96.2
REMARK 600                             1     2     3     4
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2094  THE COORDINATION ANGLES ARE:
REMARK 600  1 HOH   304Z  O
REMARK 600  2 HIS  1081A  ND1       109.2
REMARK 600  3 HOH   306Z  O          64.6 122.6
REMARK 600                             1     2
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2095  THE COORDINATION ANGLES ARE:
REMARK 600  1 ACT  2089A  O
REMARK 600  2 ACT  2089A  OXT        52.7
REMARK 600                             1
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2096  THE COORDINATION ANGLES ARE:
REMARK 600  1 HIS  1076A  O
REMARK 600  2 HOH   293Z  O         100.6
REMARK 600  3 HOH   298Z  O          88.3 170.7
REMARK 600  4 HOH   141Z  O         170.9  82.7  88.1
REMARK 600  5 HOH   292Z  O         100.8  88.7  92.3  87.6
REMARK 600  6 HOH   296Z  O          87.3  81.0  96.9  84.9 168.0
REMARK 600                             1     2     3     4     5
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2097  THE COORDINATION ANGLES ARE:
REMARK 600  1 HOH   181Z  O
REMARK 600  2 GLU   926A  O          86.9
REMARK 600  3 TYR   929A  O         171.5  84.9
REMARK 600  4 HOH   171Z  O          93.4 109.2  91.5
REMARK 600  5 HOH   176Z  O          80.6 166.3 107.3  77.3
REMARK 600  6 HOH   182Z  O          88.3  90.3  89.4 160.5  83.8
REMARK 600                             1     2     3     4     5
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD A2098  THE COORDINATION ANGLES ARE:
REMARK 600  1 HOH   171Y  O
REMARK 600  2 HOH   334Y  O          89.8
REMARK 600  3 HOH   171Z  O         100.1  77.2
REMARK 600  4 HOH   176Z  O          87.9 148.8  72.6
REMARK 600  5 HOH   181Z  O         163.8 105.8  87.8  80.9
REMARK 600  6 HOH   184Z  O          82.7 105.3 176.3 105.2  88.9
REMARK 600                             1     2     3     4     5
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2090  THE COORDINATION ANGLES ARE:
REMARK 600  1 GLU  1017A  OE1
REMARK 600  2 GLU  1017A  OE2        53.3
REMARK 600  3 CYS   823B  SG        106.7 153.3
REMARK 600  4 HIS   886B  ND1        90.1 101.2  95.8
REMARK 600  5 HOH   137Y  O         125.7  73.4 127.2  90.5
REMARK 600                             1     2     3     4
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2091  THE COORDINATION ANGLES ARE:
REMARK 600  1 GLU  1079B  OE1
REMARK 600  2 GLU  1079B  OE2        54.9
REMARK 600  3 GLU   894B  OE2       121.2 172.0
REMARK 600  4 HIS  1076B  ND1        97.4  98.8  88.5
REMARK 600  5 HIS  1083B  ND1        88.0  87.7  85.1 173.2
REMARK 600  6 HIS  1085B  NE2       140.8  86.2  97.9  83.1  95.4
REMARK 600                             1     2     3     4     5
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2092  THE COORDINATION ANGLES ARE:
REMARK 600  1 HIS  1082A  NE2
REMARK 600  2 HIS  1084A  NE2       101.8
REMARK 600  3 GLU  1007B  OE1       155.2  90.4
REMARK 600  4 GLU  1007B  OE2       101.0 113.1  54.2
REMARK 600  5 HOH   240Y  O         102.7 100.9  95.9 132.9
REMARK 600                             1     2     3     4
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2093  THE COORDINATION ANGLES ARE:
REMARK 600  1 HIS   947B  NE2
REMARK 600  2 HIS  1080B  NE2        90.0
REMARK 600  3 HOH   194Y  O          91.8 102.0
REMARK 600  4 HOH   302Y  O          92.7  98.8 158.8
REMARK 600                             1     2     3
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2094  THE COORDINATION ANGLES ARE:
REMARK 600  1 HOH   314Y  O
REMARK 600  2 HIS  1081B  ND1       124.7
REMARK 600  3 HOH   312Y  O          58.6 120.1
REMARK 600                             1     2
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2095  THE COORDINATION ANGLES ARE:
REMARK 600  1 ACT  2089B  OXT
REMARK 600  2 ACT  2089B  C          27.3
REMARK 600  3 ACT  2089B  O          54.3  27.1
REMARK 600                             1     2
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2096  THE COORDINATION ANGLES ARE:
REMARK 600  1 HOH   173Z  O
REMARK 600  2 GOL  2088B  O2         95.6
REMARK 600  3 GOL  2088B  O3         87.4  69.9
REMARK 600  4 HOH   177Y  O          89.9  79.3 148.6
REMARK 600  5 ALA   933B  O          91.3 173.0 111.5  99.9
REMARK 600  6 HOH   178Y  O         168.1  83.3  81.0 101.5  90.2
REMARK 600                             1     2     3     4     5
REMARK 600
REMARK 600 FOR METAL ATOM CD    CD B2097  THE COORDINATION ANGLES ARE:
REMARK 600  1 HIS  1076B  O
REMARK 600  2 HOH   299Y  O          97.2
REMARK 600  3 HOH   303Y  O          97.0  92.0
REMARK 600  4 HOH   304Y  O          91.6  90.3 170.7
REMARK 600  5 HOH   306Y  O          88.9 173.0  83.7  93.1
REMARK 600                             1     2     3     4
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 SITE_DESCRIPTION: SYR BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 SITE_DESCRIPTION: GOL BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 SITE_DESCRIPTION: GOL BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 SITE_DESCRIPTION: ACT BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 SITE_DESCRIPTION: SYR BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 SITE_DESCRIPTION: GOL BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 SITE_DESCRIPTION: GOL BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 SITE_DESCRIPTION: ACT BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC6
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC7
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC8
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC9
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC1
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC2
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC3
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC4
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN B
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC5
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC6
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC7
REMARK 800 SITE_DESCRIPTION: CD BINDING SITE FOR CHAIN A
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 1DYO   RELATED DB: PDB
REMARK 900  XYLAN-BINDING DOMAIN FROM CBM 22, FORMALLY
REMARK 900  X6B DOMAIN
REMARK 900 RELATED ID: 1GKK   RELATED DB: PDB
REMARK 900  FERULOYL ESTERASE DOMAIN OF XYNY FROM
REMARK 900  CLOSTRIDIUM THERMOCELLUM
REMARK 900 RELATED ID: 1GKL   RELATED DB: PDB
REMARK 900  S954A MUTANT OF THE FERULOYL ESTERASE MODULE
REMARK 900   FROM CLOSTRIDIUM THERMOCELLUM COMPLEXED WITH
REMARK 900  FERULIC ACID
REMARK 900 RELATED ID: 1H6X   RELATED DB: PDB
REMARK 900  THE ROLE OF CONSERVED AMONI ACIDS IN THE
REMARK 900  CLEFT OF THE C-TERMINAL FAMILY 22
REMARK 900  CARBOHYDRATE BINDING MODULE OF CLOSTRIDIUM
REMARK 900  THERMOCELLUM XYN10B IN LIGAND BINDING
REMARK 900 RELATED ID: 1H6Y   RELATED DB: PDB
REMARK 900  THE ROLE OF CONSERVED AMONI ACIDS IN THE
REMARK 900  CLEFT OF THE C-TERMINAL FAMILY 22
REMARK 900  CARBOHYDRATE BINDING MODULE OF CLOSTRIDIUM
REMARK 900  THERMOCELLUM XYN10B IN LIGAND BINDING
REMARK 900 RELATED ID: 1OHZ   RELATED DB: PDB
REMARK 900  COHESIN-DOCKERIN COMPLEX FROM THE CELLULOSOME
REMARK 900   OF CLOSTRIDIUM THERMOCELLUM
REMARK 900 RELATED ID: 1WB4   RELATED DB: PDB
REMARK 900  S954A MUTANT OF THE FERULOYL ESTERASE MODULE FROM
REMARK 900   CLOSTRIDIUM THERMOCELLUM COMPLEXED WITH SINAPINATE
REMARK 900 RELATED ID: 1WB6   RELATED DB: PDB
REMARK 900  S954A MUTANT OF THE FERULOYL ESTERASE MODULE FROM
REMARK 900   CLOSTRIDIUM THERMOCELLUM COMPLEXED WITH VANILLATE
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 ONLY THE FERULOYL ESTERASE DOMAIN WAS SUBCLONED. S954A
REMARK 999 MUTANT. THE SEQUENCE CONFLICTS (RESIDUES 1017 AND 1018) ARE
REMARK 999 DUE TO ERRORS IN THE UNIPROT ENTRY FROM THE ORIGINAL
REMARK 999 SEQUENCING OF THE PROTEIN.
DBREF  1WB5 A  789   791  PDB    1WB5     1WB5           789    791
DBREF  1WB5 A  792  1077  UNP    P51584   XYNY_CLOTM     792   1077
DBREF  1WB5 A 1078  1085  PDB    1WB5     1WB5          1078   1085
DBREF  1WB5 B  789   791  PDB    1WB5     1WB5           789    791
DBREF  1WB5 B  792  1077  UNP    P51584   XYNY_CLOTM     792   1077
DBREF  1WB5 B 1078  1085  PDB    1WB5     1WB5          1078   1085
SEQADV 1WB5 ALA A  954  UNP  P51584    SER   954 ENGINEERED MUTATION
SEQADV 1WB5 GLU A 1017  UNP  P51584    ASP  1017 CONFLICT SEE REMARK 999
SEQADV 1WB5 ASP A 1018  UNP  P51584    HIS  1018 CONFLICT SEE REMARK 999
SEQADV 1WB5 ALA B  954  UNP  P51584    SER   954 ENGINEERED MUTATION
SEQADV 1WB5 GLU B 1017  UNP  P51584    ASP  1017 CONFLICT SEE REMARK 999
SEQADV 1WB5 ASP B 1018  UNP  P51584    HIS  1018 CONFLICT SEE REMARK 999
SEQRES   1 A  297  MET ALA SER ASP LYS PHE PRO VAL ALA GLU ASN PRO SER
SEQRES   2 A  297  SER SER PHE LYS TYR GLU SER ALA VAL GLN TYR ARG PRO
SEQRES   3 A  297  ALA PRO ASP SER TYR LEU ASN PRO CYS PRO GLN ALA GLY
SEQRES   4 A  297  ARG ILE VAL LYS GLU THR TYR THR GLY ILE ASN GLY THR
SEQRES   5 A  297  LYS SER LEU ASN VAL TYR LEU PRO TYR GLY TYR ASP PRO
SEQRES   6 A  297  ASN LYS LYS TYR ASN ILE PHE TYR LEU MET HIS GLY GLY
SEQRES   7 A  297  GLY GLU ASN GLU ASN THR ILE PHE SER ASN ASP VAL LYS
SEQRES   8 A  297  LEU GLN ASN ILE LEU ASP HIS ALA ILE MET ASN GLY GLU
SEQRES   9 A  297  LEU GLU PRO LEU ILE VAL VAL THR PRO THR PHE ASN GLY
SEQRES  10 A  297  GLY ASN CYS THR ALA GLN ASN PHE TYR GLN GLU PHE ARG
SEQRES  11 A  297  GLN ASN VAL ILE PRO PHE VAL GLU SER LYS TYR SER THR
SEQRES  12 A  297  TYR ALA GLU SER THR THR PRO GLN GLY ILE ALA ALA SER
SEQRES  13 A  297  ARG MET HIS ARG GLY PHE GLY GLY PHE ALA MET GLY GLY
SEQRES  14 A  297  LEU THR THR TRP TYR VAL MET VAL ASN CYS LEU ASP TYR
SEQRES  15 A  297  VAL ALA TYR PHE MET PRO LEU SER GLY ASP TYR TRP TYR
SEQRES  16 A  297  GLY ASN SER PRO GLN ASP LYS ALA ASN SER ILE ALA GLU
SEQRES  17 A  297  ALA ILE ASN ARG SER GLY LEU SER LYS ARG GLU TYR PHE
SEQRES  18 A  297  VAL PHE ALA ALA THR GLY SER GLU ASP ILE ALA TYR ALA
SEQRES  19 A  297  ASN MET ASN PRO GLN ILE GLU ALA MET LYS ALA LEU PRO
SEQRES  20 A  297  HIS PHE ASP TYR THR SER ASP PHE SER LYS GLY ASN PHE
SEQRES  21 A  297  TYR PHE LEU VAL ALA PRO GLY ALA THR HIS TRP TRP GLY
SEQRES  22 A  297  TYR VAL ARG HIS TYR ILE TYR ASP ALA LEU PRO TYR PHE
SEQRES  23 A  297  PHE HIS GLU LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  297  MET ALA SER ASP LYS PHE PRO VAL ALA GLU ASN PRO SER
SEQRES   2 B  297  SER SER PHE LYS TYR GLU SER ALA VAL GLN TYR ARG PRO
SEQRES   3 B  297  ALA PRO ASP SER TYR LEU ASN PRO CYS PRO GLN ALA GLY
SEQRES   4 B  297  ARG ILE VAL LYS GLU THR TYR THR GLY ILE ASN GLY THR
SEQRES   5 B  297  LYS SER LEU ASN VAL TYR LEU PRO TYR GLY TYR ASP PRO
SEQRES   6 B  297  ASN LYS LYS TYR ASN ILE PHE TYR LEU MET HIS GLY GLY
SEQRES   7 B  297  GLY GLU ASN GLU ASN THR ILE PHE SER ASN ASP VAL LYS
SEQRES   8 B  297  LEU GLN ASN ILE LEU ASP HIS ALA ILE MET ASN GLY GLU
SEQRES   9 B  297  LEU GLU PRO LEU ILE VAL VAL THR PRO THR PHE ASN GLY
SEQRES  10 B  297  GLY ASN CYS THR ALA GLN ASN PHE TYR GLN GLU PHE ARG
SEQRES  11 B  297  GLN ASN VAL ILE PRO PHE VAL GLU SER LYS TYR SER THR
SEQRES  12 B  297  TYR ALA GLU SER THR THR PRO GLN GLY ILE ALA ALA SER
SEQRES  13 B  297  ARG MET HIS ARG GLY PHE GLY GLY PHE ALA MET GLY GLY
SEQRES  14 B  297  LEU THR THR TRP TYR VAL MET VAL ASN CYS LEU ASP TYR
SEQRES  15 B  297  VAL ALA TYR PHE MET PRO LEU SER GLY ASP TYR TRP TYR
SEQRES  16 B  297  GLY ASN SER PRO GLN ASP LYS ALA ASN SER ILE ALA GLU
SEQRES  17 B  297  ALA ILE ASN ARG SER GLY LEU SER LYS ARG GLU TYR PHE
SEQRES  18 B  297  VAL PHE ALA ALA THR GLY SER GLU ASP ILE ALA TYR ALA
SEQRES  19 B  297  ASN MET ASN PRO GLN ILE GLU ALA MET LYS ALA LEU PRO
SEQRES  20 B  297  HIS PHE ASP TYR THR SER ASP PHE SER LYS GLY ASN PHE
SEQRES  21 B  297  TYR PHE LEU VAL ALA PRO GLY ALA THR HIS TRP TRP GLY
SEQRES  22 B  297  TYR VAL ARG HIS TYR ILE TYR ASP ALA LEU PRO TYR PHE
SEQRES  23 B  297  PHE HIS GLU LEU GLU HIS HIS HIS HIS HIS HIS
HET    SYR  A2086      15
HET    GOL  A2087       6
HET    GOL  A2088       6
HET    ACT  A2089       4
HET    SYR  B2086      15
HET    GOL  B2087       6
HET    GOL  B2088       6
HET    ACT  B2089       4
HET     CD  B2090       1
HET     CD  B2091       1
HET     CD  B2092       1
HET     CD  B2093       1
HET     CD  A2090       1
HET     CD  A2091       1
HET     CD  A2092       1
HET     CD  A2093       1
HET     CD  A2094       1
HET     CD  B2094       1
HET     CD  A2095       1
HET     CD  B2095       1
HET     CD  B2096       1
HET     CD  B2097       1
HET     CD  A2096       1
HET     CD  A2097       1
HET     CD  A2098       1
HETNAM      CD CADMIUM ION
HETNAM     ACT ACETATE ACID
HETNAM     SYR SYRINGATE
HETNAM     GOL GLYCEROL
FORMUL   3   CD    17(CD1 2+)
FORMUL   4  ACT    2(C2 H3 O2 1-)
FORMUL   5  SYR    2(C10 H12 O5)
FORMUL   6  GOL    4(C3 H8 O3)
FORMUL   7  HOH   *659(H2 O1)
HELIX    1   1 PRO A  816  ASN A  821  5                                   6
HELIX    2   2 LYS A  879  ASN A  890  1                                  12
HELIX    3   3 ASN A  912  ASN A  920  1                                   9
HELIX    4   4 ASN A  920  TYR A  929  1                                  10
HELIX    5   5 THR A  937  ALA A  943  1                                   7
HELIX    6   6 SER A  944  MET A  946  5                                   3
HELIX    7   7 ALA A  954  LEU A  968  1                                  15
HELIX    8   8 SER A  986  GLY A 1002  1                                  17
HELIX    9   9 ALA A 1020  ALA A 1033  1                                  14
HELIX   10  10 TRP A 1059  LEU A 1071  1                                  13
HELIX   11  11 PRO A 1072  PHE A 1074  5                                   3
HELIX   12  12 PRO B  816  ASN B  821  5                                   6
HELIX   13  13 LYS B  879  ASN B  890  1                                  12
HELIX   14  14 ASN B  912  ASN B  920  1                                   9
HELIX   15  15 ASN B  920  TYR B  929  1                                  10
HELIX   16  16 THR B  937  ALA B  943  1                                   7
HELIX   17  17 SER B  944  MET B  946  5                                   3
HELIX   18  18 ALA B  954  LEU B  968  1                                  15
HELIX   19  19 SER B  986  GLY B 1002  1                                  17
HELIX   20  20 ALA B 1020  ALA B 1033  1                                  14
HELIX   21  21 TRP B 1059  LEU B 1071  1                                  13
HELIX   22  22 PRO B 1072  PHE B 1074  5                                   3
SHEET    1  AA 8 ARG A 828  GLY A 836  0
SHEET    2  AA 8 GLY A 839  LEU A 847 -1  O  GLY A 839   N  GLY A 836
SHEET    3  AA 8 LEU A 896  THR A 900 -1  O  VAL A 898   N  TYR A 846
SHEET    4  AA 8 ASN A 858  MET A 863  1  O  ASN A 858   N  ILE A 897
SHEET    5  AA 8 ARG A 948  PHE A 953  1  O  GLY A 949   N  TYR A 861
SHEET    6  AA 8 TYR A 973  LEU A 977  1  O  TYR A 973   N  PHE A 950
SHEET    7  AA 8 PHE A1009  GLY A1015  1  O  PHE A1009   N  PHE A 974
SHEET    8  AA 8 PHE A1048  ALA A1053  1  O  TYR A1049   N  ALA A1012
SHEET    1  BA 8 ARG B 828  GLY B 836  0
SHEET    2  BA 8 GLY B 839  LEU B 847 -1  O  GLY B 839   N  GLY B 836
SHEET    3  BA 8 LEU B 896  THR B 900 -1  O  VAL B 898   N  TYR B 846
SHEET    4  BA 8 ASN B 858  MET B 863  1  O  ASN B 858   N  ILE B 897
SHEET    5  BA 8 ARG B 948  PHE B 953  1  O  GLY B 949   N  TYR B 861
SHEET    6  BA 8 TYR B 973  LEU B 977  1  O  TYR B 973   N  PHE B 950
SHEET    7  BA 8 PHE B1009  GLY B1015  1  O  PHE B1009   N  PHE B 974
SHEET    8  BA 8 PHE B1048  ALA B1053  1  O  TYR B1049   N  ALA B1012
LINK        CD    CD A2090                 SG  CYS A 823     1555   1555
LINK        CD    CD A2090                 ND1 HIS A 886     1555   1555
LINK        CD    CD A2090                 OE1 GLU B1017     1555   2574
LINK        CD    CD A2090                 OE2 GLU B1017     1555   2574
LINK        CD    CD A2090                 O   HOH Z 140     1555   1555
LINK        CD    CD A2091                 OE1 GLU A1079     1555   1555
LINK        CD    CD A2091                 OE2 GLU A1079     1555   1555
LINK        CD    CD A2091                 OE2 GLU A 894     1555   1555
LINK        CD    CD A2091                 ND1 HIS A1076     1555   1555
LINK        CD    CD A2091                 ND1 HIS A1083     1555   1555
LINK        CD    CD A2091                 NE2 HIS A1085     1555   1555
LINK        CD    CD A2092                 NE2 HIS B1082     1555   1655
LINK        CD    CD A2092                 NE2 HIS B1084     1555   1655
LINK        CD    CD A2092                 O   HOH Y 313     1555   1655
LINK        CD    CD A2092                 OE1 GLU A1007     1555   1555
LINK        CD    CD A2092                 OE2 GLU A1007     1555   1555
LINK        CD    CD A2093                 NE2 HIS A 947     1555   1555
LINK        CD    CD A2093                 O   HOH Z 191     1555   1555
LINK        CD    CD A2093                 O   HOH Z 194     1555   1555
LINK        CD    CD A2093                 NE2 HIS A1080     1555   1555
LINK        CD    CD A2093                 O   HOH Z 295     1555   1555
LINK        CD    CD A2094                 O   HOH Z 304     1555   1555
LINK        CD    CD A2094                 ND1 HIS A1081     1555   1555
LINK        CD    CD A2094                 O   HOH Z 306     1555   1555
LINK        CD    CD A2095                 O   ACT A2089     1555   1555
LINK        CD    CD A2095                 OXT ACT A2089     1555   1555
LINK        CD    CD A2096                 O   HIS A1076     1555   1555
LINK        CD    CD A2096                 O   HOH Z 293     1555   1555
LINK        CD    CD A2096                 O   HOH Z 298     1555   1555
LINK        CD    CD A2096                 O   HOH Z 141     1555   1555
LINK        CD    CD A2096                 O   HOH Z 292     1555   1555
LINK        CD    CD A2096                 O   HOH Z 296     1555   1555
LINK        CD    CD A2097                 O   HOH Z 181     1555   1555
LINK        CD    CD A2097                 O   GLU A 926     1555   1555
LINK        CD    CD A2097                 O   TYR A 929     1555   1555
LINK        CD    CD A2097                 O   HOH Z 171     1555   1555
LINK        CD    CD A2097                 O   HOH Z 176     1555   1555
LINK        CD    CD A2097                 O   HOH Z 182     1555   1555
LINK        CD    CD A2098                 O   HOH Z 184     1555   4465
LINK        CD    CD A2098                 O   HOH Y 334     1555   1555
LINK        CD    CD A2098                 O   HOH Z 171     1555   4465
LINK        CD    CD A2098                 O   HOH Z 176     1555   4465
LINK        CD    CD A2098                 O   HOH Z 181     1555   4465
LINK        CD    CD A2098                 O   HOH Y 171     1555   1555
LINK        CD    CD B2090                 OE2 GLU A1017     1555   3545
LINK        CD    CD B2090                 SG  CYS B 823     1555   1555
LINK        CD    CD B2090                 ND1 HIS B 886     1555   1555
LINK        CD    CD B2090                 O   HOH Y 137     1555   1555
LINK        CD    CD B2090                 OE1 GLU A1017     1555   3545
LINK        CD    CD B2091                 OE2 GLU B1079     1555   1555
LINK        CD    CD B2091                 OE2 GLU B 894     1555   1555
LINK        CD    CD B2091                 ND1 HIS B1076     1555   1555
LINK        CD    CD B2091                 ND1 HIS B1083     1555   1555
LINK        CD    CD B2091                 NE2 HIS B1085     1555   1555
LINK        CD    CD B2091                 OE1 GLU B1079     1555   1555
LINK        CD    CD B2092                 NE2 HIS A1084     1555   1455
LINK        CD    CD B2092                 OE1 GLU B1007     1555   1555
LINK        CD    CD B2092                 OE2 GLU B1007     1555   1555
LINK        CD    CD B2092                 O   HOH Y 240     1555   1555
LINK        CD    CD B2092                 NE2 HIS A1082     1555   1455
LINK        CD    CD B2093                 NE2 HIS B1080     1555   1555
LINK        CD    CD B2093                 O   HOH Y 194     1555   1555
LINK        CD    CD B2093                 O   HOH Y 302     1555   1555
LINK        CD    CD B2093                 NE2 HIS B 947     1555   1555
LINK        CD    CD B2094                 ND1 HIS B1081     1555   1555
LINK        CD    CD B2094                 O   HOH Y 312     1555   1555
LINK        CD    CD B2094                 O   HOH Y 314     1555   1555
LINK        CD    CD B2095                 C   ACT B2089     1555   1555
LINK        CD    CD B2095                 O   ACT B2089     1555   1555
LINK        CD    CD B2095                 OXT ACT B2089     1555   1555
LINK        CD    CD B2096                 O2  GOL B2088     1555   1555
LINK        CD    CD B2096                 O3  GOL B2088     1555   1555
LINK        CD    CD B2096                 O   HOH Y 177     1555   1555
LINK        CD    CD B2096                 O   ALA B 933     1555   1555
LINK        CD    CD B2096                 O   HOH Y 178     1555   1555
LINK        CD    CD B2096                 O   HOH Z 173     1555   4465
LINK        CD    CD B2097                 O   HOH Y 299     1555   1555
LINK        CD    CD B2097                 O   HOH Y 303     1555   1555
LINK        CD    CD B2097                 O   HOH Y 304     1555   1555
LINK        CD    CD B2097                 O   HOH Y 306     1555   1555
LINK        CD    CD B2097                 O   HIS B1076     1555   1555
SITE     1 AC1  8 ALA A 954  GLY A 979  ASP A 980  TRP A 982
SITE     2 AC1  8 ILE A1019  ALA A1020  ASN A1023  HOH Z  99
SITE     1 AC2 11 GLY A 865  GLY A 866  GLU A 868  PHE A 953
SITE     2 AC2 11 ALA A 954  HIS A1058  TRP A1060  HOH Z  99
SITE     3 AC2 11 HOH Z 106  HOH Z 319  HOH Z 320
SITE     1 AC3  8 LYS A 856  TYR A 857  ASN A 858  GLU A 894
SITE     2 AC3  8 PRO A 895  TYR A 932  HIS A1081  HOH Z 321
SITE     1 AC4  5 LYS A 856  TYR A 857  HIS A1081  HOH Z 322
SITE     2 AC4  5 HOH Z 323
SITE     1 AC5 10 ALA B 954  GLY B 979  ASP B 980  TRP B 982
SITE     2 AC5 10 ILE B1019  ALA B1020  ASN B1023  HIS B1058
SITE     3 AC5 10 HOH Y 327  HOH Y 331
SITE     1 AC6 10 GLY B 865  GLY B 866  GLU B 868  PHE B 953
SITE     2 AC6 10 ALA B 954  HIS B1058  HOH Y 103  HOH Y 330
SITE     3 AC6 10 HOH Y 331  HOH Y 332
SITE     1 AC7 11 SER A 927  LYS A 928  GLU B 926  SER B 927
SITE     2 AC7 11 LYS B 928  TYR B 929  SER B 930  HOH Y 176
SITE     3 AC7 11 HOH Y 177  HOH Y 333  HOH Y 334
SITE     1 AC8  6 LYS B 855  LYS B 856  TYR B 857  HIS B1081
SITE     2 AC8  6 HOH Y 335  HOH Y 336
SITE     1 AC9  5 GLU A1017  CYS B 823  HIS B 886  MET B 889
SITE     2 AC9  5 HOH Y 137
SITE     1 BC1  5 GLU B 894  HIS B1076  GLU B1079  HIS B1083
SITE     2 BC1  5 HIS B1085
SITE     1 BC2  4 HIS A1082  HIS A1084  GLU B1007  HOH Y 240
SITE     1 BC3  4 HIS B 947  HIS B1080  HOH Y 194  HOH Y 302
SITE     1 BC4  5 CYS A 823  HIS A 886  MET A 889  GLU B1017
SITE     2 BC4  5 HOH Z 140
SITE     1 BC5  5 GLU A 894  HIS A1076  GLU A1079  HIS A1083
SITE     2 BC5  5 HIS A1085
SITE     1 BC6  4 GLU A1007  HIS B1082  HIS B1084  HOH Y 313
SITE     1 BC7  5 HIS A 947  HIS A1080  HOH Z 191  HOH Z 194
SITE     2 BC7  5 HOH Z 295
SITE     1 BC8  3 HIS A1081  HOH Z 304  HOH Z 306
SITE     1 BC9  3 HIS B1081  HOH Y 312  HOH Y 314
SITE     1 CC1  1 HIS A1081
SITE     1 CC2  1 HIS B1081
SITE     1 CC3  4 ALA B 933  HOH Y 177  HOH Y 178  HOH Z 173
SITE     1 CC4  5 HIS B1076  HOH Y 299  HOH Y 303  HOH Y 304
SITE     2 CC4  5 HOH Y 306
SITE     1 CC5  6 HIS A1076  HOH Z 141  HOH Z 292  HOH Z 293
SITE     2 CC5  6 HOH Z 296  HOH Z 298
SITE     1 CC6  6 GLU A 926  TYR A 929  HOH Z 171  HOH Z 176
SITE     2 CC6  6 HOH Z 181  HOH Z 182
SITE     1 CC7  6 HOH Y 171  HOH Y 334  HOH Z 171  HOH Z 176
SITE     2 CC7  6 HOH Z 181  HOH Z 184
CRYST1   64.933  108.631  112.969  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015400  0.000000  0.000000        0.00000
SCALE2      0.000000  0.009205  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008852        0.00000
MASTER      580    0   25   22   16    0   46    6 5458    2  146   46
END