longtext: 1WOM-pdb

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HEADER    SIGNALING PROTEIN                       21-AUG-04   1WOM
TITLE     CRYSTAL STRUCTURE OF RSBQ
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: SIGMA FACTOR SIGB REGULATION PROTEIN RSBQ;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: RESIDUES 5-269;
COMPND   5 SYNONYM: RSBQ;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;
SOURCE   3 ORGANISM_COMMON: BACTERIA;
SOURCE   4 GENE: RSBQ;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_COMMON: BACTERIA;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: ER2566;
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PTYB12
KEYWDS    ALPHA/BETA HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    T.KANEKO,T.KUMASAKA,N.TANAKA
REVDAT   1   01-FEB-05 1WOM    0
JRNL        AUTH   T.KANEKO,N.TANAKA,T.KUMASAKA
JRNL        TITL   CRYSTAL STRUCTURES OF RSBQ, A STRESS-RESPONSE
JRNL        TITL 2 REGULATOR IN BACILLUS SUBTILIS
JRNL        REF    PROTEIN SCI.                  V.  14   558 2005
JRNL        REFN   ASTM PRCIEI  US ISSN 0961-8368
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.50 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.1
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 31.23
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 1707875.880
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 99.4
REMARK   3   NUMBER OF REFLECTIONS             : 30951
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.217
REMARK   3   FREE R VALUE                     : 0.262
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 1519
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.007
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 6
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.50
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.66
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 100.00
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 4877
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2630
REMARK   3   BIN FREE R VALUE                    : 0.3050
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 4.30
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 218
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.021
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4213
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 67
REMARK   3   SOLVENT ATOMS            : 148
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 47.40
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 51.10
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -8.17000
REMARK   3    B22 (A**2) : 16.27000
REMARK   3    B33 (A**2) : -8.10000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.31
REMARK   3   ESD FROM SIGMAA              (A) : 0.32
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.39
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.36
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.006
REMARK   3   BOND ANGLES            (DEGREES) : 1.20
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 22.60
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.80
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.330 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 2.240 ; 2.000
REMARK   3   SIDE-CHAIN BOND              (A**2) : 2.070 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 3.050 ; 2.500
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : FLAT MODEL
REMARK   3   KSOL        : 0.34
REMARK   3   BSOL        : 44.76
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM
REMARK   3  PARAMETER FILE  2  : WATER_REP.PARAM
REMARK   3  PARAMETER FILE  3  : MLA.PARAM
REMARK   3  PARAMETER FILE  4  : PGQ.PARAM
REMARK   3  PARAMETER FILE  5  : NULL
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP
REMARK   3  TOPOLOGY FILE  2   : PROST.TOP
REMARK   3  TOPOLOGY FILE  3   : NULL
REMARK   3  TOPOLOGY FILE  4   : NULL
REMARK   3  TOPOLOGY FILE  5   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 1WOM COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 24-AUG-2004.
REMARK 100 THE RCSB ID CODE IS RCSB023819.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-MAR-2004
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL38B1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00
REMARK 200  MONOCHROMATOR                  : GRAPHITE
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : CRYSTALCLEAR 1.35
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 31002
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500
REMARK 200  RESOLUTION RANGE LOW       (A) : 31.230
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.59
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 65.10
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.50
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM MALONIC ACID, VAPOR
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   1/2-X,-Y,1/2+Z
REMARK 290       3555   -X,1/2+Y,1/2-Z
REMARK 290       4555   1/2+X,1/2-Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       38.75400
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       68.67950
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       41.20200
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       68.67950
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       38.75400
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       41.20200
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   2  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ALA B    -1
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     MET A   2    CG    SD    CE
REMARK 470     HIS A  57    CG    ND1   CD2   CE1   NE2
REMARK 470     SER A  58    OG
REMARK 470     ARG A  61    CG    CD    NE    CZ    NH1   NH2
REMARK 470     MET B   2    CG    SD    CE
REMARK 470     ASP B  59    CG    OD1   OD2
REMARK 470     ARG B  61    CG    CD    NE    CZ    NH1   NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    MET A  22   SD    MET A  22   CE    -0.066
REMARK 500    MET A 148   SD    MET A 148   CE    -0.042
REMARK 500    MET A 251   CG    MET A 251   SD     0.050
REMARK 500    GLY B   0   N     GLY B   0   CA     0.051
REMARK 500    MET B 251   CG    MET B 251   SD     0.040
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    GLY A   0   N   -  CA  -  C   ANGL. DEV. = -8.7 DEGREES
REMARK 500    HIS A   1   N   -  CA  -  C   ANGL. DEV. =  7.7 DEGREES
REMARK 500    ALA A  38   N   -  CA  -  C   ANGL. DEV. =  7.3 DEGREES
REMARK 500    ARG A  46   N   -  CA  -  C   ANGL. DEV. =-12.8 DEGREES
REMARK 500    TYR A  52   N   -  CA  -  C   ANGL. DEV. =-11.0 DEGREES
REMARK 500    VAL A  91   N   -  CA  -  C   ANGL. DEV. = -9.7 DEGREES
REMARK 500    GLU A 137   N   -  CA  -  C   ANGL. DEV. = -8.5 DEGREES
REMARK 500    HIS A 233   N   -  CA  -  C   ANGL. DEV. =  7.6 DEGREES
REMARK 500    LEU A 234   CA  -  CB  -  CG  ANGL. DEV. =  8.0 DEGREES
REMARK 500    LEU A 234   N   -  CA  -  C   ANGL. DEV. = -8.4 DEGREES
REMARK 500    PRO A 235   N   -  CA  -  C   ANGL. DEV. =  7.9 DEGREES
REMARK 500    ARG B  46   N   -  CA  -  C   ANGL. DEV. =-12.5 DEGREES
REMARK 500    VAL B  91   N   -  CA  -  C   ANGL. DEV. = -7.9 DEGREES
REMARK 525
REMARK 525 SOLVENT
REMARK 525 THE FOLLOWING SOLVENT MOLECULES LIE FARTHER THAN EXPECTED
REMARK 525 FROM THE PROTEIN OR NUCLEIC ACID MOLECULE AND MAY BE
REMARK 525 ASSOCIATED WITH A SYMMETRY RELATED MOLECULE (M=MODEL
REMARK 525 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH    85        DISTANCE =  5.46 ANGSTROMS
REMARK 525    HOH    89        DISTANCE =  5.72 ANGSTROMS
REMARK 525    HOH   122        DISTANCE =  5.22 ANGSTROMS
REMARK 525    HOH   126        DISTANCE =  5.89 ANGSTROMS
REMARK 525    HOH   140        DISTANCE =  5.72 ANGSTROMS
REMARK 525    HOH   147        DISTANCE =  5.02 ANGSTROMS
DBREF  1WOM A    5   269  SWS    O07015   RSBQ_BACSU       5    269
DBREF  1WOM B    5   269  SWS    O07015   RSBQ_BACSU       5    269
SEQADV 1WOM ALA A   -1  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM GLY A    0  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM HIS A    1  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM MET A    2  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM THR A    3  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM SER A    4  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM ALA B   -1  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM GLY B    0  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM HIS B    1  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM MET B    2  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM THR B    3  SWS  O07015              CLONING ARTIFACT
SEQADV 1WOM SER B    4  SWS  O07015              CLONING ARTIFACT
SEQRES   1 A  271  ALA GLY HIS MET THR SER ILE LEU SER ARG ASN HIS VAL
SEQRES   2 A  271  LYS VAL LYS GLY SER GLY LYS ALA SER ILE MET PHE ALA
SEQRES   3 A  271  PRO GLY PHE GLY CYS ASP GLN SER VAL TRP ASN ALA VAL
SEQRES   4 A  271  ALA PRO ALA PHE GLU GLU ASP HIS ARG VAL ILE LEU PHE
SEQRES   5 A  271  ASP TYR VAL GLY SER GLY HIS SER ASP LEU ARG ALA TYR
SEQRES   6 A  271  ASP LEU ASN ARG TYR GLN THR LEU ASP GLY TYR ALA GLN
SEQRES   7 A  271  ASP VAL LEU ASP VAL CYS GLU ALA LEU ASP LEU LYS GLU
SEQRES   8 A  271  THR VAL PHE VAL GLY HIS SER VAL GLY ALA LEU ILE GLY
SEQRES   9 A  271  MET LEU ALA SER ILE ARG ARG PRO GLU LEU PHE SER HIS
SEQRES  10 A  271  LEU VAL MET VAL GLY PRO SER PRO CYS TYR LEU ASN ASP
SEQRES  11 A  271  PRO PRO GLU TYR TYR GLY GLY PHE GLU GLU GLU GLN LEU
SEQRES  12 A  271  LEU GLY LEU LEU GLU MET MET GLU LYS ASN TYR ILE GLY
SEQRES  13 A  271  TRP ALA THR VAL PHE ALA ALA THR VAL LEU ASN GLN PRO
SEQRES  14 A  271  ASP ARG PRO GLU ILE LYS GLU GLU LEU GLU SER ARG PHE
SEQRES  15 A  271  CYS SER THR ASP PRO VAL ILE ALA ARG GLN PHE ALA LYS
SEQRES  16 A  271  ALA ALA PHE PHE SER ASP HIS ARG GLU ASP LEU SER LYS
SEQRES  17 A  271  VAL THR VAL PRO SER LEU ILE LEU GLN CYS ALA ASP ASP
SEQRES  18 A  271  ILE ILE ALA PRO ALA THR VAL GLY LYS TYR MET HIS GLN
SEQRES  19 A  271  HIS LEU PRO TYR SER SER LEU LYS GLN MET GLU ALA ARG
SEQRES  20 A  271  GLY HIS CYS PRO HIS MET SER HIS PRO ASP GLU THR ILE
SEQRES  21 A  271  GLN LEU ILE GLY ASP TYR LEU LYS ALA HIS VAL
SEQRES   1 B  271  ALA GLY HIS MET THR SER ILE LEU SER ARG ASN HIS VAL
SEQRES   2 B  271  LYS VAL LYS GLY SER GLY LYS ALA SER ILE MET PHE ALA
SEQRES   3 B  271  PRO GLY PHE GLY CYS ASP GLN SER VAL TRP ASN ALA VAL
SEQRES   4 B  271  ALA PRO ALA PHE GLU GLU ASP HIS ARG VAL ILE LEU PHE
SEQRES   5 B  271  ASP TYR VAL GLY SER GLY HIS SER ASP LEU ARG ALA TYR
SEQRES   6 B  271  ASP LEU ASN ARG TYR GLN THR LEU ASP GLY TYR ALA GLN
SEQRES   7 B  271  ASP VAL LEU ASP VAL CYS GLU ALA LEU ASP LEU LYS GLU
SEQRES   8 B  271  THR VAL PHE VAL GLY HIS SER VAL GLY ALA LEU ILE GLY
SEQRES   9 B  271  MET LEU ALA SER ILE ARG ARG PRO GLU LEU PHE SER HIS
SEQRES  10 B  271  LEU VAL MET VAL GLY PRO SER PRO CYS TYR LEU ASN ASP
SEQRES  11 B  271  PRO PRO GLU TYR TYR GLY GLY PHE GLU GLU GLU GLN LEU
SEQRES  12 B  271  LEU GLY LEU LEU GLU MET MET GLU LYS ASN TYR ILE GLY
SEQRES  13 B  271  TRP ALA THR VAL PHE ALA ALA THR VAL LEU ASN GLN PRO
SEQRES  14 B  271  ASP ARG PRO GLU ILE LYS GLU GLU LEU GLU SER ARG PHE
SEQRES  15 B  271  CYS SER THR ASP PRO VAL ILE ALA ARG GLN PHE ALA LYS
SEQRES  16 B  271  ALA ALA PHE PHE SER ASP HIS ARG GLU ASP LEU SER LYS
SEQRES  17 B  271  VAL THR VAL PRO SER LEU ILE LEU GLN CYS ALA ASP ASP
SEQRES  18 B  271  ILE ILE ALA PRO ALA THR VAL GLY LYS TYR MET HIS GLN
SEQRES  19 B  271  HIS LEU PRO TYR SER SER LEU LYS GLN MET GLU ALA ARG
SEQRES  20 B  271  GLY HIS CYS PRO HIS MET SER HIS PRO ASP GLU THR ILE
SEQRES  21 B  271  GLN LEU ILE GLY ASP TYR LEU LYS ALA HIS VAL
HET    MLA    501       7
HET    PGQ    601       5
HET    PGQ    602       5
HET    PGQ    603       5
HET    PGQ    604       5
HET    PGQ    605       5
HET    PGQ    606       5
HET    PGQ    607       5
HET    PGQ    608       5
HET    PGQ    609       5
HET    PGQ    610       5
HET    PGQ    611       5
HET    PGQ    612       5
HETNAM     MLA MALONIC ACID
HETNAM     PGQ S-1,2-PROPANEDIOL
HETSYN     MLA DICARBOXYLIC ACID C3; PROPANEDIOLIC ACID;
HETSYN   2 MLA  METAHNEDICARBOXYLIC ACID
FORMUL   3  MLA    C3 H4 O4
FORMUL   4  PGQ    12(C3 H8 O2)
FORMUL  16  HOH   *148(H2 O1)
HELIX    1   1 GLY A    0  ASN A    9  1                                  10
HELIX    2   2 ASP A   30  ASN A   35  5                                   6
HELIX    3   3 VAL A   37  GLU A   42  5                                   6
HELIX    4   4 ASN A   66  GLN A   69  5                                   4
HELIX    5   5 THR A   70  LEU A   85  1                                  16
HELIX    6   6 SER A   96  ARG A  109  1                                  14
HELIX    7   7 GLU A  137  ASN A  151  1                                  15
HELIX    8   8 ASN A  151  ASN A  165  1                                  15
HELIX    9   9 ARG A  169  THR A  183  1                                  15
HELIX   10  10 ASP A  184  PHE A  197  1                                  14
HELIX   11  11 HIS A  200  VAL A  207  5                                   8
HELIX   12  12 PRO A  223  LEU A  234  1                                  12
HELIX   13  13 CYS A  248  HIS A  253  1                                   6
HELIX   14  14 HIS A  253  VAL A  269  1                                  17
HELIX   15  15 HIS B    1  ASN B    9  1                                   9
HELIX   16  16 ASP B   30  ASN B   35  5                                   6
HELIX   17  17 VAL B   37  GLU B   42  5                                   6
HELIX   18  18 SER B   58  TYR B   63  5                                   6
HELIX   19  19 ASN B   66  GLN B   69  5                                   4
HELIX   20  20 THR B   70  LEU B   85  1                                  16
HELIX   21  21 SER B   96  ARG B  109  1                                  14
HELIX   22  22 GLU B  137  ASN B  151  1                                  15
HELIX   23  23 ASN B  151  ASN B  165  1                                  15
HELIX   24  24 ARG B  169  CYS B  181  1                                  13
HELIX   25  25 ASP B  184  PHE B  197  1                                  14
HELIX   26  26 ARG B  201  VAL B  207  5                                   7
HELIX   27  27 PRO B  223  LEU B  234  1                                  12
HELIX   28  28 CYS B  248  HIS B  253  1                                   6
HELIX   29  29 HIS B  253  ALA B  267  1                                  15
SHEET    1   A 7 LYS A  12  GLY A  15  0
SHEET    2   A 7 ARG A  46  LEU A  49 -1  O  VAL A  47   N  LYS A  14
SHEET    3   A 7 SER A  20  ALA A  24  1  N  ILE A  21   O  ILE A  48
SHEET    4   A 7 THR A  90  HIS A  95  1  O  VAL A  93   N  MET A  22
SHEET    5   A 7 PHE A 113  VAL A 119  1  O  VAL A 117   N  PHE A  92
SHEET    6   A 7 SER A 211  ALA A 217  1  O  LEU A 212   N  MET A 118
SHEET    7   A 7 SER A 237  ARG A 245  1  O  MET A 242   N  GLN A 215
SHEET    1   B 2 ASN A 127  ASP A 128  0
SHEET    2   B 2 TYR A 132  TYR A 133 -1  O  TYR A 132   N  ASP A 128
SHEET    1   C 7 LYS B  12  GLY B  15  0
SHEET    2   C 7 HIS B  45  LEU B  49 -1  O  VAL B  47   N  LYS B  14
SHEET    3   C 7 ALA B  19  ALA B  24  1  N  ILE B  21   O  ILE B  48
SHEET    4   C 7 THR B  90  HIS B  95  1  O  VAL B  93   N  MET B  22
SHEET    5   C 7 PHE B 113  VAL B 119  1  O  VAL B 117   N  GLY B  94
SHEET    6   C 7 SER B 211  ALA B 217  1  O  LEU B 212   N  MET B 118
SHEET    7   C 7 SER B 238  ARG B 245  1  O  SER B 238   N  ILE B 213
SHEET    1   D 2 ASN B 127  ASP B 128  0
SHEET    2   D 2 TYR B 132  TYR B 133 -1  O  TYR B 132   N  ASP B 128
CISPEP   1 PRO A  129    PRO A  130          0         0.02
CISPEP   2 PRO B  129    PRO B  130          0        -0.08
CRYST1   77.508   82.404  137.359  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012902  0.000000  0.000000        0.00000
SCALE2      0.000000  0.012135  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007280        0.00000
TER    2111      VAL A 269
TER    4215      VAL B 269
MASTER      304    0   13   29   18    0    0    6 4428    2   67   42
END